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Platelet factor 4 (PF-4) (C-X-C motif chemokine 4)

 PLF4_RAT                Reviewed;         105 AA.
P06765;
01-JAN-1988, integrated into UniProtKB/Swiss-Prot.
01-JAN-1988, sequence version 1.
05-JUL-2017, entry version 132.
RecName: Full=Platelet factor 4;
Short=PF-4;
AltName: Full=C-X-C motif chemokine 4;
Flags: Precursor;
Name=Pf4; Synonyms=Cxcl4, Scyb4;
Rattus norvegicus (Rat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
NCBI_TaxID=10116;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=3821732; DOI=10.1128/MCB.7.2.898;
Doi T., Greenberg S.M., Rosenberg R.D.;
"Structure of the rat platelet factor 4 gene: a marker for
megakaryocyte differentiation.";
Mol. Cell. Biol. 7:898-904(1987).
[2]
GLYCOSYLATION AT THR-31.
PubMed=8033893; DOI=10.1111/j.1432-1033.1994.tb18984.x;
Ravanat C., Gachet C., Herbert J.-M., Schuhler S., Guillemot J.-C.,
Uzabiaga F., Picard C., Ferrara P., Freund M., Cazenave J.-P.;
"Rat platelets contain glycosylated and non-glycosylated forms of
platelet factor 4. Identification and characterization by mass
spectrometry.";
Eur. J. Biochem. 223:203-210(1994).
[3]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-61, AND IDENTIFICATION
BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
PubMed=22673903; DOI=10.1038/ncomms1871;
Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A.,
Lundby C., Olsen J.V.;
"Quantitative maps of protein phosphorylation sites across 14
different rat organs and tissues.";
Nat. Commun. 3:876-876(2012).
-!- FUNCTION: Released during platelet aggregation. Neutralizes the
anticoagulant effect of heparin because it binds more strongly to
heparin than to the chondroitin-4-sulfate chains of the carrier
molecule. Chemotactic for neutrophils and monocytes. Inhibits
endothelial cell proliferation.
-!- SUBUNIT: Homotetramer.
-!- SUBCELLULAR LOCATION: Secreted.
-!- PTM: O-linked glycan consists of Gal-GalNAc disaccharide which is
modified with sialic acid residues (microheterogeneity).
{ECO:0000269|PubMed:8033893}.
-!- SIMILARITY: Belongs to the intercrine alpha (chemokine CxC)
family. {ECO:0000305}.
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EMBL; M15254; AAA41832.1; -; Genomic_DNA.
PIR; A26774; A26774.
RefSeq; NP_001007730.1; NM_001007729.1.
UniGene; Rn.6800; -.
ProteinModelPortal; P06765; -.
SMR; P06765; -.
IntAct; P06765; 1.
STRING; 10116.ENSRNOP00000032276; -.
iPTMnet; P06765; -.
PhosphoSitePlus; P06765; -.
PaxDb; P06765; -.
PRIDE; P06765; -.
Ensembl; ENSRNOT00000033406; ENSRNOP00000032276; ENSRNOG00000028015.
GeneID; 360918; -.
KEGG; rno:360918; -.
UCSC; RGD:3305; rat.
CTD; 5196; -.
RGD; 3305; Pf4.
eggNOG; ENOG410J314; Eukaryota.
eggNOG; ENOG4111556; LUCA.
GeneTree; ENSGT00530000062901; -.
HOGENOM; HOG000220915; -.
HOVERGEN; HBG107789; -.
InParanoid; P06765; -.
KO; K05407; -.
OMA; GAGLHCP; -.
OrthoDB; EOG091G14JD; -.
PhylomeDB; P06765; -.
TreeFam; TF333433; -.
Reactome; R-RNO-114608; Platelet degranulation.
Reactome; R-RNO-140875; Common Pathway of Fibrin Clot Formation.
Reactome; R-RNO-202733; Cell surface interactions at the vascular wall.
Reactome; R-RNO-380108; Chemokine receptors bind chemokines.
Reactome; R-RNO-418594; G alpha (i) signalling events.
PRO; PR:P06765; -.
Proteomes; UP000002494; Chromosome 14.
Bgee; ENSRNOG00000028015; -.
Genevisible; P06765; RN.
GO; GO:0005615; C:extracellular space; IBA:GO_Central.
GO; GO:0031091; C:platelet alpha granule; IDA:RGD.
GO; GO:0043234; C:protein complex; IDA:RGD.
GO; GO:0031982; C:vesicle; IDA:RGD.
GO; GO:0008009; F:chemokine activity; IBA:GO_Central.
GO; GO:0045236; F:CXCR chemokine receptor binding; IBA:GO_Central.
GO; GO:0048248; F:CXCR3 chemokine receptor binding; ISS:UniProtKB.
GO; GO:0008201; F:heparin binding; ISS:UniProtKB.
GO; GO:0061844; P:antimicrobial humoral immune response mediated by antimicrobial peptide; IEA:Ensembl.
GO; GO:0070098; P:chemokine-mediated signaling pathway; IBA:GO_Central.
GO; GO:0019221; P:cytokine-mediated signaling pathway; ISS:UniProtKB.
GO; GO:0042832; P:defense response to protozoan; IEA:Ensembl.
GO; GO:0007186; P:G-protein coupled receptor signaling pathway; IBA:GO_Central.
GO; GO:0006955; P:immune response; IDA:RGD.
GO; GO:0006954; P:inflammatory response; IBA:GO_Central.
GO; GO:0030595; P:leukocyte chemotaxis; ISS:UniProtKB.
GO; GO:0016525; P:negative regulation of angiogenesis; ISS:UniProtKB.
GO; GO:0045653; P:negative regulation of megakaryocyte differentiation; ISS:UniProtKB.
GO; GO:0030168; P:platelet activation; ISS:UniProtKB.
GO; GO:0030816; P:positive regulation of cAMP metabolic process; ISS:UniProtKB.
GO; GO:0043950; P:positive regulation of cAMP-mediated signaling; ISS:UniProtKB.
GO; GO:0090023; P:positive regulation of neutrophil chemotaxis; IBA:GO_Central.
GO; GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; ISS:UniProtKB.
GO; GO:0006461; P:protein complex assembly; IPI:RGD.
GO; GO:0042127; P:regulation of cell proliferation; ISS:UniProtKB.
GO; GO:0032496; P:response to lipopolysaccharide; IBA:GO_Central.
CDD; cd00273; Chemokine_CXC; 1.
InterPro; IPR001089; Chemokine_CXC.
InterPro; IPR018048; Chemokine_CXC_CS.
InterPro; IPR001811; Chemokine_IL8-like_dom.
InterPro; IPR033899; CXC_Chemokine_domain.
InterPro; IPR027222; PF4.
PANTHER; PTHR10179; PTHR10179; 1.
PANTHER; PTHR10179:SF57; PTHR10179:SF57; 1.
Pfam; PF00048; IL8; 1.
PRINTS; PR00437; SMALLCYTKCXC.
SMART; SM00199; SCY; 1.
SUPFAM; SSF54117; SSF54117; 1.
PROSITE; PS00471; SMALL_CYTOKINES_CXC; 1.
1: Evidence at protein level;
Chemotaxis; Complete proteome; Cytokine; Disulfide bond; Glycoprotein;
Heparin-binding; Phosphoprotein; Reference proteome; Secreted; Signal.
SIGNAL 1 29
CHAIN 30 105 Platelet factor 4.
/FTId=PRO_0000005070.
REGION 96 102 Heparin-binding. {ECO:0000250}.
MOD_RES 61 61 Phosphoserine.
{ECO:0000244|PubMed:22673903}.
CARBOHYD 31 31 O-linked (GalNAc...) threonine; partial.
{ECO:0000269|PubMed:8033893}.
DISULFID 44 71 {ECO:0000250}.
DISULFID 46 87 {ECO:0000250}.
SEQUENCE 105 AA; 11287 MW; D9CCAD2B6A284496 CRC64;
MSAAAVFRGL RPSPELLLLG LLLLPAVVAV TRASPEESDG DLSCVCVKTS SSRIHLKRIT
SLEVIKAGPH CAVPQLIATL KNGSKICLDR QVPLYKKIIK KLLES


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