Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Pleckstrin homology-like domain family A member 2 (Imprinted in placenta and liver protein) (Protein 50C15)

 PHLA2_MOUSE             Reviewed;         144 AA.
O08969;
20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
01-JUL-1997, sequence version 1.
28-MAR-2018, entry version 119.
RecName: Full=Pleckstrin homology-like domain family A member 2;
AltName: Full=Imprinted in placenta and liver protein;
AltName: Full=Protein 50C15;
Name=Phlda2; Synonyms=Ipl, Tssc3;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=9328465; DOI=10.1093/hmg/6.12.2021;
Qian N., Frank D., O'Keefe D., Dao D., Zhao L., Yuan L., Wang Q.,
Keating M., Walsh C., Tycko B.;
"The IPL gene on chromosome 11p15.5 is imprinted in humans and mice
and is similar to TDAG51, implicated in Fas expression and
apoptosis.";
Hum. Mol. Genet. 6:2021-2029(1997).
[2]
NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=C57BL/6 X DBA;
Dunwoodie S.L., Beddington R.S.P.;
Submitted (NOV-1997) to the EMBL/GenBank/DDBJ databases.
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=C57BL/6J;
PubMed=16141072; DOI=10.1126/science.1112014;
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M.,
Davis M.J., Wilming L.G., Aidinis V., Allen J.E.,
Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L.,
Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M.,
Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R.,
Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G.,
di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G.,
Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M.,
Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N.,
Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T.,
Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H.,
Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K.,
Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J.,
Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L.,
Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K.,
Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P.,
Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O.,
Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G.,
Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M.,
Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B.,
Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K.,
Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A.,
Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K.,
Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C.,
Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J.,
Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y.,
Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T.,
Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N.,
Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N.,
Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S.,
Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J.,
Hayashizaki Y.;
"The transcriptional landscape of the mammalian genome.";
Science 309:1559-1563(2005).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=FVB/N; TISSUE=Kidney;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[5]
TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
PubMed=10594239; DOI=10.1007/s003359901182;
Frank D., Mendelsohn C.L., Ciccone E., Svensson K., Ohlsson R.,
Tycko B.;
"A novel pleckstrin homology-related gene family defined by Ipl/Tssc3,
TDAG51, and Tih1: tissue-specific expression, chromosomal location,
and parental imprinting.";
Mamm. Genome 10:1150-1159(1999).
[6]
PHOSPHOINOSITIDE-BINDING, SUBCELLULAR LOCATION, AND MUTAGENESIS OF
ARG-27; LYS-38 AND ARG-39.
PubMed=12374806; DOI=10.1074/jbc.M206497200;
Saxena A., Morozov P., Frank D., Musalo R., Lemmon M.A., Skolnik E.Y.,
Tycko B.;
"Phosphoinositide binding by the pleckstrin homology domains of Ipl
and Tih1.";
J. Biol. Chem. 277:49935-49944(2002).
[7]
FUNCTION, DISRUPTION PHENOTYPE, AND DEVELOPMENTAL STAGE.
PubMed=12032310; DOI=10.1073/pnas.122039999;
Frank D., Fortino W., Clark L., Musalo R., Wang W., Saxena A.,
Li C.M., Reik W., Ludwig T., Tycko B.;
"Placental overgrowth in mice lacking the imprinted gene Ipl.";
Proc. Natl. Acad. Sci. U.S.A. 99:7490-7495(2002).
[8]
INDUCTION, AND IMPRINTING.
PubMed=15327781; DOI=10.1016/j.mod.2004.05.017;
Salas M., John R., Saxena A., Barton S., Frank D., Fitzpatrick G.,
Higgins M.J., Tycko B.;
"Placental growth retardation due to loss of imprinting of Phlda2.";
Mech. Dev. 121:1199-1210(2004).
-!- FUNCTION: Plays a role in regulating placenta growth. May act via
its PH domain that competes with other PH domain-containing
proteins, thereby preventing their binding to membrane lipids.
{ECO:0000269|PubMed:12032310}.
-!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12374806}.
Membrane {ECO:0000269|PubMed:12374806}; Peripheral membrane
protein {ECO:0000269|PubMed:12374806}.
-!- TISSUE SPECIFICITY: Specifically expressed at high levels in
extraembryonic tissues in the developing conceptus (at protein
level). Expressed in placenta and yolc sac. Expressed at low
levels in fetal liver and kidney. {ECO:0000269|PubMed:10594239}.
-!- DEVELOPMENTAL STAGE: Expressed at high levels in the very early
conceptus limited to polar trophectoderm. Strongly expressed in
the ectoplacental cone shortly after implantation at 5.5 dpc, and
the high expression remains restricted to the extraembryonic
tissues at later stages. By 10.5 dpc expression is restricted to
the labyrinthine trophoblast and the endodermal component of the
visceral yolk sac. Between 12.5 and 14.4 dpc expression in
placenta decreases, due to a number of expressing cells. On day 12
of gestation, the abundant expressing cells are trophoblast at the
chorionic plate, and clustered type II trophoblast deeper in the
labyrinth. Less expressed by terminally differentiated
trophoblast. As early as 14.5 dpc, becomes confined to a monolayer
of cells at the chorionic plate and to rare cells in septa that
protrude into the labyrinth (at protein level).
{ECO:0000269|PubMed:10594239, ECO:0000269|PubMed:12032310}.
-!- INDUCTION: Maternal Phlda2 allele is activated, while paternal
Phlda2 is repressed due to genomic imprinting.
{ECO:0000269|PubMed:15327781}.
-!- DOMAIN: The PH domain binds phosphoinositides with a broad
specificity. It may compete with the PH domain of some other
proteins, thereby interfering with their binding to
phosphatidylinositol 4,5-bisphosphate (PIP2) and
phosphatidylinositol 3,4,5-trisphosphate (PIP3) (By similarity).
{ECO:0000250}.
-!- DISRUPTION PHENOTYPE: Mice are viable, and show overgrowth of
placentas with expansion of the spongiotrophoblast. These larger
placentas do not confer a fetal growth advantage.
{ECO:0000269|PubMed:12032310}.
-!- MISCELLANEOUS: The Phlda2 locus is imprinted. Loss of imprinting
results in overexpression, leading to placental growth retardation
phenotypes.
-!- SIMILARITY: Belongs to the PHLDA2 family. {ECO:0000305}.
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
Distributed under the Creative Commons Attribution-NoDerivs License
-----------------------------------------------------------------------
EMBL; AF002708; AAB86681.1; -; Genomic_DNA.
EMBL; Y15443; CAA75634.1; -; mRNA.
EMBL; AK131929; BAE20878.1; -; mRNA.
EMBL; BC019141; AAH19141.1; -; mRNA.
CCDS; CCDS22042.1; -.
RefSeq; NP_033460.1; NM_009434.2.
RefSeq; XP_006508660.1; XM_006508597.2.
UniGene; Mm.334344; -.
ProteinModelPortal; O08969; -.
STRING; 10090.ENSMUSP00000010904; -.
PhosphoSitePlus; O08969; -.
PaxDb; O08969; -.
PeptideAtlas; O08969; -.
PRIDE; O08969; -.
Ensembl; ENSMUST00000010904; ENSMUSP00000010904; ENSMUSG00000010760.
GeneID; 22113; -.
KEGG; mmu:22113; -.
UCSC; uc009kpj.1; mouse.
CTD; 7262; -.
MGI; MGI:1202307; Phlda2.
eggNOG; ENOG410IZC3; Eukaryota.
eggNOG; ENOG4111IXF; LUCA.
GeneTree; ENSGT00440000039564; -.
HOGENOM; HOG000115528; -.
HOVERGEN; HBG052730; -.
InParanoid; O08969; -.
OMA; KKVDCVE; -.
OrthoDB; EOG091G0RST; -.
PhylomeDB; O08969; -.
TreeFam; TF332320; -.
PRO; PR:O08969; -.
Proteomes; UP000000589; Chromosome 7.
Bgee; ENSMUSG00000010760; -.
ExpressionAtlas; O08969; baseline and differential.
Genevisible; O08969; MM.
GO; GO:0005737; C:cytoplasm; TAS:MGI.
GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
GO; GO:0009887; P:animal organ morphogenesis; IMP:MGI.
GO; GO:0001890; P:placenta development; IDA:MGI.
GO; GO:0030334; P:regulation of cell migration; IDA:MGI.
GO; GO:0045995; P:regulation of embryonic development; IDA:MGI.
GO; GO:0010468; P:regulation of gene expression; IDA:MGI.
GO; GO:0070873; P:regulation of glycogen metabolic process; IDA:MGI.
GO; GO:1903547; P:regulation of growth hormone activity; IMP:MGI.
GO; GO:0060721; P:regulation of spongiotrophoblast cell proliferation; IMP:MGI.
Gene3D; 2.30.29.30; -; 1.
InterPro; IPR011993; PH-like_dom_sf.
InterPro; IPR001849; PH_domain.
SMART; SM00233; PH; 1.
1: Evidence at protein level;
Complete proteome; Cytoplasm; Membrane; Phosphoprotein;
Reference proteome.
CHAIN 1 144 Pleckstrin homology-like domain family A
member 2.
/FTId=PRO_0000053901.
DOMAIN 18 111 PH.
MOD_RES 140 140 Phosphoserine.
{ECO:0000250|UniProtKB:Q53GA4}.
MUTAGEN 27 27 R->L: Impairs the ability to rescue
growth in cdc25ts mutant yeasts.
{ECO:0000269|PubMed:12374806}.
MUTAGEN 38 38 K->A: Impairs the ability to rescue
growth in cdc25ts mutant yeasts.
{ECO:0000269|PubMed:12374806}.
MUTAGEN 39 39 R->A: Impairs the ability to rescue
growth in cdc25ts mutant yeasts.
{ECO:0000269|PubMed:12374806}.
SEQUENCE 144 AA; 16727 MW; 9BD64B97BA22C1A9 CRC64;
MASKIVMSSK TVKTSDEILC EGELEKRSDS LFQVWKKKRC VLTADRLRLF SGKTSPAKEL
FFHSILKVDC VEHTSKYVYF TIVTNYYKEI DFRCTVESCW NAAITMALID FQNRRALQDF
PRYRYQRSES EMPSEPGEQS ALGP


Related products :

Catalog number Product name Quantity
E0401m ELISA Imprinted in placenta and liver protein,Ipl,Mouse,Mus musculus,Phlda2,Pleckstrin homology-like domain family A member 2,Protein 50C15,Tssc3 96T
E0401m ELISA kit Imprinted in placenta and liver protein,Ipl,Mouse,Mus musculus,Phlda2,Pleckstrin homology-like domain family A member 2,Protein 50C15,Tssc3 96T
U0401m CLIA Imprinted in placenta and liver protein,Ipl,Mouse,Mus musculus,Phlda2,Pleckstrin homology-like domain family A member 2,Protein 50C15,Tssc3 96T
E0401b ELISA kit Bos taurus,Bovine,Imprinted in placenta and liver protein,IPL,PHLDA2,Pleckstrin homology-like domain family A member 2 96T
U0401b CLIA Bos taurus,Bovine,Imprinted in placenta and liver protein,IPL,PHLDA2,Pleckstrin homology-like domain family A member 2 96T
E0401b ELISA Bos taurus,Bovine,Imprinted in placenta and liver protein,IPL,PHLDA2,Pleckstrin homology-like domain family A member 2 96T
15-288-22385F Pleckstrin homology-like domain family A member 2 - Imprinted in placenta and liver protein; Tumor-suppressing subchromosomal transferable fragment candidate gene 3 protein; Tumor-suppressing STF cDNA 0.1 mg
10-288-22385F Pleckstrin homology-like domain family A member 2 - Imprinted in placenta and liver protein; Tumor-suppressing subchromosomal transferable fragment candidate gene 3 protein; Tumor-suppressing STF cDNA 0.1 mg
15-288-22385F Pleckstrin homology-like domain family A member 2 - Imprinted in placenta and liver protein; Tumor-suppressing subchromosomal transferable fragment candidate gene 3 protein; Tumor-suppressing STF cDNA 0.05 mg
