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Pol polyprotein [Cleaved into: Protease (EC 3.4.23.-) (Retropepsin); Reverse transcriptase/ribonuclease H (RT) (EC 2.7.7.49) (EC 3.1.26.13) (Exoribonuclease H) (EC 3.1.13.2); Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) (EC 3.6.1.23); Integrase (IN) (EC 2.7.7.-) (EC 3.1.-.-)]

 POL_FIVT2               Reviewed;        1124 AA.
P31822;
01-JUL-1993, integrated into UniProtKB/Swiss-Prot.
01-JUL-1993, sequence version 1.
25-OCT-2017, entry version 127.
RecName: Full=Pol polyprotein;
Contains:
RecName: Full=Protease;
EC=3.4.23.-;
AltName: Full=Retropepsin;
Contains:
RecName: Full=Reverse transcriptase/ribonuclease H;
Short=RT;
EC=2.7.7.49;
EC=3.1.26.13;
AltName: Full=Exoribonuclease H;
EC=3.1.13.2;
Contains:
RecName: Full=Deoxyuridine 5'-triphosphate nucleotidohydrolase;
Short=dUTPase;
EC=3.6.1.23;
Contains:
RecName: Full=Integrase;
Short=IN;
EC=2.7.7.- {ECO:0000250|UniProtKB:P04585};
EC=3.1.-.- {ECO:0000250|UniProtKB:P04585};
Name=pol;
Feline immunodeficiency virus (isolate TM2) (FIV).
Viruses; Retro-transcribing viruses; Retroviridae; Orthoretrovirinae;
Lentivirus; Feline lentivirus group.
NCBI_TaxID=31676;
NCBI_TaxID=9681; Felidae (cat family).
[1]
NUCLEOTIDE SEQUENCE [GENOMIC RNA].
PubMed=1649349;
Kiyomasu T., Miyazawa T., Furuya T., Shibata R., Sakai H.,
Sakuragi J.I., Fukasawa M., Maki N., Hasegawa A., Mikami T.,
Adachi A.;
"Identification of feline immunodeficiency virus rev gene activity.";
J. Virol. 65:4539-4542(1991).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC RNA].
PubMed=1312825; DOI=10.1007/BF01317136;
Maki N., Miyazawa T., Fukasawa M., Hasegawa A., Hayami M., Miki K.,
Mikami T.;
"Molecular characterization and heterogeneity of feline
immunodeficiency virus isolates.";
Arch. Virol. 123:29-45(1992).
-!- FUNCTION: During replicative cycle of retroviruses, the reverse-
transcribed viral DNA is integrated into the host chromosome by
the viral integrase enzyme. RNase H activity is associated with
the reverse transcriptase.
-!- CATALYTIC ACTIVITY: Endohydrolysis of RNA in RNA/DNA hybrids.
Three different cleavage modes: 1. sequence-specific internal
cleavage of RNA. Human immunodeficiency virus type 1 and Moloney
murine leukemia virus enzymes prefer to cleave the RNA strand one
nucleotide away from the RNA-DNA junction. 2. RNA 5'-end directed
cleavage 13-19 nucleotides from the RNA end. 3. DNA 3'-end
directed cleavage 15-20 nucleotides away from the primer terminus.
-!- CATALYTIC ACTIVITY: 3'-end directed exonucleolytic cleavage of
viral RNA-DNA hybrid.
-!- CATALYTIC ACTIVITY: dUTP + H(2)O = dUMP + diphosphate.
-!- CATALYTIC ACTIVITY: Deoxynucleoside triphosphate + DNA(n) =
diphosphate + DNA(n+1). {ECO:0000255|PROSITE-ProRule:PRU00405}.
-!- PTM: Cleavage sites that yield the mature proteins remain to be
determined.
-!- SIMILARITY: Belongs to the retroviral Pol polyprotein family.
{ECO:0000305}.
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EMBL; M59418; AAA43071.1; -; Genomic_RNA.
PIR; B45557; B45557.
ProteinModelPortal; P31822; -.
SMR; P31822; -.
MEROPS; A02.007; -.
PRIDE; P31822; -.
GO; GO:0004190; F:aspartic-type endopeptidase activity; IEA:UniProtKB-KW.
GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
GO; GO:0004170; F:dUTP diphosphatase activity; IEA:UniProtKB-EC.
GO; GO:0004533; F:exoribonuclease H activity; IEA:UniProtKB-EC.
GO; GO:0003964; F:RNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
GO; GO:0004523; F:RNA-DNA hybrid ribonuclease activity; IEA:InterPro.
GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
GO; GO:0015074; P:DNA integration; IEA:UniProtKB-KW.
GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
GO; GO:0075713; P:establishment of integrated proviral latency; IEA:UniProtKB-KW.
GO; GO:0009117; P:nucleotide metabolic process; IEA:UniProtKB-KW.
GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-KW.
GO; GO:0044826; P:viral genome integration into host DNA; IEA:UniProtKB-KW.
CDD; cd05482; HIV_retropepsin_like; 1.
CDD; cd07557; trimeric_dUTPase; 1.
Gene3D; 1.10.10.200; -; 1.
Gene3D; 2.30.30.10; -; 1.
Gene3D; 2.40.70.10; -; 1.
Gene3D; 3.30.420.10; -; 2.
InterPro; IPR001969; Aspartic_peptidase_AS.
InterPro; IPR029054; dUTPase-like.
InterPro; IPR036157; dUTPase-like_sf.
InterPro; IPR033704; dUTPase_trimeric.
InterPro; IPR036862; Integrase_C_dom_sf_retrovir.
InterPro; IPR001037; Integrase_C_retrovir.
InterPro; IPR001584; Integrase_cat-core.
InterPro; IPR017856; Integrase_Zn-bd_dom-like_N.
InterPro; IPR003308; Integrase_Zn-bd_dom_N.
InterPro; IPR001995; Peptidase_A2_cat.
InterPro; IPR021109; Peptidase_aspartic_dom.
InterPro; IPR034170; Retropepsin-like_cat_dom.
InterPro; IPR018061; Retropepsins.
InterPro; IPR012337; RNaseH-like_sf.
InterPro; IPR002156; RNaseH_domain.
InterPro; IPR036397; RNaseH_sf.
InterPro; IPR000477; RT_dom.
InterPro; IPR010659; RVT_connect.
InterPro; IPR010661; RVT_thumb.
Pfam; PF00692; dUTPase; 1.
Pfam; PF00552; IN_DBD_C; 1.
Pfam; PF02022; Integrase_Zn; 1.
Pfam; PF00075; RNase_H; 1.
Pfam; PF00665; rve; 1.
Pfam; PF00077; RVP; 1.
Pfam; PF00078; RVT_1; 1.
Pfam; PF06815; RVT_connect; 1.
Pfam; PF06817; RVT_thumb; 1.
SUPFAM; SSF46919; SSF46919; 1.
SUPFAM; SSF50122; SSF50122; 1.
SUPFAM; SSF50630; SSF50630; 1.
SUPFAM; SSF51283; SSF51283; 1.
SUPFAM; SSF53098; SSF53098; 2.
PROSITE; PS50175; ASP_PROT_RETROV; 1.
PROSITE; PS00141; ASP_PROTEASE; 1.
PROSITE; PS50994; INTEGRASE; 1.
PROSITE; PS51027; INTEGRASE_DBD; 1.
PROSITE; PS50879; RNASE_H; 1.
PROSITE; PS50878; RT_POL; 1.
PROSITE; PS50876; ZF_INTEGRASE; 1.
3: Inferred from homology;
Aspartyl protease; DNA integration; DNA recombination; DNA-binding;
Endonuclease; Hydrolase; Metal-binding; Multifunctional enzyme;
Nuclease; Nucleotide metabolism; Nucleotidyltransferase; Protease;
RNA-directed DNA polymerase; Transferase; Viral genome integration;
Virus entry into host cell; Zinc; Zinc-finger.
CHAIN 1 153 Protease. {ECO:0000250}.
/FTId=PRO_0000038849.
CHAIN 154 709 Reverse transcriptase/ribonuclease H.
{ECO:0000250}.
/FTId=PRO_0000038850.
CHAIN 710 843 Deoxyuridine 5'-triphosphate
nucleotidohydrolase. {ECO:0000250}.
/FTId=PRO_0000038851.
CHAIN 844 1124 Integrase. {ECO:0000250}.
/FTId=PRO_0000038852.
DOMAIN 62 143 Peptidase A2. {ECO:0000255|PROSITE-
ProRule:PRU00275}.
DOMAIN 199 388 Reverse transcriptase.
{ECO:0000255|PROSITE-ProRule:PRU00405}.
DOMAIN 591 711 RNase H. {ECO:0000255|PROSITE-
ProRule:PRU00408}.
DOMAIN 899 1049 Integrase catalytic.
{ECO:0000255|PROSITE-ProRule:PRU00457}.
ZN_FING 848 889 Integrase-type. {ECO:0000255|PROSITE-
ProRule:PRU00450}.
DNA_BIND 1067 1115 Integrase-type. {ECO:0000255|PROSITE-
ProRule:PRU00506}.
ACT_SITE 67 67 For protease activity.
{ECO:0000255|PROSITE-ProRule:PRU10094}.
SEQUENCE 1124 AA; 128101 MW; F287FE90FC978296 CRC64;
ENLGKREGGA SCSPSKPSAA NSTICTSNGG ETIRFINYNT IGTTTTLERR PEIQIFVNGH
PIKFLLDTGA DITILNRKDF QIGNSIENGK QNMIGVGGGK RGTNYINVHL EIRDENYRMQ
CIFGNVCVLE DNSLIQPLLG RDNMIKFNIR LVMAQISEKI PIVKVRMKDP TQGPQVKQWP
LSNEKIEALT DIVERLESEG KVKRADPNNP WNTPVFAIKK KSGKWRMLID FRVLNKLTDK
GAEVQLGLPH PAGLQMKKQV TVLDIGDAYF TIPLDPDYAP YTAFTLPRKN NAGPGRRYVW
CSLPQGWVLS PLIYQSTLNN ILQPFIKQNS ELDIYQYMDD IYIGSNLNKK EHKQKVEELR
KLLLWWGFET PEDKLQEEPP YKWMGYELHP LTWSIQQKQL EIPERPTLNE LQKLAGKINW
ASQTIPDLSI KELTNMMRGD QKLDSIREWT VEAKREVQKA KEAIETQAQL NYYDPNRGLY
AKLSLVGPHQ ICYQVYQKNP EHILWYGKIN RQKKKAENTC DIALRACYKI REESIIRIGK
EPVYEIPASR EAWESNLIRS PYLKAPPPEV EFIHAALSIK RALSMIQDAP IIGAETWYID
GSRKQGKAAR AAYWTNTGKW QIMEIEGSNQ KAEVQALLLA LKAGSEEMNI ITDSQYILNI
LNQQPDLMEG LWQEVLEQME KKIAIFIDWV PGHKGIPGNE EVDKLCQTMM IIEGEGILEK
RSEDAGYDLL AAAQETHFLP GEVRIVPTKT RIMLPKGHWG LIMGKSSIGS KGVDVLGGVI
DEGYRGELGV IMINLTKKSI TILEKQKIAQ LIILPCRHEG LQQGEIQMNS ERGEKGFGSA
GVFSSWVDRI EEAELNHEKF HSDPQYLRTE FNLPRIVAEE IKRKCPLCRI RGEQVGGQLK
IRPGIWQMDC THFNGKIIIV AVHVESGFLW AQIIPQETAD CTVKALLQLI CAHNVTELQT
DNGPNFKNQK MEGLLNYMGI KHKLGIPGNP QSQALVENAN NTLKVWIQKF LPETTSLDNA
LALALHCLNF KQRGRLGRMA PYELYIQQES LRIQDYFSAI PQKLMMQWLY YKDQKDKKWK
GPMRVEYWGQ GSVLLKDEEK GIFLVPRRHI RRVPEPCTLP EGDE


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