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Plasminogen activator inhibitor 2, macrophage (PAI-2) (Serpin B2)

 PAI2_MOUSE              Reviewed;         415 AA.
P12388; O35687; Q9QWP6; Q9QWP7; Q9QWP8; Q9QWP9; Q9QWQ0; Q9QWZ5;
Q9QWZ6;
01-OCT-1989, integrated into UniProtKB/Swiss-Prot.
01-OCT-1989, sequence version 1.
12-SEP-2018, entry version 152.
RecName: Full=Plasminogen activator inhibitor 2, macrophage;
Short=PAI-2;
AltName: Full=Serpin B2;
Name=Serpinb2; Synonyms=Pai2, Planh2;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [MRNA] OF 1-27.
STRAIN=AKR/J; TISSUE=Myeloid;
PubMed=2583099;
Belin D., Wohlwend A., Schleuning W.-D., Kruithof E.K.O.,
Vassalli J.-D.;
"Facultative polypeptide translocation allows a single mRNA to encode
the secreted and cytosolic forms of plasminogen activators inhibitor
2.";
EMBO J. 8:3287-3294(1989).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=AKR/J; TISSUE=Myeloid;
Belin D.;
Submitted (SEP-1989) to the EMBL/GenBank/DDBJ databases.
[3]
NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS GLU-239; TYR-258;
ILE-259 AND ARG-284.
STRAIN=129; TISSUE=Liver;
Belin D., Tapparel C., Sappino N., Silva F.;
"Sequence and tissue-specific expression of the murine PAI-2 gene.";
Submitted (JUL-1997) to the EMBL/GenBank/DDBJ databases.
[4]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-34; 54-74; 89-115; 124-156;
163-237 AND 265-302.
STRAIN=129/Sv;
PubMed=9892694; DOI=10.1073/pnas.96.2.686;
Dougherty K.M., Pearson J.M., Yang A.Y., Westrick R.J., Baker M.S.,
Ginsburg D.;
"The plasminogen activator inhibitor-2 gene is not required for normal
murine development or survival.";
Proc. Natl. Acad. Sci. U.S.A. 96:686-691(1999).
[5]
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Spleen;
PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
"A tissue-specific atlas of mouse protein phosphorylation and
expression.";
Cell 143:1174-1189(2010).
-!- FUNCTION: Inhibits urokinase-type plasminogen activator. The
monocyte derived PAI-2 is distinct from the endothelial cell-
derived PAI-1. Not required for normal murine development or
survival.
-!- SUBUNIT: Interacts with PSMB1. {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Cytoplasm. Secreted, extracellular space.
-!- PTM: The signal sequence is not cleaved.
-!- SIMILARITY: Belongs to the serpin family. Ov-serpin subfamily.
{ECO:0000305}.
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EMBL; X16490; CAA34507.1; -; mRNA.
EMBL; AJ000386; CAA04047.1; -; Genomic_DNA.
EMBL; AJ000384; CAA04047.1; JOINED; Genomic_DNA.
EMBL; AJ000385; CAA04047.1; JOINED; Genomic_DNA.
EMBL; AF069683; AAD08915.1; -; Genomic_DNA.
EMBL; AF069685; AAD08916.1; -; Genomic_DNA.
EMBL; AF069684; AAD08916.1; JOINED; Genomic_DNA.
EMBL; AF069687; AAD08917.1; -; Genomic_DNA.
EMBL; AF069686; AAD08917.1; JOINED; Genomic_DNA.
EMBL; AF069689; AAD08918.1; -; Genomic_DNA.
EMBL; AF069688; AAD08918.1; JOINED; Genomic_DNA.
EMBL; AF069690; AAD08919.1; -; Genomic_DNA.
EMBL; AF069692; AAD08920.1; -; Genomic_DNA.
EMBL; AF069691; AAD08920.1; JOINED; Genomic_DNA.
EMBL; AF069694; AAD08921.1; -; Genomic_DNA.
EMBL; AF069693; AAD08921.1; JOINED; Genomic_DNA.
CCDS; CCDS15219.1; -.
PIR; S20047; S20047.
RefSeq; NP_001167641.1; NM_001174170.1.
RefSeq; NP_035241.1; NM_011111.4.
UniGene; Mm.271870; -.
ProteinModelPortal; P12388; -.
SMR; P12388; -.
STRING; 10090.ENSMUSP00000009356; -.
MEROPS; I04.007; -.
PhosphoSitePlus; P12388; -.
PaxDb; P12388; -.
PeptideAtlas; P12388; -.
PRIDE; P12388; -.
Ensembl; ENSMUST00000009356; ENSMUSP00000009356; ENSMUSG00000062345.
Ensembl; ENSMUST00000064916; ENSMUSP00000065277; ENSMUSG00000062345.
GeneID; 18788; -.
KEGG; mmu:18788; -.
UCSC; uc007chn.2; mouse.
CTD; 5055; -.
MGI; MGI:97609; Serpinb2.
eggNOG; KOG2392; Eukaryota.
eggNOG; COG4826; LUCA.
GeneTree; ENSGT00760000118789; -.
HOVERGEN; HBG005957; -.
InParanoid; P12388; -.
KO; K19821; -.
OMA; QIQKGTY; -.
OrthoDB; EOG091G0ION; -.
PhylomeDB; P12388; -.
TreeFam; TF352619; -.
Reactome; R-MMU-75205; Dissolution of Fibrin Clot.
ChiTaRS; Serpinb2; mouse.
PRO; PR:P12388; -.
Proteomes; UP000000589; Chromosome 1.
Bgee; ENSMUSG00000062345; Expressed in 65 organ(s), highest expression level in skin epidermis.
ExpressionAtlas; P12388; baseline and differential.
Genevisible; P12388; MM.
GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO; GO:0005615; C:extracellular space; IBA:GO_Central.
GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IBA:GO_Central.
GO; GO:0043066; P:negative regulation of apoptotic process; IEA:InterPro.
GO; GO:0042060; P:wound healing; ISO:MGI.
InterPro; IPR015556; PAI-2.
InterPro; IPR023795; Serpin_CS.
InterPro; IPR023796; Serpin_dom.
InterPro; IPR000215; Serpin_fam.
InterPro; IPR036186; Serpin_sf.
PANTHER; PTHR11461; PTHR11461; 1.
PANTHER; PTHR11461:SF61; PTHR11461:SF61; 1.
Pfam; PF00079; Serpin; 1.
SMART; SM00093; SERPIN; 1.
SUPFAM; SSF56574; SSF56574; 2.
PROSITE; PS00284; SERPIN; 1.
1: Evidence at protein level;
Complete proteome; Cytoplasm; Glycoprotein; Plasminogen activation;
Polymorphism; Protease inhibitor; Reference proteome; Secreted;
Serine protease inhibitor; Signal.
CHAIN 1 415 Plasminogen activator inhibitor 2,
macrophage.
/FTId=PRO_0000223297.
SIGNAL 1 ? Not cleaved.
SITE 380 381 Reactive bond.
CARBOHYD 23 23 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 75 75 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 261 261 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 339 339 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
VARIANT 239 239 A -> E. {ECO:0000269|Ref.3}.
VARIANT 258 258 H -> Y. {ECO:0000269|Ref.3}.
VARIANT 259 259 T -> I. {ECO:0000269|Ref.3}.
VARIANT 284 284 S -> R. {ECO:0000269|Ref.3}.
CONFLICT 55 55 A -> T (in Ref. 3 and 4). {ECO:0000305}.
SEQUENCE 415 AA; 46292 MW; C4FC78C5C3CA7D8B CRC64;
MEELSMANTM FALNLLKQIE KSNSTQNIFI SPWSISSTLA IVLLGAGGNT EQQMAKVLQF
NEIGSYGITT RNPENFSGCD FAQQIQKENY PSAILQAQAG DKIHSAFSSL SSTINTPQGD
YLLESANKLF GEKSARFKEE YIQLSKKYYS TEPEAVDFLE CAEEAREKIN SWVKTQTKGE
IPNLLPEGSV DEDTKMVLVN AVYFKGKWKT PFEKKLNGLY PFRVNSHESI PVQMMFLHAK
LNIGYIKDLK TQILELPHTG NISMLLLLPD EIEDASTGLE LLESEINFAN FNKWISKDTL
DEDDVVVYIP KFKLAQSYEL KSILQSMGME DAFNKGKANF SGMSERNDLF LSEVFHQASV
DVTEEGTVAA GGTGAVMTGR TGHGGPQFVA DHPFLFFIMD KITHTILFVG RFSSP


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