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Plasminogen-like protein A (Plasminogen-like protein A1) (Plasminogen-related protein A)

 PLGA_HUMAN              Reviewed;          96 AA.
Q15195;
02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
01-NOV-1996, sequence version 1.
20-JUN-2018, entry version 91.
RecName: Full=Plasminogen-like protein A;
AltName: Full=Plasminogen-like protein A1;
AltName: Full=Plasminogen-related protein A;
Flags: Precursor;
Name=PLGLA; Synonyms=PLGLA1, PLGP2, PRGA;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=1554698; DOI=10.1021/bi00127a011;
Ichinose A.;
"Multiple members of the plasminogen-apolipoprotein(a) gene family
associated with thrombosis.";
Biochemistry 31:3113-3118(1992).
[2]
TISSUE SPECIFICITY.
PubMed=10092845; DOI=10.1046/j.1432-1327.1999.00055.x;
Lewis V.O., Gehrmann M., Weissbach L., Hyman J.E., Rielly A.,
Jones D.G., Llinas M., Schaller J.;
"Homologous plasminogen N-terminal and plasminogen-related gene A and
B peptides. Characterization of cDNAs and recombinant fusion
proteins.";
Eur. J. Biochem. 259:618-625(1999).
-!- FUNCTION: May bind non-covalently to lysine binding sites present
in the kringle structures of plasminogen. This may interfere with
the binding of fibrin or alpha-2-antiplasmin to plasminogen and
may result in the localization of activity at sites necessary for
extracellular matrix destruction (By similarity). {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
-!- TISSUE SPECIFICITY: Expressed in liver.
{ECO:0000269|PubMed:10092845}.
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EMBL; M86873; AAA60168.1; -; Genomic_DNA.
EMBL; M86871; AAA60168.1; JOINED; Genomic_DNA.
EMBL; M86872; AAA60168.1; JOINED; Genomic_DNA.
UniGene; Hs.652169; -.
ProteinModelPortal; Q15195; -.
SMR; Q15195; -.
iPTMnet; Q15195; -.
PhosphoSitePlus; Q15195; -.
DMDM; 74706526; -.
PeptideAtlas; Q15195; -.
PRIDE; Q15195; -.
ProteomicsDB; 60487; -.
GeneCards; PLGLA; -.
H-InvDB; HIX0030043; -.
HGNC; HGNC:9074; PLGLA.
HPA; HPA053770; -.
MIM; 612212; gene.
neXtProt; NX_Q15195; -.
HOGENOM; HOG000115578; -.
HOVERGEN; HBG003051; -.
InParanoid; Q15195; -.
PhylomeDB; Q15195; -.
PRO; PR:Q15195; -.
Proteomes; UP000005640; Unplaced.
GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
InterPro; IPR003609; Pan_app.
InterPro; IPR016351; Plasminogen-rel.
Pfam; PF00024; PAN_1; 1.
PIRSF; PIRSF002483; Plasminogen-related; 1.
SMART; SM00473; PAN_AP; 1.
PROSITE; PS50948; PAN; 1.
2: Evidence at transcript level;
Complete proteome; Disulfide bond; Reference proteome; Secreted;
Signal.
SIGNAL 1 19 {ECO:0000255}.
CHAIN 20 96 Plasminogen-like protein A.
/FTId=PRO_0000305905.
DOMAIN 20 96 PAN. {ECO:0000255|PROSITE-
ProRule:PRU00315}.
DISULFID 49 73 {ECO:0000255|PROSITE-ProRule:PRU00315}.
DISULFID 53 61 {ECO:0000255|PROSITE-ProRule:PRU00315}.
SEQUENCE 96 AA; 10915 MW; CE2C29452F2BA171 CRC64;
MEHKEVVLLL LLFLKSGQGE PLDDYVNAQG ASLFSVTKKQ LGAGSREECA AKCEEDKEFT
CRAFQYHSKE QQCVIMAENK KSSIIIRMRD VVLFEK


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