Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Platelet factor 4 (PF-4) (C-X-C motif chemokine 4)

 PLF4_BOVIN              Reviewed;          88 AA.
P02777;
21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
21-JUL-1986, sequence version 1.
25-OCT-2017, entry version 115.
RecName: Full=Platelet factor 4;
Short=PF-4;
AltName: Full=C-X-C motif chemokine 4;
Name=PF4; Synonyms=CXCL4, SCYB4;
Bos taurus (Bovine).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
Pecora; Bovidae; Bovinae; Bos.
NCBI_TaxID=9913;
[1]
PROTEIN SEQUENCE.
PubMed=3767377; DOI=10.1016/0003-9861(86)90723-X;
Ciaglowski R.E., Snow J., Walz D.A.;
"Isolation and amino acid sequence of bovine platelet factor 4.";
Arch. Biochem. Biophys. 250:249-256(1986).
[2]
STRUCTURE BY NMR.
PubMed=2065087;
Talpas C.J., Walz D.A., Lee L.;
"1H-NMR studies of bovine platelet factor 4: histidine assignments and
interactions with heparin.";
Biochim. Biophys. Acta 1078:208-218(1991).
[3]
X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS), AND GLYCOSYLATION.
PubMed=2914894;
St Charles R., Walz D.A., Edwards B.F.P.;
"The three-dimensional structure of bovine platelet factor 4 at 3.0-A
resolution.";
J. Biol. Chem. 264:2092-2099(1989).
[4]
X-RAY CRYSTALLOGRAPHY (2.6 ANGSTROMS).
PubMed=1409574; DOI=10.1002/prot.340140213;
Stuckey J.A., St Charles R., Edwards B.F.P.;
"A model of the platelet factor 4 complex with heparin.";
Proteins 14:277-287(1992).
-!- FUNCTION: Released during platelet aggregation. Neutralizes the
anticoagulant effect of heparin because it binds more strongly to
heparin than to the chondroitin-4-sulfate chains of the carrier
molecule. Chemotactic for neutrophils and monocytes. Inhibits
endothelial cell proliferation.
-!- SUBUNIT: Homotetramer.
-!- SUBCELLULAR LOCATION: Secreted.
-!- PTM: O-linked glycan consists of Gal-GalNAc disaccharide which is
modified with sialic acid residues (microheterogeneity).
{ECO:0000269|PubMed:2914894}.
-!- SIMILARITY: Belongs to the intercrine alpha (chemokine CxC)
family. {ECO:0000305}.
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
Distributed under the Creative Commons Attribution-NoDerivs License
-----------------------------------------------------------------------
PIR; A03242; PFBO4.
UniGene; Bt.11581; -.
PDB; 1PLF; X-ray; 2.20 A; A/B/C/D=14-83.
PDBsum; 1PLF; -.
ProteinModelPortal; P02777; -.
SMR; P02777; -.
iPTMnet; P02777; -.
PRIDE; P02777; -.
HOVERGEN; HBG107789; -.
InParanoid; P02777; -.
EvolutionaryTrace; P02777; -.
Proteomes; UP000009136; Unplaced.
GO; GO:0005615; C:extracellular space; IBA:GO_Central.
GO; GO:0008009; F:chemokine activity; IBA:GO_Central.
GO; GO:0045236; F:CXCR chemokine receptor binding; IBA:GO_Central.
GO; GO:0048248; F:CXCR3 chemokine receptor binding; ISS:UniProtKB.
GO; GO:0008201; F:heparin binding; ISS:UniProtKB.
GO; GO:0070098; P:chemokine-mediated signaling pathway; IBA:GO_Central.
GO; GO:0019221; P:cytokine-mediated signaling pathway; ISS:UniProtKB.
GO; GO:0007186; P:G-protein coupled receptor signaling pathway; IBA:GO_Central.
GO; GO:0006955; P:immune response; IBA:GO_Central.
GO; GO:0006954; P:inflammatory response; IBA:GO_Central.
GO; GO:0030595; P:leukocyte chemotaxis; ISS:UniProtKB.
GO; GO:0016525; P:negative regulation of angiogenesis; ISS:UniProtKB.
GO; GO:0045653; P:negative regulation of megakaryocyte differentiation; ISS:UniProtKB.
GO; GO:0030168; P:platelet activation; ISS:UniProtKB.
GO; GO:0030816; P:positive regulation of cAMP metabolic process; ISS:UniProtKB.
GO; GO:0043950; P:positive regulation of cAMP-mediated signaling; ISS:UniProtKB.
GO; GO:0090023; P:positive regulation of neutrophil chemotaxis; IBA:GO_Central.
GO; GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; ISS:UniProtKB.
GO; GO:0042127; P:regulation of cell proliferation; ISS:UniProtKB.
GO; GO:0032496; P:response to lipopolysaccharide; IBA:GO_Central.
CDD; cd00273; Chemokine_CXC; 1.
InterPro; IPR001089; Chemokine_CXC.
InterPro; IPR018048; Chemokine_CXC_CS.
InterPro; IPR001811; Chemokine_IL8-like_dom.
InterPro; IPR033899; CXC_Chemokine_domain.
InterPro; IPR036048; Interleukin_8-like_sf.
InterPro; IPR027222; PF4.
PANTHER; PTHR10179; PTHR10179; 1.
PANTHER; PTHR10179:SF43; PTHR10179:SF43; 1.
Pfam; PF00048; IL8; 1.
PRINTS; PR00437; SMALLCYTKCXC.
SMART; SM00199; SCY; 1.
SUPFAM; SSF54117; SSF54117; 1.
PROSITE; PS00471; SMALL_CYTOKINES_CXC; 1.
1: Evidence at protein level;
3D-structure; Chemotaxis; Complete proteome; Cytokine;
Direct protein sequencing; Disulfide bond; Glycoprotein;
Heparin-binding; Phosphoprotein; Proteoglycan; Reference proteome;
Secreted.
CHAIN 1 88 Platelet factor 4.
/FTId=PRO_0000144298.
REGION 76 82 Heparin-binding. {ECO:0000250}.
MOD_RES 41 41 Phosphoserine.
{ECO:0000250|UniProtKB:P06765}.
CARBOHYD 7 7 O-linked (GalNAc...) threonine.
{ECO:0000269|PubMed:2914894}.
DISULFID 25 51
DISULFID 27 67
HELIX 36 38 {ECO:0000244|PDB:1PLF}.
STRAND 39 45 {ECO:0000244|PDB:1PLF}.
STRAND 55 60 {ECO:0000244|PDB:1PLF}.
STRAND 65 68 {ECO:0000244|PDB:1PLF}.
STRAND 70 72 {ECO:0000244|PDB:1PLF}.
HELIX 74 83 {ECO:0000244|PDB:1PLF}.
SEQUENCE 88 AA; 9523 MW; 9288E16455250FFB CRC64;
ESSFPATFVP LPADSEGGED EDLQCVCLKT TSGINPRHIS SLEVIGAGTH CPSPQLLATK
KTGRKICLDQ QRPLYKKILK KLLDGDES


Related products :

Catalog number Product name Quantity
E0172p ELISA kit C-X-C motif chemokine 4,CXCL4,PF4,PF-4,Pig,Platelet factor 4,SCYB4,Sus scrofa 96T
U0172p CLIA C-X-C motif chemokine 4,CXCL4,PF4,PF-4,Pig,Platelet factor 4,SCYB4,Sus scrofa 96T
E0172p ELISA C-X-C motif chemokine 4,CXCL4,PF4,PF-4,Pig,Platelet factor 4,SCYB4,Sus scrofa 96T
E0172m ELISA kit C-X-C motif chemokine 4,Cxcl4,Mouse,Mus musculus,Pf4,PF-4,Platelet factor 4,Scyb4 96T
U0172m CLIA C-X-C motif chemokine 4,Cxcl4,Mouse,Mus musculus,Pf4,PF-4,Platelet factor 4,Scyb4 96T
U0172r CLIA C-X-C motif chemokine 4,Cxcl4,Pf4,PF-4,Platelet factor 4,Rat,Rattus norvegicus,Scyb4 96T
U0172b CLIA Bos taurus,Bovine,C-X-C motif chemokine 4,CXCL4,PF4,PF-4,Platelet factor 4,SCYB4 96T
E0172b ELISA kit Bos taurus,Bovine,C-X-C motif chemokine 4,CXCL4,PF4,PF-4,Platelet factor 4,SCYB4 96T
E0172r ELISA kit C-X-C motif chemokine 4,Cxcl4,Pf4,PF-4,Platelet factor 4,Rat,Rattus norvegicus,Scyb4 96T
E0172b ELISA Bos taurus,Bovine,C-X-C motif chemokine 4,CXCL4,PF4,PF-4,Platelet factor 4,SCYB4 96T
E0172r ELISA C-X-C motif chemokine 4,Cxcl4,Pf4,PF-4,Platelet factor 4,Rat,Rattus norvegicus,Scyb4 96T
E0172m ELISA C-X-C motif chemokine 4,Cxcl4,Mouse,Mus musculus,Pf4,PF-4,Platelet factor 4,Scyb4 96T
E0172Rb ELISA kit C-X-C motif chemokine 4,CXCL4,Oryctolagus cuniculus,PF4,PF-4,Platelet factor 4,Rabbit,SCYB4 96T
E0172Rb ELISA C-X-C motif chemokine 4,CXCL4,Oryctolagus cuniculus,PF4,PF-4,Platelet factor 4,Rabbit,SCYB4 96T
U0172Rb CLIA C-X-C motif chemokine 4,CXCL4,Oryctolagus cuniculus,PF4,PF-4,Platelet factor 4,Rabbit,SCYB4 96T
E0172h ELISA kit C-X-C motif chemokine 4,CXCL4,Homo sapiens,Human,Iroplact,Oncostatin-A,PF4,PF-4,Platelet factor 4,SCYB4 96T
E0172h ELISA C-X-C motif chemokine 4,CXCL4,Homo sapiens,Human,Iroplact,Oncostatin-A,PF4,PF-4,Platelet factor 4,SCYB4 96T
U0172h CLIA C-X-C motif chemokine 4,CXCL4,Homo sapiens,Human,Iroplact,Oncostatin-A,PF4,PF-4,Platelet factor 4,SCYB4 96T
EIAAB30644 C-X-C motif chemokine 4 variant,CXCL4L1,CXCL4V1,Homo sapiens,Human,PF4alt,PF4V1,PF4var1,Platelet factor 4 variant,SCYB4V1
E0041h ELISA CTAP3,C-X-C motif chemokine 7,CXCL7,Homo sapiens,Human,LDGF,Leukocyte-derived growth factor,Macrophage-derived growth factor,MDGF,PBP,Platelet basic protein,PPBP,SCYB7,Small-inducible cytokine B 96T
U0041h CLIA CTAP3,C-X-C motif chemokine 7,CXCL7,Homo sapiens,Human,LDGF,Leukocyte-derived growth factor,Macrophage-derived growth factor,MDGF,PBP,Platelet basic protein,PPBP,SCYB7,Small-inducible cytokine B7 96T
E0041h ELISA kit CTAP3,C-X-C motif chemokine 7,CXCL7,Homo sapiens,Human,LDGF,Leukocyte-derived growth factor,Macrophage-derived growth factor,MDGF,PBP,Platelet basic protein,PPBP,SCYB7,Small-inducible cytok 96T
E0138h ELISA C-C motif chemokine 16,CCL16,Chemokine CC-4,Chemokine LEC,HCC-4,Homo sapiens,Human,IL-10-inducible chemokine,ILINCK,LCC-1,Liver-expressed chemokine,LMC,Lymphocyte and monocyte chemoattractant,Mo 96T
E0138h ELISA kit C-C motif chemokine 16,CCL16,Chemokine CC-4,Chemokine LEC,HCC-4,Homo sapiens,Human,IL-10-inducible chemokine,ILINCK,LCC-1,Liver-expressed chemokine,LMC,Lymphocyte and monocyte chemoattracta 96T
U0138h CLIA C-C motif chemokine 16,CCL16,Chemokine CC-4,Chemokine LEC,HCC-4,Homo sapiens,Human,IL-10-inducible chemokine,ILINCK,LCC-1,Liver-expressed chemokine,LMC,Lymphocyte and monocyte chemoattractant,Mon 96T


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur