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Phosphoinositide 3-kinase adapter protein 1 (B-cell adapter for phosphoinositide 3-kinase) (B-cell phosphoinositide 3-kinase adapter protein 1)

 BCAP_MOUSE              Reviewed;         811 AA.
Q9EQ32; Q2KHL6; Q3TBW6; Q3TC39; Q3U5J3; Q8BN25; Q8C2Y4;
10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
01-MAR-2001, sequence version 1.
25-OCT-2017, entry version 108.
RecName: Full=Phosphoinositide 3-kinase adapter protein 1;
AltName: Full=B-cell adapter for phosphoinositide 3-kinase;
AltName: Full=B-cell phosphoinositide 3-kinase adapter protein 1;
Name=Pik3ap1; Synonyms=Bcap;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY,
INTERACTION WITH PIK3R1, AND PHOSPHORYLATION AT TYR-264; TYR-420;
TYR-445 AND TYR-460.
PubMed=11163197; DOI=10.1016/S1074-7613(00)00079-0;
Okada T., Maeda A., Iwamatsu A., Gotoh K., Kurosaki T.;
"BCAP: the tyrosine kinase substrate that connects B cell receptor to
phosphoinositide 3-kinase activation.";
Immunity 13:817-827(2000).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3).
STRAIN=C57BL/6J, and NOD; TISSUE=Bone marrow, Ovary, and Spleen;
PubMed=16141072; DOI=10.1126/science.1112014;
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M.,
Davis M.J., Wilming L.G., Aidinis V., Allen J.E.,
Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L.,
Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M.,
Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R.,
Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G.,
di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G.,
Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M.,
Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N.,
Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T.,
Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H.,
Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K.,
Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J.,
Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L.,
Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K.,
Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P.,
Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O.,
Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G.,
Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M.,
Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B.,
Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K.,
Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A.,
Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K.,
Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C.,
Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J.,
Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y.,
Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T.,
Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N.,
Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N.,
Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S.,
Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J.,
Hayashizaki Y.;
"The transcriptional landscape of the mammalian genome.";
Science 309:1559-1563(2005).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[4]
FUNCTION, AND TYROSINE PHOSPHORYLATION (ISOFORMS 1 AND 2).
PubMed=11781242; DOI=10.1182/blood.V99.2.584;
Inabe K., Kurosaki T.;
"Tyrosine phosphorylation of B-cell adaptor for phosphoinositide 3-
kinase is required for Akt activation in response to CD19
engagement.";
Blood 99:584-589(2002).
[5]
FUNCTION, AND DISRUPTION PHENOTYPE.
PubMed=11877477; DOI=10.1084/jem.20011751;
Yamazaki T., Takeda K., Gotoh K., Takeshima H., Akira S., Kurosaki T.;
"Essential immunoregulatory role for BCAP in B cell development and
function.";
J. Exp. Med. 195:535-545(2002).
[6]
HOMOOLIGOMERIZATION, AND DBB DOMAIN.
PubMed=12767830; DOI=10.1016/S0022-2836(03)00489-3;
Battersby A., Csiszar A., Leptin M., Wilson R.;
"Isolation of proteins that interact with the signal transduction
molecule Dof and identification of a functional domain conserved
between Dof and vertebrate BCAP.";
J. Mol. Biol. 329:479-493(2003).
[7]
FUNCTION.
PubMed=12833156; DOI=10.1038/ni949;
Yamazaki T., Kurosaki T.;
"Contribution of BCAP to maintenance of mature B cells through c-
Rel.";
Nat. Immunol. 4:780-786(2003).
[8]
FUNCTION, INTERACTION WITH PIK3R1, PHOSPHORYLATION AT TYR-264;
TYR-420; TYR-445 AND TYR-460, MUTAGENESIS OF TYR-264; TYR-420; TYR-445
AND TYR-460, AND DISRUPTION PHENOTYPE.
PubMed=18025150; DOI=10.1182/blood-2007-08-109769;
Aiba Y., Kameyama M., Yamazaki T., Tedder T.F., Kurosaki T.;
"Regulation of B-cell development by BCAP and CD19 through their
binding to phosphoinositide 3-kinase.";
Blood 111:1497-1503(2008).
[9]
FUNCTION, TISSUE SPECIFICITY, AND DISRUPTION PHENOTYPE.
PubMed=18337558; DOI=10.1182/blood-2007-08-107847;
Macfarlane A.W. IV, Yamazaki T., Fang M., Sigal L.J., Kurosaki T.,
Campbell K.S.;
"Enhanced NK cell development and function in BCAP-deficient mice.";
Blood 112:131-140(2008).
[10]
FUNCTION IN TOLL-LIKE RECEPTOR SIGNALING (ISOFORMS 1 AND 2), AND
PHOSPHORYLATION AT TYR-420; TYR-445 AND TYR-460 BY SYK.
PubMed=20728433; DOI=10.1016/j.bbrc.2010.08.055;
Matsumura T., Oyama M., Kozuka-Hata H., Ishikawa K., Inoue T.,
Muta T., Semba K., Inoue J.;
"Identification of BCAP-(L) as a negative regulator of the TLR
signaling-induced production of IL-6 and IL-10 in macrophages by
tyrosine phosphoproteomics.";
Biochem. Biophys. Res. Commun. 400:265-270(2010).
[11]
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Liver, Lung, Pancreas, and Spleen;
PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
"A tissue-specific atlas of mouse protein phosphorylation and
expression.";
Cell 143:1174-1189(2010).
[12]
FUNCTION IN TOLL-LIKE RECEPTOR SIGNALING, DISRUPTION PHENOTYPE,
PHOSPHORYLATION, AND SUBCELLULAR LOCATION.
PubMed=22187458; DOI=10.1073/pnas.1111957108;
Ni M., MacFarlane A.W. IV, Toft M., Lowell C.A., Campbell K.S.,
Hamerman J.A.;
"B-cell adaptor for PI3K (BCAP) negatively regulates Toll-like
receptor signaling through activation of PI3K.";
Proc. Natl. Acad. Sci. U.S.A. 109:267-272(2012).
[13]
FUNCTION IN TOLL-LIKE RECEPTOR SIGNALING, INTERACTION WITH MYD88 AND
TIRAP, AND PHOSPHORYLATION.
PubMed=22187460; DOI=10.1073/pnas.1118579109;
Troutman T.D., Hu W., Fulenchek S., Yamazaki T., Kurosaki T.,
Bazan J.F., Pasare C.;
"Role for B-cell adapter for PI3K (BCAP) as a signaling adapter
linking Toll-like receptors (TLRs) to serine/threonine kinases
PI3K/Akt.";
Proc. Natl. Acad. Sci. U.S.A. 109:273-278(2012).
-!- FUNCTION: Signaling adapter that contributes to B-cell development
by linking B-cell receptor (BCR) signaling to the phosphoinositide
3-kinase (PI3K)-Akt signaling pathway. Has a complementary role to
the BCR coreceptor CD19, coupling BCR and PI3K activation by
providing a docking site for the PI3K subunit PIK3R1.
Alternatively, links Toll-like receptor (TLR) signaling to PI3K
activation, a process preventing excessive inflammatory cytokine
production. Also involved in the activation of PI3K in natural
killer cells. May be involved in the survival of mature B-cells
via activation of REL. {ECO:0000269|PubMed:11781242,
ECO:0000269|PubMed:11877477, ECO:0000269|PubMed:12833156,
ECO:0000269|PubMed:18025150, ECO:0000269|PubMed:18337558,
ECO:0000269|PubMed:22187458, ECO:0000269|PubMed:22187460}.
-!- SUBUNIT: Homooligomer (Probable). Interacts (phosphorylated on
tyrosine residues within YXXM motifs) with PIK3R1 (via SH2
domain); required for BCR- and TLR-mediated activation of
phosphoinositide 3-kinase. Interacts (via polyproline C-terminal
region) with ABI1 (via SH3 domain); the interaction promotes
phosphorylation of PIK3AP1 by ABL1 (By similarity). May interact
with MYD88 and TIRAP. {ECO:0000250, ECO:0000269|PubMed:11163197,
ECO:0000269|PubMed:18025150, ECO:0000269|PubMed:22187460,
ECO:0000305}.
-!- INTERACTION:
Self; NbExp=3; IntAct=EBI-643949, EBI-643949;
P22366:Myd88; NbExp=2; IntAct=EBI-643949, EBI-525108;
Q99JY1:Tirap; NbExp=2; IntAct=EBI-643949, EBI-6559589;
-!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:22187458}.
Cell membrane {ECO:0000305|PubMed:22187458}; Peripheral membrane
protein {ECO:0000305|PubMed:22187458}.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=3;
Name=1; Synonyms=BCAP-L;
IsoId=Q9EQ32-1; Sequence=Displayed;
Name=2; Synonyms=BCAP-S;
IsoId=Q9EQ32-2; Sequence=VSP_034241;
Name=3;
IsoId=Q9EQ32-3; Sequence=VSP_034242, VSP_034243;
-!- TISSUE SPECIFICITY: Predominantly expressed in spleen (at protein
level). Expressed at lower levels in thymus, liver and lung.
Expressed in B-cells, macrophages and natural killer (NK) cells.
{ECO:0000269|PubMed:11163197, ECO:0000269|PubMed:18337558}.
-!- DOMAIN: The DBB domain is required for dimerization.
-!- PTM: Constitutively phosphorylated. Phosphorylated on tyrosine
residues in C-terminal region by ABL1 (By similarity).
Phosphorylated on tyrosine residues within the YXXM motifs by BTK
and SYK. Isoform 1 and isoform 2 are phosphorylated on tyrosine
residues, most likely within the YXXM motifs, via CD19 activation.
Toll-like receptor activation induces appearance of a
phosphorylated form associated with membranes. {ECO:0000250,
ECO:0000269|PubMed:11163197, ECO:0000269|PubMed:18025150,
ECO:0000269|PubMed:20728433, ECO:0000269|PubMed:22187458,
ECO:0000269|PubMed:22187460}.
-!- DISRUPTION PHENOTYPE: Mice lacking Pik3ap1 display altered B-cell
maturation and impaired immune function. Pik3ap1 depletion has an
opposite effect in NK cells by promoting their maturation. Mice
lacking Pik3ap1 and Cd19 have severe defects in generation of
immature and mature B-cells. Moreover, mice lacking Pik3ap1
display increased IL-10, Il-12 and TNF proinflammatory cytokine
secretion upon activation of the Toll-like receptors TLR4, TLR7
and TLR9. {ECO:0000269|PubMed:11877477,
ECO:0000269|PubMed:18025150, ECO:0000269|PubMed:18337558,
ECO:0000269|PubMed:22187458}.
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EMBL; AF293806; AAG48584.1; -; mRNA.
EMBL; AK087722; BAC39980.1; -; mRNA.
EMBL; AK089785; BAC40962.1; -; mRNA.
EMBL; AK150114; BAE29318.1; -; mRNA.
EMBL; AK153548; BAE32085.1; -; mRNA.
EMBL; AK170130; BAE41584.1; -; mRNA.
EMBL; AK170925; BAE42118.1; -; mRNA.
EMBL; AK171021; BAE42191.1; -; mRNA.
EMBL; BC113141; AAI13142.1; -; mRNA.
CCDS; CCDS37987.1; -. [Q9EQ32-1]
RefSeq; NP_113553.1; NM_031376.3. [Q9EQ32-1]
RefSeq; XP_006527535.1; XM_006527472.3. [Q9EQ32-2]
UniGene; Mm.222266; -.
ProteinModelPortal; Q9EQ32; -.
SMR; Q9EQ32; -.
BioGrid; 219934; 1.
IntAct; Q9EQ32; 7.
MINT; MINT-1612514; -.
STRING; 10090.ENSMUSP00000052777; -.
iPTMnet; Q9EQ32; -.
PhosphoSitePlus; Q9EQ32; -.
EPD; Q9EQ32; -.
PaxDb; Q9EQ32; -.
PeptideAtlas; Q9EQ32; -.
PRIDE; Q9EQ32; -.
Ensembl; ENSMUST00000059672; ENSMUSP00000052777; ENSMUSG00000025017. [Q9EQ32-1]
GeneID; 83490; -.
KEGG; mmu:83490; -.
UCSC; uc008hlu.1; mouse. [Q9EQ32-1]
UCSC; uc008hlv.1; mouse. [Q9EQ32-3]
CTD; 118788; -.
MGI; MGI:1933177; Pik3ap1.
eggNOG; ENOG410IKKC; Eukaryota.
eggNOG; ENOG4110NCP; LUCA.
GeneTree; ENSGT00390000008787; -.
HOVERGEN; HBG104426; -.
InParanoid; Q9EQ32; -.
KO; K12230; -.
OMA; NPGCDEE; -.
OrthoDB; EOG091G0125; -.
PhylomeDB; Q9EQ32; -.
TreeFam; TF328570; -.
Reactome; R-MMU-1257604; PIP3 activates AKT signaling.
Reactome; R-MMU-6811558; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.
Reactome; R-MMU-983695; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers.
PRO; PR:Q9EQ32; -.
Proteomes; UP000000589; Chromosome 19.
Bgee; ENSMUSG00000025017; -.
Genevisible; Q9EQ32; MM.
GO; GO:0005737; C:cytoplasm; IDA:MGI.
GO; GO:0005829; C:cytosol; IDA:UniProtKB.
GO; GO:0016020; C:membrane; IDA:UniProtKB.
GO; GO:0005886; C:plasma membrane; IDA:MGI.
GO; GO:0042802; F:identical protein binding; IPI:IntAct.
GO; GO:0036312; F:phosphatidylinositol 3-kinase regulatory subunit binding; IDA:UniProtKB.
GO; GO:0034122; P:negative regulation of toll-like receptor signaling pathway; IMP:UniProtKB.
GO; GO:0014068; P:positive regulation of phosphatidylinositol 3-kinase signaling; IMP:UniProtKB.
GO; GO:0034123; P:positive regulation of toll-like receptor signaling pathway; IMP:UniProtKB.
GO; GO:0050727; P:regulation of inflammatory response; IMP:UniProtKB.
GO; GO:0034134; P:toll-like receptor 2 signaling pathway; IMP:UniProtKB.
GO; GO:0034142; P:toll-like receptor 4 signaling pathway; IMP:UniProtKB.
GO; GO:0034154; P:toll-like receptor 7 signaling pathway; IMP:UniProtKB.
GO; GO:0034162; P:toll-like receptor 9 signaling pathway; IMP:UniProtKB.
Gene3D; 1.25.40.20; -; 1.
InterPro; IPR036770; Ankyrin_rpt-contain_sf.
InterPro; IPR017893; DBB_domain.
Pfam; PF14545; DBB; 1.
SMART; SM01282; DBB; 1.
PROSITE; PS51376; DBB; 1.
1: Evidence at protein level;
Alternative splicing; Cell membrane; Complete proteome; Cytoplasm;
Membrane; Phosphoprotein; Reference proteome.
CHAIN 1 811 Phosphoinositide 3-kinase adapter protein
1.
/FTId=PRO_0000341274.
DOMAIN 182 318 DBB. {ECO:0000255|PROSITE-
ProRule:PRU00707}.
REGION 10 145 Necessary and sufficient to mediate
inhibition of NF-kappa-B downstream of
activated TLRs; may mediate interaction
with MYD88 and TIRAP.
{ECO:0000269|PubMed:22187460}.
COMPBIAS 760 808 Pro-rich.
MOD_RES 264 264 Phosphotyrosine.
{ECO:0000269|PubMed:11163197,
ECO:0000269|PubMed:18025150}.
MOD_RES 420 420 Phosphotyrosine; by SYK.
{ECO:0000305|PubMed:11163197,
ECO:0000305|PubMed:18025150,
ECO:0000305|PubMed:20728433}.
MOD_RES 445 445 Phosphotyrosine; by SYK.
{ECO:0000305|PubMed:11163197,
ECO:0000305|PubMed:18025150,
ECO:0000305|PubMed:20728433}.
MOD_RES 460 460 Phosphotyrosine; by SYK.
{ECO:0000305|PubMed:11163197,
ECO:0000305|PubMed:18025150,
ECO:0000305|PubMed:20728433}.
MOD_RES 513 513 Phosphotyrosine; by ABL1.
{ECO:0000250|UniProtKB:Q6ZUJ8}.
MOD_RES 553 553 Phosphotyrosine; by ABL1.
{ECO:0000250|UniProtKB:Q6ZUJ8}.
MOD_RES 570 570 Phosphotyrosine; by ABL1.
{ECO:0000250|UniProtKB:Q6ZUJ8}.
MOD_RES 594 594 Phosphotyrosine; by ABL1.
{ECO:0000250|UniProtKB:Q6ZUJ8}.
MOD_RES 642 642 Phosphoserine.
{ECO:0000250|UniProtKB:Q6ZUJ8}.
MOD_RES 694 694 Phosphotyrosine; by ABL1.
{ECO:0000250|UniProtKB:Q6ZUJ8}.
MOD_RES 718 718 Phosphoserine.
{ECO:0000250|UniProtKB:Q6ZUJ8}.
VAR_SEQ 1 179 Missing (in isoform 2).
{ECO:0000303|PubMed:16141072}.
/FTId=VSP_034241.
VAR_SEQ 493 517 NSVKPASWEREQHHPYGEELYHIVD -> KLSLIREAETLV
FKGQVATDMACDD (in isoform 3).
{ECO:0000303|PubMed:16141072}.
/FTId=VSP_034242.
VAR_SEQ 518 811 Missing (in isoform 3).
{ECO:0000303|PubMed:16141072}.
/FTId=VSP_034243.
MUTAGEN 264 264 Y->F: Fails to bind PIK3R1 in a BCR-
signaling dependent manner; when
associated with Y-420; Y-445 and Y-460.
Loss of regulatory function in Toll-like
receptor signaling probably due to loss
of interaction with PIK3R1; when
associated with Y-420; Y-445 and Y-460.
Impairs mature B-cell generation; when
associated with Y-420; Y-445 and Y-460.
{ECO:0000269|PubMed:18025150}.
MUTAGEN 420 420 Y->F: Fails to bind PIK3R1 in a BCR-
signaling dependent manner; when
associated with Y-264; Y-445 and Y-460.
Loss of regulatory function in Toll-like
receptor signaling probably due to loss
of interaction with PIK3R1; when
associated with Y-264; Y-445 and Y-460.
Impairs mature B-cell generation; when
associated with Y-264; Y-445 and Y-460.
{ECO:0000269|PubMed:18025150}.
MUTAGEN 445 445 Y->F: Fails to bind PIK3R1 in a BCR-
signaling dependent manner; when
associated with Y-264; Y-420 and Y-460.
Loss of regulatory function in Toll-like
receptor signaling probably due to loss
of interaction with PIK3R1; when
associated with Y-264; Y-420 and Y-460.
Impairs mature B-cell generation; when
associated with Y-264; Y-420 and Y-460.
{ECO:0000269|PubMed:18025150}.
MUTAGEN 460 460 Y->F: Fails to bind PIK3R1 in a BCR-
signaling dependent manner; when
associated with Y-264; Y-420 and Y-445.
Loss of regulatory function in Toll-like
receptor signaling probably due to loss
of interaction with PIK3R1; when
associated with Y-264; Y-420 and Y-445.
Impairs mature B-cell generation; when
associated with Y-264; Y-420 and Y-445.
{ECO:0000269|PubMed:18025150}.
CONFLICT 206 206 K -> N (in Ref. 2; BAE42191).
{ECO:0000305}.
CONFLICT 414 414 E -> G (in Ref. 2; BAE41584/BAE42118).
{ECO:0000305}.
CONFLICT 509 509 G -> GE (in Ref. 3; AAI13142).
{ECO:0000305}.
CONFLICT 768 768 A -> AP (in Ref. 2; BAC40962/BAE42191).
{ECO:0000305}.
SEQUENCE 811 AA; 90928 MW; 3268E89B5C73F218 CRC64;
MAASGWGRGC DILIFYSPDA EEWCQYLQDL FVSCRQVRSQ KTQTYRLVPD ASFSAQDLWV
FRDARCVLVL LSAGLVGCFG QPGLLPMLQR ACHPPQRVVR LLCGVQPGDE DFQAFFPDWA
HWQEMTCDDE PETYLAAVRK AISEDSGCDS VTDTEPEDER ELPFSKQTNL PPEISPGNLM
VVQPDRIRCG AETTVYIIVR CKLDEKVSTE AEFSPEDSPS IRVEGTLENE YTVSVKAPDL
SSGNVSLKVY SGDLVVCETT VSYYTDMEEI GNLLSSAANP VEFMCQAFKI VPYNTETLDK
LLTESLKNNI PASGLHLFGI NQLEEDDMMT NQRDEELPTL LHFAAKYGLK NLTALLLTCP
GALQAYSVAN KHGHYPNTIA EKHGFRDLRQ FIDEYVETVD MLKTHIKEEL MQGEEADDVY
ESMAHLSTDL LMKCSLNPGC DDELYESMAA FAPAATEDLY VEMLQASAGN PVSGESFSRP
TKDSMIRKFL EGNSVKPASW EREQHHPYGE ELYHIVDEDE TFSVDLANRP PVPVPRPEAS
APGPPPPPDN EPYISKVFAE KSQERLGNFY VSSESIRKEP LVRPWRDRPP SSIYDPFAGM
KTPGQRQLIT LQEQVKLGIV NVDEAVLHFK EWQLNQKKRS ESFRFQQENL KRLRESITRR
RKEKPKSGKH TDLEITVPIR HSQHLPEKVE FGVYESGPRK SVLPARTELR RGDWKTDSMS
STASSTSNRS STRSLLSVSS GMEGDNEDNE IPEITRSRGP GPTQVDGAPV VTGTPVGTLE
RPPRVPPRAA SQRPLTRESF HPPPPVPPRG R


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EIAAB10419 B lymphocyte adapter protein Bam32,BAM32,B-cell adapter molecule of 32 kDa,DAPP1,Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide,hDAPP1,Homo sapiens,HSPC066,Human
E10446h Mouse ELISA Kit FOR Phosphoinositide 3-kinase adapter protein 1 96T
CSB-EL017993HU Human Phosphoinositide 3-kinase adapter protein 1(PIK3AP1) ELISA kit 96T
CSB-EL017993MO Mouse Phosphoinositide 3-kinase adapter protein 1(PIK3AP1) ELISA kit 96T
CSB-EL017993CH Chicken Phosphoinositide 3-kinase adapter protein 1(PIK3AP1) ELISA kit 96T
CSB-EL017993HU Human Phosphoinositide 3-kinase adapter protein 1(PIK3AP1) ELISA kit SpeciesHuman 96T
CSB-EL017993MO Mouse Phosphoinositide 3-kinase adapter protein 1(PIK3AP1) ELISA kit SpeciesMouse 96T
CSB-EL017993CH Chicken Phosphoinositide 3-kinase adapter protein 1(PIK3AP1) ELISA kit SpeciesChicken 96T
BCAP_MOUSE ELISA Kit FOR Phosphoinositide 3-kinase adapter protein 1; organism: Mouse; gene name: Pik3ap1 96T
E1541c Mouse ELISA Kit FOR Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 2 96T
EIAAB30987 Homo sapiens,Human,Phosphoinositide 3-kinase adaptor protein,Phosphoinositide 3-kinase regulatory subunit 4,PI3-kinase p150 subunit,PI3-kinase regulatory subunit 4,PIK3R4
E1600h ELISA BASH,B-cell adapter containing a SH2 domain protein,B-cell adapter containing a Src homology 2 domain protein,B-cell linker protein,BLNK,Cytoplasmic adapter protein,Homo sapiens,Human,SLP65,SLP- 96T
U1600h CLIA BASH,B-cell adapter containing a SH2 domain protein,B-cell adapter containing a Src homology 2 domain protein,B-cell linker protein,BLNK,Cytoplasmic adapter protein,Homo sapiens,Human,SLP65,SLP-6 96T
E1600h ELISA kit BASH,B-cell adapter containing a SH2 domain protein,B-cell adapter containing a Src homology 2 domain protein,B-cell linker protein,BLNK,Cytoplasmic adapter protein,Homo sapiens,Human,SLP65 96T
orb80843 Human Phosphoinositide 3-kinase beta P110beta _p85a protein Phosphoinositide 3-kinase beta Human Recombinant is glycosilated protein having molecular weight as follows p85a chain 83.5 kDa, p110d chai 1
U1600m CLIA Bash,B-cell adapter containing a SH2 domain protein,B-cell adapter containing a Src homology 2 domain protein,B-cell linker protein,Blnk,Cytoplasmic adapter protein,Ly57,Lymphocyte antigen 57,Mou 96T
E1600m ELISA Bash,B-cell adapter containing a SH2 domain protein,B-cell adapter containing a Src homology 2 domain protein,B-cell linker protein,Blnk,Cytoplasmic adapter protein,Ly57,Lymphocyte antigen 57,Mo 96T
E1600m ELISA kit Bash,B-cell adapter containing a SH2 domain protein,B-cell adapter containing a Src homology 2 domain protein,B-cell linker protein,Blnk,Cytoplasmic adapter protein,Ly57,Lymphocyte antigen 96T
orb80839 bovine Phosphoinositide 3-kinase alpha p110a_p85a protein The PI3Ka catalytic and regulatory subunits are coexpressed in Sf9 insect cells. Phosphoinositide 3-kinase alpha Bovine Recombinant is glycosi 1
orb80838 bovine Phosphoinositide 3-kinase a, regulatory subunit protein Phosphoinositide 3-kinase subunit p85a Bovine Recombinant has molecular weight of 83.5 kDa. For research use only. 2


 

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