Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Platinum sensitivity protein 3

 PSY3_YEAST              Reviewed;         242 AA.
Q12318; D6VZ12;
28-NOV-2006, integrated into UniProtKB/Swiss-Prot.
01-NOV-1996, sequence version 1.
22-NOV-2017, entry version 118.
RecName: Full=Platinum sensitivity protein 3;
Name=PSY3; OrderedLocusNames=YLR376C; ORFNames=L8039.17;
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces.
NCBI_TaxID=559292;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=ATCC 28383 / FL100 / VTT C-80102;
Mercado J., Gancedo J.M.;
"A new open reading frame.";
Submitted (NOV-1993) to the EMBL/GenBank/DDBJ databases.
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 204508 / S288c;
PubMed=9169871;
Johnston M., Hillier L.W., Riles L., Albermann K., Andre B.,
Ansorge W., Benes V., Brueckner M., Delius H., Dubois E.,
Duesterhoeft A., Entian K.-D., Floeth M., Goffeau A., Hebling U.,
Heumann K., Heuss-Neitzel D., Hilbert H., Hilger F., Kleine K.,
Koetter P., Louis E.J., Messenguy F., Mewes H.-W., Miosga T.,
Moestl D., Mueller-Auer S., Nentwich U., Obermaier B., Piravandi E.,
Pohl T.M., Portetelle D., Purnelle B., Rechmann S., Rieger M.,
Rinke M., Rose M., Scharfe M., Scherens B., Scholler P., Schwager C.,
Schwarz S., Underwood A.P., Urrestarazu L.A., Vandenbol M.,
Verhasselt P., Vierendeels F., Voet M., Volckaert G., Voss H.,
Wambutt R., Wedler E., Wedler H., Zimmermann F.K., Zollner A.,
Hani J., Hoheisel J.D.;
"The nucleotide sequence of Saccharomyces cerevisiae chromosome XII.";
Nature 387:87-90(1997).
[3]
GENOME REANNOTATION.
STRAIN=ATCC 204508 / S288c;
PubMed=24374639; DOI=10.1534/g3.113.008995;
Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M.,
Cherry J.M.;
"The reference genome sequence of Saccharomyces cerevisiae: Then and
now.";
G3 (Bethesda) 4:389-398(2014).
[4]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=ATCC 204508 / S288c;
PubMed=17322287; DOI=10.1101/gr.6037607;
Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F.,
Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A.,
Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F.,
Williamson J., Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G.,
Kolodner R.D., LaBaer J.;
"Approaching a complete repository of sequence-verified protein-
encoding clones for Saccharomyces cerevisiae.";
Genome Res. 17:536-543(2007).
[5]
FUNCTION.
PubMed=12149442; DOI=10.1073/pnas.152264899;
Hanway D., Chin J.K., Xia G., Oshiro G., Winzeler E.A.,
Romesberg F.E.;
"Previously uncharacterized genes in the UV- and MMS-induced DNA
damage response in yeast.";
Proc. Natl. Acad. Sci. U.S.A. 99:10605-10610(2002).
[6]
FUNCTION IN MMS RESISTANCE.
PubMed=12482937; DOI=10.1073/pnas.262669299;
Chang M., Bellaoui M., Boone C., Brown G.W.;
"A genome-wide screen for methyl methanesulfonate-sensitive mutants
reveals genes required for S phase progression in the presence of DNA
damage.";
Proc. Natl. Acad. Sci. U.S.A. 99:16934-16939(2002).
[7]
LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
PubMed=14562106; DOI=10.1038/nature02046;
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A.,
Dephoure N., O'Shea E.K., Weissman J.S.;
"Global analysis of protein expression in yeast.";
Nature 425:737-741(2003).
[8]
FUNCTION IN MUTATION SUPPRESSION.
PubMed=12972632; DOI=10.1073/pnas.2035018100;
Huang M.-E., Rio A.-G., Nicolas A., Kolodner R.D.;
"A genomewide screen in Saccharomyces cerevisiae for genes that
suppress the accumulation of mutations.";
Proc. Natl. Acad. Sci. U.S.A. 100:11529-11534(2003).
[9]
FUNCTION.
PubMed=15173006; DOI=10.1158/0008-5472.CAN-03-3113;
Wu H.I., Brown J.A., Dorie M.J., Lazzeroni L., Brown J.M.;
"Genome-wide identification of genes conferring resistance to the
anticancer agents cisplatin, oxaliplatin, and mitomycin C.";
Cancer Res. 64:3940-3948(2004).
[10]
IDENTIFICATION IN THE SHU COMPLEX, SUBCELLULAR LOCATION, AND FUNCTION.
PubMed=15654096; DOI=10.1534/genetics.104.036764;
Shor E., Weinstein J., Rothstein R.;
"A genetic screen for top3 suppressors in Saccharomyces cerevisiae
identifies SHU1, SHU2, PSY3 and CSM2: four genes involved in error-
free DNA repair.";
Genetics 169:1275-1289(2005).
[11]
IDENTIFICATION IN THE SHU COMPLEX, AND FUNCTION.
PubMed=19496932; DOI=10.1111/j.1365-2958.2009.06748.x;
Ball L.G., Zhang K., Cobb J.A., Boone C., Xiao W.;
"The yeast Shu complex couples error-free post-replication repair to
homologous recombination.";
Mol. Microbiol. 73:89-102(2009).
[12]
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
PubMed=22814378; DOI=10.1073/pnas.1210303109;
Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A.,
Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E.,
Timmerman E., Prieto J., Arnesen T., Sherman F., Gevaert K.,
Aldabe R.;
"N-terminal acetylome analyses and functional insights of the N-
terminal acetyltransferase NatB.";
Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012).
-!- FUNCTION: Required for resistance to the DNA-damaging agents
methyl methanesulfonate (MMS), cisplatin and oxaliplatin, but not
to mitomycin C. Plays a role in protection against mutation
accumulation. May be a component of the recombination-repair
pathway. {ECO:0000269|PubMed:12149442,
ECO:0000269|PubMed:12482937, ECO:0000269|PubMed:12972632,
ECO:0000269|PubMed:15173006, ECO:0000269|PubMed:15654096,
ECO:0000269|PubMed:19496932}.
-!- SUBUNIT: Component of the SHU complex composed of at least CSM2,
PSY3, SHU1 and SHU2. {ECO:0000269|PubMed:15654096,
ECO:0000269|PubMed:19496932}.
-!- INTERACTION:
P40465:CSM2; NbExp=4; IntAct=EBI-37340, EBI-25229;
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15654096}.
-!- MISCELLANEOUS: Present with 876 molecules/cell in log phase SD
medium. {ECO:0000269|PubMed:14562106}.
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
Distributed under the Creative Commons Attribution-NoDerivs License
-----------------------------------------------------------------------
EMBL; Z27407; CAA81795.1; -; Genomic_DNA.
EMBL; U19103; AAB67578.1; -; Genomic_DNA.
EMBL; AY692738; AAT92757.1; -; Genomic_DNA.
EMBL; BK006945; DAA09678.1; -; Genomic_DNA.
PIR; S47544; S47544.
RefSeq; NP_013480.1; NM_001182265.1.
PDB; 3VU9; X-ray; 1.75 A; A=1-242.
PDB; 4DT1; X-ray; 1.90 A; B=1-242.
PDB; 4EQ6; X-ray; 1.80 A; B=1-242.
PDBsum; 3VU9; -.
PDBsum; 4DT1; -.
PDBsum; 4EQ6; -.
ProteinModelPortal; Q12318; -.
SMR; Q12318; -.
BioGrid; 31635; 66.
DIP; DIP-1903N; -.
IntAct; Q12318; 4.
MINT; MINT-399337; -.
STRING; 4932.YLR376C; -.
iPTMnet; Q12318; -.
PRIDE; Q12318; -.
EnsemblFungi; YLR376C; YLR376C; YLR376C.
GeneID; 851091; -.
KEGG; sce:YLR376C; -.
EuPathDB; FungiDB:YLR376C; -.
SGD; S000004368; PSY3.
HOGENOM; HOG000001140; -.
InParanoid; Q12318; -.
OMA; MNSTSIC; -.
OrthoDB; EOG092C5GV7; -.
BioCyc; YEAST:G3O-32444-MONOMER; -.
PRO; PR:Q12318; -.
Proteomes; UP000002311; Chromosome XII.
GO; GO:0005634; C:nucleus; IDA:SGD.
GO; GO:0097196; C:Shu complex; IDA:SGD.
GO; GO:0035861; C:site of double-strand break; IMP:SGD.
GO; GO:0000730; P:DNA recombinase assembly; IMP:SGD.
GO; GO:0070987; P:error-free translesion synthesis; IGI:SGD.
GO; GO:0000725; P:recombinational repair; IMP:SGD.
InterPro; IPR031779; Psy3.
Pfam; PF16836; PSY3; 1.
1: Evidence at protein level;
3D-structure; Complete proteome; DNA damage; DNA repair; Nucleus;
Reference proteome.
CHAIN 1 242 Platinum sensitivity protein 3.
/FTId=PRO_0000262753.
HELIX 2 6 {ECO:0000244|PDB:4EQ6}.
HELIX 12 16 {ECO:0000244|PDB:3VU9}.
HELIX 27 29 {ECO:0000244|PDB:3VU9}.
STRAND 31 33 {ECO:0000244|PDB:3VU9}.
HELIX 35 38 {ECO:0000244|PDB:3VU9}.
STRAND 43 47 {ECO:0000244|PDB:3VU9}.
HELIX 55 61 {ECO:0000244|PDB:3VU9}.
STRAND 66 74 {ECO:0000244|PDB:3VU9}.
HELIX 82 84 {ECO:0000244|PDB:3VU9}.
STRAND 89 92 {ECO:0000244|PDB:3VU9}.
STRAND 97 99 {ECO:0000244|PDB:3VU9}.
HELIX 100 112 {ECO:0000244|PDB:3VU9}.
HELIX 114 120 {ECO:0000244|PDB:3VU9}.
STRAND 128 136 {ECO:0000244|PDB:3VU9}.
HELIX 138 140 {ECO:0000244|PDB:3VU9}.
HELIX 152 171 {ECO:0000244|PDB:3VU9}.
STRAND 174 179 {ECO:0000244|PDB:3VU9}.
HELIX 182 185 {ECO:0000244|PDB:3VU9}.
TURN 189 192 {ECO:0000244|PDB:3VU9}.
HELIX 213 216 {ECO:0000244|PDB:3VU9}.
STRAND 220 236 {ECO:0000244|PDB:3VU9}.
SEQUENCE 242 AA; 28251 MW; B652FD8113EB4C12 CRC64;
MEVLKNIRIY PLSNFITSTK NYINLPNELR NLISEEQESK LGFLHIIESD FKPSVALQKL
VNCTTGDEKI LIIDIVSIWS QQKQRQHGAI YMNSLSCINI TGLIVFLELL YDSPMDALRR
CQVDNFNFQL RGIVIDNLSF LNFESDKNYD VINLSKFEKL FKILRKLREF LGCWIITKSF
PTDFYNGIEN TLVDKWSIKR KSGVTLYPTK LPDSYMKGMD LIIYREVVDG RPQYRRIAAL
EE


Related products :

Catalog number Product name Quantity
BMS601HS Mouse IL-2 High Sensitivity Platinum ELISA
68412-56-6 Platinum-octanal_octanol complex Platinum-octanal_octan 1g
ET104-02-01 Taq Platinum DNA Polymerase (10×Taq Platinum Buffer mixed with Mg2+) 500 U, 2.5 U/µl
ET104-01-01 Taq Platinum DNA Polymerase (10×Taq Platinum Buffer mixed with Mg2+) 250 U, 2.5 U/µl
68413-57-0 platinum(2+) hexasodium tetrasulphite platinum(2+) hexasodiu 1g
ET104-02-02 Taq Platinum DNA Polymerase (10×Taq Platinum Buffer and Mg2+) 500 U, 2.5 U/µl
100432-46-0 platinum(4+) 2,6,6-trimethylbicyclo[3.1.1] platinum(4+) 2,6,6-trim 1g
ET104-01-02 Taq Platinum DNA Polymerase (10×Taq Platinum Buffer and Mg2+) 250 U, 2.5 U/µl
100432-45-9 platinum(4+) 2,6,6-trimethylbicyclo[3.1.1] platinum(4+) 2,6,6-trim 1g
60819-03-6 Platinum (II) (2,2 6,12-terpyridine)Chlorid Platinum (II) (2,2 6,12-t 1g
68585-32-0 Platinum - cyclovinylmethylsiloxane com Platinum - cyclovinylme 1g
656353-51-7 Platinum(II) hexafluoroacetylacetonate Platinum(II) hexafluoro 1g
P-07009 PLATINUM OXIDE (80 percent Pt) (Hydrated) (App.80 percent ) (Adam's Catalyst) (Platinum Dioxide) CAS: 52785-06-5 1 gm
65353-51-7 Platinum(II) 1,1,1,5,5,5-hexafluoro 2,4-p Platinum(II) 1,1,1,5,5,5- 1g
1550-1000 Cisplatin cis-Dichlorodiammine platinum(II), cis-Platinum(II) diammine dichloride, Cis-Diamineplatinum (II) dichloride 1 g
1550-100 Cisplatin cis-Dichlorodiammine platinum(II), cis-Platinum(II) diammine dichloride, Cis-Diamineplatinum (II) dichloride 100 mg
TM 1504 ANTIMYCOTIC SENSITIVITY TEST AGAR (for testing antimycotic sensitivity by diffusion method using antimycotic sensitivity discs.) 500 gm
12137-21-2 Platinum(IV) oxide monohydrate Platinum(IV) oxide hydr 1g
14221-02-4 Tetrakis(triphenylphosphine)platinum(0) Platinum(0) tetrakis(trip 1g
73018-55-0 Platinum carbonyl cyclovinylmethylsiloxa Platinum carbonyl cyclo 1g
B1137 Antimycotic Sensitivity Test Agar USE For antimycotic sensitivity by diffusion method using antimycotic sensitivity discs. Qty per Litre of Medium: 85
B1137 Antimycotic Sensitivity Test Agar USE : For antimycotic sensitivity by diffusion method using antimycotic sensitivity discs. 5x500gm
12038-21-0 Platinum(IV) sulfide, Pt 75.26 percent Platinum(IV) sulfide, Pt 1g
26035-31-4 Platinum ammonium chloride Platinum ammonium ch 1g
EL10030H Human Growth Hormone, High Sensitivity (H-hGH), ELISA Kits , Sensitivity: <0.1 ng-mL 96 wells


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur