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Platelet factor 4 (PF-4) (C-X-C motif chemokine 4)

 PLF4_PIG                Reviewed;          90 AA.
P30034;
01-APR-1993, integrated into UniProtKB/Swiss-Prot.
01-OCT-1994, sequence version 2.
12-SEP-2018, entry version 105.
RecName: Full=Platelet factor 4;
Short=PF-4;
AltName: Full=C-X-C motif chemokine 4;
Name=PF4; Synonyms=CXCL4, SCYB4;
Sus scrofa (Pig).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Suina; Suidae;
Sus.
NCBI_TaxID=9823;
[1]
PROTEIN SEQUENCE, PYROGLUTAMATE FORMATION AT GLN-1, AND GLYCOSYLATION
AT THR-8.
TISSUE=Platelet;
PubMed=7737160; DOI=10.1111/j.1432-1033.1995.0658m.x;
Proudfoot A.E.I., Magnenat E., Haley T.M., Maione T.E., Wells T.N.C.;
"The complete primary structure of glycosylated porcine platelet
factor 4.";
Eur. J. Biochem. 228:658-664(1995).
[2]
PROTEIN SEQUENCE OF 18-86.
TISSUE=Platelet;
PubMed=1788836; DOI=10.1016/0049-3848(91)90351-V;
Shigeta O., Lu W., Holt J.C., Edmunds L.H. Jr., Niewiarowski S.;
"Ovine platelet factor 4: purification, amino acid sequence,
radioimmunoassay and comparison with platelet factor 4 of other
species.";
Thromb. Res. 64:509-520(1991).
-!- FUNCTION: Released during platelet aggregation. Neutralizes the
anticoagulant effect of heparin because it binds more strongly to
heparin than to the chondroitin-4-sulfate chains of the carrier
molecule. Chemotactic for neutrophils and monocytes. Inhibits
endothelial cell proliferation.
-!- SUBUNIT: Homotetramer.
-!- SUBCELLULAR LOCATION: Secreted.
-!- PTM: O-linked glycan consists of Gal-GalNAc disaccharide which is
modified with sialic acid residues (microheterogeneity).
{ECO:0000269|PubMed:7737160}.
-!- SIMILARITY: Belongs to the intercrine alpha (chemokine CxC)
family. {ECO:0000305}.
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PIR; S69133; S69133.
ProteinModelPortal; P30034; -.
SMR; P30034; -.
STRING; 9823.ENSSSCP00000000258; -.
iPTMnet; P30034; -.
PaxDb; P30034; -.
PeptideAtlas; P30034; -.
PRIDE; P30034; -.
eggNOG; ENOG410J314; Eukaryota.
eggNOG; ENOG4111556; LUCA.
HOGENOM; HOG000220915; -.
HOVERGEN; HBG107789; -.
InParanoid; P30034; -.
OrthoDB; EOG091G14JD; -.
Proteomes; UP000008227; Unplaced.
Genevisible; P30034; SS.
GO; GO:0005615; C:extracellular space; IBA:GO_Central.
GO; GO:0005622; C:intracellular; IEA:GOC.
GO; GO:0008009; F:chemokine activity; IBA:GO_Central.
GO; GO:0045236; F:CXCR chemokine receptor binding; IBA:GO_Central.
GO; GO:0048248; F:CXCR3 chemokine receptor binding; ISS:UniProtKB.
GO; GO:0008201; F:heparin binding; ISS:UniProtKB.
GO; GO:0007189; P:adenylate cyclase-activating G-protein coupled receptor signaling pathway; ISS:UniProtKB.
GO; GO:0070098; P:chemokine-mediated signaling pathway; IBA:GO_Central.
GO; GO:0019221; P:cytokine-mediated signaling pathway; ISS:UniProtKB.
GO; GO:0007186; P:G-protein coupled receptor signaling pathway; IBA:GO_Central.
GO; GO:0006955; P:immune response; IBA:GO_Central.
GO; GO:0006954; P:inflammatory response; IBA:GO_Central.
GO; GO:0030595; P:leukocyte chemotaxis; ISS:UniProtKB.
GO; GO:0016525; P:negative regulation of angiogenesis; ISS:UniProtKB.
GO; GO:0045653; P:negative regulation of megakaryocyte differentiation; ISS:UniProtKB.
GO; GO:0030168; P:platelet activation; ISS:UniProtKB.
GO; GO:0043950; P:positive regulation of cAMP-mediated signaling; ISS:UniProtKB.
GO; GO:0090023; P:positive regulation of neutrophil chemotaxis; IBA:GO_Central.
GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISS:UniProtKB.
GO; GO:0042127; P:regulation of cell proliferation; ISS:UniProtKB.
GO; GO:0032496; P:response to lipopolysaccharide; IBA:GO_Central.
CDD; cd00273; Chemokine_CXC; 1.
InterPro; IPR001089; Chemokine_CXC.
InterPro; IPR018048; Chemokine_CXC_CS.
InterPro; IPR001811; Chemokine_IL8-like_dom.
InterPro; IPR033899; CXC_Chemokine_domain.
InterPro; IPR036048; Interleukin_8-like_sf.
InterPro; IPR027222; PF4.
PANTHER; PTHR10179; PTHR10179; 1.
PANTHER; PTHR10179:SF43; PTHR10179:SF43; 1.
Pfam; PF00048; IL8; 1.
PRINTS; PR00437; SMALLCYTKCXC.
SMART; SM00199; SCY; 1.
SUPFAM; SSF54117; SSF54117; 1.
PROSITE; PS00471; SMALL_CYTOKINES_CXC; 1.
1: Evidence at protein level;
Chemotaxis; Complete proteome; Cytokine; Direct protein sequencing;
Disulfide bond; Glycoprotein; Heparin-binding; Phosphoprotein;
Pyrrolidone carboxylic acid; Reference proteome; Secreted.
CHAIN 1 90 Platelet factor 4.
/FTId=PRO_0000144299.
REGION 76 82 Heparin-binding. {ECO:0000250}.
MOD_RES 1 1 Pyrrolidone carboxylic acid.
{ECO:0000269|PubMed:7737160}.
MOD_RES 41 41 Phosphoserine.
{ECO:0000250|UniProtKB:P06765}.
CARBOHYD 8 8 O-linked (GalNAc...) threonine.
{ECO:0000269|PubMed:7737160}.
DISULFID 25 51 {ECO:0000250}.
DISULFID 27 67 {ECO:0000250}.
CONFLICT 43 43 E -> I (in Ref. 2; AA sequence).
{ECO:0000305}.
CONFLICT 85 86 SQ -> PE (in Ref. 2; AA sequence).
{ECO:0000305}.
SEQUENCE 90 AA; 9644 MW; 108F15AC828FDE6F CRC64;
QEWSLPGTRV PPPADPEGGD ANLRCVCVKT ISGVSPKHIS SLEVIGAGPH CPSPQLIATL
KKGHKICLDP QNLLYKKIIK KLLKSQLLTA


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