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Platelet factor 4 (PF-4) (C-X-C motif chemokine 4)

 PLF4_MOUSE              Reviewed;         105 AA.
Q9Z126;
01-NOV-2002, integrated into UniProtKB/Swiss-Prot.
01-MAY-1999, sequence version 1.
20-JUN-2018, entry version 136.
RecName: Full=Platelet factor 4;
Short=PF-4;
AltName: Full=C-X-C motif chemokine 4;
Flags: Precursor;
Name=Pf4; Synonyms=Cxcl4, Scyb4;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=C57BL/6J; TISSUE=Spleen;
PubMed=10319581; DOI=10.1007/s100380050136;
Watanabe O., Natori K., Tamari M., Shiomoto Y., Kubo S., Nakamura Y.;
"Significantly elevated expression of PF4 (platelet factor 4) and
eotaxin in the NOA mouse, a model for atopic dermatitis.";
J. Hum. Genet. 44:173-176(1999).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=11468158; DOI=10.1182/blood.V98.3.610;
Zhang C., Thornton M.A., Kowalska M.A., Sachis B.S., Feldman M.,
Poncz M., McKenzie S.E., Reilly M.P.;
"Localization of distal regulatory domains in the megakaryocyte-
specific platelet basic protein/platelet factor 4 gene locus.";
Blood 98:610-617(2001).
[3]
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Spleen;
PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
"A tissue-specific atlas of mouse protein phosphorylation and
expression.";
Cell 143:1174-1189(2010).
-!- FUNCTION: Released during platelet aggregation. Neutralizes the
anticoagulant effect of heparin because it binds more strongly to
heparin than to the chondroitin-4-sulfate chains of the carrier
molecule. Chemotactic for neutrophils and monocytes. Inhibits
endothelial cell proliferation (By similarity). {ECO:0000250}.
-!- SUBUNIT: Homotetramer. {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Secreted.
-!- SIMILARITY: Belongs to the intercrine alpha (chemokine CxC)
family. {ECO:0000305}.
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EMBL; AB017491; BAA75660.1; -; mRNA.
EMBL; AF349465; AAK30163.1; -; Genomic_DNA.
CCDS; CCDS19416.1; -.
RefSeq; NP_064316.1; NM_019932.4.
UniGene; Mm.332490; -.
ProteinModelPortal; Q9Z126; -.
SMR; Q9Z126; -.
DIP; DIP-61569N; -.
IntAct; Q9Z126; 2.
MINT; Q9Z126; -.
STRING; 10090.ENSMUSP00000031320; -.
iPTMnet; Q9Z126; -.
PhosphoSitePlus; Q9Z126; -.
MaxQB; Q9Z126; -.
PaxDb; Q9Z126; -.
PeptideAtlas; Q9Z126; -.
PRIDE; Q9Z126; -.
Ensembl; ENSMUST00000031320; ENSMUSP00000031320; ENSMUSG00000029373.
GeneID; 56744; -.
KEGG; mmu:56744; -.
UCSC; uc008ybi.2; mouse.
CTD; 5196; -.
MGI; MGI:1888711; Pf4.
eggNOG; ENOG410J314; Eukaryota.
eggNOG; ENOG4111556; LUCA.
GeneTree; ENSGT00910000144355; -.
HOGENOM; HOG000220915; -.
HOVERGEN; HBG107789; -.
InParanoid; Q9Z126; -.
KO; K05407; -.
OMA; GAGLHCP; -.
OrthoDB; EOG091G14JD; -.
PhylomeDB; Q9Z126; -.
TreeFam; TF333433; -.
Reactome; R-MMU-114608; Platelet degranulation.
Reactome; R-MMU-140875; Common Pathway of Fibrin Clot Formation.
Reactome; R-MMU-202733; Cell surface interactions at the vascular wall.
Reactome; R-MMU-380108; Chemokine receptors bind chemokines.
Reactome; R-MMU-418594; G alpha (i) signalling events.
PRO; PR:Q9Z126; -.
Proteomes; UP000000589; Chromosome 5.
Bgee; ENSMUSG00000029373; -.
CleanEx; MM_PF4; -.
ExpressionAtlas; Q9Z126; baseline and differential.
Genevisible; Q9Z126; MM.
GO; GO:0005737; C:cytoplasm; ISO:MGI.
GO; GO:0005615; C:extracellular space; IBA:GO_Central.
GO; GO:0097679; C:other organism cytoplasm; ISO:MGI.
GO; GO:0031091; C:platelet alpha granule; ISO:MGI.
GO; GO:0032991; C:protein-containing complex; ISO:MGI.
GO; GO:0020005; C:symbiont-containing vacuole membrane; ISO:MGI.
GO; GO:0031982; C:vesicle; ISO:MGI.
GO; GO:0008009; F:chemokine activity; IBA:GO_Central.
GO; GO:0045236; F:CXCR chemokine receptor binding; IBA:GO_Central.
GO; GO:0048248; F:CXCR3 chemokine receptor binding; ISS:UniProtKB.
GO; GO:0008201; F:heparin binding; ISS:UniProtKB.
GO; GO:0061844; P:antimicrobial humoral immune response mediated by antimicrobial peptide; IMP:UniProtKB.
GO; GO:0070098; P:chemokine-mediated signaling pathway; IBA:GO_Central.
GO; GO:0019221; P:cytokine-mediated signaling pathway; ISS:UniProtKB.
GO; GO:0042832; P:defense response to protozoan; IMP:UniProtKB.
GO; GO:0007186; P:G-protein coupled receptor signaling pathway; IBA:GO_Central.
GO; GO:0006955; P:immune response; ISO:MGI.
GO; GO:0006954; P:inflammatory response; IBA:GO_Central.
GO; GO:0051873; P:killing by host of symbiont cells; ISO:MGI.
GO; GO:0030595; P:leukocyte chemotaxis; ISS:UniProtKB.
GO; GO:0016525; P:negative regulation of angiogenesis; ISS:UniProtKB.
GO; GO:0045918; P:negative regulation of cytolysis; ISO:MGI.
GO; GO:2001240; P:negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; ISO:MGI.
GO; GO:0045653; P:negative regulation of megakaryocyte differentiation; ISS:UniProtKB.
GO; GO:0045347; P:negative regulation of MHC class II biosynthetic process; ISO:MGI.
GO; GO:0030168; P:platelet activation; ISS:UniProtKB.
GO; GO:0030816; P:positive regulation of cAMP metabolic process; ISS:UniProtKB.
GO; GO:0043950; P:positive regulation of cAMP-mediated signaling; ISS:UniProtKB.
GO; GO:0010628; P:positive regulation of gene expression; ISO:MGI.
GO; GO:0010744; P:positive regulation of macrophage derived foam cell differentiation; ISO:MGI.
GO; GO:0045651; P:positive regulation of macrophage differentiation; ISO:MGI.
GO; GO:0090023; P:positive regulation of neutrophil chemotaxis; IBA:GO_Central.
GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISS:UniProtKB.
GO; GO:0032760; P:positive regulation of tumor necrosis factor production; ISO:MGI.
GO; GO:0065003; P:protein-containing complex assembly; ISO:MGI.
GO; GO:0042127; P:regulation of cell proliferation; ISS:UniProtKB.
GO; GO:0032496; P:response to lipopolysaccharide; IBA:GO_Central.
CDD; cd00273; Chemokine_CXC; 1.
InterPro; IPR001089; Chemokine_CXC.
InterPro; IPR018048; Chemokine_CXC_CS.
InterPro; IPR001811; Chemokine_IL8-like_dom.
InterPro; IPR033899; CXC_Chemokine_domain.
InterPro; IPR036048; Interleukin_8-like_sf.
InterPro; IPR027222; PF4.
PANTHER; PTHR10179; PTHR10179; 1.
PANTHER; PTHR10179:SF43; PTHR10179:SF43; 1.
Pfam; PF00048; IL8; 1.
PRINTS; PR00437; SMALLCYTKCXC.
SMART; SM00199; SCY; 1.
SUPFAM; SSF54117; SSF54117; 1.
PROSITE; PS00471; SMALL_CYTOKINES_CXC; 1.
1: Evidence at protein level;
Chemotaxis; Complete proteome; Cytokine; Disulfide bond; Glycoprotein;
Heparin-binding; Phosphoprotein; Reference proteome; Secreted; Signal.
SIGNAL 1 29 {ECO:0000250}.
CHAIN 30 105 Platelet factor 4.
/FTId=PRO_0000005069.
REGION 96 102 Heparin-binding. {ECO:0000250}.
MOD_RES 61 61 Phosphoserine.
{ECO:0000250|UniProtKB:P06765}.
CARBOHYD 31 31 O-linked (GalNAc...) threonine.
{ECO:0000250}.
DISULFID 44 71 {ECO:0000250}.
DISULFID 46 87 {ECO:0000250}.
SEQUENCE 105 AA; 11243 MW; 94F0190EFACF1A6C CRC64;
MSVAAVFRGL RPSPELLLLG LLFLPAVVAV TSAGPEESDG DLSCVCVKTI SSGIHLKHIT
SLEVIKAGRH CAVPQLIATL KNGRKICLDR QAPLYKKVIK KILES


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