Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Pleiotrophin-B (PTN-B) (Pleiotrophic factor-beta-2) (PTF-beta-2) (X-PTF-beta2)

 PTNB_XENLA              Reviewed;         161 AA.
P48533; Q6DDL1;
01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
01-FEB-1996, sequence version 1.
22-NOV-2017, entry version 71.
RecName: Full=Pleiotrophin-B;
Short=PTN-B;
AltName: Full=Pleiotrophic factor-beta-2;
Short=PTF-beta-2;
Short=X-PTF-beta2;
Flags: Precursor;
Name=ptn-b;
Xenopus laevis (African clawed frog).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus;
Xenopus.
NCBI_TaxID=8355;
[1]
NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND VARIANTS LEU-3;
MET-17; THR-68 AND LEU-138.
TISSUE=Brain;
PubMed=7677748; DOI=10.1006/bbrc.1995.2305;
Tsujimura A., Yasojima K., Kuboki Y., Suzuki A., Ueno N., Shiokawa K.,
Hashimoto-Gotoh T.;
"Developmental and differential regulations in gene expression of
Xenopus pleiotrophic factors-alpha and -beta.";
Biochem. Biophys. Res. Commun. 214:432-439(1995).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT THR-68.
TISSUE=Eye;
NIH - Xenopus Gene Collection (XGC) project;
Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
[3]
FUNCTION.
PubMed=20308059; DOI=10.1074/jbc.M109.081232;
Svensson S.L., Pasupuleti M., Walse B., Malmsten M., Morgelin M.,
Sjogren C., Olin A.I., Collin M., Schmidtchen A., Palmer R.,
Egesten A.;
"Midkine and pleiotrophin have bactericidal properties: preserved
antibacterial activity in a family of heparin-binding growth factors
during evolution.";
J. Biol. Chem. 285:16105-16115(2010).
-!- FUNCTION: May be involved in neuronal and bone metabolism. Has
antibacterial activity against both Gram-positive and Gram-
negative bacteria (PubMed:20308059). Binds to cell-surface target
proteins via their chondroitin sulfate groups (By similarity).
{ECO:0000250|UniProtKB:P21246, ECO:0000269|PubMed:20308059}.
-!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P21246}.
-!- TISSUE SPECIFICITY: Expressed in high levels in brain and eye.
Lower levels in bone. In the tailbud embryo stage, it is expressed
exclusively in the central nervous system, especially in the hind
region of the brain. {ECO:0000269|PubMed:7677748}.
-!- SIMILARITY: Belongs to the pleiotrophin family. {ECO:0000305}.
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
Distributed under the Creative Commons Attribution-NoDerivs License
-----------------------------------------------------------------------
EMBL; D42060; BAA07660.1; -; mRNA.
EMBL; BC077546; AAH77546.1; -; mRNA.
PIR; JC4275; JC4275.
RefSeq; NP_001184206.1; NM_001197277.1.
RefSeq; NP_001184208.1; NM_001197279.1.
UniGene; Xl.58669; -.
UniGene; Xl.901; -.
ProteinModelPortal; P48533; -.
SMR; P48533; -.
GeneID; 100505441; -.
GeneID; 100505443; -.
KEGG; xla:100505441; -.
KEGG; xla:100505443; -.
HOVERGEN; HBG008317; -.
KO; K16642; -.
GO; GO:0005615; C:extracellular space; ISS:UniProtKB.
GO; GO:0035374; F:chondroitin sulfate binding; ISS:UniProtKB.
GO; GO:0008083; F:growth factor activity; ISS:UniProtKB.
GO; GO:0008201; F:heparin binding; ISS:UniProtKB.
GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
GO; GO:0007275; P:multicellular organism development; IEA:UniProtKB-KW.
GO; GO:0051781; P:positive regulation of cell division; IEA:UniProtKB-KW.
GO; GO:0008284; P:positive regulation of cell proliferation; ISS:UniProtKB.
GO; GO:0009617; P:response to bacterium; IMP:UniProtKB.
Gene3D; 2.20.60.10; -; 1.
InterPro; IPR000762; Midkine_heparin-bd_GF.
InterPro; IPR020090; PTN/MK_C_dom.
InterPro; IPR020091; PTN/MK_diS_sf.
InterPro; IPR020089; PTN/MK_N_dom.
InterPro; IPR037122; PTN/MK_N_dom_sf.
InterPro; IPR020092; PTN_MK_heparin-bd_GF_CS.
PANTHER; PTHR13850; PTHR13850; 1.
Pfam; PF01091; PTN_MK_C; 1.
Pfam; PF05196; PTN_MK_N; 1.
PRINTS; PR00269; PTNMIDKINE.
ProDom; PD005592; PTN_MK_hepar_bd; 1.
SMART; SM00193; PTN; 1.
SUPFAM; SSF57288; SSF57288; 2.
PROSITE; PS00619; PTN_MK_1; 1.
PROSITE; PS00620; PTN_MK_2; 1.
2: Evidence at transcript level;
Antibiotic; Antimicrobial; Developmental protein; Disulfide bond;
Growth factor; Heparin-binding; Mitogen; Secreted; Signal.
SIGNAL 1 23 {ECO:0000255}.
CHAIN 24 161 Pleiotrophin-B.
/FTId=PRO_0000024669.
REGION 86 93 Chondroitin sulfate binding.
{ECO:0000250|UniProtKB:P21246}.
REGION 117 125 Chondroitin sulfate binding.
{ECO:0000250|UniProtKB:P21246}.
REGION 141 161 Chondroitin sulfate A binding.
{ECO:0000250|UniProtKB:P21246}.
DISULFID 41 70 {ECO:0000250|UniProtKB:P21246}.
DISULFID 49 79 {ECO:0000250|UniProtKB:P21246}.
DISULFID 56 83 {ECO:0000250|UniProtKB:P21246}.
DISULFID 93 125 {ECO:0000250|UniProtKB:P21246}.
DISULFID 103 135 {ECO:0000250|UniProtKB:P21246}.
VARIANT 3 3 H -> L (in variant 1).
{ECO:0000269|PubMed:7677748}.
VARIANT 17 17 L -> M (in variants 2 and 3).
{ECO:0000269|PubMed:7677748}.
VARIANT 68 68 K -> T (in variants 2, 3 and 4).
{ECO:0000269|PubMed:7677748,
ECO:0000269|Ref.2}.
VARIANT 138 138 V -> L (in variant 2).
{ECO:0000269|PubMed:7677748}.
CONFLICT 4 4 Q -> H (in Ref. 2; AAH77546).
{ECO:0000305}.
CONFLICT 11 11 A -> T (in Ref. 2; AAH77546).
{ECO:0000305}.
SEQUENCE 161 AA; 18173 MW; 1C0EF43227EA9D14 CRC64;
MHHQHGLFML ALLAFLLVMT VLGTDTGKKD KQEKKVKKSD CGDWQWSVCV PTSGDCGLGT
REGTRSGKEC KQTIKTQKCK IPCNWKKQFG AECKYQFQEW GDCDPETGLK TRNGNLKRAL
HNAECQKTVT LSKPCGKVTK PKLQESKKKK KEGKNKEKLL D


Related products :

Catalog number Product name Quantity
E1309p ELISA kit Pig,Pleiotrophic factor beta,Pleiotrophin,PTF-beta,PTN,PTN,Sus scrofa 96T
U1309p CLIA Pig,Pleiotrophic factor beta,Pleiotrophin,PTF-beta,PTN,PTN,Sus scrofa 96T
E1309p ELISA Pig,Pleiotrophic factor beta,Pleiotrophin,PTF-beta,PTN,PTN,Sus scrofa 96T
PNb-004-I TGF-beta2 (inactive) Human Host: Nicotiana benthamiana TGFB2; TGF-beta2 Transforming growth factor beta-2; TGF-beta-2 5
PNb-004 TGF-beta2 Human Host: Nicotiana benthamiana TGFB2; TGF-beta2 Transforming growth factor beta-2; TGF-beta-2 5
PNb-003 TGF-beta2 Human Host: Nicotiana benthamiana TGFB2; TGF-beta2 Transforming growth factor beta-2; TGF-beta-2 2,5
gen16875 PTN_PIG Pleiotrophic factor beta ELISA tesk kit 1
EIAAB30507 Cbfb,CBF-beta,Core-binding factor subunit beta,Mouse,Mus musculus,PEA2-beta,Pebp2b,PEBP2-beta,Pebpb2,Polyomavirus enhancer-binding protein 2 beta subunit,SL3_AKV core-binding factor beta subunit,SL3-3
EIAAB30508 CBFB,CBF-beta,Core-binding factor subunit beta,Homo sapiens,Human,PEA2-beta,PEBP2-beta,Polyomavirus enhancer-binding protein 2 beta subunit,SL3_AKV core-binding factor beta subunit,SL3-3 enhancer fact
orb82615 Murine GMF beta protein Glia maturation factor beta(GMF beta) coded by GMFb gene at chromosome 14 in mouse, is identical to human GMF beta, with the exception of two amino acid residues. It is a brain 2
18-003-42988 Core-binding factor subunit beta - CBF-beta; Polyomavirus enhancer-binding protein 2 beta subunit; PEBP2-beta; PEA2-beta; SL3-3 enhancer factor 1 beta subunit; SL3_AKV core-binding factor beta subunit 0.05 mg Aff Pur
EIAAB26620 Beta2,Beta-cell E-box transcriptional activator 2,Mouse,Mus musculus,Neurod,NeuroD1,Neurod1,Neurogenic differentiation factor 1
18-003-43318 Transcription factor AP-2 beta - AP2-beta; Activating enhancer-binding protein 2 beta Polyclonal 0.1 mg Protein A
RF004-5 rHuman TGF beta-3 Active; Transforming growth factor beta-3; TGF-beta-3 5ug
RF004-2.5 rHuman TGF beta-3 Active; Transforming growth factor beta-3; TGF-beta-3 2.5ug
RF004-2.5 Transforming growth factor beta-3; TGF-beta-3 , rHuman TGF beta-3 Active 2.5ug
RF003-5 rHuman TGF beta-2 Active; Transforming growth factor beta-2; TGF-beta-2 5ug
RF003-2.5 rHuman TGF beta-2 Active; Transforming growth factor beta-2; TGF-beta-2 2.5ug
RF004-5 Transforming growth factor beta-3; TGF-beta-3 , rHuman TGF beta-3 Active 5ug
RF003-2.5 Transforming growth factor beta-2; TGF-beta-2 , rHuman TGF beta-2 Active 2.5ug
RF003-5 Transforming growth factor beta-2; TGF-beta-2 , rHuman TGF beta-2 Active 5ug
AS10 1397 Antibody: TGF-beta | transforming growth factor beta , Host: chicken, polyclonal, Comfirmed reactivity: human, mouse, rat, swine TGF (beta) 100
EIAAB41304 Mouse,Mus musculus,Paf65b,PAF65-beta,PCAF-associated factor 65 beta,Taf5l,TAF5-like RNA polymerase II p300_CBP-associated factor-associated factor 65 kDa subunit 5L
RF002-5 Transforming growth factor beta-3; TGF-beta-3 , rHuman TGF beta-3 5ug
RF002-2.5 Transforming growth factor beta-3; TGF-beta-3 , rHuman TGF beta-3 2.5ug


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur