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Phosphoenolpyruvate carboxykinase [GTP] (PEP carboxykinase) (PEPCK) (EC 4.1.1.32) (GTP-dependent phosphoenolpyruvate carboxykinase) (GTP-PEPCK)

 W0ZDW1_9MICO            Unreviewed;       620 AA.
W0ZDW1;
19-MAR-2014, integrated into UniProtKB/TrEMBL.
19-MAR-2014, sequence version 1.
27-SEP-2017, entry version 24.
RecName: Full=Phosphoenolpyruvate carboxykinase [GTP] {ECO:0000256|HAMAP-Rule:MF_00452};
Short=PEP carboxykinase {ECO:0000256|HAMAP-Rule:MF_00452};
Short=PEPCK {ECO:0000256|HAMAP-Rule:MF_00452};
EC=4.1.1.32 {ECO:0000256|HAMAP-Rule:MF_00452};
AltName: Full=GTP-dependent phosphoenolpyruvate carboxykinase {ECO:0000256|HAMAP-Rule:MF_00452};
Short=GTP-PEPCK {ECO:0000256|HAMAP-Rule:MF_00452};
Name=pckG {ECO:0000256|HAMAP-Rule:MF_00452,
ECO:0000313|EMBL:CDK01432.1};
ORFNames=MIC448_620008 {ECO:0000313|EMBL:CDK01432.1};
Microbacterium sp. C448.
Bacteria; Actinobacteria; Micrococcales; Microbacteriaceae;
Microbacterium.
NCBI_TaxID=1177594 {ECO:0000313|EMBL:CDK01432.1, ECO:0000313|Proteomes:UP000028883};
[1] {ECO:0000313|EMBL:CDK01432.1, ECO:0000313|Proteomes:UP000028883}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=C448 {ECO:0000313|EMBL:CDK01432.1,
ECO:0000313|Proteomes:UP000028883};
PubMed=24526651; DOI=10.1128/genomeA.01113-13;
Martin-Laurent F., Marti R., Waglechner N., Wright G.D., Topp E.;
"Draft Genome Sequence of the Sulfonamide Antibiotic-Degrading
Microbacterium sp. Strain C448.";
Genome Announc. Announc.2:e01113-e01113(2014).
-!- FUNCTION: Catalyzes the conversion of oxaloacetate (OAA) to
phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic
pathway that produces glucose from lactate and other precursors
derived from the citric acid cycle. {ECO:0000256|HAMAP-
Rule:MF_00452}.
-!- CATALYTIC ACTIVITY: GTP + oxaloacetate = GDP + phosphoenolpyruvate
+ CO(2). {ECO:0000256|HAMAP-Rule:MF_00452}.
-!- COFACTOR:
Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
Evidence={ECO:0000256|HAMAP-Rule:MF_00452};
Note=Binds 1 Mn(2+) ion per subunit. {ECO:0000256|HAMAP-
Rule:MF_00452};
-!- PATHWAY: Carbohydrate biosynthesis; gluconeogenesis.
{ECO:0000256|HAMAP-Rule:MF_00452}.
-!- SUBUNIT: Monomer. {ECO:0000256|HAMAP-Rule:MF_00452}.
-!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00452}.
-!- SIMILARITY: Belongs to the phosphoenolpyruvate carboxykinase [GTP]
family. {ECO:0000256|HAMAP-Rule:MF_00452}.
-!- CAUTION: The sequence shown here is derived from an
EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
preliminary data. {ECO:0000313|EMBL:CDK01432.1}.
-----------------------------------------------------------------------
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EMBL; CBVQ010000228; CDK01432.1; -; Genomic_DNA.
EnsemblBacteria; CDK01432; CDK01432; MIC448_620008.
UniPathway; UPA00138; -.
Proteomes; UP000028883; Unassembled WGS sequence.
GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO; GO:0005525; F:GTP binding; IEA:UniProtKB-UniRule.
GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
GO; GO:0030145; F:manganese ion binding; IEA:UniProtKB-UniRule.
GO; GO:0004613; F:phosphoenolpyruvate carboxykinase (GTP) activity; IEA:UniProtKB-UniRule.
GO; GO:0006094; P:gluconeogenesis; IEA:UniProtKB-UniRule.
CDD; cd00819; PEPCK_GTP; 1.
Gene3D; 3.40.449.10; -; 1.
Gene3D; 3.90.228.20; -; 2.
HAMAP; MF_00452; PEPCK_GTP; 1.
InterPro; IPR018091; PEP_carboxykin_GTP_CS.
InterPro; IPR013035; PEP_carboxykinase_C.
InterPro; IPR008209; PEP_carboxykinase_GTP.
InterPro; IPR035077; PEP_carboxykinase_GTP_C.
InterPro; IPR035078; PEP_carboxykinase_GTP_N.
InterPro; IPR008210; PEP_carboxykinase_N.
PANTHER; PTHR11561; PTHR11561; 1.
Pfam; PF00821; PEPCK_C; 1.
Pfam; PF17297; PEPCK_N; 1.
PIRSF; PIRSF001348; PEP_carboxykinase_GTP; 1.
SUPFAM; SSF68923; SSF68923; 1.
PROSITE; PS00505; PEPCK_GTP; 1.
3: Inferred from homology;
Complete proteome {ECO:0000313|Proteomes:UP000028883};
Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00452};
Decarboxylase {ECO:0000256|HAMAP-Rule:MF_00452,
ECO:0000256|SAAS:SAAS00647546};
Gluconeogenesis {ECO:0000256|HAMAP-Rule:MF_00452};
GTP-binding {ECO:0000256|HAMAP-Rule:MF_00452};
Kinase {ECO:0000313|EMBL:CDK01432.1};
Lyase {ECO:0000256|HAMAP-Rule:MF_00452,
ECO:0000256|SAAS:SAAS00647546};
Manganese {ECO:0000256|HAMAP-Rule:MF_00452};
Metal-binding {ECO:0000256|HAMAP-Rule:MF_00452};
Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00452};
Pyruvate {ECO:0000313|EMBL:CDK01432.1};
Reference proteome {ECO:0000313|Proteomes:UP000028883};
Transferase {ECO:0000313|EMBL:CDK01432.1}.
DOMAIN 36 255 PEPCK_N. {ECO:0000259|Pfam:PF17297}.
DOMAIN 259 618 PEPCK_C. {ECO:0000259|Pfam:PF00821}.
NP_BIND 286 291 GTP. {ECO:0000256|HAMAP-Rule:MF_00452}.
NP_BIND 528 531 GTP. {ECO:0000256|HAMAP-Rule:MF_00452}.
REGION 234 236 Substrate binding. {ECO:0000256|HAMAP-
Rule:MF_00452}.
REGION 400 402 Substrate binding. {ECO:0000256|HAMAP-
Rule:MF_00452}.
ACT_SITE 287 287 {ECO:0000256|HAMAP-Rule:MF_00452}.
METAL 243 243 Manganese. {ECO:0000256|HAMAP-
Rule:MF_00452}.
METAL 263 263 Manganese; via tele nitrogen.
{ECO:0000256|HAMAP-Rule:MF_00452}.
METAL 310 310 Manganese. {ECO:0000256|HAMAP-
Rule:MF_00452}.
BINDING 95 95 Substrate. {ECO:0000256|HAMAP-
Rule:MF_00452}.
BINDING 285 285 Substrate. {ECO:0000256|HAMAP-
Rule:MF_00452}.
BINDING 402 402 GTP. {ECO:0000256|HAMAP-Rule:MF_00452}.
BINDING 433 433 GTP. {ECO:0000256|HAMAP-Rule:MF_00452}.
SEQUENCE 620 AA; 68025 MW; 200888BFE539569F CRC64;
MALAESLSTR IAVPRRVTDF GQRPADEAGL TELLAWVDEV AALTQPARVH WIDGSRAENE
ALLRQMVDDG TLIRLNPEWR PGSYLARSHP KDVARTEGRT FIASEREEDA GPTNNWADPT
EMRGTMSQIF SGSMRGRTMY VVPFSMGAVG GPLSHIGVQI TDSPYAVTSI GIMTRVGADV
TDLIANGAPW VRTVHSVGAP LAPGEKDVAW PCNDDKYIVH FPDTLEVWSY GSGYGGNAIL
AKKCFALRIA SVIGRDEGWL AEHMLLIRVI DPQGRKYHIA AAFPSACGKT NLAMLRPTIP
GWRVETLGDD IAWIRPGEDG RLWAINPEAG FFGVAPGTGE STNVTAVETL WGNTIFTNVA
LRPDGDVWWE GLTDEAPPHL TDWEGNPWTP ASGRPAAHPN SRFTVSAGQC PQIAPDWDAA
EGVPLDAILF GGRRATNVPL VVEATDWTHG VFIGSNISSE RTAAAEGTLG ELRRDPFAML
PFCGYNMADY FGHWLKVGQK LRFDRAPRIF QVNWFRRGAD GRFLWPGFGD NSRVIEWVVR
RIQGDVGAVD SPIGRLPRIE DLNLDGIDVP EADLEELFSV DPATWQAEAD NTEAFYATFE
GRVPAALQSE LSALRYRLRN


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