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Phosphoinositide-interacting protein

 PIRT_MOUSE              Reviewed;         135 AA.
Q8BFY0;
02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
01-MAR-2003, sequence version 1.
25-OCT-2017, entry version 93.
RecName: Full=Phosphoinositide-interacting protein;
Name=Pirt;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY,
DEVELOPMENTAL STAGE, PHOSPHOINOSITIDE-BINDING, DISRUPTION PHENOTYPE,
INTERACTION WITH TRPV1, AND MUTAGENESIS OF 113-LYS--LYS-115 AND
113-LYS--LYS-121.
PubMed=18455988; DOI=10.1016/j.cell.2008.02.053;
Kim A.Y., Tang Z., Liu Q., Patel K.N., Maag D., Geng Y., Dong X.;
"Pirt, a phosphoinositide-binding protein, functions as a regulatory
subunit of TRPV1.";
Cell 133:475-485(2008).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=C57BL/6J; TISSUE=Aorta, Spinal ganglion, and Vein;
PubMed=16141072; DOI=10.1126/science.1112014;
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M.,
Davis M.J., Wilming L.G., Aidinis V., Allen J.E.,
Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L.,
Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M.,
Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R.,
Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G.,
di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G.,
Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M.,
Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N.,
Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T.,
Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H.,
Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K.,
Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J.,
Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L.,
Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K.,
Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P.,
Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O.,
Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G.,
Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M.,
Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B.,
Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K.,
Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A.,
Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K.,
Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C.,
Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J.,
Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y.,
Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T.,
Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N.,
Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N.,
Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S.,
Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J.,
Hayashizaki Y.;
"The transcriptional landscape of the mammalian genome.";
Science 309:1559-1563(2005).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Brain;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
-!- FUNCTION: Regulatory subunit of TRPV1, a molecular sensor of
noxious heat and capsaicin. Positively regulates TRPV1 channel
activity via phosphatidylinositol 4,5-bisphosphate (PIP2). Binds
various phosphoinositide, including phosphatidylinositol 4,5-
bisphosphate (PIP2), but not phosphatidylinositol (PI).
{ECO:0000269|PubMed:18455988}.
-!- SUBUNIT: Interacts with TRPV1. {ECO:0000269|PubMed:18455988}.
-!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
protein {ECO:0000305}.
-!- TISSUE SPECIFICITY: Strongly expressed in most dorsal root ganglia
(DRG) and trigeminal neurons. Expressed by most peptidergic
(CGRP+) and non-peptidergic (IB4+) DRG neurons. Weakly expressed
in other parts of the peripheral nervous system (PNS) including
sympathetic and enteric neurons. Not expressed in the spinal cord.
{ECO:0000269|PubMed:18455988}.
-!- DEVELOPMENTAL STAGE: First expressed in DRG neurons around
embryonic day 11.5, and expression is maintained throughout
adulthood. {ECO:0000269|PubMed:18455988}.
-!- DISRUPTION PHENOTYPE: Mice show impaired responsiveness to noxious
heat and capsaicin. Noxious heat- and capsaicin-sensitive currents
in DRG neurons are significantly attenuated.
{ECO:0000269|PubMed:18455988}.
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EMBL; EU447173; ACC60974.1; -; mRNA.
EMBL; AK041182; BAC30853.1; -; mRNA.
EMBL; AK051285; BAC34593.1; -; mRNA.
EMBL; AK051645; BAC34704.1; -; mRNA.
EMBL; AK084056; BAC39108.1; -; mRNA.
EMBL; CH466601; EDL10416.1; -; Genomic_DNA.
EMBL; BC147296; AAI47297.1; -; mRNA.
EMBL; BC147297; AAI47298.1; -; mRNA.
CCDS; CCDS24849.1; -.
RefSeq; NP_848771.1; NM_178656.3.
RefSeq; XP_006532642.1; XM_006532579.3.
UniGene; Mm.440256; -.
STRING; 10090.ENSMUSP00000128117; -.
PaxDb; Q8BFY0; -.
PRIDE; Q8BFY0; -.
Ensembl; ENSMUST00000123434; ENSMUSP00000128117; ENSMUSG00000048070.
GeneID; 193003; -.
KEGG; mmu:193003; -.
UCSC; uc007jln.1; mouse.
CTD; 644139; -.
MGI; MGI:2443635; Pirt.
eggNOG; ENOG410IWQ6; Eukaryota.
eggNOG; ENOG410YYIW; LUCA.
GeneTree; ENSGT00390000016891; -.
HOGENOM; HOG000082413; -.
HOVERGEN; HBG106144; -.
InParanoid; Q8BFY0; -.
OMA; VWIPIIR; -.
OrthoDB; EOG091G0ZPU; -.
PhylomeDB; Q8BFY0; -.
TreeFam; TF328608; -.
PRO; PR:Q8BFY0; -.
Proteomes; UP000000589; Chromosome 11.
Bgee; ENSMUSG00000048070; -.
Genevisible; Q8BFY0; MM.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0005622; C:intracellular; IEA:GOC.
GO; GO:0005886; C:plasma membrane; IDA:MGI.
GO; GO:0044325; F:ion channel binding; IPI:MGI.
GO; GO:1902936; F:phosphatidylinositol bisphosphate binding; IDA:MGI.
GO; GO:0005547; F:phosphatidylinositol-3,4,5-trisphosphate binding; IDA:MGI.
GO; GO:0048266; P:behavioral response to pain; IMP:MGI.
GO; GO:0048015; P:phosphatidylinositol-mediated signaling; IDA:MGI.
GO; GO:2001259; P:positive regulation of cation channel activity; IMP:MGI.
GO; GO:0009408; P:response to heat; IMP:MGI.
InterPro; IPR028068; PIRT.
Pfam; PF15099; PIRT; 1.
1: Evidence at protein level;
Complete proteome; Membrane; Reference proteome; Transmembrane;
Transmembrane helix.
CHAIN 1 135 Phosphoinositide-interacting protein.
/FTId=PRO_0000347061.
TRANSMEM 54 74 Helical. {ECO:0000255}.
TRANSMEM 92 112 Helical. {ECO:0000255}.
MUTAGEN 113 121 KKKQKQRQK->AAAQAQAQA: Abolishes
phosphoinositide-binding but does not
affect the interaction with TRPV1.
{ECO:0000269|PubMed:18455988}.
MUTAGEN 113 115 KKK->QQQ: Abolishes phosphoinositide-
binding and ability to activate TRPV1
without affecting the interaction with
TRPV1. {ECO:0000269|PubMed:18455988}.
SEQUENCE 135 AA; 15264 MW; E171F42CFEFC86CC CRC64;
MEVLPKALEV DERSPESKDL LPSQTASSLC ISSRSESVWT TTPKSNWEIY HKPIIIMSVG
AAILLFGVAI TCVAYILEEK HKVVQVLRMI GPAFLSLGLM MLVCGLVWVP IIKKKQKQRQ
KSNFFQSLKF FLLNR


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