Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Plasminogen (EC 3.4.21.7)

 F1SB81_PIG              Unreviewed;       816 AA.
F1SB81;
03-MAY-2011, integrated into UniProtKB/TrEMBL.
22-NOV-2017, sequence version 2.
12-SEP-2018, entry version 72.
RecName: Full=Plasminogen {ECO:0000256|PIRNR:PIRNR001150};
EC=3.4.21.7 {ECO:0000256|PIRNR:PIRNR001150};
Name=PLG {ECO:0000313|Ensembl:ENSSSCP00000004364};
Sus scrofa (Pig).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Suina; Suidae;
Sus.
NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000004364, ECO:0000313|Proteomes:UP000008227};
[1] {ECO:0000313|Ensembl:ENSSSCP00000004364, ECO:0000313|Proteomes:UP000008227}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000004364};
Porcine genome sequencing project;
Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
[2] {ECO:0000313|Ensembl:ENSSSCP00000004364}
IDENTIFICATION.
Ensembl;
Submitted (JUL-2011) to UniProtKB.
-!- FUNCTION: Plasmin dissolves the fibrin of blood clots and acts as
a proteolytic factor in a variety of other processes including
embryonic development, tissue remodeling, tumor invasion, and
inflammation. In ovulation, weakens the walls of the Graafian
follicle. It activates the urokinase-type plasminogen activator,
collagenases and several complement zymogens, such as C1 and C5.
Cleavage of fibronectin and laminin leads to cell detachment and
apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand
factor. Its role in tissue remodeling and tumor invasion may be
modulated by CSPG4. Binds to cells.
{ECO:0000256|PIRNR:PIRNR001150}.
-!- CATALYTIC ACTIVITY: Preferential cleavage: Lys-|-Xaa > Arg-|-Xaa;
higher selectivity than trypsin. Converts fibrin into soluble
products. {ECO:0000256|PIRNR:PIRNR001150}.
-!- ACTIVITY REGULATION: Converted into plasmin by plasminogen
activators, both plasminogen and its activator being bound to
fibrin. {ECO:0000256|PIRNR:PIRNR001150}.
-!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|PIRNR:PIRNR001150}.
-!- SIMILARITY: Belongs to the peptidase S1 family. Plasminogen
subfamily. {ECO:0000256|PIRNR:PIRNR001150}.
-!- CAUTION: Lacks conserved residue(s) required for the propagation
of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00121}.
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
Distributed under the Creative Commons Attribution (CC BY 4.0) License
-----------------------------------------------------------------------
EMBL; AEMK02000001; -; NOT_ANNOTATED_CDS; Genomic_DNA.
PeptideAtlas; F1SB81; -.
PRIDE; F1SB81; -.
Ensembl; ENSSSCT00000004466; ENSSSCP00000004364; ENSSSCG00000004038.
eggNOG; ENOG410IDXR; Eukaryota.
eggNOG; COG5640; LUCA.
GeneTree; ENSGT00760000119133; -.
OrthoDB; EOG091G0AH5; -.
TreeFam; TF329901; -.
Reactome; R-SSC-114608; Platelet degranulation.
Reactome; R-SSC-1474228; Degradation of the extracellular matrix.
Reactome; R-SSC-1592389; Activation of Matrix Metalloproteinases.
Reactome; R-SSC-186797; Signaling by PDGF.
Reactome; R-SSC-381426; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs).
Reactome; R-SSC-75205; Dissolution of Fibrin Clot.
Reactome; R-SSC-8964041; LDL remodeling.
Proteomes; UP000008227; Chromosome 1.
Bgee; ENSSSCG00000004038; Expressed in 4 organ(s), highest expression level in liver.
GO; GO:0005615; C:extracellular space; IEA:Ensembl.
GO; GO:0031232; C:extrinsic component of external side of plasma membrane; IEA:Ensembl.
GO; GO:0044218; C:other organism cell membrane; IEA:Ensembl.
GO; GO:0034185; F:apolipoprotein binding; IEA:Ensembl.
GO; GO:0051087; F:chaperone binding; IEA:Ensembl.
GO; GO:0019900; F:kinase binding; IEA:Ensembl.
GO; GO:1904854; F:proteasome core complex binding; IEA:Ensembl.
GO; GO:1990405; F:protein antigen binding; IEA:Ensembl.
GO; GO:0019904; F:protein domain specific binding; IEA:Ensembl.
GO; GO:0004252; F:serine-type endopeptidase activity; IEA:UniProtKB-UniRule.
GO; GO:0005102; F:signaling receptor binding; IEA:Ensembl.
GO; GO:0007596; P:blood coagulation; IEA:UniProtKB-UniRule.
GO; GO:0022617; P:extracellular matrix disassembly; IEA:Ensembl.
GO; GO:0042730; P:fibrinolysis; IEA:UniProtKB-UniRule.
GO; GO:0060716; P:labyrinthine layer blood vessel development; IEA:Ensembl.
GO; GO:0052182; P:modification by host of symbiont morphology or physiology via secreted substance; IEA:Ensembl.
GO; GO:0071674; P:mononuclear cell migration; IEA:Ensembl.
GO; GO:0046716; P:muscle cell cellular homeostasis; IEA:Ensembl.
GO; GO:0045445; P:myoblast differentiation; IEA:Ensembl.
GO; GO:0010812; P:negative regulation of cell-substrate adhesion; IEA:Ensembl.
GO; GO:0051918; P:negative regulation of fibrinolysis; IEA:Ensembl.
GO; GO:0051919; P:positive regulation of fibrinolysis; IEA:Ensembl.
GO; GO:0042246; P:tissue regeneration; IEA:Ensembl.
GO; GO:0048771; P:tissue remodeling; IEA:UniProtKB-UniRule.
GO; GO:0060707; P:trophoblast giant cell differentiation; IEA:Ensembl.
CDD; cd00108; KR; 5.
CDD; cd00190; Tryp_SPc; 1.
Gene3D; 2.40.20.10; -; 4.
InterPro; IPR000001; Kringle.
InterPro; IPR013806; Kringle-like.
InterPro; IPR018056; Kringle_CS.
InterPro; IPR038178; Kringle_sf.
InterPro; IPR003609; Pan_app.
InterPro; IPR023317; Pept_S1A_plasmin.
InterPro; IPR009003; Peptidase_S1_PA.
InterPro; IPR001314; Peptidase_S1A.
InterPro; IPR001254; Trypsin_dom.
InterPro; IPR033116; TRYPSIN_SER.
Pfam; PF00051; Kringle; 5.
Pfam; PF00024; PAN_1; 1.
Pfam; PF00089; Trypsin; 1.
PIRSF; PIRSF001150; Plasmin; 1.
PRINTS; PR00722; CHYMOTRYPSIN.
SMART; SM00130; KR; 5.
SMART; SM00473; PAN_AP; 1.
SMART; SM00020; Tryp_SPc; 1.
SUPFAM; SSF50494; SSF50494; 1.
SUPFAM; SSF57440; SSF57440; 5.
PROSITE; PS00021; KRINGLE_1; 5.
PROSITE; PS50070; KRINGLE_2; 5.
PROSITE; PS50948; PAN; 1.
PROSITE; PS50240; TRYPSIN_DOM; 1.
PROSITE; PS00135; TRYPSIN_SER; 1.
1: Evidence at protein level;
Blood coagulation {ECO:0000256|PIRNR:PIRNR001150};
Complete proteome {ECO:0000313|Proteomes:UP000008227};
Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00121,
ECO:0000256|SAAS:SAAS00731840};
Fibrinolysis {ECO:0000256|PIRNR:PIRNR001150};
Hemostasis {ECO:0000256|PIRNR:PIRNR001150};
Hydrolase {ECO:0000256|PIRNR:PIRNR001150,
ECO:0000256|SAAS:SAAS00745848};
Kringle {ECO:0000256|PROSITE-ProRule:PRU00121,
ECO:0000256|SAAS:SAAS00045973};
Protease {ECO:0000256|PIRNR:PIRNR001150,
ECO:0000256|SAAS:SAAS00745848};
Proteomics identification {ECO:0000213|PeptideAtlas:F1SB81};
Reference proteome {ECO:0000313|Proteomes:UP000008227};
Secreted {ECO:0000256|PIRNR:PIRNR001150};
Serine protease {ECO:0000256|PIRNR:PIRNR001150,
ECO:0000256|SAAS:SAAS00745848}; Signal {ECO:0000256|SAM:SignalP};
Tissue remodeling {ECO:0000256|PIRNR:PIRNR001150}.
SIGNAL 1 26 {ECO:0000256|SAM:SignalP}.
CHAIN 27 816 Plasminogen. {ECO:0000256|SAM:SignalP}.
/FTId=PRO_5012113090.
DOMAIN 25 105 Apple. {ECO:0000259|PROSITE:PS50948}.
DOMAIN 109 188 Kringle. {ECO:0000259|PROSITE:PS50070}.
DOMAIN 191 269 Kringle. {ECO:0000259|PROSITE:PS50070}.
DOMAIN 281 359 Kringle. {ECO:0000259|PROSITE:PS50070}.
DOMAIN 383 461 Kringle. {ECO:0000259|PROSITE:PS50070}.
DOMAIN 486 566 Kringle. {ECO:0000259|PROSITE:PS50070}.
DOMAIN 587 814 Peptidase S1.
{ECO:0000259|PROSITE:PS50240}.
ACT_SITE 628 628 Charge relay system.
{ECO:0000256|PIRSR:PIRSR001150-1}.
ACT_SITE 671 671 Charge relay system.
{ECO:0000256|PIRSR:PIRSR001150-1}.
ACT_SITE 766 766 Charge relay system.
{ECO:0000256|PIRSR:PIRSR001150-1}.
DISULFID 192 269 {ECO:0000256|PROSITE-ProRule:PRU00121}.
DISULFID 213 252 {ECO:0000256|PROSITE-ProRule:PRU00121}.
DISULFID 241 264 {ECO:0000256|PROSITE-ProRule:PRU00121}.
DISULFID 282 359 {ECO:0000256|PROSITE-ProRule:PRU00121}.
DISULFID 303 342 {ECO:0000256|PROSITE-ProRule:PRU00121}.
DISULFID 331 354 {ECO:0000256|PROSITE-ProRule:PRU00121}.
DISULFID 384 461 {ECO:0000256|PROSITE-ProRule:PRU00121}.
DISULFID 405 444 {ECO:0000256|PROSITE-ProRule:PRU00121}.
DISULFID 433 456 {ECO:0000256|PROSITE-ProRule:PRU00121}.
SEQUENCE 816 AA; 91276 MW; 89763DFBE14C08CC CRC64;
TLLASPKMDH KEVVLLLLLF LKSGLGDSLD DYVNTQGAFL FSLSRKQVAA RSVEECAAKC
EAETNFICRA FQYHSKDQQC VVMAENSKTS PIARMRDVVL FEKRIYLSEC KTGNGKNYRG
TTSKTKSGVI CQKWSVSSPH IPKYSPEKFP LAGLEENYCR NPDNDEKGPW CYTTDPETRF
DYCDIPECED ECMHCSGEHY EGKISKTMSG IECQSWGSQS PHAHGYLPSK FPNKNLKMNY
CRNPDGEPRP WCFTTDPNKR WEFCDIPRCT TPPPTSGPTY QCLKGRGENY RGTVSVTASG
HTCQRWSAQS PHKHNRTPEN FPCKNLEENY CRNPDGETAP WCYTTDSEVR WDYCKIPSCG
SSTTSTEYLD APVPPEQTPV AQDCYRGNGE SYRGTSSTTI TGRKCQSWVS MTPHRHEKTP
GNFPNAGLTM NYCRNPDADK SPWCYTTDPR VRWEYCNLKK CSETEQQVTN FPAIAQVPSV
EDLSEDCMFG NGKRYRGKRA TTVAGVPCQE WAAQEPHRHS IFTPETNPRA GLEKNYCRNP
DGDDNGPWCY TTNPQKLFDY CDVPQCVTSS FDCGKPKVEP KKCPARVVGG CVSIPHSWPW
QISLRHRYGG HFCGGTLISP EWVLTAKHCL EKSSSPSSYK VILGAHEEHH LGEGVQEIDV
SKLFKEPSGA DIALLKLSSP AIITDKVIPA CLPTPNYVVA DRTACYITGW GETKGTYGAG
LLKEARLPVI ENKVCNRYEY LDGKVSSNEL CAGHLAGGID SCQGDSGGPL VCFEKDKYIL
QGVTSWGLGC ALPNKPGVYV RVSRFVTWIE EIMRRN


Related products :

Catalog number Product name Quantity
EIAAB31515 Homo sapiens,Human,Plasminogen-like protein A,Plasminogen-like protein A1,Plasminogen-related protein A,PLGLA,PLGLA1,PLGP2
orb21997 Goat Serum Against Human Plasminogen Polyclonal Precipitating polyclonal goat antiserum to human plasminogen. Native plasminogen is a single polypeptide chain, synthesized in the liver. Its molecular 1 ml
orb82135 Human Plasminogen protein Plasminogen is a purified platelets_hemostasis antigen. For research use only. 1 mg
PLG13C3B10 PLASMINOGEN MONOCLONAL ANTIBODIES Anti Human Plasminogen, Clone 13C3-B10 1.0 mg
PLG1C10F2 PLASMINOGEN MONOCLONAL ANTIBODIES Anti Human Plasminogen, Clone 1C10-F2 1.0 mg
PLG-MABPACK PLASMINOGEN MONOCLONAL ANTIBODIES Anti Human Plasminogen MAb Sample Pack 1 pack
PLG11B5B2 PLASMINOGEN MONOCLONAL ANTIBODIES Anti Human Plasminogen, Clone 11B5-B2 1.0 mg
'BM5136 Plasminogen _ PLG (Glu-Plasminogen) Clone '1PG antibody Isotype IgG1 Host Mouse 0.5 mg
PLG13C3B10 PLASMINOGEN MONOCLONAL ANTIBODIES Anti Human Plasminogen, Clone 13C3-B10 10 mg
PLG1C10F2 PLASMINOGEN MONOCLONAL ANTIBODIES Anti Human Plasminogen, Clone 1C10-F2 10 mg
PLG11B5B2 PLASMINOGEN MONOCLONAL ANTIBODIES Anti Human Plasminogen, Clone 11B5-B2 10 mg
PLG-MABPACK PLASMINOGEN MONOCLONAL ANTIBODIES Anti Human Plasminogen MAb Sample Pack 10 packs
'BM5136 Plasminogen PLG (Glu-Plasminogen) Clone '1PG antibody Isotype IgG1 Host Mouse 0.5 mg
PLG2F6C6 PLASMINOGEN MONOCLONAL ANTIBODIES Anti Human Plasminogen, Clone 2F6-C6 1.0 mg
PLG2F6C6 PLASMINOGEN MONOCLONAL ANTIBODIES Anti Human Plasminogen, Clone 2F6-C6 10 mg
PLG9F9C4 PLASMINOGEN MONOCLONAL ANTIBODIES Anti Human Plasminogen, Clone 9F9-C4 1.0 mg
PLG9F9C4 PLASMINOGEN MONOCLONAL ANTIBODIES Anti Human Plasminogen, Clone 9F9-C4 10 mg
PLG4G6B11 PLASMINOGEN MONOCLONAL ANTIBODIES Anti Human Plasminogen, Clone 4G6-B11 10 mg
PLG4G6B11 PLASMINOGEN MONOCLONAL ANTIBODIES Anti Human Plasminogen, Clone 4G6-B11 1.0 mg
ASCKPG-GF PLASMINOGEN POLYCLONAL ANTIBODIES (HOST RABBIT OR SHEEP) Anti Chicken Plasminogen IgG 10 mg
ASCKPG-GF PLASMINOGEN POLYCLONAL ANTIBODIES (HOST RABBIT OR SHEEP) Anti Chicken Plasminogen IgG 1.0 mg
AS10 1393 Antibody: Plasminogen , Host: goat, polyclonal, Comfirmed reactivity: human plasminogen 1 mg
18-271-81026 Plasminogen - Sheep Anti Human Plasminogen Polyclonal 0.1 mg
9001-91-6 Plasminogen from human plasma Plasminogen 1g
ASMPLG-GF-HRP PLASMINOGEN POLYCLONAL ANTIBODIES (HOST RABBIT OR SHEEP) Rabbit anti mouse plasminogen IgG fraction, HRP labeled 10 mg


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur