Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Platelet glycoprotein 4 (Glycoprotein IIIb) (GPIIIB) (PAS IV) (PAS-4) (Platelet glycoprotein IV) (GPIV) (CD antigen CD36)

 CD36_MOUSE              Reviewed;         472 AA.
01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
23-JAN-2007, sequence version 2.
12-SEP-2018, entry version 156.
RecName: Full=Platelet glycoprotein 4;
AltName: Full=Glycoprotein IIIb;
AltName: Full=PAS IV;
AltName: Full=PAS-4;
AltName: Full=Platelet glycoprotein IV;
AltName: CD_antigen=CD36;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
TISSUE=Peritoneal macrophage;
Endemann G., Stanton L.W., Madden K.S., Bryant C.M., White R.T.,
Protter A.A.;
"CD36 is a receptor for oxidized low density lipoprotein.";
J. Biol. Chem. 268:11811-11816(1993).
STRAIN=C57BL/6J; TISSUE=Mammary gland;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
PubMed=16276419; DOI=10.1172/JCI25299;
Laugerette F., Passilly-Degrace P., Patris B., Niot I., Febbraio M.,
Montmayeur J.P., Besnard P.;
"CD36 involvement in orosensory detection of dietary lipids,
spontaneous fat preference, and digestive secretions.";
J. Clin. Invest. 115:3177-3184(2005).
PubMed=15748999; DOI=10.1016/j.matbio.2004.11.005;
Simantov R., Febbraio M., Silverstein R.L.;
"The antiangiogenic effect of thrombospondin-2 is mediated by CD36 and
modulated by histidine-rich glycoprotein.";
Matrix Biol. 24:27-34(2005).
PubMed=15690042; DOI=10.1038/nature03253;
Hoebe K., Georgel P., Rutschmann S., Du X., Mudd S., Crozat K.,
Sovath S., Shamel L., Hartung T., Zaehringer U., Beutler B.;
"CD36 is a sensor of diacylglycerides.";
Nature 433:523-527(2005).
PubMed=16020694; DOI=10.1126/science.1116006;
Philips J.A., Rubin E.J., Perrimon N.;
"Drosophila RNAi screen reveals CD36 family member required for
mycobacterial infection.";
Science 309:1251-1253(2005).
PubMed=17507371; DOI=10.1074/jbc.M703330200;
Nassir F., Wilson B., Han X., Gross R.W., Abumrad N.A.;
"CD36 is important for fatty acid and cholesterol uptake by the
proximal but not distal intestine.";
J. Biol. Chem. 282:19493-19501(2007).
PubMed=18162488; DOI=10.1096/fj.07-8415com;
Gaillard D., Laugerette F., Darcel N., El-Yassimi A.,
Passilly-Degrace P., Hichami A., Khan N.A., Montmayeur J.P.,
Besnard P.;
"The gustatory pathway is involved in CD36-mediated orosensory
perception of long-chain fatty acids in the mouse.";
FASEB J. 22:1458-1468(2008).
PubMed=18353783; DOI=10.1074/jbc.M800008200;
Smith J., Su X., El-Maghrabi R., Stahl P.D., Abumrad N.A.;
"Opposite regulation of CD36 ubiquitination by fatty acids and
insulin: effects on fatty acid uptake.";
J. Biol. Chem. 283:13578-13585(2008).
PubMed=19362712; DOI=10.1016/j.cellimm.2009.03.008;
Drage M.G., Pecora N.D., Hise A.G., Febbraio M., Silverstein R.L.,
Golenbock D.T., Boom W.H., Harding C.V.;
"TLR2 and its co-receptors determine responses of macrophages and
dendritic cells to lipoproteins of Mycobacterium tuberculosis.";
Cell. Immunol. 258:29-37(2009).
PubMed=19864601; DOI=10.4049/jimmunol.0901374;
Erdman L.K., Cosio G., Helmers A.J., Gowda D.C., Grinstein S.,
Kain K.C.;
"CD36 and TLR interactions in inflammation and phagocytosis:
implications for malaria.";
J. Immunol. 183:6452-6459(2009).
PubMed=18753675; DOI=10.1194/jlr.P700032-JLR200;
Masuda D., Hirano K., Oku H., Sandoval J.C., Kawase R.,
Yuasa-Kawase M., Yamashita Y., Takada M., Tsubakio-Yamamoto K.,
Tochino Y., Koseki M., Matsuura F., Nishida M., Kawamoto T.,
Ishigami M., Hori M., Shimomura I., Yamashita S.;
"Chylomicron remnants are increased in the postprandial state in CD36
J. Lipid Res. 50:999-1011(2009).
PubMed=19847289; DOI=10.1371/journal.pone.0007411;
Jimenez-Dalmaroni M.J., Xiao N., Corper A.L., Verdino P., Ainge G.D.,
Larsen D.S., Painter G.F., Rudd P.M., Dwek R.A., Hoebe K., Beutler B.,
Wilson I.A.;
"Soluble CD36 ectodomain binds negatively charged diacylglycerol
ligands and acts as a co-receptor for TLR2.";
PLoS ONE 4:E7411-E7411(2009).
PubMed=19471024; DOI=10.1126/scisignal.272re3;
Silverstein R.L., Febbraio M.;
"CD36, a scavenger receptor involved in immunity, metabolism,
angiogenesis, and behavior.";
Sci. Signal. 2:RE3-RE3(2009).
TISSUE=Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas,
Spleen, and Testis;
PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
"A tissue-specific atlas of mouse protein phosphorylation and
Cell 143:1174-1189(2010).
PubMed=20037584; DOI=10.1038/ni.1836;
Stewart C.R., Stuart L.M., Wilkinson K., van Gils J.M., Deng J.,
Halle A., Rayner K.J., Boyer L., Zhong R., Frazier W.A.,
Lacy-Hulbert A., El Khoury J., Golenbock D.T., Moore K.J.;
"CD36 ligands promote sterile inflammation through assembly of a Toll-
like receptor 4 and 6 heterodimer.";
Nat. Immunol. 11:155-161(2010).
PubMed=21610069; DOI=10.1074/jbc.M111.233551;
Tran T.T., Poirier H., Clement L., Nassir F., Pelsers M.M., Petit V.,
Degrace P., Monnot M.C., Glatz J.F., Abumrad N.A., Besnard P.,
Niot I.;
"Luminal lipid regulates CD36 levels and downstream signaling to
stimulate chylomicron synthesis.";
J. Biol. Chem. 286:25201-25210(2011).
PubMed=21901153; DOI=10.1371/journal.pone.0024014;
Martin C., Passilly-Degrace P., Gaillard D., Merlin J.F., Chevrot M.,
Besnard P.;
"The lipid-sensor candidates CD36 and GPR120 are differentially
regulated by dietary lipids in mouse taste buds: impact on spontaneous
fat preference.";
PLoS ONE 6:E24014-E24014(2011).
PubMed=23395392; DOI=10.1016/j.devcel.2013.01.007;
Heit B., Kim H., Cosio G., Castano D., Collins R., Lowell C.A.,
Kain K.C., Trimble W.S., Grinstein S.;
"Multimolecular signaling complexes enable Syk-mediated signaling of
CD36 internalization.";
Dev. Cell 24:372-383(2013).
PubMed=23557700; DOI=10.2337/db12-1689;
Le Foll C., Dunn-Meynell A., Musatov S., Magnan C., Levin B.E.;
"FAT/CD36: a major regulator of neuronal fatty acid sensing and energy
homeostasis in rats and mice.";
Diabetes 62:2709-2716(2013).
PubMed=23812099; DOI=10.1038/ni.2639;
Sheedy F.J., Grebe A., Rayner K.J., Kalantari P., Ramkhelawon B.,
Carpenter S.B., Becker C.E., Ediriweera H.N., Mullick A.E.,
Golenbock D.T., Stuart L.M., Latz E., Fitzgerald K.A., Moore K.J.;
"CD36 coordinates NLRP3 inflammasome activation by facilitating
intracellular nucleation of soluble ligands into particulate ligands
in sterile inflammation.";
Nat. Immunol. 14:812-820(2013).
-!- FUNCTION: Multifunctional glycoprotein that acts as receptor for a
broad range of ligands. Ligands can be of proteinaceous nature
like thrombospondin, fibronectin, collagen or amyloid-beta as well
as of lipidic nature such as oxidized low-density lipoprotein
(oxLDL), anionic phospholipids, long-chain fatty acids and
bacterial diacylated lipopeptides (PubMed:7685021). They are
generally multivalent and can therefore engage multiple receptors
simultaneously, the resulting formation of CD36 clusters initiates
signal transduction and internalization of receptor-ligand
complexes. The dependency on coreceptor signaling is strongly
ligand specific. Cellular responses to these ligands are involved
in angiogenesis, inflammatory response, fatty acid metabolism,
taste and dietary fat processing in the intestine (Probable)
(PubMed:19847289, PubMed:20037584, PubMed:23395392). Binds long-
chain fatty acids and facilitates their transport into cells, thus
participating in muscle lipid utilization, adipose energy storage,
and gut fat absorption (By similarity). In the small intestine,
plays a role in proximal absorption of dietary fatty acid and
cholesterol for optimal chylomicron formation, possibly through
the activation of MAPK1/3 (ERK1/2) signaling pathway (By
similarity) (PubMed:17507371, PubMed:18753675, PubMed:21610069).
Involved in oral fat perception and preferences (PubMed:16276419).
Detection into the tongue of long-chain fatty acids leads to a
rapid and sustained rise in flux and protein content of
pancreatobiliary secretions (By similarity) (PubMed:16276419). In
taste receptor cells, mediates the induction of an increase in
intracellular calcium levels by long-chain fatty acids, leading to
the activation of the gustatory neurons in the nucleus of the
solitary tract (PubMed:18162488). Important factor in both
ventromedial hypothalamus neuronal sensing of long-chain fatty
acid and the regulation of energy and glucose homeostasis (By
similarity) (PubMed:23557700). Receptor for thombospondins, THBS1
and THBS2, mediating their antiangiogenic effects
(PubMed:15748999). As a coreceptor for TLR4:TLR6 heterodimer,
promotes inflammation in monocytes/macrophages. Upon ligand
binding, such as oxLDL or amyloid-beta 42, interacts with the
heterodimer TLR4:TLR6, the complex is internalized and triggers
inflammatory response, leading to NF-kappa-B-dependent production
of CXCL1, CXCL2 and CCL9 cytokines, via MYD88 signaling pathway,
and CCL5 cytokine, via TICAM1 signaling pathway, as well as IL1B
secretion, through the priming and activation of the NLRP3
inflammasome (PubMed:20037584, PubMed:23812099). Selective and
nonredundant sensor of microbial diacylated lipopeptide that
signal via TLR2:TLR6 heterodimer, this cluster triggers signaling
from the cell surface, leading to the NF-kappa-B-dependent
production of TNF, via MYD88 signaling pathway and subsequently is
targeted to the Golgi in a lipid-raft dependent pathway (By
similarity) (PubMed:15690042, PubMed:19847289).
{ECO:0000250|UniProtKB:P16671, ECO:0000250|UniProtKB:Q07969,
ECO:0000269|PubMed:15690042, ECO:0000269|PubMed:15748999,
ECO:0000269|PubMed:16276419, ECO:0000269|PubMed:17507371,
ECO:0000269|PubMed:18162488, ECO:0000269|PubMed:18753675,
ECO:0000269|PubMed:19847289, ECO:0000269|PubMed:20037584,
ECO:0000269|PubMed:21610069, ECO:0000269|PubMed:23395392,
ECO:0000269|PubMed:23557700, ECO:0000269|PubMed:23812099,
ECO:0000269|PubMed:7685021, ECO:0000305|PubMed:19471024}.
-!- FUNCTION: (Microbial infection) Acts as an accessory receptor for
M.tuberculosis lipoprotein LprA, in conjunction with coreceptors
TLR2 and TLR1; the lipoprotein acts as an agonist to modulate
antigen presenting cell functions in response to the pathogen
(PubMed:19362712). Directly mediates cytoadherence of Plasmodium
falciparum parasitized erythrocytes and the internalization of
particles independently of TLR signaling (PubMed:19864601,
PubMed:23395392). Mediates uptake of E.coli and S.aureus but has
no effect on uptake of M.fortuitum (PubMed:16020694).
{ECO:0000269|PubMed:16020694, ECO:0000269|PubMed:19362712,
ECO:0000269|PubMed:19864601, ECO:0000269|PubMed:23395392}.
-!- SUBUNIT: Interacts with THBS1 and THBS2; the interactions mediate
the THBS antiangiogenic activity (By similarity)
(PubMed:15748999). Upon interaction with a ligand, such as
oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42,
rapidly forms a complex with TLR4 and TLR6; the complex is
internalized and triggers an inflammatory signal. Through its C-
terminus, interacts with PTK2, PXN and LYN, but not with SRC. LYN
kinase activity is required for facilitating TLR4-TLR6
heterodimerization and signal initiation (By similarity).
Interacts with CD9, CD81, FCER1G, ITGB2 and/or ITGB2; forming a
membrane heteromeric complex required for the internalization of
CD36 and its ligands (PubMed:23395392).
{ECO:0000250|UniProtKB:P16671, ECO:0000269|PubMed:15748999,
P07948:LYN (xeno); NbExp=2; IntAct=EBI-8346984, EBI-79452;
-!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:23395392};
Multi-pass membrane protein {ECO:0000255}. Apical cell membrane
{ECO:0000269|PubMed:16276419, ECO:0000269|PubMed:21610069}.
Membrane raft {ECO:0000250|UniProtKB:P16671}. Golgi apparatus
{ECO:0000250|UniProtKB:P16671}. Note=Upon ligand-binding,
internalized through dynamin-dependent endocytosis.
-!- TISSUE SPECIFICITY: Expressed in the apical side of lingual taste
bud cells of the circumvallate papillae (PubMed:16276419,
PubMed:21901153). Highly expressed in the intestine on the luminal
surface of enterocytes. In small intestines expression levels
follow a steep decreasing gradient from proximal to distal
segments (PubMed:17507371). Expressed in macrophages
(PubMed:23395392, PubMed:23812099). Cell surface expression
detected in lung alveolar macrophages, dendritic macrophages and
lung macrophages (at protein level) (PubMed:19362712).
{ECO:0000269|PubMed:16276419, ECO:0000269|PubMed:17507371,
ECO:0000269|PubMed:19362712, ECO:0000269|PubMed:21901153,
ECO:0000269|PubMed:23395392, ECO:0000269|PubMed:23812099}.
-!- INDUCTION: Expressed in a circadian manner in the circumvallate
papillae, levels being lower during the dark period. Protein
levels decrease in presence of lipids.
-!- PTM: Ubiquitinated at Lys-469 and Lys-472. Ubiquitination is
induced by fatty acids such as oleic acid and leads to degradation
by the proteasome (PubMed:21610069, PubMed:18353783).
Ubiquitination and degradation are inhibited by insulin which
blocks the effect of fatty acids (PubMed:18353783).
{ECO:0000269|PubMed:18353783, ECO:0000269|PubMed:21610069}.
-!- DISRUPTION PHENOTYPE: The preference to lipids such linoleic acid
is fully abolished in mutant mice as well as the induction of both
flux and protein content of pancreatobiliary secretions
(PubMed:21901153, PubMed:16276419). Animals with a double knockout
of APOE and CD36, fed a Western diet for 12 weeks, exhibit much
lower levels of CXCL1, CXCL2 and CCL5 cytokine mRNA expression in
the descending aorta and a corresponding decrease in
atherosclerotic lesion formation, compared to APOE single knockout
mice. Enterocytes from proximal small intestine exhibit reduced
uptake of fatty acid and cholesterol. They also show reduced fatty
acid incorporation into triglycerides and triglyceride secretion
(PubMed:17507371). After oral fat loading, animals have
lipoproteins smaller than chylomicron in size in plasma and
intestinal lymph (PubMed:18753675). {ECO:0000269|PubMed:16276419,
ECO:0000269|PubMed:17507371, ECO:0000269|PubMed:18753675,
ECO:0000269|PubMed:20037584, ECO:0000269|PubMed:21901153}.
-!- SIMILARITY: Belongs to the CD36 family. {ECO:0000305}.
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
Distributed under the Creative Commons Attribution (CC BY 4.0) License
EMBL; L23108; AAA53028.1; -; mRNA.
EMBL; BC010262; AAH10262.1; -; mRNA.
CCDS; CCDS19100.1; -.
PIR; I49590; I49590.
RefSeq; NP_001153027.1; NM_001159555.1.
RefSeq; NP_001153028.1; NM_001159556.1.
RefSeq; NP_001153029.1; NM_001159557.1.
RefSeq; NP_001153030.1; NM_001159558.1.
RefSeq; NP_031669.3; NM_007643.4.
RefSeq; XP_006535683.1; XM_006535620.3.
RefSeq; XP_006535684.1; XM_006535621.3.
RefSeq; XP_006535685.1; XM_006535622.3.
RefSeq; XP_006535686.1; XM_006535623.3.
RefSeq; XP_006535687.1; XM_006535624.3.
RefSeq; XP_006535688.1; XM_006535625.1.
UniGene; Mm.18628; -.
UniGene; Mm.406799; -.
ProteinModelPortal; Q08857; -.
SMR; Q08857; -.
BioGrid; 198587; 2.
CORUM; Q08857; -.
IntAct; Q08857; 10.
MINT; Q08857; -.
STRING; 10090.ENSMUSP00000080974; -.
ChEMBL; CHEMBL2176845; -.
TCDB; 9.B.39.1.1; the long chain fatty acid translocase (lcfat) family.
iPTMnet; Q08857; -.
PhosphoSitePlus; Q08857; -.
SwissPalm; Q08857; -.
PaxDb; Q08857; -.
PeptideAtlas; Q08857; -.
PRIDE; Q08857; -.
Ensembl; ENSMUST00000082367; ENSMUSP00000080974; ENSMUSG00000002944.
Ensembl; ENSMUST00000165232; ENSMUSP00000126300; ENSMUSG00000002944.
Ensembl; ENSMUST00000169095; ENSMUSP00000131832; ENSMUSG00000002944.
Ensembl; ENSMUST00000170051; ENSMUSP00000133008; ENSMUSG00000002944.
Ensembl; ENSMUST00000197890; ENSMUSP00000143061; ENSMUSG00000002944.
GeneID; 12491; -.
KEGG; mmu:12491; -.
UCSC; uc008wnn.2; mouse.
CTD; 948; -.
MGI; MGI:107899; Cd36.
eggNOG; KOG3776; Eukaryota.
eggNOG; ENOG410XS17; LUCA.
GeneTree; ENSGT00530000062927; -.
HOGENOM; HOG000252951; -.
HOVERGEN; HBG002754; -.
InParanoid; Q08857; -.
KO; K06259; -.
OrthoDB; EOG091G0CH9; -.
PhylomeDB; Q08857; -.
TreeFam; TF317925; -.
Reactome; R-MMU-114608; Platelet degranulation.
Reactome; R-MMU-1236973; Cross-presentation of particulate exogenous antigens (phagosomes).
Reactome; R-MMU-3000471; Scavenging by Class B Receptors.
Reactome; R-MMU-5686938; Regulation of TLR by endogenous ligand.
Reactome; R-MMU-6798695; Neutrophil degranulation.
ChiTaRS; Scarb1; mouse.
PRO; PR:Q08857; -.
Proteomes; UP000000589; Chromosome 5.
Bgee; ENSMUSG00000002944; Expressed in 238 organ(s), highest expression level in brown adipose tissue.
CleanEx; MM_CD36; -.
ExpressionAtlas; Q08857; baseline and differential.
Genevisible; Q08857; MM.
GO; GO:0045177; C:apical part of cell; IDA:UniProtKB.
GO; GO:0016324; C:apical plasma membrane; IEA:UniProtKB-SubCell.
GO; GO:0031526; C:brush border membrane; IDA:UniProtKB.
GO; GO:0005901; C:caveola; ISO:MGI.
GO; GO:0009986; C:cell surface; ISS:BHF-UCL.
GO; GO:0005783; C:endoplasmic reticulum; ISO:MGI.
GO; GO:0009897; C:external side of plasma membrane; IDA:MGI.
GO; GO:0005794; C:Golgi apparatus; IDA:MGI.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0005622; C:intracellular; ISO:MGI.
GO; GO:0043231; C:intracellular membrane-bounded organelle; ISO:MGI.
GO; GO:0016020; C:membrane; IDA:UniProtKB.
GO; GO:0045121; C:membrane raft; IDA:MGI.
GO; GO:0005739; C:mitochondrion; ISO:MGI.
GO; GO:0005886; C:plasma membrane; IDA:MGI.
GO; GO:0032991; C:protein-containing complex; ISO:MGI.
GO; GO:0043235; C:receptor complex; ISO:MGI.
GO; GO:0042383; C:sarcolemma; ISO:MGI.
GO; GO:0008035; F:high-density lipoprotein particle binding; IDA:MGI.
GO; GO:0008289; F:lipid binding; ISS:BHF-UCL.
GO; GO:0071813; F:lipoprotein particle binding; ISO:MGI.
GO; GO:0070892; F:lipoteichoic acid receptor activity; IMP:MGI.
GO; GO:0030169; F:low-density lipoprotein particle binding; IMP:BHF-UCL.
GO; GO:0005041; F:low-density lipoprotein particle receptor activity; IMP:BHF-UCL.
GO; GO:0070538; F:oleic acid binding; ISO:MGI.
GO; GO:0150025; F:oxidised low-density lipoprotein particle receptor activity; ISO:MGI.
GO; GO:0070053; F:thrombospondin receptor activity; ISO:MGI.
GO; GO:0035325; F:Toll-like receptor binding; ISO:MGI.
GO; GO:0050431; F:transforming growth factor beta binding; ISO:MGI.
GO; GO:1990000; P:amyloid fibril formation; IDA:UniProtKB.
GO; GO:0043277; P:apoptotic cell clearance; IMP:MGI.
GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
GO; GO:0007166; P:cell surface receptor signaling pathway; IDA:BHF-UCL.
GO; GO:1904646; P:cellular response to amyloid-beta; ISO:MGI.
GO; GO:0071221; P:cellular response to bacterial lipopeptide; IMP:MGI.
GO; GO:0071726; P:cellular response to diacyl bacterial lipopeptide; ISS:UniProtKB.
GO; GO:0071447; P:cellular response to hydroperoxide; IMP:BHF-UCL.
GO; GO:0071222; P:cellular response to lipopolysaccharide; IMP:MGI.
GO; GO:0071223; P:cellular response to lipoteichoic acid; IDA:MGI.
GO; GO:0071404; P:cellular response to low-density lipoprotein particle stimulus; IDA:UniProtKB.
GO; GO:0140052; P:cellular response to oxidised low-density lipoprotein particle stimulus; ISO:MGI.
GO; GO:0019934; P:cGMP-mediated signaling; ISO:MGI.
GO; GO:0070508; P:cholesterol import; IMP:UniProtKB.
GO; GO:0030301; P:cholesterol transport; IMP:BHF-UCL.
GO; GO:0050830; P:defense response to Gram-positive bacterium; IMP:MGI.
GO; GO:0042755; P:eating behavior; ISO:MGI.
GO; GO:0097009; P:energy homeostasis; IMP:UniProtKB.
GO; GO:0006631; P:fatty acid metabolic process; ISO:MGI.
GO; GO:0019395; P:fatty acid oxidation; ISO:MGI.
GO; GO:0015908; P:fatty acid transport; ISO:MGI.
GO; GO:0042593; P:glucose homeostasis; ISO:MGI.
GO; GO:0006955; P:immune response; IEA:InterPro.
GO; GO:0050702; P:interleukin-1 beta secretion; IDA:UniProtKB.
GO; GO:0050892; P:intestinal absorption; IMP:UniProtKB.
GO; GO:0030299; P:intestinal cholesterol absorption; IMP:UniProtKB.
GO; GO:0019915; P:lipid storage; IMP:BHF-UCL.
GO; GO:0042953; P:lipoprotein transport; IMP:BHF-UCL.
GO; GO:0044539; P:long-chain fatty acid import; IMP:UniProtKB.
GO; GO:0001676; P:long-chain fatty acid metabolic process; ISO:MGI.
GO; GO:0015909; P:long-chain fatty acid transport; ISO:MGI.
GO; GO:0034383; P:low-density lipoprotein particle clearance; IMP:BHF-UCL.
GO; GO:0055096; P:low-density lipoprotein particle mediated signaling; IDA:BHF-UCL.
GO; GO:0016525; P:negative regulation of angiogenesis; ISO:MGI.
GO; GO:0010629; P:negative regulation of gene expression; IMP:BHF-UCL.
GO; GO:0044130; P:negative regulation of growth of symbiont in host; IMP:MGI.
GO; GO:0042308; P:negative regulation of protein import into nucleus; IMP:BHF-UCL.
GO; GO:0003085; P:negative regulation of systemic arterial blood pressure; ISO:MGI.
GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IMP:BHF-UCL.
GO; GO:0007263; P:nitric oxide mediated signal transduction; ISO:MGI.
GO; GO:0150024; P:oxidised low-density lipoprotein particle clearance; ISO:MGI.
GO; GO:0006910; P:phagocytosis, recognition; IDA:MGI.
GO; GO:0034381; P:plasma lipoprotein particle clearance; IMP:BHF-UCL.
GO; GO:0030194; P:positive regulation of blood coagulation; IMP:BHF-UCL.
GO; GO:2000334; P:positive regulation of blood microparticle formation; IMP:BHF-UCL.
GO; GO:0010942; P:positive regulation of cell death; ISO:MGI.
GO; GO:0001954; P:positive regulation of cell-matrix adhesion; ISO:MGI.
GO; GO:0010886; P:positive regulation of cholesterol storage; IMP:BHF-UCL.
GO; GO:0120162; P:positive regulation of cold-induced thermogenesis; IMP:YuBioLab.
GO; GO:0050715; P:positive regulation of cytokine secretion; ISO:MGI.
GO; GO:0007204; P:positive regulation of cytosolic calcium ion concentration; IDA:UniProtKB.
GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IMP:UniProtKB.
GO; GO:0010628; P:positive regulation of gene expression; IMP:ARUK-UCL.
GO; GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB signaling; IMP:MGI.
GO; GO:0032735; P:positive regulation of interleukin-12 production; IMP:MGI.
GO; GO:0032755; P:positive regulation of interleukin-6 production; IMP:MGI.
GO; GO:0060907; P:positive regulation of macrophage cytokine production; IMP:MGI.
GO; GO:0010744; P:positive regulation of macrophage derived foam cell differentiation; IMP:BHF-UCL.
GO; GO:0043410; P:positive regulation of MAPK cascade; IMP:MGI.
GO; GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; ISO:MGI.
GO; GO:0045429; P:positive regulation of nitric oxide biosynthetic process; IGI:ARUK-UCL.
GO; GO:1900227; P:positive regulation of NLRP3 inflammasome complex assembly; IDA:UniProtKB.
GO; GO:0050731; P:positive regulation of peptidyl-tyrosine phosphorylation; IDA:BHF-UCL.
GO; GO:0050766; P:positive regulation of phagocytosis; ISO:MGI.
GO; GO:0060100; P:positive regulation of phagocytosis, engulfment; IDA:MGI.
GO; GO:1903428; P:positive regulation of reactive oxygen species biosynthetic process; IMP:ARUK-UCL.
GO; GO:2000379; P:positive regulation of reactive oxygen species metabolic process; IMP:BHF-UCL.
GO; GO:0090208; P:positive regulation of triglyceride metabolic process; ISO:MGI.
GO; GO:0032760; P:positive regulation of tumor necrosis factor production; IMP:MGI.
GO; GO:0031623; P:receptor internalization; IDA:UniProtKB.
GO; GO:0043497; P:regulation of protein heterodimerization activity; ISO:MGI.
GO; GO:2000121; P:regulation of removal of superoxide radicals; IMP:BHF-UCL.
GO; GO:0034121; P:regulation of toll-like receptor signaling pathway; ISO:MGI.
GO; GO:0043619; P:regulation of transcription from RNA polymerase II promoter in response to oxidative stress; IC:BHF-UCL.
GO; GO:0009617; P:response to bacterium; IEP:MGI.
GO; GO:0070542; P:response to fatty acid; IDA:UniProtKB.
GO; GO:0070543; P:response to linoleic acid; IDA:UniProtKB.
GO; GO:0033993; P:response to lipid; IDA:UniProtKB.
GO; GO:0009612; P:response to mechanical stimulus; ISO:MGI.
GO; GO:0035634; P:response to stilbenoid; IEP:UniProtKB.
GO; GO:0050909; P:sensory perception of taste; IDA:UniProtKB.
GO; GO:0006641; P:triglyceride metabolic process; ISO:MGI.
GO; GO:0034197; P:triglyceride transport; IMP:UniProtKB.
InterPro; IPR005428; CD36/SCARB1/SNMP1.
InterPro; IPR033076; CD36_chordates.
InterPro; IPR002159; CD36_fam.
PANTHER; PTHR11923; PTHR11923; 1.
PANTHER; PTHR11923:SF12; PTHR11923:SF12; 1.
Pfam; PF01130; CD36; 1.
1: Evidence at protein level;
Cell adhesion; Cell membrane; Complete proteome; Disulfide bond;
Glycoprotein; Golgi apparatus; Isopeptide bond; Lipoprotein; Membrane;
Palmitate; Receptor; Reference proteome; Transmembrane;
Transmembrane helix; Transport; Ubl conjugation.
CHAIN 1 472 Platelet glycoprotein 4.
TOPO_DOM 1 7 Cytoplasmic. {ECO:0000255}.
TRANSMEM 8 29 Helical. {ECO:0000255}.
TOPO_DOM 30 439 Extracellular. {ECO:0000255}.
TRANSMEM 440 461 Helical. {ECO:0000255}.
TOPO_DOM 462 472 Cytoplasmic. {ECO:0000255}.
REGION 93 120 Required for interaction with
thrombospondins, THBS1 and THBS2.
REGION 460 472 Interaction with PTK2, PXN and LYN.
SITE 463 463 Critical for TLR4-TLR6 dimerization and
LIPID 3 3 S-palmitoyl cysteine. {ECO:0000250}.
LIPID 7 7 S-palmitoyl cysteine. {ECO:0000250}.
LIPID 464 464 S-palmitoyl cysteine. {ECO:0000250}.
LIPID 466 466 S-palmitoyl cysteine. {ECO:0000250}.
CARBOHYD 79 79 N-linked (GlcNAc...) asparagine.
CARBOHYD 134 134 N-linked (GlcNAc...) asparagine.
CARBOHYD 205 205 N-linked (GlcNAc...) asparagine.
CARBOHYD 220 220 N-linked (GlcNAc...) asparagine.
CARBOHYD 235 235 N-linked (GlcNAc...) asparagine.
CARBOHYD 247 247 N-linked (GlcNAc...) asparagine.
CARBOHYD 321 321 N-linked (GlcNAc...) asparagine.
CARBOHYD 417 417 N-linked (GlcNAc...) asparagine.
DISULFID 243 311 {ECO:0000250}.
DISULFID 272 333 {ECO:0000250}.
DISULFID 313 322 {ECO:0000250}.
CROSSLNK 469 469 Glycyl lysine isopeptide (Lys-Gly)
(interchain with G-Cter in ubiquitin).
CROSSLNK 472 472 Glycyl lysine isopeptide (Lys-Gly)
(interchain with G-Cter in ubiquitin).
SEQUENCE 472 AA; 52698 MW; 80AEABB18206534F CRC64;

Related products :

Catalog number Product name Quantity
20-783-72449 MOUSE ANTI HUMAN CD36 Azide Free - GPIV (IIIb); Platelet glycoprotein IV; GPIV; Glycoprotein IIIb; GPIIIB; Leukocyte differentiation antigen CD36; CD36 antigen; PAS IV; PAS-4; Platelet collagen recept 1 mg
20-783-72448 MOUSE ANTI HUMAN CD36 - GPIV (IIIb); Platelet glycoprotein IV; GPIV; Glycoprotein IIIb; GPIIIB; Leukocyte differentiation antigen CD36; CD36 antigen; PAS IV; PAS-4; Platelet collagen receptor; Fatty a 0.1 mg
20-783-72446 MOUSE ANTI HUMAN CD36 - GPIV (IIIb); Platelet glycoprotein IV; GPIV; Glycoprotein IIIb; GPIIIB; Leukocyte differentiation antigen CD36; CD36 antigen; PAS IV; PAS-4; Platelet collagen receptor; Fatty a 0.2 mg
20-783-72447 MOUSE ANTI HUMAN CD36 FITC - GPIV (IIIb); Platelet glycoprotein IV; GPIV; Glycoprotein IIIb; GPIIIB; Leukocyte differentiation antigen CD36; CD36 antigen; PAS IV; PAS-4; Platelet collagen receptor; Fa 0.1 mg
20-321-175191 CD36 - MONOCLONAL ANTIBODY TO HUMAN CD36; Platelet glycoprotein IV; GPIV; Glycoprotein IIIb; GPIIIB; Leukocyte differentiation antigen CD36; CD36 antigen; PAS IV; PAS-4 protein; Platelet collagen rece 0.1 mg
20-321-175238 CD36 - MONOCLONAL ANTIBODY TO RAT CD36; Platelet glycoprotein IV; GPIV; Glycoprotein IIIb; GPIIIB; Leukocyte differentiation antigen CD36; CD36 antigen; PAS IV; PAS-4 protein; Platelet collagen recept 0.1 mg
20-272-191920 CD36 - Mouse monoclonal [SMO] to CD36; Platelet glycoprotein IV; GPIV; Glycoprotein IIIb; GPIIIB; Leukocyte differentiation antigen CD36; CD36 antigen; PAS IV; PAS-4 protein; Platelet collagen recepto 0.1 mg
U0674b CLIA Bos taurus,Bovine,CD36,Glycoprotein IIIb,GPIIIB,GPIV,PAS IV,PAS4,PAS-4,Platelet glycoprotein 4,Platelet glycoprotein IV 96T
E0674b ELISA Bos taurus,Bovine,CD36,Glycoprotein IIIb,GPIIIB,GPIV,PAS IV,PAS4,PAS-4,Platelet glycoprotein 4,Platelet glycoprotein IV 96T
E0674b ELISA kit Bos taurus,Bovine,CD36,Glycoprotein IIIb,GPIIIB,GPIV,PAS IV,PAS4,PAS-4,Platelet glycoprotein 4,Platelet glycoprotein IV 96T
E0674m ELISA Cd36,Glycoprotein IIIb,GPIIIB,GPIV,Mouse,Mus musculus,PAS IV,PAS-4,Platelet glycoprotein 4,Platelet glycoprotein IV 96T
E0674m ELISA kit Cd36,Glycoprotein IIIb,GPIIIB,GPIV,Mouse,Mus musculus,PAS IV,PAS-4,Platelet glycoprotein 4,Platelet glycoprotein IV 96T
U0674m CLIA Cd36,Glycoprotein IIIb,GPIIIB,GPIV,Mouse,Mus musculus,PAS IV,PAS-4,Platelet glycoprotein 4,Platelet glycoprotein IV 96T
E0674h ELISA CD36,FAT,Fatty acid translocase,Glycoprotein IIIb,GP3B,GP4,GPIIIB,GPIV,Homo sapiens,Human,Leukocyte differentiation antigen CD36,PAS IV,PAS-4,Platelet collagen receptor,Platelet glycoprotein 4,P 96T
U0674h CLIA CD36,FAT,Fatty acid translocase,Glycoprotein IIIb,GP3B,GP4,GPIIIB,GPIV,Homo sapiens,Human,Leukocyte differentiation antigen CD36,PAS IV,PAS-4,Platelet collagen receptor,Platelet glycoprotein 4,Pl 96T
U0674r CLIA Adipocyte membrane protein,Cd36,Fat,Fatty acid translocase,Fatty acid transport protein,Glycoprotein IIIb,GPIIIB,GPIV,PAS IV,PAS-4,Platelet glycoprotein 4,Platelet glycoprotein IV,Rat,Rattus norv 96T
E0674h ELISA kit CD36,FAT,Fatty acid translocase,Glycoprotein IIIb,GP3B,GP4,GPIIIB,GPIV,Homo sapiens,Human,Leukocyte differentiation antigen CD36,PAS IV,PAS-4,Platelet collagen receptor,Platelet glycoprotei 96T
E0674r ELISA Adipocyte membrane protein,Cd36,Fat,Fatty acid translocase,Fatty acid transport protein,Glycoprotein IIIb,GPIIIB,GPIV,PAS IV,PAS-4,Platelet glycoprotein 4,Platelet glycoprotein IV,Rat,Rattus nor 96T
E0674r ELISA kit Adipocyte membrane protein,Cd36,Fat,Fatty acid translocase,Fatty acid transport protein,Glycoprotein IIIb,GPIIIB,GPIV,PAS IV,PAS-4,Platelet glycoprotein 4,Platelet glycoprotein IV,Rat,Rattu 96T
1107NF-V1105 Monoclonal Antibodies: Mab to CD61, Platelet Glycoprotein IIIa; reactive species: Human; Clone: Y2_51; Isotype: IgG1; Specificity: CD61, Platelet Glycoprotein IIIa 0.5/ml
CSB-EL004927RA Rat Platelet glycoprotein 4(CD36) ELISA kit 96T
CSB-EL004927BO Bovine Platelet glycoprotein 4(CD36) ELISA kit 96T
CSB-EL004927MO Mouse Platelet glycoprotein 4(CD36) ELISA kit 96T
CSB-EL004927RA Rat Platelet glycoprotein 4(CD36) ELISA kit SpeciesRat 96T
E2206h ELISA kit Glycoprotein 6,GP6,GPVI,Homo sapiens,Human,Platelet glycoprotein VI 96T


GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur | Gentaur

Unicorn House, Station Cl
Hertfordshire, Potters Bar EN6 1TL
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur | Gentaur



9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017
RIB 30004 00187 00010092253 10
IBAN FR76 3000 4001 8700 0100 9225 310
france@gentaur.com | Gentaur | Gentaur

Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur | Gentaur

Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123

GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U

spain@gentaur.com | Gentaur | Gentaur

ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur | Gentaur
IBAN: BG11FINV91501014771636

GENTAUR Poland Sp. z o.o.

ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556


Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur | Gentaur