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Pleiotrophin (PTN) (Pleiotrophic factor beta) (PTF-beta)

 PTN_PIG                 Reviewed;         168 AA.
P79281;
13-JUN-2006, integrated into UniProtKB/Swiss-Prot.
01-MAY-1997, sequence version 1.
25-APR-2018, entry version 86.
RecName: Full=Pleiotrophin;
Short=PTN;
AltName: Full=Pleiotrophic factor beta;
Short=PTF-beta;
Flags: Precursor;
Name=PTN;
Sus scrofa (Pig).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Suina; Suidae;
Sus.
NCBI_TaxID=9823;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Brain;
Tsujimura A., Yasojima K., Hashimoto T.;
"Isolation of pig pleiotrophic factor beta.";
Submitted (NOV-1996) to the EMBL/GenBank/DDBJ databases.
-!- FUNCTION: Secreted growth factor that induces neurite outgrowth
and which is mitogenic for fibroblasts, epithelial, and
endothelial cells. Binds anaplastic lymphoma kinase (ALK) which
induces MAPK pathway activation, an important step in the anti-
apoptotic signaling of PTN and regulation of cell proliferation.
Binds to cell-surface target proteins via their chondroitin
sulfate groups. Down-regulates PTPRZ1 activity.
{ECO:0000250|UniProtKB:P21246}.
-!- SUBUNIT: Interacts with ALK and NEK6. Interacts with PTPRZ1
(probably via chondroitin sulfate groups).
{ECO:0000250|UniProtKB:P21246}.
-!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P21246}.
-!- PTM: Phosphorylated by NEK6. {ECO:0000250|UniProtKB:P21246}.
-!- SIMILARITY: Belongs to the pleiotrophin family. {ECO:0000305}.
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EMBL; D89546; BAA13972.1; -; mRNA.
RefSeq; NP_999501.1; NM_214336.1.
RefSeq; XP_013841040.1; XM_013985586.1.
UniGene; Ssc.12975; -.
ProteinModelPortal; P79281; -.
STRING; 9823.ENSSSCP00000017506; -.
PaxDb; P79281; -.
PRIDE; P79281; -.
Ensembl; ENSSSCT00000017990; ENSSSCP00000017506; ENSSSCG00000016522.
Ensembl; ENSSSCT00000045414; ENSSSCP00000040565; ENSSSCG00000016522.
GeneID; 397609; -.
KEGG; ssc:397609; -.
CTD; 5764; -.
eggNOG; ENOG410IWNA; Eukaryota.
eggNOG; ENOG4111ZWP; LUCA.
GeneTree; ENSGT00390000007640; -.
HOGENOM; HOG000231473; -.
HOVERGEN; HBG008317; -.
InParanoid; P79281; -.
KO; K16642; -.
OMA; GEDICNS; -.
OrthoDB; EOG091G0VCN; -.
TreeFam; TF332376; -.
Proteomes; UP000008227; Chromosome 18.
Bgee; ENSSSCG00000016522; -.
Genevisible; P79281; SS.
GO; GO:0005783; C:endoplasmic reticulum; IEA:Ensembl.
GO; GO:0005615; C:extracellular space; ISS:UniProtKB.
GO; GO:0032991; C:protein-containing complex; IEA:Ensembl.
GO; GO:0035374; F:chondroitin sulfate binding; ISS:UniProtKB.
GO; GO:0008083; F:growth factor activity; ISS:UniProtKB.
GO; GO:0008201; F:heparin binding; ISS:UniProtKB.
GO; GO:0019901; F:protein kinase binding; IEA:Ensembl.
GO; GO:0030282; P:bone mineralization; IEA:Ensembl.
GO; GO:0007612; P:learning; IEA:Ensembl.
GO; GO:0051781; P:positive regulation of cell division; IEA:UniProtKB-KW.
GO; GO:0008284; P:positive regulation of cell proliferation; ISS:UniProtKB.
Gene3D; 2.20.60.10; -; 1.
Gene3D; 2.30.90.10; -; 1.
InterPro; IPR000762; Midkine_heparin-bd_GF.
InterPro; IPR020090; PTN/MK_C_dom.
InterPro; IPR038130; PTN/MK_C_dom_sf.
InterPro; IPR020091; PTN/MK_diS_sf.
InterPro; IPR020089; PTN/MK_N_dom.
InterPro; IPR037122; PTN/MK_N_dom_sf.
InterPro; IPR020092; PTN_MK_heparin-bd_GF_CS.
PANTHER; PTHR13850; PTHR13850; 1.
Pfam; PF01091; PTN_MK_C; 1.
Pfam; PF05196; PTN_MK_N; 1.
PRINTS; PR00269; PTNMIDKINE.
ProDom; PD005592; PTN_MK_hepar_bd; 1.
SMART; SM00193; PTN; 1.
SUPFAM; SSF57288; SSF57288; 2.
PROSITE; PS00619; PTN_MK_1; 1.
PROSITE; PS00620; PTN_MK_2; 1.
2: Evidence at transcript level;
Complete proteome; Disulfide bond; Heparin-binding; Mitogen;
Reference proteome; Secreted; Signal.
SIGNAL 1 32 {ECO:0000255}.
CHAIN 33 168 Pleiotrophin.
/FTId=PRO_0000239426.
REGION 92 99 Chondroitin sulfate binding.
{ECO:0000250|UniProtKB:P21246}.
REGION 123 131 Chondroitin sulfate binding.
{ECO:0000250|UniProtKB:P21246}.
REGION 147 168 Chondroitin sulfate A binding.
{ECO:0000250|UniProtKB:P21246}.
DISULFID 47 76 {ECO:0000250|UniProtKB:P21246}.
DISULFID 55 85 {ECO:0000250|UniProtKB:P21246}.
DISULFID 62 89 {ECO:0000250|UniProtKB:P21246}.
DISULFID 99 131 {ECO:0000250|UniProtKB:P21246}.
DISULFID 109 141 {ECO:0000250|UniProtKB:P21246}.
SEQUENCE 168 AA; 18910 MW; BFA2A91DA2C6DCA0 CRC64;
MQTPQFLQQR RKFAAAFLAF IFLLAVVDTA EAGKKEKPEK KVKKSDCGEW QWSVCVPTSG
DCGLGTREGT RTGAECKQTM KTQRCKIPCN WKKQFGAECK YQFQAWGECD LNTALKTRTG
SLKRALHNAD CQKTVTISKP CGKVTKPKPQ AESKKKKKEG KKQEKMLD


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