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Polyadenylate-binding protein, cytoplasmic and nuclear (PABP) (Poly(A)-binding protein) (Polyadenylate tail-binding protein)

 PABP_NEUCR              Reviewed;         764 AA.
Q7S6N6;
24-JUL-2007, integrated into UniProtKB/Swiss-Prot.
15-DEC-2003, sequence version 1.
28-FEB-2018, entry version 107.
RecName: Full=Polyadenylate-binding protein, cytoplasmic and nuclear;
Short=PABP;
Short=Poly(A)-binding protein;
AltName: Full=Polyadenylate tail-binding protein;
Name=pabp-1; Synonyms=pab1; ORFNames=NCU04799;
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM
1257 / FGSC 987).
Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina;
Sordariomycetes; Sordariomycetidae; Sordariales; Sordariaceae;
Neurospora.
NCBI_TaxID=367110;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
PubMed=12712197; DOI=10.1038/nature01554;
Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D.,
Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B.,
Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M.,
Qui D., Ianakiev P., Bell-Pedersen D., Nelson M.A.,
Werner-Washburne M., Selitrennikoff C.P., Kinsey J.A., Braun E.L.,
Zelter A., Schulte U., Kothe G.O., Jedd G., Mewes H.-W., Staben C.,
Marcotte E., Greenberg D., Roy A., Foley K., Naylor J.,
Stange-Thomann N., Barrett R., Gnerre S., Kamal M., Kamvysselis M.,
Mauceli E.W., Bielke C., Rudd S., Frishman D., Krystofova S.,
Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S., Cogoni C.,
Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A.,
DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R.,
Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R.,
Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M.,
Paulsen I., Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.;
"The genome sequence of the filamentous fungus Neurospora crassa.";
Nature 422:859-868(2003).
-!- FUNCTION: Binds the poly(A) tail of mRNA. Appears to be an
important mediator of the multiple roles of the poly(A) tail in
mRNA biogenesis, stability and translation. In the nucleus,
involved in both mRNA cleavage and polyadenylation. Is also
required for efficient mRNA export to the cytoplasm. Acts in
concert with a poly(A)-specific nuclease (PAN) to affect poly(A)
tail shortening, which may occur concomitantly with either
nucleocytoplasmic mRNA transport or translational initiation. In
the cytoplasm, stimulates translation initiation and regulates
mRNA decay through translation termination-coupled poly(A)
shortening, probably mediated by PAN (By similarity).
{ECO:0000250}.
-!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus
{ECO:0000250}.
-!- SIMILARITY: Belongs to the polyadenylate-binding protein type-1
family. {ECO:0000305}.
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EMBL; CM002241; EAA31189.1; -; Genomic_DNA.
RefSeq; XP_960425.1; XM_955332.3.
ProteinModelPortal; Q7S6N6; -.
SMR; Q7S6N6; -.
PRIDE; Q7S6N6; -.
EnsemblFungi; EAA31189; EAA31189; NCU04799.
GeneID; 3876563; -.
KEGG; ncr:NCU04799; -.
EuPathDB; FungiDB:NCU04799; -.
HOGENOM; HOG000217922; -.
InParanoid; Q7S6N6; -.
KO; K13126; -.
OMA; KKVYVGH; -.
OrthoDB; EOG092C3SCB; -.
Proteomes; UP000001805; Chromosome 5, Linkage Group VI.
GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
GO; GO:0051028; P:mRNA transport; IEA:UniProtKB-KW.
GO; GO:0006417; P:regulation of translation; IEA:UniProtKB-KW.
Gene3D; 3.30.70.330; -; 3.
InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
InterPro; IPR036053; PABP-dom.
InterPro; IPR006515; PABP_1234.
InterPro; IPR002004; PABP_HYD.
InterPro; IPR035979; RBD_domain_sf.
InterPro; IPR000504; RRM_dom.
InterPro; IPR003954; RRM_dom_euk.
Pfam; PF00658; PABP; 1.
Pfam; PF00076; RRM_1; 5.
SMART; SM00517; PolyA; 1.
SMART; SM00360; RRM; 4.
SMART; SM00361; RRM_1; 3.
SUPFAM; SSF54928; SSF54928; 3.
SUPFAM; SSF63570; SSF63570; 1.
TIGRFAMs; TIGR01628; PABP-1234; 1.
PROSITE; PS51309; PABC; 1.
PROSITE; PS50102; RRM; 4.
3: Inferred from homology;
Complete proteome; Cytoplasm; mRNA processing; mRNA transport;
Nucleus; Reference proteome; Repeat; RNA-binding;
Translation regulation; Transport.
CHAIN 1 764 Polyadenylate-binding protein,
cytoplasmic and nuclear.
/FTId=PRO_0000295396.
DOMAIN 60 138 RRM 1. {ECO:0000255|PROSITE-
ProRule:PRU00176}.
DOMAIN 148 225 RRM 2. {ECO:0000255|PROSITE-
ProRule:PRU00176}.
DOMAIN 241 318 RRM 3. {ECO:0000255|PROSITE-
ProRule:PRU00176}.
DOMAIN 344 462 RRM 4. {ECO:0000255|PROSITE-
ProRule:PRU00176}.
DOMAIN 657 734 PABC. {ECO:0000255|PROSITE-
ProRule:PRU00641}.
COMPBIAS 504 643 Gly-rich.
SEQUENCE 764 AA; 82317 MW; 44E2BD4A9169A572 CRC64;
MAATSTAAVD QLAADLGNTS LDNKAAAPAP IDTSAVPEAQ AEGAEAAPTP TAAPHPQASA
SLYVGELDPS VTEAMLFELF SQIGSVASIR VCRDAVTRRS LGYAYVNYNT TADGEKALEE
LNYTLIKGRP CRIMWSQRDP ALRKTGAGNI FIKNLDAAID NKALHDTFAA FGNILSCKVA
QDEHGNSKGY GFVHYETDEA ASQAIKHVNG MLLNEKKVYV GHHIPKKDRQ SKFEEMKANF
TNVYVKNINN EVTDEEFREL FAKFGEVTSS SLARDQEGKS RGFGFVNFTT HEAAAQAVDE
LNGKDFRGQD LYVGRAQKKH EREEELRKSY EAARLEKANK YQGVNLYIKN LGDDVDDDKL
RAMFSEYGPI TSAKVMRDSL IEGSEEKDEK DKENKKEGET KEEEQNEGSE KKTEKKGDRK
LGKSKGFGFV CFSNPDDATK AVTEMNQRMV DGKPLYVALA QRKDVRKSQL EASIQARNQL
RMQQAAAQAG MPQQYMQAPV YYAGQQPGFM PAPGGRGVPF PQGGIVPGVQ GGRPGQYPYQ
QGGRGGVPPQ QMPPMGYPIN QFGPGAFPPN TPQYMAAMGQ VGALGGGRGG PAGRGPQGIP
AGIPQGLQGG PAVPGYPPAG RPQNGGGRGT PRGNANFMAA GRGASPIPGA PADLSAGSFL
QAQLATTQDP QAQKQIIGEN LFPKIQAIQP ALAGKITGML LEMDNAELIN LFEDDNALNV
KVQEALAVYD EYLKTQGQQP TQQPAEANGE QPKAEEQKPE EQKA


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