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Pituitary adenylate cyclase-activating polypeptide (PACAP) [Cleaved into: PACAP-related peptide (PRP-48); Pituitary adenylate cyclase-activating polypeptide 27 (PACAP-27) (PACAP27); Pituitary adenylate cyclase-activating polypeptide 38 (PACAP-38) (PACAP38)]

 PACA_MOUSE              Reviewed;         175 AA.
O70176;
27-APR-2001, integrated into UniProtKB/Swiss-Prot.
01-AUG-1998, sequence version 1.
30-AUG-2017, entry version 137.
RecName: Full=Pituitary adenylate cyclase-activating polypeptide;
Short=PACAP;
Contains:
RecName: Full=PACAP-related peptide;
AltName: Full=PRP-48;
Contains:
RecName: Full=Pituitary adenylate cyclase-activating polypeptide 27;
Short=PACAP-27;
Short=PACAP27;
Contains:
RecName: Full=Pituitary adenylate cyclase-activating polypeptide 38;
Short=PACAP-38;
Short=PACAP38;
Flags: Precursor;
Name=Adcyap1; Synonyms=Pacap;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=129/SvJ;
PubMed=9573339; DOI=10.1016/S0378-1119(98)00110-3;
Yamamoto K., Hashimoto H., Hagihara N., Nishino A., Fujita T.,
Matsuda T., Baba A.;
"Cloning and characterization of the mouse pituitary adenylate
cyclase-activating polypeptide (PACAP) gene.";
Gene 211:63-69(1998).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=C57BL/6J; TISSUE=Brain;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[3]
FUNCTION.
PubMed=23913443; DOI=10.1210/en.2013-1167;
Prevost G., Arabo A., Jian L., Quelennec E., Cartier D., Hassan S.,
Falluel-Morel A., Tanguy Y., Gargani S., Lihrmann I., Kerr-Conte J.,
Lefebvre H., Pattou F., Anouar Y.;
"The PACAP-regulated gene selenoprotein T is abundantly expressed in
mouse and human beta-cells and its targeted inactivation impairs
glucose tolerance.";
Endocrinology 154:3796-3806(2013).
-!- FUNCTION: Binding to its receptor activates G proteins and
stimulates adenylate cyclase in pituitary cells (By similarity).
Promotes neuron projection development through the RAPGEF2/Rap1/B-
Raf/ERK pathway (By similarity). In chromaffin cells, induces
long-lasting increase of intracellular calcium concentrations and
neuroendocrine secretion (By similarity). Involved in the control
of glucose homeostasis, induces insulin secretion by pancreatic
beta cells (PubMed:23913443). {ECO:0000250|UniProtKB:P13589,
ECO:0000250|UniProtKB:P18509, ECO:0000250|UniProtKB:Q29W19,
ECO:0000269|PubMed:23913443}.
-!- SUBUNIT: Interacts with ADCYAP1R1 (via N-terminal extracellular
domain). {ECO:0000250|UniProtKB:P18509}.
-!- SUBCELLULAR LOCATION: Secreted.
-!- SIMILARITY: Belongs to the glucagon family. {ECO:0000305}.
-----------------------------------------------------------------------
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EMBL; AB010149; BAA28355.1; -; Genomic_DNA.
EMBL; BC057344; AAH57344.1; -; mRNA.
CCDS; CCDS29029.1; -.
RefSeq; NP_001302432.1; NM_001315503.1.
RefSeq; NP_001302433.1; NM_001315504.1.
RefSeq; NP_033755.1; NM_009625.3.
UniGene; Mm.3407; -.
ProteinModelPortal; O70176; -.
SMR; O70176; -.
BioGrid; 197979; 1.
MINT; MINT-1512367; -.
STRING; 10090.ENSMUSP00000067057; -.
PhosphoSitePlus; O70176; -.
PaxDb; O70176; -.
PRIDE; O70176; -.
Ensembl; ENSMUST00000064775; ENSMUSP00000067057; ENSMUSG00000024256.
GeneID; 11516; -.
KEGG; mmu:11516; -.
UCSC; uc008dwi.1; mouse.
CTD; 116; -.
MGI; MGI:105094; Adcyap1.
eggNOG; ENOG410IWIZ; Eukaryota.
eggNOG; ENOG4111FZG; LUCA.
GeneTree; ENSGT00530000063592; -.
HOGENOM; HOG000253943; -.
HOVERGEN; HBG018069; -.
InParanoid; O70176; -.
KO; K05262; -.
OMA; RYRQRIR; -.
OrthoDB; EOG091G0J1P; -.
PhylomeDB; O70176; -.
TreeFam; TF332804; -.
Reactome; R-MMU-418555; G alpha (s) signalling events.
Reactome; R-MMU-420092; Glucagon-type ligand receptors.
PRO; PR:O70176; -.
Proteomes; UP000000589; Chromosome 17.
Bgee; ENSMUSG00000024256; -.
CleanEx; MM_ADCYAP1; -.
ExpressionAtlas; O70176; baseline and differential.
Genevisible; O70176; MM.
GO; GO:0005615; C:extracellular space; IEA:Ensembl.
GO; GO:0005622; C:intracellular; IEA:GOC.
GO; GO:0043195; C:terminal bouton; IEA:Ensembl.
GO; GO:0005184; F:neuropeptide hormone activity; ISS:UniProtKB.
GO; GO:0051428; F:peptide hormone receptor binding; ISS:UniProtKB.
GO; GO:0016521; F:pituitary adenylate cyclase activating polypeptide activity; IDA:BHF-UCL.
GO; GO:0031858; F:pituitary adenylate cyclase-activating polypeptide receptor binding; IEA:Ensembl.
GO; GO:0005102; F:receptor binding; ISO:MGI.
GO; GO:0005057; F:signal transducer activity, downstream of receptor; IDA:MGI.
GO; GO:0007190; P:activation of adenylate cyclase activity; TAS:MGI.
GO; GO:0046034; P:ATP metabolic process; IEA:Ensembl.
GO; GO:0001662; P:behavioral fear response; IEA:Ensembl.
GO; GO:0019933; P:cAMP-mediated signaling; ISS:UniProtKB.
GO; GO:0071385; P:cellular response to glucocorticoid stimulus; IEA:Ensembl.
GO; GO:0001821; P:histamine secretion; IEA:Ensembl.
GO; GO:0030073; P:insulin secretion; IDA:UniProtKB.
GO; GO:0002865; P:negative regulation of acute inflammatory response to antigenic stimulus; IEA:Ensembl.
GO; GO:0002878; P:negative regulation of acute inflammatory response to non-antigenic stimulus; IEA:Ensembl.
GO; GO:0045786; P:negative regulation of cell cycle; IDA:MGI.
GO; GO:0060253; P:negative regulation of glial cell proliferation; IEA:Ensembl.
GO; GO:0034260; P:negative regulation of GTPase activity; IEA:Ensembl.
GO; GO:0010656; P:negative regulation of muscle cell apoptotic process; IEA:Ensembl.
GO; GO:0043267; P:negative regulation of potassium ion transport; IEA:Ensembl.
GO; GO:0031175; P:neuron projection development; ISS:UniProtKB.
GO; GO:0007218; P:neuropeptide signaling pathway; ISS:UniProtKB.
GO; GO:0001541; P:ovarian follicle development; IEA:Ensembl.
GO; GO:0021983; P:pituitary gland development; IEA:Ensembl.
GO; GO:0010579; P:positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway; IDA:BHF-UCL.
GO; GO:0097755; P:positive regulation of blood vessel diameter; IEA:Ensembl.
GO; GO:0008284; P:positive regulation of cell proliferation; IEA:Ensembl.
GO; GO:0071651; P:positive regulation of chemokine (C-C motif) ligand 5 production; ISO:MGI.
GO; GO:0007204; P:positive regulation of cytosolic calcium ion concentration; ISS:UniProtKB.
GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; ISS:UniProtKB.
GO; GO:0010628; P:positive regulation of gene expression; IDA:MGI.
GO; GO:0060124; P:positive regulation of growth hormone secretion; ISS:UniProtKB.
GO; GO:0043547; P:positive regulation of GTPase activity; ISS:UniProtKB.
GO; GO:0032755; P:positive regulation of interleukin-6 production; IEA:Ensembl.
GO; GO:0010976; P:positive regulation of neuron projection development; IEA:Ensembl.
GO; GO:0045860; P:positive regulation of protein kinase activity; ISS:UniProtKB.
GO; GO:0090274; P:positive regulation of somatostatin secretion; IEA:Ensembl.
GO; GO:0051968; P:positive regulation of synaptic transmission, glutamatergic; IEA:Ensembl.
GO; GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; ISS:UniProtKB.
GO; GO:0008277; P:regulation of G-protein coupled receptor protein signaling pathway; ISS:UniProtKB.
GO; GO:0070445; P:regulation of oligodendrocyte progenitor proliferation; IEA:Ensembl.
GO; GO:0060078; P:regulation of postsynaptic membrane potential; IEA:Ensembl.
GO; GO:0032880; P:regulation of protein localization; IDA:BHF-UCL.
GO; GO:0045471; P:response to ethanol; IEA:Ensembl.
GO; GO:0042594; P:response to starvation; IEA:Ensembl.
GO; GO:0019233; P:sensory perception of pain; IEA:Ensembl.
InterPro; IPR000532; Glucagon_GIP_secretin_VIP.
Pfam; PF00123; Hormone_2; 2.
PRINTS; PR00275; GLUCAGON.
SMART; SM00070; GLUCA; 2.
PROSITE; PS00260; GLUCAGON; 1.
2: Evidence at transcript level;
Amidation; Cleavage on pair of basic residues; Complete proteome;
Hormone; Neurogenesis; Reference proteome; Secreted; Signal.
SIGNAL 1 24 {ECO:0000255}.
PROPEP 25 78
/FTId=PRO_0000011491.
PEPTIDE 81 128 PACAP-related peptide.
/FTId=PRO_0000011492.
PEPTIDE 131 168 Pituitary adenylate cyclase-activating
polypeptide 38.
/FTId=PRO_0000011493.
PEPTIDE 131 157 Pituitary adenylate cyclase-activating
polypeptide 27.
/FTId=PRO_0000011494.
PROPEP 172 175
/FTId=PRO_0000011495.
REGION 149 157 Important for receptor binding.
{ECO:0000250}.
MOD_RES 157 157 Leucine amide.
{ECO:0000250|UniProtKB:P18509}.
MOD_RES 168 168 Lysine amide.
{ECO:0000250|UniProtKB:P18509}.
SEQUENCE 175 AA; 19381 MW; D0E2007DB0C6E8C2 CRC64;
MTMCSGARLA LLVYGIIMHS SVSCSPAAGL SFPGIRPEDE AYDQDGNPLQ DFYDWDPPGV
GSPASALRDA YALYYPADRR DVAHEILNEA YRKVLDQLSA RKYLQSVVAR GAGENLGGSA
VDDPAPLTKR HSDGIFTDSY SRYRKQMAVK KYLAAVLGKR YKQRVKNKGR RIAYL


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