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Platelet factor 4 (PF-4) (C-X-C motif chemokine 4)

 PLF4_SHEEP              Reviewed;          85 AA.
P30035;
01-APR-1993, integrated into UniProtKB/Swiss-Prot.
01-APR-1993, sequence version 1.
23-MAY-2018, entry version 79.
RecName: Full=Platelet factor 4;
Short=PF-4;
AltName: Full=C-X-C motif chemokine 4;
Name=PF4; Synonyms=CXCL4, SCYB4;
Ovis aries (Sheep).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
Pecora; Bovidae; Caprinae; Ovis.
NCBI_TaxID=9940;
[1]
PROTEIN SEQUENCE.
PubMed=1788836; DOI=10.1016/0049-3848(91)90351-V;
Shigeta O., Lu W., Holt J.C., Edmunds L.H. Jr., Niewiarowski S.;
"Ovine platelet factor 4: purification, amino acid sequence,
radioimmunoassay and comparison with platelet factor 4 of other
species.";
Thromb. Res. 64:509-520(1991).
-!- FUNCTION: Released during platelet aggregation. Neutralizes the
anticoagulant effect of heparin because it binds more strongly to
heparin than to the chondroitin-4-sulfate chains of the carrier
molecule. Chemotactic for neutrophils and monocytes. Inhibits
endothelial cell proliferation.
-!- SUBUNIT: Homotetramer.
-!- SUBCELLULAR LOCATION: Secreted.
-!- SIMILARITY: Belongs to the intercrine alpha (chemokine CxC)
family. {ECO:0000305}.
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ProteinModelPortal; P30035; -.
PRIDE; P30035; -.
HOVERGEN; HBG107789; -.
Proteomes; UP000002356; Unplaced.
GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
GO; GO:0008009; F:chemokine activity; IEA:InterPro.
GO; GO:0048248; F:CXCR3 chemokine receptor binding; ISS:UniProtKB.
GO; GO:0008201; F:heparin binding; ISS:UniProtKB.
GO; GO:0019221; P:cytokine-mediated signaling pathway; ISS:UniProtKB.
GO; GO:0006952; P:defense response; IEA:InterPro.
GO; GO:0006955; P:immune response; IEA:InterPro.
GO; GO:0030595; P:leukocyte chemotaxis; ISS:UniProtKB.
GO; GO:0016525; P:negative regulation of angiogenesis; ISS:UniProtKB.
GO; GO:0045653; P:negative regulation of megakaryocyte differentiation; ISS:UniProtKB.
GO; GO:0030168; P:platelet activation; ISS:UniProtKB.
GO; GO:0030816; P:positive regulation of cAMP metabolic process; ISS:UniProtKB.
GO; GO:0043950; P:positive regulation of cAMP-mediated signaling; ISS:UniProtKB.
GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISS:UniProtKB.
GO; GO:0042127; P:regulation of cell proliferation; ISS:UniProtKB.
CDD; cd00273; Chemokine_CXC; 1.
InterPro; IPR001089; Chemokine_CXC.
InterPro; IPR018048; Chemokine_CXC_CS.
InterPro; IPR001811; Chemokine_IL8-like_dom.
InterPro; IPR033899; CXC_Chemokine_domain.
InterPro; IPR036048; Interleukin_8-like_sf.
InterPro; IPR027222; PF4.
PANTHER; PTHR10179; PTHR10179; 1.
PANTHER; PTHR10179:SF43; PTHR10179:SF43; 1.
Pfam; PF00048; IL8; 1.
PRINTS; PR00437; SMALLCYTKCXC.
SMART; SM00199; SCY; 1.
SUPFAM; SSF54117; SSF54117; 1.
PROSITE; PS00471; SMALL_CYTOKINES_CXC; 1.
1: Evidence at protein level;
Chemotaxis; Complete proteome; Cytokine; Direct protein sequencing;
Disulfide bond; Heparin-binding; Phosphoprotein; Reference proteome;
Secreted.
CHAIN 1 85 Platelet factor 4.
/FTId=PRO_0000144301.
REGION 76 82 Heparin-binding. {ECO:0000250}.
MOD_RES 41 41 Phosphoserine.
{ECO:0000250|UniProtKB:P06765}.
DISULFID 25 51 {ECO:0000250}.
DISULFID 27 67 {ECO:0000250}.
SEQUENCE 85 AA; 9130 MW; 925A76512095ECF7 CRC64;
XSSLPAASVS LPADSEGGEE EDLQCVCLKT TSGIHPRHIS SLEVIGAGLH CPSPQLIATL
KTGRKICLDQ QNPLYKKIIK RLLKN


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