Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

PiggyBac transposable element-derived protein 3

 PGBD3_HUMAN             Reviewed;         593 AA.
Q8N328; B3KQC4; Q5W0M0; Q6PIH0;
29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
18-MAY-2010, sequence version 3.
12-SEP-2018, entry version 110.
RecName: Full=PiggyBac transposable element-derived protein 3;
Name=PGBD3;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT LYS-382.
TISSUE=Mammary gland;
PubMed=14702039; DOI=10.1038/ng1285;
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
"Complete sequencing and characterization of 21,243 full-length human
cDNAs.";
Nat. Genet. 36:40-45(2004).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=15164054; DOI=10.1038/nature02462;
Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L.,
Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K.,
Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L.,
Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P.,
Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J.,
Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J.,
Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D.,
Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L.,
Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S.,
Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L.,
Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J.,
Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M.,
Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S.,
Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M.,
Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A.,
Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T.,
Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I.,
Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T.,
Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M.,
Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W.,
Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H.,
Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L.,
Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K.,
Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T.,
Doucette-Stamm L., Beck S., Smith D.R., Rogers J.;
"The DNA sequence and comparative analysis of human chromosome 10.";
Nature 429:375-381(2004).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT LYS-382.
TISSUE=Liver, and Urinary bladder;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[4]
ALTERNATIVE SPLICING, AND MISCELLANEOUS.
PubMed=18369450; DOI=10.1371/journal.pgen.1000031;
Newman J.C., Bailey A.D., Fan H.Y., Pavelitz T., Weiner A.M.;
"An abundant evolutionarily conserved CSB-PiggyBac fusion protein
expressed in Cockayne syndrome.";
PLoS Genet. 4:E1000031-E1000031(2008).
[5]
FUNCTION.
PubMed=22483866; DOI=10.1016/j.dnarep.2012.02.004;
Bailey A.D., Gray L.T., Pavelitz T., Newman J.C., Horibata K.,
Tanaka K., Weiner A.M.;
"The conserved Cockayne syndrome B-piggyBac fusion protein (CSB-PGBD3)
affects DNA repair and induces both interferon-like and innate
antiviral responses in CSB-null cells.";
DNA Repair 11:488-501(2012).
[6]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-86, AND IDENTIFICATION
BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Cervix carcinoma;
PubMed=23186163; DOI=10.1021/pr300630k;
Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
Mohammed S.;
"Toward a comprehensive characterization of a human cancer cell
phosphoproteome.";
J. Proteome Res. 12:260-271(2013).
[7]
SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
PubMed=26218421; DOI=10.1371/journal.pgen.1005419;
Qin Y., Guo T., Li G., Tang T.S., Zhao S., Jiao X., Gong J., Gao F.,
Guo C., Simpson J.L., Chen Z.J.;
"CSB-PGBD3 mutations cause premature ovarian failure.";
PLoS Genet. 11:E1005419-E1005419(2015).
[8]
VARIANT [LARGE SCALE ANALYSIS] GLY-415.
PubMed=16959974; DOI=10.1126/science.1133427;
Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D.,
Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S.,
Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J.,
Dawson D., Willson J.K.V., Gazdar A.F., Hartigan J., Wu L., Liu C.,
Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N.,
Vogelstein B., Kinzler K.W., Velculescu V.E.;
"The consensus coding sequences of human breast and colorectal
cancers.";
Science 314:268-274(2006).
-!- FUNCTION: Binds in vitro to PGBD3-related transposable elements,
called MER85s; these non-autonomous 140 bp elements are
characterized by the presence of PGBD3 terminal inverted repeats
and the absence of internal transposase ORF.
{ECO:0000269|PubMed:22483866}.
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:26218421}.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=2;
Name=PGBD3;
IsoId=Q8N328-1; Sequence=Displayed;
Name=CSB-PGBD3 {ECO:0000303|PubMed:18369450};
IsoId=P0DP91-1, Q03468-2;
Sequence=External;
Note=Produced by an alternative splicing event that joins the
first 5 exons of ERCC6 gene in frame to the entire PGBD3 coding
region, which is located within ERCC6 intron 5. The resulting
chimeric protein consists of the N-terminal 465 residues of
ERCC6 tethered to the entire PGBD3 sequence.
{ECO:0000269|PubMed:18369450};
-!- TISSUE SPECIFICITY: Expressed in heart and oocytes, but not in
granulosa cells (at protein level). {ECO:0000269|PubMed:26218421}.
-!- MISCELLANEOUS: PGBD3 gene is located within ERCC6 intron 5.
{ECO:0000269|PubMed:18369450}.
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
Distributed under the Creative Commons Attribution (CC BY 4.0) License
-----------------------------------------------------------------------
EMBL; AK074682; BAG51986.1; -; mRNA.
EMBL; AL138760; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; BC028954; AAH28954.2; -; mRNA.
EMBL; BC063690; AAH63690.1; -; mRNA.
CCDS; CCDS7230.1; -. [Q8N328-1]
RefSeq; NP_736609.2; NM_170753.3. [Q8N328-1]
UniGene; Hs.49063; -.
ProteinModelPortal; Q8N328; -.
SMR; Q8N328; -.
BioGrid; 129356; 3.
IntAct; Q8N328; 1.
STRING; 9606.ENSP00000387966; -.
iPTMnet; Q8N328; -.
PhosphoSitePlus; Q8N328; -.
DMDM; 296439278; -.
EPD; Q8N328; -.
MaxQB; Q8N328; -.
PaxDb; Q8N328; -.
PeptideAtlas; Q8N328; -.
PRIDE; Q8N328; -.
ProteomicsDB; 71758; -.
GeneID; 267004; -.
KEGG; hsa:267004; -.
UCSC; uc057tet.1; human. [Q8N328-1]
CTD; 267004; -.
DisGeNET; 2074; -.
DisGeNET; 267004; -.
EuPathDB; HostDB:ENSG00000243251.5; -.
GeneCards; PGBD3; -.
HGNC; HGNC:19400; PGBD3.
HPA; HPA071297; -.
MIM; 609413; gene.
neXtProt; NX_Q8N328; -.
OpenTargets; ENSG00000225830; -.
PharmGKB; PA134927747; -.
eggNOG; ENOG410IHMN; Eukaryota.
eggNOG; ENOG410ZDPG; LUCA.
GeneTree; ENSGT00590000083118; -.
HOGENOM; HOG000168721; -.
HOVERGEN; HBG059393; -.
InParanoid; Q8N328; -.
OrthoDB; EOG091G05IL; -.
TreeFam; TF328011; -.
PRO; PR:Q8N328; -.
Proteomes; UP000005640; Unplaced.
Bgee; ENSG00000243251; Expressed in 88 organ(s), highest expression level in skeletal muscle tissue.
ExpressionAtlas; Q8N328; baseline and differential.
Genevisible; Q8N328; HS.
GO; GO:0016604; C:nuclear body; IDA:HPA.
GO; GO:0005654; C:nucleoplasm; IDA:HPA.
GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
InterPro; IPR029526; PGBD.
Pfam; PF13843; DDE_Tnp_1_7; 1.
1: Evidence at protein level;
Alternative splicing; Complete proteome; DNA-binding; Nucleus;
Phosphoprotein; Polymorphism; Reference proteome.
CHAIN 1 593 PiggyBac transposable element-derived
protein 3.
/FTId=PRO_0000288054.
MOD_RES 86 86 Phosphoserine.
{ECO:0000244|PubMed:23186163}.
VARIANT 382 382 R -> K (in dbSNP:rs4253072).
{ECO:0000269|PubMed:14702039,
ECO:0000269|PubMed:15489334}.
/FTId=VAR_032391.
VARIANT 415 415 D -> G (in a breast cancer sample;
somatic mutation).
{ECO:0000269|PubMed:16959974}.
/FTId=VAR_035621.
VARIANT 446 446 Q -> E (in dbSNP:rs11101143).
/FTId=VAR_051274.
SEQUENCE 593 AA; 67595 MW; B2387127F9A9A369 CRC64;
MPRTLSLHEI TDLLETDDSI EASAIVIQPP ENATAPVSDE ESGDEEGGTI NNLPGSLLHT
AAYLIQDGSD AESDSDDPSY APKDDSPDEV PSTFTVQQPP PSRRRKMTKI LCKWKKADLT
VQPVAGRVTA PPNDFFTVMR TPTEILELFL DDEVIELIVK YSNLYACSKG VHLGLTSSEF
KCFLGIIFLS GYVSVPRRRM FWEQRTDVHN VLVSAAMRRD RFETIFSNLH VADNANLDPV
DKFSKLRPLI SKLNERCMKF VPNETYFSFD EFMVPYFGRH GCKQFIRGKP IRFGYKFWCG
ATCLGYICWF QPYQGKNPNT KHEEYGVGAS LVLQFSEALT EAHPGQYHFV FNNFFTSIAL
LDKLSSMGHQ ATGTVRKDHI DRVPLESDVA LKKKERGTFD YRIDGKGNIV CRWNDNSVVT
VASSGAGIHP LCLVSRYSQK LKKKIQVQQP NMIKVYNQFM GGVDRADENI DKYRASIRGK
KWYSSPLLFC FELVLQNAWQ LHKTYDEKPV DFLEFRRRVV CHYLETHGHP PEPGQKGRPQ
KRNIDSRYDG INHVIVKQGK QTRCAECHKN TTFRCEKCDV ALHVKCSVEY HTE


Related products :

Catalog number Product name Quantity
E0108b Human ELISA Kit FOR PiggyBac transposable element-derived protein 5 96T
PGBD3_HUMAN Human ELISA Kit FOR PiggyBac transposable element-derived protein 3 96T
DRGX_HUMAN Human ELISA Kit FOR PiggyBac transposable element-derived protein 5 96T
TFPT_MOUSE Human ELISA Kit FOR PiggyBac transposable element-derived protein 5 96T
E1616r Human ELISA Kit FOR PiggyBac transposable element-derived protein 1 96T
BMA1035 PiggyBac transposable element-derived protein 5, PGBD5, Monoclonal antibody 100 μg
CSB-EL017848HU Human PiggyBac transposable element-derived protein 5(PGBD5) ELISA kit 96T
CSB-EL017840HU Human PiggyBac transposable element-derived protein 1(PGBD1) ELISA kit 96T
CSB-EL017841HU Human PiggyBac transposable element-derived protein 2(PGBD2) ELISA kit 96T
CSB-EL017847HU Human PiggyBac transposable element-derived protein 4(PGBD4) ELISA kit 96T
CSB-EL017842HU Human PiggyBac transposable element-derived protein 3(PGBD3) ELISA kit 96T
BMA1035 PiggyBac transposable element-derived protein 5, PGBD5 Monoclonal Antibodie 100 μg
BPA1085 PiggyBac transposable element-derived protein 5, PGBD5 Polyclonal Antibodie 100 μg
CSB-EL017842HU Human PiggyBac transposable element-derived protein 3(PGBD3) ELISA kit SpeciesHuman 96T
CSB-EL017841HU Human PiggyBac transposable element-derived protein 2(PGBD2) ELISA kit SpeciesHuman 96T
CSB-EL017847HU Human PiggyBac transposable element-derived protein 4(PGBD4) ELISA kit SpeciesHuman 96T
BPA1085 PiggyBac transposable element-derived protein 5, PGBD5, Polyclonal primary Antibodies 100 μg
EIAAB30697 Homo sapiens,Human,PGBD4,PiggyBac transposable element-derived protein 4
CSB-EL017840HU Human PiggyBac transposable element-derived protein 1(PGBD1) ELISA kit SpeciesHuman 96T
EIAAB30698 Homo sapiens,Human,PGBD5,PiggyBac transposable element-derived protein 5
EIAAB30696 Homo sapiens,Human,PGBD3,PiggyBac transposable element-derived protein 3
CSB-EL017848HU Human PiggyBac transposable element-derived protein 5(PGBD5) ELISA kit SpeciesHuman 96T
EIAAB30695 Homo sapiens,Human,PGBD2,PiggyBac transposable element-derived protein 2
ARP39703_T100 PGBD1 (piggyBac transposable element derived 1) 100 µg
ARP36534_T100 PGBD3 (piggyBac transposable element derived 3) 100 µg


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur