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Platelet factor 4 variant (C-X-C motif chemokine 4 variant) (CXCL4L1) (PF4alt) (PF4var1) [Cleaved into: Platelet factor 4 variant(4-74); Platelet factor 4 variant(5-74); Platelet factor 4 variant(6-74)]

 PF4V_HUMAN              Reviewed;         104 AA.
P10720; A1L4S0;
01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
01-JUL-1989, sequence version 1.
12-SEP-2018, entry version 154.
RecName: Full=Platelet factor 4 variant;
AltName: Full=C-X-C motif chemokine 4 variant;
AltName: Full=CXCL4L1;
AltName: Full=PF4alt;
AltName: Full=PF4var1;
Contains:
RecName: Full=Platelet factor 4 variant(4-74);
Contains:
RecName: Full=Platelet factor 4 variant(5-74);
Contains:
RecName: Full=Platelet factor 4 variant(6-74);
Flags: Precursor;
Name=PF4V1; Synonyms=CXCL4V1, SCYB4V1;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=2725510; DOI=10.1128/MCB.9.4.1445;
Green C.J., St Charles R., Edwards B.F.P., Johnson P.H.;
"Identification and characterization of PF4var1, a human gene variant
of platelet factor 4.";
Mol. Cell. Biol. 9:1445-1451(1989).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
Venter J.C.;
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[4]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 27-104.
PubMed=1695112;
Eisman R., Surrey S., Ramachandran B., Schwartz E., Poncz M.;
"Structural and functional comparison of the genes for human platelet
factor 4 and PF4alt.";
Blood 76:336-344(1990).
[5]
PROTEIN SEQUENCE OF 31-54, FUNCTION, AND MASS SPECTROMETRY.
PubMed=15459074; DOI=10.1161/01.RES.0000146674.38319.07;
Struyf S., Burdick M.D., Proost P., Van Damme J., Strieter R.M.;
"Platelets release CXCL4L1, a nonallelic variant of the chemokine
platelet factor-4/CXCL4 and potent inhibitor of angiogenesis.";
Circ. Res. 95:855-857(2004).
[6]
X-RAY CRYSTALLOGRAPHY (2.08 ANGSTROMS) OF 35-104, DISULFIDE BONDS,
HEPARIN-BINDING REGION, AND SUBUNIT.
PubMed=23536183; DOI=10.1074/jbc.M113.455329;
Kuo J.H., Chen Y.P., Liu J.S., Dubrac A., Quemener C., Prats H.,
Bikfalvi A., Wu W.G., Sue S.C.;
"Alternative C-terminal helix orientation alters chemokine function:
Structure of the Anti-angiogenic Chemokine, CXCL4L1.";
J. Biol. Chem. 288:13522-13533(2013).
-!- FUNCTION: Inhibitor of angiogenesis. Inhibitor of endothelial cell
chemotaxis (in vitro). {ECO:0000269|PubMed:15459074}.
-!- SUBUNIT: Homotetramer. {ECO:0000269|PubMed:23536183}.
-!- INTERACTION:
O00585:CCL21; NbExp=2; IntAct=EBI-1223944, EBI-953695;
O15444:CCL25; NbExp=2; IntAct=EBI-1223944, EBI-7783341;
O14625:CXCL11; NbExp=2; IntAct=EBI-1223944, EBI-2871971;
P48061:CXCL12; NbExp=4; IntAct=EBI-1223944, EBI-3913254;
P47992:XCL1; NbExp=2; IntAct=EBI-1223944, EBI-10209901;
-!- SUBCELLULAR LOCATION: Secreted.
-!- PTM: The N-terminal processed forms of platelet factor 4 variant
seems to be produced by proteolytic cleavage. The most abundant
form is Platelet factor 4 variant(5-74).
-!- MASS SPECTROMETRY: Mass=8250.9; Method=Electrospray; Range=31-104;
Note=Platelet factor 4 variant.;
Evidence={ECO:0000269|PubMed:15459074};
-!- MASS SPECTROMETRY: Mass=7877.7; Method=Electrospray; Range=34-104;
Note=Platelet factor 4 variant(4-74).;
Evidence={ECO:0000269|PubMed:15459074};
-!- MASS SPECTROMETRY: Mass=7805.8; Method=Electrospray; Range=35-104;
Note=Platelet factor 4 variant(5-74).;
Evidence={ECO:0000269|PubMed:15459074};
-!- MASS SPECTROMETRY: Mass=7678.6; Method=Electrospray; Range=36-104;
Note=Platelet factor 4 variant(6-74).;
Evidence={ECO:0000269|PubMed:15459074};
-!- MISCELLANEOUS: Binding to heparin is much weaker than in the close
homolog PF4/CXCL4.
-!- SIMILARITY: Belongs to the intercrine alpha (chemokine CxC)
family. {ECO:0000305}.
-----------------------------------------------------------------------
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-----------------------------------------------------------------------
EMBL; M26167; AAA60067.1; -; Genomic_DNA.
EMBL; CH471057; EAX05692.1; -; Genomic_DNA.
EMBL; BC130653; AAI30654.1; -; mRNA.
EMBL; BC130657; AAI30658.1; -; mRNA.
CCDS; CCDS3561.1; -.
PIR; A31941; PFHU4A.
RefSeq; NP_002611.1; NM_002620.3.
UniGene; Hs.72933; -.
PDB; 4HSV; X-ray; 2.08 A; A/B/C/D=35-104.
PDBsum; 4HSV; -.
ProteinModelPortal; P10720; -.
SMR; P10720; -.
BioGrid; 111220; 4.
IntAct; P10720; 16.
STRING; 9606.ENSP00000226524; -.
iPTMnet; P10720; -.
PhosphoSitePlus; P10720; -.
BioMuta; PF4V1; -.
DMDM; 130306; -.
PaxDb; P10720; -.
PeptideAtlas; P10720; -.
PRIDE; P10720; -.
ProteomicsDB; 52639; -.
TopDownProteomics; P10720; -.
DNASU; 5197; -.
Ensembl; ENST00000226524; ENSP00000226524; ENSG00000109272.
GeneID; 5197; -.
KEGG; hsa:5197; -.
UCSC; uc003hhg.2; human.
CTD; 5197; -.
DisGeNET; 5197; -.
EuPathDB; HostDB:ENSG00000109272.3; -.
GeneCards; PF4V1; -.
HGNC; HGNC:8862; PF4V1.
HPA; HPA052485; -.
MIM; 173461; gene.
neXtProt; NX_P10720; -.
OpenTargets; ENSG00000109272; -.
PharmGKB; PA33204; -.
eggNOG; ENOG410J314; Eukaryota.
eggNOG; ENOG4111556; LUCA.
GeneTree; ENSGT00910000144355; -.
HOGENOM; HOG000220915; -.
HOVERGEN; HBG107789; -.
InParanoid; P10720; -.
KO; K05407; -.
OMA; RNGRKIC; -.
OrthoDB; EOG091G14JD; -.
PhylomeDB; P10720; -.
TreeFam; TF333433; -.
Reactome; R-HSA-140875; Common Pathway of Fibrin Clot Formation.
Reactome; R-HSA-202733; Cell surface interactions at the vascular wall.
GenomeRNAi; 5197; -.
PRO; PR:P10720; -.
Proteomes; UP000005640; Chromosome 4.
Bgee; ENSG00000109272; Expressed in 56 organ(s), highest expression level in blood.
CleanEx; HS_PF4V1; -.
GO; GO:0005615; C:extracellular space; IBA:GO_Central.
GO; GO:0008009; F:chemokine activity; IBA:GO_Central.
GO; GO:0045236; F:CXCR chemokine receptor binding; IBA:GO_Central.
GO; GO:0008201; F:heparin binding; IBA:GO_Central.
GO; GO:0070098; P:chemokine-mediated signaling pathway; IBA:GO_Central.
GO; GO:0007186; P:G-protein coupled receptor signaling pathway; IBA:GO_Central.
GO; GO:0006955; P:immune response; IBA:GO_Central.
GO; GO:0006954; P:inflammatory response; IBA:GO_Central.
GO; GO:0030595; P:leukocyte chemotaxis; IEA:InterPro.
GO; GO:0030168; P:platelet activation; IEA:InterPro.
GO; GO:0090023; P:positive regulation of neutrophil chemotaxis; IBA:GO_Central.
GO; GO:0042127; P:regulation of cell proliferation; IBA:GO_Central.
GO; GO:0032496; P:response to lipopolysaccharide; IBA:GO_Central.
CDD; cd00273; Chemokine_CXC; 1.
InterPro; IPR001089; Chemokine_CXC.
InterPro; IPR018048; Chemokine_CXC_CS.
InterPro; IPR001811; Chemokine_IL8-like_dom.
InterPro; IPR033899; CXC_Chemokine_domain.
InterPro; IPR036048; Interleukin_8-like_sf.
InterPro; IPR027222; PF4.
PANTHER; PTHR10179; PTHR10179; 1.
PANTHER; PTHR10179:SF38; PTHR10179:SF38; 1.
Pfam; PF00048; IL8; 1.
PRINTS; PR00437; SMALLCYTKCXC.
SMART; SM00199; SCY; 1.
SUPFAM; SSF54117; SSF54117; 1.
PROSITE; PS00471; SMALL_CYTOKINES_CXC; 1.
1: Evidence at protein level;
3D-structure; Complete proteome; Cytokine; Direct protein sequencing;
Disulfide bond; Glycoprotein; Heparin-binding; Proteoglycan;
Reference proteome; Secreted; Signal.
SIGNAL 1 30 {ECO:0000269|PubMed:15459074}.
CHAIN 31 104 Platelet factor 4 variant.
/FTId=PRO_0000005071.
CHAIN 34 104 Platelet factor 4 variant(4-74).
/FTId=PRO_0000005072.
CHAIN 35 104 Platelet factor 4 variant(5-74).
/FTId=PRO_0000005073.
CHAIN 36 104 Platelet factor 4 variant(6-74).
/FTId=PRO_0000005074.
REGION 95 101 Heparin-binding.
DISULFID 44 70 {ECO:0000269|PubMed:23536183}.
DISULFID 46 86 {ECO:0000269|PubMed:23536183}.
CONFLICT 77 77 A -> S (in Ref. 4; no nucleotide entry).
{ECO:0000305}.
STRAND 45 47 {ECO:0000244|PDB:4HSV}.
TURN 55 57 {ECO:0000244|PDB:4HSV}.
STRAND 58 64 {ECO:0000244|PDB:4HSV}.
STRAND 70 72 {ECO:0000244|PDB:4HSV}.
STRAND 74 79 {ECO:0000244|PDB:4HSV}.
STRAND 84 87 {ECO:0000244|PDB:4HSV}.
HELIX 89 96 {ECO:0000244|PDB:4HSV}.
HELIX 98 101 {ECO:0000244|PDB:4HSV}.
SEQUENCE 104 AA; 11553 MW; 786FE2B288532E28 CRC64;
MSSAARSRLT RATRQEMLFL ALLLLPVVVA FARAEAEEDG DLQCLCVKTT SQVRPRHITS
LEVIKAGPHC PTAQLIATLK NGRKICLDLQ ALLYKKIIKE HLES


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