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Pituitary homeobox 2 (Homeobox protein PITX2) (Paired-like homeodomain transcription factor 2) (rPtx2)

 PITX2_RAT               Reviewed;         324 AA.
Q9R0W1;
26-SEP-2001, integrated into UniProtKB/Swiss-Prot.
01-MAY-2000, sequence version 1.
23-MAY-2018, entry version 134.
RecName: Full=Pituitary homeobox 2;
AltName: Full=Homeobox protein PITX2;
AltName: Full=Paired-like homeodomain transcription factor 2;
AltName: Full=rPtx2;
Name=Pitx2; Synonyms=Ptx2;
Rattus norvegicus (Rat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
NCBI_TaxID=10116;
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM PTX2B).
STRAIN=Sprague-Dawley;
PubMed=9748586; DOI=10.1016/S0165-3806(98)00110-2;
Lindberg C., Wunderlich M., Ratliff J., Dinsmore J., Jacoby D.B.;
"Regulated expression of the homeobox gene, rPtx2, in the developing
rat.";
Brain Res. Dev. Brain Res. 110:215-226(1998).
[2]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS PTX2A AND PTX2B).
PubMed=11032870; DOI=10.1046/j.1471-4159.2000.0751818.x;
Smidt M.P., Cox J.J., van Schaick H.S.A., Coolen M., Schepers J.,
van der Kleij A.M., Burbach J.P.H.;
"Analysis of three Ptx2 splice variants on transcriptional activity
and differential expression pattern in the brain.";
J. Neurochem. 75:1818-1825(2000).
-!- FUNCTION: Controls cell proliferation in a tissue-specific manner
and is involved in morphogenesis. During embryonic development,
exerts a role in the expansion of muscle progenitors. May play a
role in the proper localization of asymmetric organs such as the
heart and stomach (By similarity). {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Nucleus.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=2;
Name=PTX2A;
IsoId=Q9R0W1-1; Sequence=Displayed;
Name=PTX2B;
IsoId=Q9R0W1-2; Sequence=VSP_002264, VSP_002265;
-!- TISSUE SPECIFICITY: Expressed in the brain.
-!- PTM: Phosphorylation at Thr-97 impairs its association with the
CCND1 mRNA-stabilizing complex thus shortening the half-life of
CCND1. {ECO:0000250}.
-!- SIMILARITY: Belongs to the paired homeobox family. Bicoid
subfamily. {ECO:0000305}.
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EMBL; AF039832; AAC70909.1; -; mRNA.
EMBL; AJ222971; CAB52283.1; -; mRNA.
EMBL; AJ222972; CAB52284.1; -; mRNA.
RefSeq; NP_001035970.1; NM_001042505.1. [Q9R0W1-1]
RefSeq; NP_062207.1; NM_019334.2. [Q9R0W1-2]
RefSeq; XP_017446543.1; XM_017591054.1. [Q9R0W1-2]
UniGene; Rn.17591; -.
ProteinModelPortal; Q9R0W1; -.
SMR; Q9R0W1; -.
STRING; 10116.ENSRNOP00000046259; -.
PaxDb; Q9R0W1; -.
PRIDE; Q9R0W1; -.
Ensembl; ENSRNOT00000044232; ENSRNOP00000043402; ENSRNOG00000010681. [Q9R0W1-2]
Ensembl; ENSRNOT00000051009; ENSRNOP00000046259; ENSRNOG00000010681. [Q9R0W1-1]
GeneID; 54284; -.
KEGG; rno:54284; -.
UCSC; RGD:3331; rat. [Q9R0W1-1]
CTD; 5308; -.
RGD; 3331; Pitx2.
eggNOG; KOG0486; Eukaryota.
eggNOG; ENOG410ZZ6J; LUCA.
GeneTree; ENSGT00900000140776; -.
HOGENOM; HOG000273886; -.
HOVERGEN; HBG068770; -.
InParanoid; Q9R0W1; -.
KO; K04686; -.
OMA; PLNIDHH; -.
OrthoDB; EOG091G0H7U; -.
PhylomeDB; Q9R0W1; -.
TreeFam; TF351940; -.
PRO; PR:Q9R0W1; -.
Proteomes; UP000002494; Chromosome 2.
Bgee; ENSRNOG00000010681; -.
Genevisible; Q9R0W1; RN.
GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
GO; GO:0005634; C:nucleus; IDA:RGD.
GO; GO:0005667; C:transcription factor complex; IEA:Ensembl.
GO; GO:0031490; F:chromatin DNA binding; IEA:Ensembl.
GO; GO:0001102; F:RNA polymerase II activating transcription factor binding; IEA:Ensembl.
GO; GO:0000978; F:RNA polymerase II proximal promoter sequence-specific DNA binding; IDA:RGD.
GO; GO:0001105; F:RNA polymerase II transcription coactivator activity; IEA:Ensembl.
GO; GO:0001077; F:transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding; IDA:RGD.
GO; GO:0055009; P:atrial cardiac muscle tissue morphogenesis; IEA:Ensembl.
GO; GO:0003171; P:atrioventricular valve development; IEA:Ensembl.
GO; GO:0007420; P:brain development; IEP:RGD.
GO; GO:0001569; P:branching involved in blood vessel morphogenesis; IEA:Ensembl.
GO; GO:0003253; P:cardiac neural crest cell migration involved in outflow tract morphogenesis; IEA:Ensembl.
GO; GO:0061325; P:cell proliferation involved in outflow tract morphogenesis; IEA:Ensembl.
GO; GO:0035993; P:deltoid tuberosity development; IEA:Ensembl.
GO; GO:0007368; P:determination of left/right symmetry; IEA:Ensembl.
GO; GO:0031076; P:embryonic camera-type eye development; IEA:Ensembl.
GO; GO:0048557; P:embryonic digestive tract morphogenesis; IEA:Ensembl.
GO; GO:0035116; P:embryonic hindlimb morphogenesis; IEA:Ensembl.
GO; GO:0061031; P:endodermal digestive tract morphogenesis; IEA:Ensembl.
GO; GO:0002074; P:extraocular skeletal muscle development; IEA:Ensembl.
GO; GO:0008585; P:female gonad development; IEP:RGD.
GO; GO:0021855; P:hypothalamus cell migration; IEA:Ensembl.
GO; GO:0001701; P:in utero embryonic development; IEA:Ensembl.
GO; GO:0061072; P:iris morphogenesis; IEA:Ensembl.
GO; GO:0060460; P:left lung morphogenesis; IEA:Ensembl.
GO; GO:0070986; P:left/right axis specification; IEA:Ensembl.
GO; GO:0008584; P:male gonad development; IEP:RGD.
GO; GO:0007520; P:myoblast fusion; IEA:Ensembl.
GO; GO:0030182; P:neuron differentiation; IEP:RGD.
GO; GO:0001764; P:neuron migration; IEA:Ensembl.
GO; GO:0042475; P:odontogenesis of dentin-containing tooth; IEP:RGD.
GO; GO:0021983; P:pituitary gland development; IEA:Ensembl.
GO; GO:0043388; P:positive regulation of DNA binding; IEA:Ensembl.
GO; GO:2000288; P:positive regulation of myoblast proliferation; IEA:Ensembl.
GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IDA:RGD.
GO; GO:0003350; P:pulmonary myocardium development; IEA:Ensembl.
GO; GO:0060577; P:pulmonary vein morphogenesis; IEA:Ensembl.
GO; GO:0030334; P:regulation of cell migration; IEA:Ensembl.
GO; GO:0009725; P:response to hormone; IEP:RGD.
GO; GO:0033189; P:response to vitamin A; IEP:RGD.
GO; GO:0048536; P:spleen development; IEA:Ensembl.
GO; GO:0021763; P:subthalamic nucleus development; IEA:Ensembl.
GO; GO:0060578; P:superior vena cava morphogenesis; IEA:Ensembl.
GO; GO:0035886; P:vascular smooth muscle cell differentiation; IEA:Ensembl.
GO; GO:0001570; P:vasculogenesis; IEA:Ensembl.
GO; GO:0055015; P:ventricular cardiac muscle cell development; IEA:Ensembl.
GO; GO:0060412; P:ventricular septum morphogenesis; IEA:Ensembl.
GO; GO:0016055; P:Wnt signaling pathway; IEA:Ensembl.
CDD; cd00086; homeodomain; 1.
InterPro; IPR009057; Homeobox-like_sf.
InterPro; IPR017970; Homeobox_CS.
InterPro; IPR001356; Homeobox_dom.
InterPro; IPR016233; Homeobox_Pitx/unc30.
InterPro; IPR003654; OAR_dom.
Pfam; PF00046; Homeobox; 1.
Pfam; PF03826; OAR; 1.
PIRSF; PIRSF000563; Homeobox_protein_Pitx/Unc30; 1.
SMART; SM00389; HOX; 1.
SUPFAM; SSF46689; SSF46689; 1.
PROSITE; PS00027; HOMEOBOX_1; 1.
PROSITE; PS50071; HOMEOBOX_2; 1.
PROSITE; PS50803; OAR; 1.
2: Evidence at transcript level;
Alternative splicing; Complete proteome; Developmental protein;
DNA-binding; Homeobox; Nucleus; Phosphoprotein; Reference proteome.
CHAIN 1 324 Pituitary homeobox 2.
/FTId=PRO_0000049225.
DNA_BIND 92 151 Homeobox. {ECO:0000255|PROSITE-
ProRule:PRU00108}.
MOTIF 286 299 OAR. {ECO:0000255|PROSITE-
ProRule:PRU00138}.
MOTIF 292 296 Nuclear localization signal.
{ECO:0000255}.
MOD_RES 97 97 Phosphothreonine; by PKB/AKT2.
{ECO:0000250}.
VAR_SEQ 1 53 Missing (in isoform PTX2B).
{ECO:0000303|PubMed:11032870,
ECO:0000303|PubMed:9748586}.
/FTId=VSP_002264.
VAR_SEQ 54 68 LEVHTISDTSSPEVA -> METNCRKLVSACVQL (in
isoform PTX2B).
{ECO:0000303|PubMed:11032870,
ECO:0000303|PubMed:9748586}.
/FTId=VSP_002265.
SEQUENCE 324 AA; 35758 MW; 0FAB2ABA8CF180E3 CRC64;
MNCMKGPLPL EHRAAGTKLS AASSPFCHHT QALAMASVLA PGQPRSLDAS KHRLEVHTIS
DTSSPEVAEK DKGQQGKNED VGAEDPSKKK RQRRQRTHFT SQQLQELEAT FQRNRYPDMS
TREEIAVWTN LTEARVRVWF KNRRAKWRKR ERNQQAELCK NGFGPQFNGL MQPYDDMYPG
YSYNNWAAKG LTSASLSTKS FPFFNSMNVN PLSSQSMFSP PNSISSMSMS SSMVPSAVTG
VPGSSLNSLN NLNNLSSPSL NSAVPTPACP YAPPTPPYVY RDTCNSSLAS LRLKAKQHSS
FGYASVQNPA SNLSACQYAV DRPV


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