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Phosphoglycerate kinase (EC 2.7.2.3)

 PGK_DROME               Reviewed;         415 AA.
Q01604; A5XCG6; Q3KN29; Q9VQF6;
01-APR-1993, integrated into UniProtKB/Swiss-Prot.
01-JUN-2001, sequence version 2.
25-OCT-2017, entry version 138.
RecName: Full=Phosphoglycerate kinase;
EC=2.7.2.3;
Name=Pgk; ORFNames=CG3127;
Drosophila melanogaster (Fruit fly).
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha;
Ephydroidea; Drosophilidae; Drosophila; Sophophora.
NCBI_TaxID=7227;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=Oregon-R;
PubMed=1465095; DOI=10.1007/BF00279363;
Roselli-Rehfuss L., Ye F., Lissemore J.L., Sullivan D.T.;
"Structure and expression of the phosphoglycerate kinase (Pgk) gene of
Drosophila melanogaster.";
Mol. Gen. Genet. 235:213-220(1992).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT ALA-388.
STRAIN=DPF96_10, DPF96_26, DPF96_5.1, DPF96_8.3, HFL97_15e, HFL97_23e,
HFL97_3e2, HFL97_61e, HFL97_68e, MA96_24.2, MA96_26.4, MA96_3.5,
MA96_4.4, MA96_40.1, MA96_42.4, MA96_49.2, MA96_9.3, Z(H)_26e2,
Z(H)_28e2, Z(H)_36e2, Z(H)_38e2, Z(H)_44e2, Z(S)_11e2, Z(S)_28e2, and
Z(S)_49e2;
PubMed=17379620; DOI=10.1093/molbev/msm057;
Flowers J., Sezgin E., Kumagai S., Duvernell D., Matzkin L.,
Schmidt P., Eanes W.;
"Adaptive evolution of metabolic pathways in Drosophila.";
Mol. Biol. Evol. 24:1347-1354(2007).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Berkeley;
PubMed=10731132; DOI=10.1126/science.287.5461.2185;
Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X.,
Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D.,
Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G.,
Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D.,
Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M.,
Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S.,
Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P.,
Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I.,
Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P.,
de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M.,
Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P.,
Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W.,
Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K.,
Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J.,
Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C.,
Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A.,
Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z.,
Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X.,
Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D.,
Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A.,
Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L.,
Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M.,
Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G.,
Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H.,
Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
Spier E., Spradling A.C., Stapleton M., Strong R., Sun E.,
Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X.,
Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J.,
Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A.,
Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L.,
Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X.,
Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.;
"The genome sequence of Drosophila melanogaster.";
Science 287:2185-2195(2000).
[4]
GENOME REANNOTATION.
STRAIN=Berkeley;
PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q.,
Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M.,
Lewis S.E.;
"Annotation of the Drosophila melanogaster euchromatic genome: a
systematic review.";
Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=Berkeley; TISSUE=Head;
Stapleton M., Carlson J.W., Frise E., Kapadia B., Park S., Wan K.H.,
Yu C., Celniker S.E.;
Submitted (NOV-2006) to the EMBL/GenBank/DDBJ databases.
-!- CATALYTIC ACTIVITY: ATP + 3-phospho-D-glycerate = ADP + 3-phospho-
D-glyceroyl phosphate.
-!- PATHWAY: Carbohydrate degradation; glycolysis; pyruvate from D-
glyceraldehyde 3-phosphate: step 2/5.
-!- SUBUNIT: Monomer.
-!- SUBCELLULAR LOCATION: Cytoplasm.
-!- SIMILARITY: Belongs to the phosphoglycerate kinase family.
{ECO:0000305}.
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EMBL; Z14029; CAA78404.1; -; Genomic_DNA.
EMBL; DQ863952; ABH06587.1; -; Genomic_DNA.
EMBL; DQ863953; ABH06588.1; -; Genomic_DNA.
EMBL; DQ863954; ABH06589.1; -; Genomic_DNA.
EMBL; DQ863955; ABH06590.1; -; Genomic_DNA.
EMBL; DQ863956; ABH06591.1; -; Genomic_DNA.
EMBL; DQ863957; ABH06592.1; -; Genomic_DNA.
EMBL; DQ863958; ABH06593.1; -; Genomic_DNA.
EMBL; DQ863959; ABH06594.1; -; Genomic_DNA.
EMBL; DQ863960; ABH06595.1; -; Genomic_DNA.
EMBL; DQ863961; ABH06596.1; -; Genomic_DNA.
EMBL; DQ863962; ABH06597.1; -; Genomic_DNA.
EMBL; DQ863963; ABH06598.1; -; Genomic_DNA.
EMBL; DQ863964; ABH06599.1; -; Genomic_DNA.
EMBL; DQ863965; ABH06600.1; -; Genomic_DNA.
EMBL; DQ863966; ABH06601.1; -; Genomic_DNA.
EMBL; DQ863967; ABH06602.1; -; Genomic_DNA.
EMBL; DQ863968; ABH06603.1; -; Genomic_DNA.
EMBL; DQ863969; ABH06604.1; -; Genomic_DNA.
EMBL; DQ863970; ABH06605.1; -; Genomic_DNA.
EMBL; DQ863971; ABH06606.1; -; Genomic_DNA.
EMBL; DQ863972; ABH06607.1; -; Genomic_DNA.
EMBL; DQ863973; ABH06608.1; -; Genomic_DNA.
EMBL; DQ863974; ABH06609.1; -; Genomic_DNA.
EMBL; DQ863975; ABH06610.1; -; Genomic_DNA.
EMBL; DQ863976; ABH06611.1; -; Genomic_DNA.
EMBL; AE014134; AAF51218.1; -; Genomic_DNA.
EMBL; BT023910; ABA81844.1; -; mRNA.
PIR; S30111; KIFFPG.
RefSeq; NP_001259956.1; NM_001273027.1.
RefSeq; NP_001259957.1; NM_001273028.1.
RefSeq; NP_001259958.1; NM_001273029.1.
RefSeq; NP_001259959.1; NM_001273030.1.
RefSeq; NP_476676.1; NM_057328.4.
UniGene; Dm.6415; -.
ProteinModelPortal; Q01604; -.
SMR; Q01604; -.
BioGrid; 59686; 38.
IntAct; Q01604; 3.
STRING; 7227.FBpp0303562; -.
PaxDb; Q01604; -.
PRIDE; Q01604; -.
EnsemblMetazoa; FBtr0077739; FBpp0077419; FBgn0250906.
EnsemblMetazoa; FBtr0330716; FBpp0303560; FBgn0250906.
EnsemblMetazoa; FBtr0330717; FBpp0303561; FBgn0250906.
EnsemblMetazoa; FBtr0330718; FBpp0303562; FBgn0250906.
EnsemblMetazoa; FBtr0334162; FBpp0306279; FBgn0250906.
GeneID; 33461; -.
KEGG; dme:Dmel_CG3127; -.
CTD; 33461; -.
FlyBase; FBgn0250906; Pgk.
eggNOG; KOG1367; Eukaryota.
eggNOG; COG0126; LUCA.
GeneTree; ENSGT00390000008820; -.
HOGENOM; HOG000242304; -.
InParanoid; Q01604; -.
KO; K00927; -.
OMA; DMIFDIG; -.
OrthoDB; EOG091G08S6; -.
PhylomeDB; Q01604; -.
Reactome; R-DME-70171; Glycolysis.
Reactome; R-DME-70263; Gluconeogenesis.
UniPathway; UPA00109; UER00185.
GenomeRNAi; 33461; -.
PRO; PR:Q01604; -.
Proteomes; UP000000803; Chromosome 2L.
Bgee; FBgn0250906; -.
ExpressionAtlas; Q01604; differential.
Genevisible; Q01604; DM.
GO; GO:0031430; C:M band; IDA:FlyBase.
GO; GO:0030018; C:Z disc; IDA:FlyBase.
GO; GO:0005524; F:ATP binding; ISS:UniProtKB.
GO; GO:0004618; F:phosphoglycerate kinase activity; ISS:UniProtKB.
GO; GO:0007268; P:chemical synaptic transmission; IDA:FlyBase.
GO; GO:0006096; P:glycolytic process; ISS:FlyBase.
GO; GO:0046716; P:muscle cell cellular homeostasis; IGI:FlyBase.
GO; GO:0007520; P:myoblast fusion; IMP:FlyBase.
GO; GO:0016310; P:phosphorylation; ISS:UniProtKB.
GO; GO:0007525; P:somatic muscle development; IMP:FlyBase.
CDD; cd00318; Phosphoglycerate_kinase; 1.
Gene3D; 3.40.50.1260; -; 2.
HAMAP; MF_00145; Phosphoglyc_kinase; 1.
InterPro; IPR001576; Phosphoglycerate_kinase.
InterPro; IPR015911; Phosphoglycerate_kinase_CS.
InterPro; IPR015824; Phosphoglycerate_kinase_N.
InterPro; IPR036043; Phosphoglycerate_kinase_sf.
PANTHER; PTHR11406; PTHR11406; 1.
Pfam; PF00162; PGK; 1.
PIRSF; PIRSF000724; Pgk; 1.
PRINTS; PR00477; PHGLYCKINASE.
SUPFAM; SSF53748; SSF53748; 1.
PROSITE; PS00111; PGLYCERATE_KINASE; 1.
2: Evidence at transcript level;
ATP-binding; Complete proteome; Cytoplasm; Glycolysis; Kinase;
Nucleotide-binding; Reference proteome; Transferase.
CHAIN 1 415 Phosphoglycerate kinase.
/FTId=PRO_0000145843.
NP_BIND 371 374 ATP. {ECO:0000250}.
REGION 23 25 Substrate binding. {ECO:0000250}.
REGION 62 65 Substrate binding. {ECO:0000250}.
BINDING 38 38 Substrate. {ECO:0000250}.
BINDING 121 121 Substrate. {ECO:0000250}.
BINDING 169 169 Substrate. {ECO:0000250}.
BINDING 218 218 ATP. {ECO:0000250}.
BINDING 311 311 ATP; via carbonyl oxygen. {ECO:0000250}.
BINDING 342 342 ATP. {ECO:0000250}.
VARIANT 388 388 S -> A (in strain: HFL97_3e2).
{ECO:0000269|PubMed:17379620}.
CONFLICT 410 410 A -> R (in Ref. 1; CAA78404).
{ECO:0000305}.
SEQUENCE 415 AA; 43862 MW; 7D1225FCC81F8B42 CRC64;
MAFNKLSIEN LDLAGKRVLM RVDFNVPIKE GKITSNQRIV AALDSIKLAL SKKAKSVVLM
SHLGRPDGNK NIKYTLAPVA AELKTLLGQD VIFLSDCVGS EVEAACKDPA PGSVILLENV
RFYVEEEGKG LDASGGKVKA DPAKVKEFRA SLAKLGDVYV NDAFGTAHRA HSSMMGDGFE
QRAAGLLLNK ELKYFSQALD KPPNPFLAIL GGAKVADKIQ LIENLLDKVN EMIIGGGMAF
TFLKVLNNMK IGGSLFDEEG SKIVEKLVEK AKKNNVQLHL PVDFVCGDKF AENAAVSEAT
VEAGIPDGHM GLDVGPKTRE LFAAPIARAK LIVWNGPPGV FEFPNFANGT KSIMDGVVAA
TKNGTVSIIG GGDTASCCAK WNTEALVSHV STGGGASLEL LEGKTLPGVA ALTSA


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