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Platelet-derived growth factor subunit B (PDGF subunit B) (PDGF-2) (Platelet-derived growth factor B chain) (Platelet-derived growth factor beta polypeptide)

 PDGFB_SHEEP             Reviewed;         241 AA.
Q95229;
01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
01-FEB-1997, sequence version 1.
25-OCT-2017, entry version 95.
RecName: Full=Platelet-derived growth factor subunit B;
Short=PDGF subunit B;
AltName: Full=PDGF-2;
AltName: Full=Platelet-derived growth factor B chain;
AltName: Full=Platelet-derived growth factor beta polypeptide;
Flags: Precursor;
Name=PDGFB;
Ovis aries (Sheep).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
Pecora; Bovidae; Caprinae; Ovis.
NCBI_TaxID=9940;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=Texe1; TISSUE=Spleen;
Woodall C.J., Zhang Z., Watt N.J.;
"The entire coding sequence of sheep platelet-derived growth factor B
subunit cDNA.";
Submitted (SEP-1996) to the EMBL/GenBank/DDBJ databases.
-!- FUNCTION: Growth factor that plays an essential role in the
regulation of embryonic development, cell proliferation, cell
migration, survival and chemotaxis. Potent mitogen for cells of
mesenchymal origin. Required for normal proliferation and
recruitment of pericytes and vascular smooth muscle cells in the
central nervous system, skin, lung, heart and placenta. Required
for normal blood vessel development, and for normal development of
kidney glomeruli. Plays an important role in wound healing.
Signaling is modulated by the formation of heterodimers with PDGFA
(By similarity). {ECO:0000250|UniProtKB:P01127,
ECO:0000250|UniProtKB:P31240}.
-!- SUBUNIT: Homodimer; antiparallel disulfide-linked dimer.
Heterodimer with PDGFA; antiparallel disulfide-linked dimer. The
PDGFB homodimer interacts with PDGFRA and PDGFRB homodimers, and
with heterodimers formed by PDGFRA and PDGFRB. The heterodimer
composed of PDGFA and PDGFB interacts with PDGFRB homodimers, and
with heterodimers formed by PDGFRA and PDGFRB. Interacts with
XLKD1 (By similarity). {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}. Note=Released by
platelets upon wounding. {ECO:0000250}.
-!- SIMILARITY: Belongs to the PDGF/VEGF growth factor family.
{ECO:0000305}.
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EMBL; X97123; CAA65790.1; -; mRNA.
RefSeq; NP_001009471.1; NM_001009471.1.
UniGene; Oar.501; -.
ProteinModelPortal; Q95229; -.
SMR; Q95229; -.
GeneID; 443545; -.
KEGG; oas:443545; -.
CTD; 5155; -.
HOVERGEN; HBG053546; -.
KO; K17386; -.
Proteomes; UP000002356; Unplaced.
GO; GO:0016323; C:basolateral plasma membrane; ISS:UniProtKB.
GO; GO:0009986; C:cell surface; ISS:UniProtKB.
GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
GO; GO:0008083; F:growth factor activity; ISS:UniProtKB.
GO; GO:0005161; F:platelet-derived growth factor receptor binding; ISS:UniProtKB.
GO; GO:0042803; F:protein homodimerization activity; ISS:UniProtKB.
GO; GO:0016176; F:superoxide-generating NADPH oxidase activator activity; ISS:UniProtKB.
GO; GO:0032147; P:activation of protein kinase activity; ISS:UniProtKB.
GO; GO:0032148; P:activation of protein kinase B activity; ISS:UniProtKB.
GO; GO:0060326; P:cell chemotaxis; ISS:UniProtKB.
GO; GO:0071506; P:cellular response to mycophenolic acid; ISS:UniProtKB.
GO; GO:0001892; P:embryonic placenta development; ISS:UniProtKB.
GO; GO:0007507; P:heart development; ISS:UniProtKB.
GO; GO:0072255; P:metanephric glomerular mesangial cell development; ISS:UniProtKB.
GO; GO:0002548; P:monocyte chemotaxis; ISS:UniProtKB.
GO; GO:0010512; P:negative regulation of phosphatidylinositol biosynthetic process; ISS:UniProtKB.
GO; GO:0010544; P:negative regulation of platelet activation; ISS:UniProtKB.
GO; GO:0045892; P:negative regulation of transcription, DNA-templated; ISS:UniProtKB.
GO; GO:0038001; P:paracrine signaling; ISS:UniProtKB.
GO; GO:0018105; P:peptidyl-serine phosphorylation; ISS:UniProtKB.
GO; GO:0018108; P:peptidyl-tyrosine phosphorylation; ISS:UniProtKB.
GO; GO:0048008; P:platelet-derived growth factor receptor signaling pathway; ISS:UniProtKB.
GO; GO:0043536; P:positive regulation of blood vessel endothelial cell migration; ISS:UniProtKB.
GO; GO:0090280; P:positive regulation of calcium ion import; ISS:UniProtKB.
GO; GO:0051781; P:positive regulation of cell division; IEA:UniProtKB-KW.
GO; GO:0008284; P:positive regulation of cell proliferation; ISS:UniProtKB.
GO; GO:0050921; P:positive regulation of chemotaxis; ISS:UniProtKB.
GO; GO:0045737; P:positive regulation of cyclin-dependent protein serine/threonine kinase activity; ISS:UniProtKB.
GO; GO:2000573; P:positive regulation of DNA biosynthetic process; ISS:UniProtKB.
GO; GO:0045740; P:positive regulation of DNA replication; ISS:UniProtKB.
GO; GO:0001938; P:positive regulation of endothelial cell proliferation; ISS:UniProtKB.
GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; ISS:UniProtKB.
GO; GO:0048146; P:positive regulation of fibroblast proliferation; ISS:UniProtKB.
GO; GO:0003104; P:positive regulation of glomerular filtration; ISS:UniProtKB.
GO; GO:0072126; P:positive regulation of glomerular mesangial cell proliferation; ISS:UniProtKB.
GO; GO:1900127; P:positive regulation of hyaluronan biosynthetic process; ISS:UniProtKB.
GO; GO:0043406; P:positive regulation of MAP kinase activity; ISS:UniProtKB.
GO; GO:0043410; P:positive regulation of MAPK cascade; ISS:UniProtKB.
GO; GO:2000591; P:positive regulation of metanephric mesenchymal cell migration; ISS:UniProtKB.
GO; GO:0035793; P:positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway; ISS:UniProtKB.
GO; GO:0045840; P:positive regulation of mitotic nuclear division; ISS:UniProtKB.
GO; GO:0043552; P:positive regulation of phosphatidylinositol 3-kinase activity; ISS:UniProtKB.
GO; GO:0014068; P:positive regulation of phosphatidylinositol 3-kinase signaling; ISS:UniProtKB.
GO; GO:0031954; P:positive regulation of protein autophosphorylation; ISS:UniProtKB.
GO; GO:0061098; P:positive regulation of protein tyrosine kinase activity; ISS:UniProtKB.
GO; GO:2000379; P:positive regulation of reactive oxygen species metabolic process; ISS:UniProtKB.
GO; GO:0014911; P:positive regulation of smooth muscle cell migration; ISS:UniProtKB.
GO; GO:0048661; P:positive regulation of smooth muscle cell proliferation; ISS:UniProtKB.
GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISS:UniProtKB.
GO; GO:0006468; P:protein phosphorylation; ISS:UniProtKB.
GO; GO:0072593; P:reactive oxygen species metabolic process; ISS:UniProtKB.
GO; GO:0009611; P:response to wounding; ISS:UniProtKB.
GO; GO:0007179; P:transforming growth factor beta receptor signaling pathway; ISS:UniProtKB.
CDD; cd00135; PDGF; 1.
Gene3D; 2.10.90.10; -; 1.
InterPro; IPR029034; Cystine-knot_cytokine.
InterPro; IPR023581; PD_growth_factor_CS.
InterPro; IPR000072; PDGF/VEGF_dom.
InterPro; IPR006782; PDGF_N.
InterPro; IPR015583; PDGF_suB.
PANTHER; PTHR11633:SF2; PTHR11633:SF2; 2.
Pfam; PF00341; PDGF; 1.
Pfam; PF04692; PDGF_N; 1.
SMART; SM00141; PDGF; 1.
SUPFAM; SSF57501; SSF57501; 1.
PROSITE; PS00249; PDGF_1; 1.
PROSITE; PS50278; PDGF_2; 1.
2: Evidence at transcript level;
Cleavage on pair of basic residues; Complete proteome;
Developmental protein; Disulfide bond; Glycoprotein; Growth factor;
Mitogen; Proto-oncogene; Reference proteome; Secreted; Signal.
SIGNAL 1 20 {ECO:0000250}.
PROPEP 21 81 Removed in mature form. {ECO:0000250}.
/FTId=PRO_0000023380.
CHAIN 82 190 Platelet-derived growth factor subunit B.
/FTId=PRO_0000023381.
PROPEP 191 241 Removed in mature form. {ECO:0000250}.
/FTId=PRO_0000023382.
SITE 108 108 Involved in receptor binding.
SITE 111 111 Involved in receptor binding.
CARBOHYD 63 63 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 97 141 {ECO:0000250}.
DISULFID 124 124 Interchain. {ECO:0000250}.
DISULFID 130 178 {ECO:0000250}.
DISULFID 133 133 Interchain. {ECO:0000250}.
DISULFID 134 180 {ECO:0000250}.
SEQUENCE 241 AA; 27331 MW; 37BE1EC12E7D2863 CRC64;
MNRCWALFLS LCCYLRLVSA EGDPIPEELY EMLSDHSIRS FDDLQRLLHG DSLDEDGAEL
DLNLTRSHSG GELESLSRGR RSLGSPTVAE PAVIAECKTR TEVSEISRRL IDRTNANFLV
WPPCVEVQRC SGCCNNRNVQ CRPTQVQDRK VQVKKIEIVR KKKIFKKATV TLVDHLACRC
ETVMARAVTR TPGSSQEQRA ARTPQTRVTI RTVRVRRPPK GKHRKFKHTH DKTALKETLG
A


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