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Polycomb protein SCMH1 (Sex comb on midleg homolog 1)

 SCMH1_MOUSE             Reviewed;         706 AA.
Q8K214; B1AS51; Q9JME0;
01-MAR-2005, integrated into UniProtKB/Swiss-Prot.
01-OCT-2002, sequence version 1.
22-NOV-2017, entry version 122.
RecName: Full=Polycomb protein SCMH1;
AltName: Full=Sex comb on midleg homolog 1;
Name=Scmh1 {ECO:0000312|MGI:MGI:1352762};
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1] {ECO:0000305, ECO:0000312|EMBL:BAA90554.1}
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), TISSUE SPECIFICITY,
DEVELOPMENTAL STAGE, INDUCTION, AND INTERACTION WITH PHC1.
TISSUE=Brain {ECO:0000269|PubMed:10653359}, and
Neonatal brain {ECO:0000269|PubMed:10653359};
PubMed=10653359; DOI=10.1046/j.1432-0436.1999.6540229.x;
Tomotsune D., Takihara Y., Berger J., Duhl D., Joo S., Kyba M.,
Shirai M., Ohta H., Matsuda Y., Honda B.M., Simon J., Shimada K.,
Brock H.W., Randazzo F.;
"A novel member of murine polycomb-group proteins, Sex comb on midleg
homolog protein, is highly conserved, and interacts with RAE28/mph1 in
vitro.";
Differentiation 65:229-239(1999).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=C57BL/6J;
PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S.,
She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W.,
Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T.,
Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J.,
Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z.,
Lindblad-Toh K., Eichler E.E., Ponting C.P.;
"Lineage-specific biology revealed by a finished genome assembly of
the mouse.";
PLoS Biol. 7:E1000112-E1000112(2009).
[3] {ECO:0000305, ECO:0000312|EMBL:AAH34667.1}
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
STRAIN=FVB/N {ECO:0000312|EMBL:AAH34667.1};
TISSUE=Mammary gland {ECO:0000312|EMBL:AAH34667.1};
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
-!- FUNCTION: Associates with Polycomb group (PcG) multiprotein
complexes; the complex class is required to maintain the
transcriptionally repressive state of some genes. {ECO:0000250}.
-!- SUBUNIT: Associates with a PRC1-like complex (By similarity).
Interacts with the SAM domain of PHC1 via its SAM domain in vitro.
{ECO:0000250, ECO:0000269|PubMed:10653359}.
-!- INTERACTION:
O88513:Gmnn; NbExp=2; IntAct=EBI-445955, EBI-445922;
Q64028:Phc1; NbExp=2; IntAct=EBI-445955, EBI-927346;
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=2;
Name=1 {ECO:0000305};
IsoId=Q8K214-1; Sequence=Displayed;
Note=No experimental confirmation available. {ECO:0000305};
Name=2 {ECO:0000269|PubMed:10653359};
IsoId=Q8K214-2; Sequence=VSP_051680, VSP_051681;
-!- TISSUE SPECIFICITY: Most abundant in testis. Moderate levels
detected in heart, brain, lung, liver, skeletal muscle and kidney
and lower levels in spleen. {ECO:0000269|PubMed:10653359}.
-!- DEVELOPMENTAL STAGE: Detected throughout embryogenesis. Expressed
ubiquitously in 8.5 dpc embryos. At 10.5 dpc, strongly expressed
in nervous system including hindbrain and spinal cord, and in the
pharyngeal arches and visceral organs. By 14.5 dpc, strong
expression is detected throughout the central nervous system, and
in tongue, heart, midgut and urogenital regions.
{ECO:0000269|PubMed:10653359}.
-!- INDUCTION: By retinoic acid in F9 and F19 embryonal carcinoma cell
lines. {ECO:0000269|PubMed:10653359}.
-!- SIMILARITY: Belongs to the SCM family. {ECO:0000305}.
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EMBL; AB030906; BAA90554.1; -; mRNA.
EMBL; AL611924; CAM13481.1; -; Genomic_DNA.
EMBL; BC034667; AAH34667.1; -; mRNA.
CCDS; CCDS18589.1; -. [Q8K214-2]
CCDS; CCDS51292.1; -. [Q8K214-1]
RefSeq; NP_001153102.1; NM_001159630.1. [Q8K214-1]
RefSeq; NP_038911.1; NM_013883.2. [Q8K214-2]
RefSeq; XP_011238853.1; XM_011240551.1. [Q8K214-2]
RefSeq; XP_017175741.1; XM_017320252.1. [Q8K214-2]
RefSeq; XP_017175742.1; XM_017320253.1. [Q8K214-2]
UniGene; Mm.427014; -.
ProteinModelPortal; Q8K214; -.
SMR; Q8K214; -.
BioGrid; 205936; 5.
DIP; DIP-32567N; -.
IntAct; Q8K214; 5.
MINT; MINT-1172327; -.
STRING; 10090.ENSMUSP00000069813; -.
iPTMnet; Q8K214; -.
PhosphoSitePlus; Q8K214; -.
PaxDb; Q8K214; -.
PeptideAtlas; Q8K214; -.
PRIDE; Q8K214; -.
Ensembl; ENSMUST00000000087; ENSMUSP00000000087; ENSMUSG00000000085. [Q8K214-2]
Ensembl; ENSMUST00000064991; ENSMUSP00000069813; ENSMUSG00000000085. [Q8K214-1]
Ensembl; ENSMUST00000106298; ENSMUSP00000101905; ENSMUSG00000000085. [Q8K214-2]
Ensembl; ENSMUST00000106301; ENSMUSP00000101908; ENSMUSG00000000085. [Q8K214-1]
GeneID; 29871; -.
KEGG; mmu:29871; -.
UCSC; uc008und.2; mouse. [Q8K214-2]
UCSC; uc008une.2; mouse. [Q8K214-1]
CTD; 22955; -.
MGI; MGI:1352762; Scmh1.
eggNOG; ENOG410IMEZ; Eukaryota.
eggNOG; ENOG410XPKI; LUCA.
GeneTree; ENSGT00760000119024; -.
HOGENOM; HOG000236280; -.
HOVERGEN; HBG056406; -.
InParanoid; Q8K214; -.
KO; K11461; -.
OMA; KILNNAM; -.
OrthoDB; EOG091G05BW; -.
PhylomeDB; Q8K214; -.
TreeFam; TF106488; -.
Reactome; R-MMU-2559580; Oxidative Stress Induced Senescence.
Reactome; R-MMU-3108214; SUMOylation of DNA damage response and repair proteins.
Reactome; R-MMU-4551638; SUMOylation of chromatin organization proteins.
Reactome; R-MMU-8939243; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known.
Reactome; R-MMU-8943724; Regulation of PTEN gene transcription.
ChiTaRS; Scmh1; mouse.
PRO; PR:Q8K214; -.
Proteomes; UP000000589; Chromosome 4.
Bgee; ENSMUSG00000000085; -.
CleanEx; MM_SCMH1; -.
ExpressionAtlas; Q8K214; baseline and differential.
Genevisible; Q8K214; MM.
GO; GO:0010369; C:chromocenter; IDA:MGI.
GO; GO:0005634; C:nucleus; IDA:MGI.
GO; GO:0009952; P:anterior/posterior pattern specification; IMP:MGI.
GO; GO:0006338; P:chromatin remodeling; IMP:MGI.
GO; GO:0016458; P:gene silencing; ISS:UniProtKB.
GO; GO:0045892; P:negative regulation of transcription, DNA-templated; NAS:UniProtKB.
GO; GO:0007283; P:spermatogenesis; IMP:MGI.
GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
InterPro; IPR004092; Mbt.
InterPro; IPR001660; SAM.
InterPro; IPR013761; SAM/pointed_sf.
InterPro; IPR033763; SCML2_RBR.
InterPro; IPR021987; SLED.
Pfam; PF02820; MBT; 2.
Pfam; PF17208; RBR; 1.
Pfam; PF00536; SAM_1; 1.
Pfam; PF12140; SLED; 1.
SMART; SM00561; MBT; 2.
SMART; SM00454; SAM; 1.
SUPFAM; SSF47769; SSF47769; 1.
PROSITE; PS51079; MBT; 2.
PROSITE; PS50105; SAM_DOMAIN; 1.
1: Evidence at protein level;
Alternative splicing; Complete proteome; Developmental protein;
Nucleus; Reference proteome; Repeat; Repressor; Transcription;
Transcription regulation.
CHAIN 1 706 Polycomb protein SCMH1.
/FTId=PRO_0000114335.
REPEAT 28 126 MBT 1.
REPEAT 134 235 MBT 2.
DOMAIN 597 662 SAM. {ECO:0000255|PROSITE-
ProRule:PRU00184}.
VAR_SEQ 662 664 VFW -> GKF (in isoform 2).
{ECO:0000303|PubMed:10653359}.
/FTId=VSP_051680.
VAR_SEQ 665 706 Missing (in isoform 2).
{ECO:0000303|PubMed:10653359}.
/FTId=VSP_051681.
SEQUENCE 706 AA; 78669 MW; CC7531B46A439E39 CRC64;
MLVCYSVLAC ESLWDLPCSI MGSPLGHFTW DKYLKETCSV PAPVHCFKQS YTPPSNEFKI
SMKLEAQDPR NTTSTCIATV VGLTGARLRL RLDGSDNKND FWRLVDSSEI QPIGNCEKNG
GMLQPPLGFR LNASSWPMFL LKTLNGAEMA PIKIFHKEPP SPSHNFFKMG MKLEAVDRKN
PHFICPATIG EVRGAEVLVT FDGWRGAFDY WCRFDSRDIF PVGWCSLTGD NLQPPGTKVV
IPKNPSPSSD VSTEKPSIHS TKTVLEHQPG QRGRKPGKKR GRTPKILIPH PTSTPSKSAE
PLKFPKKRGP KPGSKRKPRT LLSPPPTSPT TSTPEPDTST VPQDAATVPS SAMQAPTVCI
YLNKSGSTGP HLDKKKIQQL PDHFGPARAS VVLQQAVQAC IDCAYHQKTV FSFLKQGHGG
EVISAVFDRE QHTLNLPAVN SITYVLRFLE KLCHNLRSDN LFGNQPFTQT HLSLTATEYN
HNHDRYLPGE TFVLGNSLAR SLETHSDLMD SALKPANLVS TSQNLRTPGY RPLLPSCGLP
LSTVSAVRRL CSKGVLKGKK ERRDVESFWK LNHSPGSDRH LESRDPPRLS GRDPSSWTVE
DVMQFVREAD PQLGSHADLF RKHEIDGKAL LLLRSDMMMK YMGLKLGPAL KLSFHIDRLK
QVFWKRETIL WSREGLSREV WPISEDTALG HFFSGMDKVF GSLSKR


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