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Pol polyprotein [Cleaved into: Protease (Retropepsin) (EC 3.4.23.-); Reverse transcriptase/ribonuclease H (RT) (EC 2.7.7.49) (EC 3.1.26.13) (Exoribonuclease H) (EC 3.1.13.2); Integrase (IN) (EC 2.7.7.-) (EC 3.1.-.-)]

 POL_EIAV9               Reviewed;        1146 AA.
P11204;
01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
01-JUL-1989, sequence version 1.
20-JUN-2018, entry version 142.
RecName: Full=Pol polyprotein;
Contains:
RecName: Full=Protease;
AltName: Full=Retropepsin;
EC=3.4.23.-;
Contains:
RecName: Full=Reverse transcriptase/ribonuclease H;
Short=RT;
EC=2.7.7.49;
EC=3.1.26.13;
AltName: Full=Exoribonuclease H;
EC=3.1.13.2;
Contains:
RecName: Full=Integrase;
Short=IN;
EC=2.7.7.- {ECO:0000250|UniProtKB:P04585};
EC=3.1.-.- {ECO:0000250|UniProtKB:P04585};
Name=pol;
Equine infectious anemia virus (isolate 1369) (EIAV).
Viruses; Ortervirales; Retroviridae; Orthoretrovirinae; Lentivirus.
NCBI_TaxID=11670;
NCBI_TaxID=9793; Equus asinus (Donkey) (Equus africanus asinus).
NCBI_TaxID=9796; Equus caballus (Horse).
[1]
NUCLEOTIDE SEQUENCE [GENOMIC RNA].
PubMed=3035786; DOI=10.1016/0042-6822(87)90202-9;
Kawakami T., Sherman L., Dahlberg J., Gazit A., Yaniv A.,
Tronick S.R., Aaronson S.A.;
"Nucleotide sequence analysis of equine infectious anemia virus
proviral DNA.";
Virology 158:300-312(1987).
-!- FUNCTION: During replicative cycle of retroviruses, the reverse-
transcribed viral DNA is integrated into the host chromosome by
the viral integrase enzyme. RNase H activity is associated with
the reverse transcriptase.
-!- CATALYTIC ACTIVITY: Endohydrolysis of RNA in RNA/DNA hybrids.
Three different cleavage modes: 1. sequence-specific internal
cleavage of RNA. Human immunodeficiency virus type 1 and Moloney
murine leukemia virus enzymes prefer to cleave the RNA strand one
nucleotide away from the RNA-DNA junction. 2. RNA 5'-end directed
cleavage 13-19 nucleotides from the RNA end. 3. DNA 3'-end
directed cleavage 15-20 nucleotides away from the primer terminus.
-!- CATALYTIC ACTIVITY: 3'-end directed exonucleolytic cleavage of
viral RNA-DNA hybrid.
-!- CATALYTIC ACTIVITY: Deoxynucleoside triphosphate + DNA(n) =
diphosphate + DNA(n+1). {ECO:0000255|PROSITE-ProRule:PRU00405}.
-!- PTM: Specific enzymatic cleavages in vivo yield mature proteins.
-!- SIMILARITY: Belongs to the retroviral Pol polyprotein family.
{ECO:0000305}.
-!- SEQUENCE CAUTION:
Sequence=AAB59862.1; Type=Erroneous initiation; Evidence={ECO:0000305};
-----------------------------------------------------------------------
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EMBL; M16575; AAB59862.1; ALT_INIT; Genomic_RNA.
PIR; B27842; GNLJEW.
PDB; 1DUC; X-ray; 2.05 A; A=742-875.
PDB; 1DUN; X-ray; 1.90 A; A=742-875.
PDBsum; 1DUC; -.
PDBsum; 1DUN; -.
ProteinModelPortal; P11204; -.
SMR; P11204; -.
PRIDE; P11204; -.
EvolutionaryTrace; P11204; -.
GO; GO:0004190; F:aspartic-type endopeptidase activity; IEA:UniProtKB-KW.
GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
GO; GO:0004170; F:dUTP diphosphatase activity; IDA:CAFA.
GO; GO:0004533; F:exoribonuclease H activity; IEA:UniProtKB-EC.
GO; GO:0000287; F:magnesium ion binding; IDA:CAFA.
GO; GO:0003964; F:RNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
GO; GO:0004523; F:RNA-DNA hybrid ribonuclease activity; IEA:InterPro.
GO; GO:0002134; F:UTP binding; IDA:CAFA.
GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
GO; GO:0015074; P:DNA integration; IEA:UniProtKB-KW.
GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
GO; GO:0006226; P:dUMP biosynthetic process; IDA:CAFA.
GO; GO:0046081; P:dUTP catabolic process; IDA:CAFA.
GO; GO:0075713; P:establishment of integrated proviral latency; IEA:UniProtKB-KW.
GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-KW.
GO; GO:0044826; P:viral genome integration into host DNA; IEA:UniProtKB-KW.
CDD; cd07557; trimeric_dUTPase; 1.
Gene3D; 1.10.10.200; -; 1.
Gene3D; 2.30.30.10; -; 1.
Gene3D; 2.40.70.10; -; 1.
Gene3D; 2.70.40.10; -; 1.
Gene3D; 3.30.420.10; -; 2.
InterPro; IPR001969; Aspartic_peptidase_AS.
InterPro; IPR029054; dUTPase-like.
InterPro; IPR036157; dUTPase-like_sf.
InterPro; IPR033704; dUTPase_trimeric.
InterPro; IPR017856; Integrase-like_N.
InterPro; IPR036862; Integrase_C_dom_sf_retrovir.
InterPro; IPR001037; Integrase_C_retrovir.
InterPro; IPR001584; Integrase_cat-core.
InterPro; IPR003308; Integrase_Zn-bd_dom_N.
InterPro; IPR001995; Peptidase_A2_cat.
InterPro; IPR021109; Peptidase_aspartic_dom_sf.
InterPro; IPR018061; Retropepsins.
InterPro; IPR012337; RNaseH-like_sf.
InterPro; IPR002156; RNaseH_domain.
InterPro; IPR036397; RNaseH_sf.
InterPro; IPR000477; RT_dom.
InterPro; IPR010659; RVT_connect.
InterPro; IPR010661; RVT_thumb.
Pfam; PF00692; dUTPase; 1.
Pfam; PF00552; IN_DBD_C; 1.
Pfam; PF02022; Integrase_Zn; 1.
Pfam; PF00075; RNase_H; 1.
Pfam; PF00665; rve; 1.
Pfam; PF00077; RVP; 1.
Pfam; PF00078; RVT_1; 1.
Pfam; PF06815; RVT_connect; 1.
Pfam; PF06817; RVT_thumb; 1.
SUPFAM; SSF46919; SSF46919; 1.
SUPFAM; SSF50122; SSF50122; 1.
SUPFAM; SSF50630; SSF50630; 1.
SUPFAM; SSF51283; SSF51283; 1.
SUPFAM; SSF53098; SSF53098; 2.
PROSITE; PS50175; ASP_PROT_RETROV; 1.
PROSITE; PS00141; ASP_PROTEASE; 1.
PROSITE; PS50994; INTEGRASE; 1.
PROSITE; PS51027; INTEGRASE_DBD; 1.
PROSITE; PS50879; RNASE_H; 1.
PROSITE; PS50878; RT_POL; 1.
PROSITE; PS50876; ZF_INTEGRASE; 1.
1: Evidence at protein level;
3D-structure; Aspartyl protease; Cleavage on pair of basic residues;
DNA integration; DNA recombination; DNA-binding; Endonuclease;
Hydrolase; Metal-binding; Multifunctional enzyme; Nuclease;
Nucleotidyltransferase; Protease; RNA-directed DNA polymerase;
Transferase; Viral genome integration; Virus entry into host cell;
Zinc; Zinc-finger.
CHAIN 1 195 Protease.
/FTId=PRO_0000038838.
CHAIN 196 914 Reverse transcriptase/ribonuclease H.
/FTId=PRO_0000038839.
CHAIN 915 1146 Integrase.
/FTId=PRO_0000038840.
DOMAIN 100 174 Peptidase A2. {ECO:0000255|PROSITE-
ProRule:PRU00275}.
DOMAIN 230 419 Reverse transcriptase.
{ECO:0000255|PROSITE-ProRule:PRU00405}.
DOMAIN 617 740 RNase H. {ECO:0000255|PROSITE-
ProRule:PRU00408}.
DOMAIN 921 1078 Integrase catalytic.
{ECO:0000255|PROSITE-ProRule:PRU00457}.
ZN_FING 878 919 Integrase-type. {ECO:0000255|PROSITE-
ProRule:PRU00450}.
DNA_BIND 1096 1144 Integrase-type. {ECO:0000255|PROSITE-
ProRule:PRU00506}.
ACT_SITE 105 105 {ECO:0000255|PROSITE-ProRule:PRU10094}.
STRAND 744 746 {ECO:0000244|PDB:1DUN}.
STRAND 748 750 {ECO:0000244|PDB:1DUN}.
STRAND 758 763 {ECO:0000244|PDB:1DUN}.
STRAND 768 770 {ECO:0000244|PDB:1DUN}.
STRAND 775 779 {ECO:0000244|PDB:1DUN}.
STRAND 783 785 {ECO:0000244|PDB:1DUN}.
STRAND 790 795 {ECO:0000244|PDB:1DUN}.
HELIX 798 802 {ECO:0000244|PDB:1DUN}.
STRAND 805 808 {ECO:0000244|PDB:1DUN}.
STRAND 811 813 {ECO:0000244|PDB:1DUN}.
STRAND 821 826 {ECO:0000244|PDB:1DUN}.
STRAND 828 830 {ECO:0000244|PDB:1DUN}.
STRAND 832 834 {ECO:0000244|PDB:1DUN}.
STRAND 839 847 {ECO:0000244|PDB:1DUN}.
SEQUENCE 1146 AA; 129510 MW; 2BEB2E04F93FA36F CRC64;
TAWTFLKAMQ KCSKKREARG SREAPETNFP DTTEESAQQI CCTRDSSDSK SVPRSERNKK
GIQCQGEGSS RGSQPGQFVG VTYNLEKRPT TIVLINDTPL NVLLDTGADT SVLTTAHYNR
LKYRGRKYQG TGIIGVGGNV ETFSTPVTIK KKGRHIKTRM LVADIPVTIL GRDILQDLGA
KLVLAQLSKE IKFRKIELKE GTMGPKIPQW PLTKEKLEGA KEIVQRLLSE GKISEASDNN
PYNSPIFVIK KRSGKWRLLQ DLRELNKTVQ VGTEISRGLP HPGGLIKCKH MTVLDIGDAY
FTIPLDPEFR PYTAFTIPSI NHQEPDKRYV WNCLPQGFVL SPYIYQKTLQ EILQPFRERY
PEVQLYQYMD DLFVGSNGSK KQHKELIIEL RAILLEEGFE TPDDKLQEVP PYSWLGYQLC
PENWKVQKMQ LDMVKNPTLN DVQKLMGNIT WMSSGVPGLT VKHIAATTKG CLELNQKVIW
TEEAQKELEE NNEKIKNAQG LQYYNPEEEM LCEVEITKNY EATYVIKQSQ GILWAGKKIM
KANKGWSTVK NLMLLLQHVA TESITRVGKC PTFKVPFTKE QVMWEMQKGW YYSWLPEIVY
THQVVHDDWR MKLVEEPTSG ITIYTDGGKQ NGEGIAAYVT SNGRTKQKRL GPVTHQVAER
MAIQMALEDT RDKQVNIVTD SYYCWKNITE GLGLEGPQSP WWPIIQNIRE KEIVYFAWVP
GHKGICGNQL ADEAAKIKEE IMLAYQGTQI KEKRDEDAGF DLCVPYDIMI PVSDTKIIPT
DVKIQVPPNS FGWVTGKSSM AKQGLLINGG IIDEGYTGEI QVICTNIGKS NIKLIEGQKF
AQLIILQHHS NSRQPWDENK ISQRGDKGFG STGVFWVENI QEAQDEHENW HTSPKILARN
YKIPLTVAKQ ITQECPHCTK QGSGPAGCVM RSPNHWQADC THLDNKIILT FVESNSGYIH
ATLLSKENAL CTSLAILEWA RLFSPKSLHT DNGTNFVAEP VVNLLKFLKI AHTTGIPYHP
ESQGIVERAN RTLKEKIQSH RDNTQTLEAA LQLALITCNK GRESMGGQTP WEVFITNQAQ
VIHEKLLLQQ AQSSKKFCFY KIPGEHDWKG PTRVLWKGDG AVVVNDEGKG IIAVPLTRTK
LLIKPN


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