10-288-22385F Pleckstrin homology-like domain family A member 2 - Imprinted in placenta and liver protein; Tumor-suppressing subchromosomal transferable fragment candidate gene 3 protein; Tumor-suppressing STF cDNA 0.05 mg
EIAAB31275 Evectin-1,Evt1,Mouse,Mus musculus,PH domain-containing family B member 1,PH domain-containing protein in retina 1,Phr1,PHRET1,Pleckstrin homology domain retinal protein 1,Pleckstrin homology domain-co
EIAAB14440 CDEP,Chondrocyte-derived ezrin-like protein,FARP1,FERM, RhoGEF and pleckstrin domain-containing protein 1,Homo sapiens,Human,PH domain-containing family C member 2,Pleckstrin homology domain-containin
EIAAB31260 Mouse,Mus musculus,PH domain-containing adaptor PHAD47,PH domain-containing family A member 2,Pleckstrin homology domain-containing family A member 2,Plekha2,Tandem PH domain-containing protein 2,Tapp
EIAAB31276 Evectin-1,EVT1,Homo sapiens,Human,KPL1,PH domain-containing family B member 1,PH domain-containing protein in retina 1,PHR1,PHRET1,PHRET1,Pleckstrin homology domain retinal protein 1,Pleckstrin homolo
EIAAB31330 Homo sapiens,Human,PH domain-containing family O member 2,PH domain-containing family Q member 1,Pleckstrin homology domain-containing family O member 2,Pleckstrin homology domain-containing family Q
EIAAB31257 Homo sapiens,Human,PH domain-containing family A member 1,Pleckstrin homology domain-containing family A member 1,PLEKHA1,Tandem PH domain-containing protein 1,TAPP1,TAPP-1
EIAAB31259 Homo sapiens,Human,PH domain-containing family A member 2,Pleckstrin homology domain-containing family A member 2,PLEKHA2,Tandem PH domain-containing protein 2,TAPP2,TAPP-2
EIAAB30917 Kiaa0606,Mouse,Mus musculus,PH domain leucine-rich repeat-containing protein phosphatase 1,PH domain-containing family E member 1,Phlpp,Phlpp1,Pleckstrin homology domain-containing family E member 1,P
EIAAB31258 Mouse,Mus musculus,PH domain-containing family A member 1,Pleckstrin homology domain-containing family A member 1,Plekha1,Tandem PH domain-containing protein 1,Tapp1,TAPP-1
EIAAB30916 PH domain leucine-rich repeat protein phosphatase 1,PH domain-containing family E member 1,Phlpp,Phlpp1,Pleckstrin homology domain-containing family E member 1,Plekhe1,Rat,Rattus norvegicus,Scop,Supra
EIAAB31271 Hadp1,Heart adapter protein 1,Mouse,Mus musculus,PH domain-containing family A member 7,Pleckstrin homology domain-containing family A member 7,Plekha7
EIAAB31313 162 kDa adapter protein,AP162,Homo sapiens,Human,KIAA0356,PH domain-containing family M member 1,Pleckstrin homology domain-containing family M member 1,PLEKHM1
EIAAB31310 Gnrpx,Guanine nucleotide-releasing protein x,Mouse,Mus musculus,PH domain-containing family J member 1,Pleckstrin homology domain-containing family J member 1,Plekhj1
EIAAB31268 Mouse,Mus musculus,Pepp3,PEPP-3,PH domain-containing family A member 6,Phosphoinositol 3-phosphate-binding protein 3,Pleckstrin homology domain-containing family A member 6,Plekha6
EIAAB31264 Pepp1,PEPP-1,PH domain-containing family A member 4,Phosphoinositol 3-phosphate-binding protein 1,Pleckstrin homology domain-containing family A member 4,Plekha4,Rat,Rattus norvegicus


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur