Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Phosphopentomutase (PPM) (EC 5.4.2.7)

 PPM_THEKO               Reviewed;         450 AA.
Q6I7B6; Q5JJ52;
24-JUN-2015, integrated into UniProtKB/Swiss-Prot.
19-JUL-2004, sequence version 1.
28-FEB-2018, entry version 98.
RecName: Full=Phosphopentomutase {ECO:0000303|PubMed:15205420};
Short=PPM {ECO:0000303|PubMed:15205420};
EC=5.4.2.7 {ECO:0000269|PubMed:15205420};
OrderedLocusNames=TK1777 {ECO:0000312|EMBL:BAD85966.1};
ORFNames=Tko0866 {ECO:0000312|EMBL:BAD23919.1};
Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1)
(Pyrococcus kodakaraensis (strain KOD1)).
Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae;
Thermococcus.
NCBI_TaxID=69014;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA], PARTIAL PROTEIN SEQUENCE OF 1-7,
FUNCTION, CATALYTIC ACTIVITY, COFACTOR, BIOPHYSICOCHEMICAL PROPERTIES,
AND SUBUNIT.
STRAIN=ATCC BAA-918 / JCM 12380 / KOD1;
PubMed=15205420; DOI=10.1128/JB.186.13.4185-4191.2004;
Rashid N., Imanaka H., Fukui T., Atomi H., Imanaka T.;
"Presence of a novel phosphopentomutase and a 2-deoxyribose 5-
phosphate aldolase reveals a metabolic link between pentoses and
central carbon metabolism in the hyperthermophilic archaeon
Thermococcus kodakaraensis.";
J. Bacteriol. 186:4185-4191(2004).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC BAA-918 / JCM 12380 / KOD1;
PubMed=15710748; DOI=10.1101/gr.3003105;
Fukui T., Atomi H., Kanai T., Matsumi R., Fujiwara S., Imanaka T.;
"Complete genome sequence of the hyperthermophilic archaeon
Thermococcus kodakaraensis KOD1 and comparison with Pyrococcus
genomes.";
Genome Res. 15:352-363(2005).
-!- FUNCTION: Catalyzes the conversion of deoxyribose 1-phosphate to
deoxyribose 5-phosphate. Shows also weak activity with glucose 1-
phosphate and mannose 1-phosphate. Could be involved in pentose
biosynthesis. {ECO:0000269|PubMed:15205420}.
-!- CATALYTIC ACTIVITY: Alpha-D-ribose 1-phosphate = D-ribose 5-
phosphate. {ECO:0000305}.
-!- CATALYTIC ACTIVITY: 2-deoxy-alpha-D-ribose 1-phosphate = 2-deoxy-
alpha-D-ribose 5-phosphate. {ECO:0000269|PubMed:15205420}.
-!- COFACTOR:
Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
Evidence={ECO:0000269|PubMed:15205420};
Note=Can also use Ni(2+), Mn(2+) and Zn(2+), to a lower extent.
{ECO:0000269|PubMed:15205420};
-!- BIOPHYSICOCHEMICAL PROPERTIES:
Kinetic parameters:
KM=2.5 mM for 2-deoxy-D-ribose 1-phosphate (at 90 degrees
Celsius) {ECO:0000269|PubMed:15205420};
Vmax=210 umol/min/mg enzyme (at 90 degrees Celsius)
{ECO:0000269|PubMed:15205420};
Note=kcat is 173 sec(-1) (at 90 degrees Celsius).
{ECO:0000269|PubMed:15205420};
pH dependence:
Optimum pH is 7.5. {ECO:0000269|PubMed:15205420};
Temperature dependence:
Optimum temperature is 90 degrees Celsius.
{ECO:0000269|PubMed:15205420};
-!- SUBUNIT: Homotetramer. {ECO:0000269|PubMed:15205420}.
-!- PTM: Activated by phosphorylation. {ECO:0000250|UniProtKB:P31120}.
-!- SIMILARITY: Belongs to the phosphohexose mutase family.
{ECO:0000305}.
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
Distributed under the Creative Commons Attribution-NoDerivs License
-----------------------------------------------------------------------
EMBL; AB126239; BAD23919.1; -; Genomic_DNA.
EMBL; AP006878; BAD85966.1; -; Genomic_DNA.
RefSeq; WP_011250728.1; NC_006624.1.
ProteinModelPortal; Q6I7B6; -.
SMR; Q6I7B6; -.
STRING; 69014.TK1777; -.
EnsemblBacteria; BAD85966; BAD85966; TK1777.
GeneID; 3233830; -.
KEGG; tko:TK1777; -.
PATRIC; fig|69014.16.peg.1733; -.
eggNOG; arCOG00767; Archaea.
eggNOG; COG1109; LUCA.
HOGENOM; HOG000268680; -.
InParanoid; Q6I7B6; -.
KO; K22199; -.
OMA; PTDNGIK; -.
OrthoDB; POG093Z0E3U; -.
BioCyc; TKOD69014:G1G2A-1787-MONOMER; -.
BRENDA; 5.4.2.7; 5246.
Proteomes; UP000000536; Chromosome.
GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
GO; GO:0008966; F:phosphoglucosamine mutase activity; IEA:InterPro.
GO; GO:0008973; F:phosphopentomutase activity; IEA:UniProtKB-EC.
GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
CDD; cd03087; PGM_like1; 1.
InterPro; IPR005844; A-D-PHexomutase_a/b/a-I.
InterPro; IPR016055; A-D-PHexomutase_a/b/a-I/II/III.
InterPro; IPR005845; A-D-PHexomutase_a/b/a-II.
InterPro; IPR005843; A-D-PHexomutase_C.
InterPro; IPR036900; A-D-PHexomutase_C_sf.
InterPro; IPR016066; A-D-PHexomutase_CS.
InterPro; IPR005841; Alpha-D-phosphohexomutase_SF.
InterPro; IPR024086; GlmM_arc-type.
Pfam; PF02878; PGM_PMM_I; 1.
Pfam; PF02879; PGM_PMM_II; 1.
Pfam; PF00408; PGM_PMM_IV; 1.
PRINTS; PR00509; PGMPMM.
SUPFAM; SSF53738; SSF53738; 3.
SUPFAM; SSF55957; SSF55957; 1.
TIGRFAMs; TIGR03990; Arch_GlmM; 1.
PROSITE; PS00710; PGM_PMM; 1.
1: Evidence at protein level;
Complete proteome; Direct protein sequencing; Isomerase; Magnesium;
Metal-binding; Phosphoprotein; Reference proteome.
CHAIN 1 450 Phosphopentomutase.
/FTId=PRO_0000433396.
ACT_SITE 93 93 Phosphoserine intermediate.
{ECO:0000250|UniProtKB:P31120}.
METAL 93 93 Magnesium; via phosphate group.
{ECO:0000250}.
METAL 231 231 Magnesium. {ECO:0000250}.
METAL 233 233 Magnesium. {ECO:0000250}.
METAL 235 235 Magnesium. {ECO:0000250}.
MOD_RES 93 93 Phosphoserine; by autocatalysis.
{ECO:0000250|UniProtKB:P31120}.
SEQUENCE 450 AA; 49532 MW; A25A4A49D21862C8 CRC64;
MRLFGTAGIR GTLWEKVTPE LAMKVGMAVG TYKSGKALVG RDGRTSSVML KNAMISGLLS
TGMEVLDADL IPTPALAWGT RKLADAGVMI TASHNPPTDN GVKVFNGDGT EFYVEQERGL
EEIIFSGNFR KARWDEIKPV RNVEVIPDYI NAVLDFVGHE TNLKVLYDGA NGAGSLVAPY
LLREMGAKVL SVNAHVDGHF PGRKPEPRYE NIAYLGKLVR ELGVDLAIAQ DGDADRIAVF
DEKGNYVDED TVIALFAKLY VEEHGGGTVV VSIDTGSRID AVVERAGGRV VRIPLGQPHD
GIKRYKAIFA AEPWKLVHPK FGPWIDPFVT MGLLIKLIDE NGPLSELVKE IPTYYLKKAN
VLCPDEYKAE VVRRAAEEVE RKLSSEIKEV LTISGFRIAL NDGSWILIRP SGTEPKIRVV
AEAPTEKRRD ELFEMAYSTV SRIVKEAEKK


Related products :

Catalog number Product name Quantity
EIAAB30733 Glucose phosphomutase 2,Mouse,Mus musculus,PGM 2,Pgm2,Phosphodeoxyribomutase,Phosphoglucomutase-2,Phosphopentomutase
EIAAB30734 Glucose phosphomutase 2,Homo sapiens,Human,MSTP006,PGM 2,PGM2,Phosphodeoxyribomutase,Phosphoglucomutase-2,Phosphopentomutase


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur