Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Poly [ADP-ribose] polymerase (PARP) (EC 2.4.2.30)

 I3LDH3_PIG              Unreviewed;      1003 AA.
I3LDH3;
11-JUL-2012, integrated into UniProtKB/TrEMBL.
22-NOV-2017, sequence version 2.
25-APR-2018, entry version 51.
RecName: Full=Poly [ADP-ribose] polymerase {ECO:0000256|RuleBase:RU362114};
Short=PARP {ECO:0000256|RuleBase:RU362114};
EC=2.4.2.30 {ECO:0000256|RuleBase:RU362114};
Name=PARP1 {ECO:0000313|Ensembl:ENSSSCP00000022104};
Sus scrofa (Pig).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Suina; Suidae;
Sus.
NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000022104, ECO:0000313|Proteomes:UP000008227};
[1] {ECO:0000313|Ensembl:ENSSSCP00000022104, ECO:0000313|Proteomes:UP000008227}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000022104};
Porcine genome sequencing project;
Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
[2] {ECO:0000313|Ensembl:ENSSSCP00000022104}
IDENTIFICATION.
Ensembl;
Submitted (MAY-2012) to UniProtKB.
-!- CATALYTIC ACTIVITY: NAD(+) + (ADP-D-ribosyl)(n)-acceptor =
nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor.
{ECO:0000256|RuleBase:RU362114}.
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
Distributed under the Creative Commons Attribution-NoDerivs License
-----------------------------------------------------------------------
EMBL; AEMK02000071; -; NOT_ANNOTATED_CDS; Genomic_DNA.
STRING; 9823.ENSSSCP00000022104; -.
PaxDb; I3LDH3; -.
PeptideAtlas; I3LDH3; -.
PRIDE; I3LDH3; -.
Ensembl; ENSSSCT00000028077; ENSSSCP00000022104; ENSSSCG00000023660.
eggNOG; KOG1037; Eukaryota.
eggNOG; ENOG410XP18; LUCA.
GeneTree; ENSGT00390000017341; -.
InParanoid; I3LDH3; -.
OrthoDB; EOG091G13H1; -.
TreeFam; TF316616; -.
Reactome; R-SSC-110362; POLB-Dependent Long Patch Base Excision Repair.
Reactome; R-SSC-2173795; Downregulation of SMAD2/3:SMAD4 transcriptional activity.
Reactome; R-SSC-3108214; SUMOylation of DNA damage response and repair proteins.
Reactome; R-SSC-5685939; HDR through MMEJ (alt-NHEJ).
Reactome; R-SSC-5696394; DNA Damage Recognition in GG-NER.
Reactome; R-SSC-5696395; Formation of Incision Complex in GG-NER.
Reactome; R-SSC-5696400; Dual Incision in GG-NER.
Proteomes; UP000008227; Chromosome 10.
Bgee; ENSSSCG00000023660; -.
Genevisible; I3LDH3; SS.
GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
GO; GO:0005739; C:mitochondrion; IEA:Ensembl.
GO; GO:0005635; C:nuclear envelope; IEA:Ensembl.
GO; GO:0005730; C:nucleolus; IEA:Ensembl.
GO; GO:0032993; C:protein-DNA complex; IEA:Ensembl.
GO; GO:0005667; C:transcription factor complex; IEA:Ensembl.
GO; GO:0003910; F:DNA ligase (ATP) activity; IBA:GO_Central.
GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
GO; GO:0051287; F:NAD binding; IEA:InterPro.
GO; GO:0003950; F:NAD+ ADP-ribosyltransferase activity; IEA:UniProtKB-UniRule.
GO; GO:1990404; F:protein ADP-ribosylase activity; IEA:Ensembl.
GO; GO:0019901; F:protein kinase binding; IEA:Ensembl.
GO; GO:0047485; F:protein N-terminus binding; IEA:Ensembl.
GO; GO:0000977; F:RNA polymerase II regulatory region sequence-specific DNA binding; IEA:Ensembl.
GO; GO:0008134; F:transcription factor binding; IEA:Ensembl.
GO; GO:0001228; F:transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding; IEA:Ensembl.
GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
GO; GO:0006915; P:apoptotic process; IEA:Ensembl.
GO; GO:1990966; P:ATP generation from poly-ADP-D-ribose; IEA:Ensembl.
GO; GO:0032869; P:cellular response to insulin stimulus; IEA:Ensembl.
GO; GO:0034599; P:cellular response to oxidative stress; IEA:Ensembl.
GO; GO:0034644; P:cellular response to UV; IEA:Ensembl.
GO; GO:0051103; P:DNA ligation involved in DNA repair; IBA:GO_Central.
GO; GO:0006302; P:double-strand break repair; IEA:Ensembl.
GO; GO:0006273; P:lagging strand elongation; IBA:GO_Central.
GO; GO:0043504; P:mitochondrial DNA repair; IEA:Ensembl.
GO; GO:2001170; P:negative regulation of ATP biosynthetic process; IEA:Ensembl.
GO; GO:0018312; P:peptidyl-serine ADP-ribosylation; IEA:Ensembl.
GO; GO:1903518; P:positive regulation of single strand break repair; IEA:Ensembl.
GO; GO:0070212; P:protein poly-ADP-ribosylation; IEA:Ensembl.
GO; GO:0050790; P:regulation of catalytic activity; IEA:Ensembl.
GO; GO:1903827; P:regulation of cellular protein localization; IEA:Ensembl.
CDD; cd00027; BRCT; 1.
Gene3D; 1.20.142.10; -; 1.
Gene3D; 2.20.140.10; -; 1.
Gene3D; 2.20.25.630; -; 1.
Gene3D; 3.30.1740.10; -; 2.
Gene3D; 3.40.50.10190; -; 1.
InterPro; IPR001357; BRCT_dom.
InterPro; IPR036420; BRCT_dom_sf.
InterPro; IPR012982; PADR1.
InterPro; IPR038650; PADR1_dom_sf.
InterPro; IPR008288; PARP.
InterPro; IPR012317; Poly(ADP-ribose)pol_cat_dom.
InterPro; IPR004102; Poly(ADP-ribose)pol_reg_dom.
InterPro; IPR036616; Poly(ADP-ribose)pol_reg_dom_sf.
InterPro; IPR036930; WGR_dom_sf.
InterPro; IPR008893; WGR_domain.
InterPro; IPR001510; Znf_PARP.
InterPro; IPR036957; Znf_PARP_sf.
Pfam; PF00533; BRCT; 1.
Pfam; PF08063; PADR1; 1.
Pfam; PF00644; PARP; 1.
Pfam; PF02877; PARP_reg; 1.
Pfam; PF05406; WGR; 1.
Pfam; PF00645; zf-PARP; 2.
PIRSF; PIRSF000489; NAD_ADPRT; 1.
SMART; SM00292; BRCT; 1.
SMART; SM01335; PADR1; 1.
SMART; SM00773; WGR; 1.
SMART; SM01336; zf-PARP; 2.
SUPFAM; SSF142921; SSF142921; 1.
SUPFAM; SSF47587; SSF47587; 1.
SUPFAM; SSF52113; SSF52113; 1.
PROSITE; PS50172; BRCT; 1.
PROSITE; PS51060; PARP_ALPHA_HD; 1.
PROSITE; PS51059; PARP_CATALYTIC; 1.
PROSITE; PS00347; PARP_ZN_FINGER_1; 1.
PROSITE; PS50064; PARP_ZN_FINGER_2; 2.
1: Evidence at protein level;
Coiled coil {ECO:0000256|SAM:Coils};
Complete proteome {ECO:0000313|Proteomes:UP000008227};
Glycosyltransferase {ECO:0000256|RuleBase:RU362114};
NAD {ECO:0000256|RuleBase:RU362114};
Proteomics identification {ECO:0000213|PeptideAtlas:I3LDH3};
Reference proteome {ECO:0000313|Proteomes:UP000008227};
Transferase {ECO:0000256|RuleBase:RU362114}.
DOMAIN 9 93 PARP-type. {ECO:0000259|PROSITE:PS50064}.
DOMAIN 113 203 PARP-type. {ECO:0000259|PROSITE:PS50064}.
DOMAIN 385 461 BRCT. {ECO:0000259|PROSITE:PS50172}.
DOMAIN 651 768 PARP alpha-helical.
{ECO:0000259|PROSITE:PS51060}.
DOMAIN 777 1003 PARP catalytic.
{ECO:0000259|PROSITE:PS51059}.
COILED 429 449 {ECO:0000256|SAM:Coils}.
SEQUENCE 1003 AA; 111525 MW; C56DA22E4A22D404 CRC64;
MAESSDKLYR VEYAKSGRAS CKKCSESIPK DSLRMAIMVQ SPMFDGKVPH WYHFSCFWKV
GHAIRHPDIE VDGFSELRWD DQQKVKKTAE AGGVTGKGQD GVGSKAEKTL GDFAAEYAKS
NRSTCKGCME KIEKGHVRLS KKMLDPEKPQ LGMIDRWYHP NCFVQNREEL GFRPEYSASQ
LKGFSLLTAE DKEALKKQLP GIKSEGKRKG DEVDGVDGVA KKKSKKEKDK ESKLEKALKA
QNDLIWNIKD ELKKVCSTND LKELLIFNKQ QVPSGESAIL DRVADGMVFG ALLPCEECSG
QLVFKSDAYY CTGDVTAWTK CMVKTQTPNR KEWVTPKEFR EITYLKKLKI KKQDRIFPPE
ASTPVATAPP PPAASAPTAV NSSAPPDKPL SNMKILTLGK LSRNKDEVKA AIEKLGGKLT
GTASKASLCV STKKEVDKMS KKMEEVKEAN VRVVSEDFLQ DVSASTKSLQ ELLCTHILSP
WGAEVKAEPV EAVAPRGKSG GALPKKSKGP IREEGANKSE KRMKLTLKGG AAVDPDSGLE
HSAHVLEKGG KVFSATLGLV DIVKGTNSYY KLQLLEDDKE SRYWIFRSWG RVGTVIGSNK
LEQMPSKEDK TGNAWHSKNF TKYPKKFYPL EIDYGQDEEA VKKLTVNPGT KSKLPKSVQE
LIKMIFDVES MKKAMVEYEI DLQKMPLGKL SKRQIQAAYA ILSEVQQAVS QGSSDSQILD
LSNRFYTLIP HDFGMKKPPL LNNADSVQAK VEMLDNLLDI EVAYSLLRGG SDDSSKDPID
VNYEKLKTDI KVVDRDSEEA ETIRKYVKNT HATTHNAYDL EVIDIFKIER EGESQRYKPF
KQLHNRRLLW HGSRTTNFAG ILSQGLRIAP PEAPVTGYMF GKGIYFADMV SKSANYCHTS
QGDPIGLILL GEVALGNMYE LKHASHISKL PKGKHSVKGL GKTTPDPAAS ITMDGVEVPL
GTGIPSGVND TCLLYNEYIV YDIAQVNLKY LLKLKFNFKT SLW


Related products :

Catalog number Product name Quantity
EIAAB29926 193 kDa vault protein,ADPRTL1,Homo sapiens,Human,KIAA0177,PARP4,PARP-4,PARPL,PARP-related_IalphaI-related H5_proline-rich,PH5P,Poly [ADP-ribose] polymerase 4,Vault poly(ADP-ribose) polymerase,VPARP
EIAAB29933 Homo sapiens,Human,PARP7,PARP-7,Poly [ADP-ribose] polymerase 7,TCDD-inducible poly [ADP-ribose] polymerase,TIPARP
AS10 675 Antibody: PARP | Poly [ADP-ribose] polymerase , Immunogen: KLH-conjugated synthetic peptide derived from Arabidopsis thaliana PARP-1 (AT4G02390) and PARP-2 (AT2G31320) and PARP from other plant specie 200
18-003-42430 Poly [ADP-ribose] polymerase 2 - EC 2.4.2.30; PARP-2; NAD(+) ADP-ribosyltransferase 2; Poly[ADP-ribose] synthetase 2; pADPRT-2; hPARP-2 Polyclonal 0.05 mg Aff Pur
18-003-42429 Poly [ADP-ribose] polymerase 1 - EC 2.4.2.30; PARP-1; ADPRT; NAD(+) ADP-ribosyltransferase 1; Poly[ADP-ribose] synthetase 1 Polyclonal 0.1 mg Protein A
EIAAB29924 ADPRT2,ADPRT-2,ADPRTL2,Homo sapiens,hPARP-2,Human,NAD(+) ADP-ribosyltransferase 2,pADPRT-2,PARP2,PARP-2,Poly [ADP-ribose] polymerase 2,Poly[ADP-ribose] synthase 2
EIAAB29923 Adprt2,ADPRT-2,Adprtl2,Aspartl2,Mouse,mPARP-2,Mus musculus,NAD(+) ADP-ribosyltransferase 2,pADPRT-2,Parp2,PARP-2,Poly [ADP-ribose] polymerase 2,Poly[ADP-ribose] synthase 2
EIAAB29925 ADPRT3,ADPRT-3,ADPRTL3,Homo sapiens,hPARP-3,Human,IRT1,NAD(+) ADP-ribosyltransferase 3,pADPRT-3,PARP3,PARP-3,Poly [ADP-ribose] polymerase 3,Poly[ADP-ribose] synthase 3
E0947h ELISA ADPRT,ADPRT 1,Homo sapiens,Human,NAD(+) ADP-ribosyltransferase 1,PARP1,PARP-1,Poly [ADP-ribose] polymerase 1,Poly[ADP-ribose] synthase 1,PPOL 96T
E0947h ELISA kit ADPRT,ADPRT 1,Homo sapiens,Human,NAD(+) ADP-ribosyltransferase 1,PARP1,PARP-1,Poly [ADP-ribose] polymerase 1,Poly[ADP-ribose] synthase 1,PPOL 96T
U0947h CLIA ADPRT,ADPRT 1,Homo sapiens,Human,NAD(+) ADP-ribosyltransferase 1,PARP1,PARP-1,Poly [ADP-ribose] polymerase 1,Poly[ADP-ribose] synthase 1,PPOL 96T
E0947m ELISA Adprp,Adprt,ADPRT 1,Adprt1,Mouse,msPARP,Mus musculus,NAD(+) ADP-ribosyltransferase 1,Parp1,PARP-1,Poly [ADP-ribose] polymerase 1,Poly[ADP-ribose] synthase 1 96T
E0947m ELISA kit Adprp,Adprt,ADPRT 1,Adprt1,Mouse,msPARP,Mus musculus,NAD(+) ADP-ribosyltransferase 1,Parp1,PARP-1,Poly [ADP-ribose] polymerase 1,Poly[ADP-ribose] synthase 1 96T
U0947m CLIA Adprp,Adprt,ADPRT 1,Adprt1,Mouse,msPARP,Mus musculus,NAD(+) ADP-ribosyltransferase 1,Parp1,PARP-1,Poly [ADP-ribose] polymerase 1,Poly[ADP-ribose] synthase 1 96T
E0947b ELISA ADPRT,ADPRT 1,Bos taurus,Bovine,NAD(+) ADP-ribosyltransferase 1,PARP1,PARP-1,Poly [ADP-ribose] polymerase 1,Poly[ADP-ribose] synthase 1 96T
U0947b CLIA ADPRT,ADPRT 1,Bos taurus,Bovine,NAD(+) ADP-ribosyltransferase 1,PARP1,PARP-1,Poly [ADP-ribose] polymerase 1,Poly[ADP-ribose] synthase 1 96T
E0947b ELISA kit ADPRT,ADPRT 1,Bos taurus,Bovine,NAD(+) ADP-ribosyltransferase 1,PARP1,PARP-1,Poly [ADP-ribose] polymerase 1,Poly[ADP-ribose] synthase 1 96T
U0947r CLIA Adprt,ADPRT 1,NAD(+) ADP-ribosyltransferase 1,Parp1,PARP-1,Poly [ADP-ribose] polymerase 1,Poly[ADP-ribose] synthase 1,Rat,Rattus norvegicus 96T
E0947r ELISA kit Adprt,ADPRT 1,NAD(+) ADP-ribosyltransferase 1,Parp1,PARP-1,Poly [ADP-ribose] polymerase 1,Poly[ADP-ribose] synthase 1,Rat,Rattus norvegicus 96T
E0947r ELISA Adprt,ADPRT 1,NAD(+) ADP-ribosyltransferase 1,Parp1,PARP-1,Poly [ADP-ribose] polymerase 1,Poly[ADP-ribose] synthase 1,Rat,Rattus norvegicus 96T
DL-PARP-Hu Human Poly ADP Ribose Polymerase (PARP) ELISA Kit 96T
E0947c ELISA ADPRT,ADPRT 1,Chicken,Gallus gallus,NAD(+) ADP-ribosyltransferase 1,PARP1,PARP-1,Poly [ADP-ribose] polymerase 1,Poly[ADP-ribose] synthase 1 96T
U0947c CLIA ADPRT,ADPRT 1,Chicken,Gallus gallus,NAD(+) ADP-ribosyltransferase 1,PARP1,PARP-1,Poly [ADP-ribose] polymerase 1,Poly[ADP-ribose] synthase 1 96T
E0947c ELISA kit ADPRT,ADPRT 1,Chicken,Gallus gallus,NAD(+) ADP-ribosyltransferase 1,PARP1,PARP-1,Poly [ADP-ribose] polymerase 1,Poly[ADP-ribose] synthase 1 96T
20312390-1 PARP-2 | Poly [ADP-ribose] polymerase 2 200 uL


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur