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Phosphoribosylaminoimidazole carboxylase (EC 4.1.1.21) (AIR carboxylase) (AIRC)

 PURE_TREDE              Reviewed;         159 AA.
Q73PV9;
14-OCT-2015, integrated into UniProtKB/Swiss-Prot.
05-JUL-2004, sequence version 1.
28-FEB-2018, entry version 87.
RecName: Full=Phosphoribosylaminoimidazole carboxylase {ECO:0000255|HAMAP-Rule:MF_02045, ECO:0000305};
EC=4.1.1.21 {ECO:0000255|HAMAP-Rule:MF_02045, ECO:0000269|PubMed:21548610};
AltName: Full=AIR carboxylase {ECO:0000255|HAMAP-Rule:MF_02045, ECO:0000303|PubMed:21548610};
Short=AIRC {ECO:0000255|HAMAP-Rule:MF_02045, ECO:0000305};
Name=purE {ECO:0000255|HAMAP-Rule:MF_02045,
ECO:0000303|PubMed:21548610};
OrderedLocusNames=TDE_0687 {ECO:0000312|EMBL:AAS11180.1};
Treponema denticola (strain ATCC 35405 / CIP 103919 / DSM 14222).
Bacteria; Spirochaetes; Spirochaetales; Spirochaetaceae; Treponema.
NCBI_TaxID=243275;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 35405 / CIP 103919 / DSM 14222;
PubMed=15064399; DOI=10.1073/pnas.0307639101;
Seshadri R., Myers G.S.A., Tettelin H., Eisen J.A., Heidelberg J.F.,
Dodson R.J., Davidsen T.M., DeBoy R.T., Fouts D.E., Haft D.H.,
Selengut J., Ren Q., Brinkac L.M., Madupu R., Kolonay J.F.,
Durkin S.A., Daugherty S.C., Shetty J., Shvartsbeyn A.,
Gebregeorgis E., Geer K., Tsegaye G., Malek J.A., Ayodeji B.,
Shatsman S., McLeod M.P., Smajs D., Howell J.K., Pal S., Amin A.,
Vashisth P., McNeill T.Z., Xiang Q., Sodergren E., Baca E.,
Weinstock G.M., Norris S.J., Fraser C.M., Paulsen I.T.;
"Comparison of the genome of the oral pathogen Treponema denticola
with other spirochete genomes.";
Proc. Natl. Acad. Sci. U.S.A. 101:5646-5651(2004).
[2] {ECO:0000244|PDB:3RG8, ECO:0000244|PDB:3RGG}
X-RAY CRYSTALLOGRAPHY (1.74 ANGSTROMS) IN COMPLEX WITH
5-AMINOIMIDAZOLE RIBONUCLEOTIDE, FUNCTION, CATALYTIC ACTIVITY,
BIOPHYSICOCHEMICAL PROPERTIES, PATHWAY, MASS SPECTROMETRY, SUBFAMILY,
AND MUTAGENESIS OF HIS-40.
STRAIN=ATCC 35405 / CIP 103919 / DSM 14222;
PubMed=21548610; DOI=10.1021/bi102033a;
Tranchimand S., Starks C.M., Mathews I.I., Hockings S.C.,
Kappock T.J.;
"Treponema denticola PurE is a bacterial AIR carboxylase.";
Biochemistry 50:4623-4637(2011).
-!- FUNCTION: Catalyzes the reversible conversion of 5-aminoimidazole
ribonucleotide (AIR) and CO(2) to 4-carboxy-5-aminoimidazole
ribonucleotide (CAIR). Does not accept N5-carboxyaminoimidazole
ribonucleotide (N5-CAIR) as a substrate.
{ECO:0000269|PubMed:21548610}.
-!- CATALYTIC ACTIVITY: 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-
carboxylate = 5-amino-1-(5-phospho-D-ribosyl)imidazole + CO(2).
{ECO:0000255|HAMAP-Rule:MF_02045, ECO:0000269|PubMed:21548610}.
-!- BIOPHYSICOCHEMICAL PROPERTIES:
Kinetic parameters:
KM=13 mM for CO(2) (at 10 degrees Celsius)
{ECO:0000269|PubMed:21548610};
KM=60 uM for AIR (at 10 degrees Celsius)
{ECO:0000269|PubMed:21548610};
Note=kcat is 77 sec(-1). {ECO:0000269|PubMed:21548610};
-!- PATHWAY: Purine metabolism; IMP biosynthesis via de novo pathway;
5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-
amino-1-(5-phospho-D-ribosyl)imidazole (carboxylase route): step
1/1. {ECO:0000255|HAMAP-Rule:MF_02045,
ECO:0000269|PubMed:21548610}.
-!- MASS SPECTROMETRY: Mass=17195; Mass_error=3; Method=Electrospray;
Range=1-159; Evidence={ECO:0000269|PubMed:21548610};
-!- SIMILARITY: Belongs to the AIR carboxylase family. Class II
subfamily. {ECO:0000255|HAMAP-Rule:MF_02045,
ECO:0000305|PubMed:21548610}.
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EMBL; AE017226; AAS11180.1; -; Genomic_DNA.
RefSeq; NP_971299.1; NC_002967.9.
RefSeq; WP_002681904.1; NC_002967.9.
PDB; 3RG8; X-ray; 1.74 A; A/B/C/D/E/F/G/H=1-159.
PDB; 3RGG; X-ray; 1.82 A; A/B/C/D=1-159.
PDB; 5C5D; X-ray; 1.69 A; A/B/C/D=1-159.
PDBsum; 3RG8; -.
PDBsum; 3RGG; -.
PDBsum; 5C5D; -.
ProteinModelPortal; Q73PV9; -.
SMR; Q73PV9; -.
STRING; 243275.TDE0687; -.
EnsemblBacteria; AAS11180; AAS11180; TDE_0687.
GeneID; 2740246; -.
KEGG; tde:TDE0687; -.
PATRIC; fig|243275.7.peg.667; -.
eggNOG; ENOG4108UM6; Bacteria.
eggNOG; COG0041; LUCA.
KO; K01588; -.
OMA; KPVIACP; -.
OrthoDB; POG091H01UJ; -.
BioCyc; TDEN243275:G1G0Q-699-MONOMER; -.
BRENDA; 4.1.1.21; 6426.
UniPathway; UPA00074; UER00130.
EvolutionaryTrace; Q73PV9; -.
Proteomes; UP000008212; Chromosome.
GO; GO:0004638; F:phosphoribosylaminoimidazole carboxylase activity; IEA:UniProtKB-EC.
GO; GO:0006189; P:'de novo' IMP biosynthetic process; IEA:UniProtKB-UniPathway.
Gene3D; 3.40.50.7700; -; 1.
HAMAP; MF_02045; PurE_classII; 1.
InterPro; IPR033626; PurE_classII.
InterPro; IPR000031; PurE_dom.
InterPro; IPR024694; PurE_prokaryotes.
InterPro; IPR035893; PurE_sf.
Pfam; PF00731; AIRC; 1.
PIRSF; PIRSF001338; AIR_carboxylase; 1.
SMART; SM01001; AIRC; 1.
SUPFAM; SSF52255; SSF52255; 1.
1: Evidence at protein level;
3D-structure; Complete proteome; Lyase; Purine biosynthesis;
Reference proteome.
CHAIN 1 159 Phosphoribosylaminoimidazole carboxylase.
/FTId=PRO_0000434131.
BINDING 11 11 Substrate. {ECO:0000244|PDB:3RGG,
ECO:0000255|HAMAP-Rule:MF_02045,
ECO:0000269|PubMed:21548610}.
BINDING 14 14 Substrate. {ECO:0000244|PDB:3RGG,
ECO:0000255|HAMAP-Rule:MF_02045,
ECO:0000269|PubMed:21548610}.
BINDING 38 38 Substrate. {ECO:0000244|PDB:3RGG,
ECO:0000255|HAMAP-Rule:MF_02045,
ECO:0000269|PubMed:21548610}.
BINDING 41 41 Substrate. {ECO:0000244|PDB:3RGG,
ECO:0000255|HAMAP-Rule:MF_02045,
ECO:0000269|PubMed:21548610}.
BINDING 67 67 Substrate; via amide nitrogen and
carbonyl oxygen. {ECO:0000244|PDB:3RGG,
ECO:0000255|HAMAP-Rule:MF_02045,
ECO:0000269|PubMed:21548610}.
BINDING 69 69 Substrate; via carbonyl oxygen.
{ECO:0000244|PDB:3RGG, ECO:0000255|HAMAP-
Rule:MF_02045,
ECO:0000269|PubMed:21548610}.
MUTAGEN 40 40 H->N: Lack of activity.
{ECO:0000269|PubMed:21548610}.
STRAND 4 11 {ECO:0000244|PDB:5C5D}.
HELIX 12 14 {ECO:0000244|PDB:5C5D}.
HELIX 15 27 {ECO:0000244|PDB:5C5D}.
STRAND 31 36 {ECO:0000244|PDB:5C5D}.
TURN 39 41 {ECO:0000244|PDB:5C5D}.
HELIX 43 54 {ECO:0000244|PDB:5C5D}.
STRAND 56 58 {ECO:0000244|PDB:5C5D}.
STRAND 60 65 {ECO:0000244|PDB:5C5D}.
HELIX 72 79 {ECO:0000244|PDB:5C5D}.
STRAND 80 82 {ECO:0000244|PDB:5C5D}.
STRAND 84 86 {ECO:0000244|PDB:5C5D}.
HELIX 93 98 {ECO:0000244|PDB:5C5D}.
HELIX 99 103 {ECO:0000244|PDB:5C5D}.
HELIX 117 128 {ECO:0000244|PDB:5C5D}.
TURN 129 131 {ECO:0000244|PDB:5C5D}.
HELIX 133 157 {ECO:0000244|PDB:5C5D}.
SEQUENCE 159 AA; 17196 MW; F91B7B6D09DD8C87 CRC64;
MRPLVIILMG SSSDMGHAEK IASELKTFGI EYAIRIGSAH KTAEHVVSML KEYEALDRPK
LYITIAGRSN ALSGFVDGFV KGATIACPPP SDSFAGADIY SSLRMPSGIS PALVLEPKNA
ALLAARIFSL YDKEIADSVK SYMESNAQKI IEDDSKLKR


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