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Polycomb protein mes-3 (Maternal-effect sterile protein 3)

 MES3_CAEEL              Reviewed;         754 AA.
Q10665; P91324;
01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
28-MAR-2003, sequence version 2.
23-MAY-2018, entry version 112.
RecName: Full=Polycomb protein mes-3;
AltName: Full=Maternal-effect sterile protein 3;
Name=mes-3; ORFNames=F54C1.3;
Caenorhabditis elegans.
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis.
NCBI_TaxID=6239;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=Bristol N2;
PubMed=8601481;
Paulsen J.E., Capowski E.E., Strome S.;
"Phenotypic and molecular analysis of mes-3, a maternal-effect gene
required for proliferation and viability of the germ line in C.
elegans.";
Genetics 141:1383-1398(1995).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Bristol N2;
PubMed=9851916; DOI=10.1126/science.282.5396.2012;
The C. elegans sequencing consortium;
"Genome sequence of the nematode C. elegans: a platform for
investigating biology.";
Science 282:2012-2018(1998).
[3]
CHARACTERIZATION, DEVELOPMENTAL STAGE, AND MUTAGENESIS OF CYS-283.
PubMed=11729149;
Xu L., Paulsen J., Yoo Y., Goodwin E.B., Strome S.;
"Caenorhabditis elegans MES-3 is a target of GLD-1 and functions
epigenetically in germline development.";
Genetics 159:1007-1017(2001).
[4]
IDENTIFICATION IN A COMPLEX WITH MES-2 AND MES-6.
PubMed=11320248; DOI=10.1073/pnas.081016198;
Xu L., Fong Y., Strome S.;
"The Caenorhabditis elegans maternal-effect sterile proteins, MES-2,
MES-3, and MES-6, are associated in a complex in embryos.";
Proc. Natl. Acad. Sci. U.S.A. 98:5061-5066(2001).
[5]
FUNCTION.
PubMed=12077420; DOI=10.1126/science.1070790;
Fong Y., Bender L., Wang W., Strome S.;
"Regulation of the different chromatin states of autosomes and X
chromosomes in the germ line of C. elegans.";
Science 296:2235-2238(2002).
[6]
FUNCTION, AND IDENTIFICATION IN A COMPLEX WITH MES-2 AND MES-6.
PubMed=15380065; DOI=10.1016/j.cub.2004.08.062;
Bender L.B., Cao R., Zhang Y., Strome S.;
"The MES-2/MES-3/MES-6 complex and regulation of histone H3
methylation in C. elegans.";
Curr. Biol. 14:1639-1643(2004).
-!- FUNCTION: Component of a Polycomb group (PcG) complex. PcG
proteins act by forming multiprotein complexes, which are required
to maintain the transcriptionally repressive state of homeotic
genes throughout development. PcG proteins are not required to
initiate repression, but to maintain it during later stages of
development. The mes-2/mes-3/mes-6 complex may participate in the
global inactivation of the X chromosomes in germline cells. The
complex may act via methylation of histone H3 'Lys-27', rendering
chromatin heritably changed in its expressibility. This complex is
required to exclude mes-4 from the inactivated X-chromosomes in
germline cells. {ECO:0000269|PubMed:12077420,
ECO:0000269|PubMed:15380065}.
-!- SUBUNIT: Forms a heterotrimeric complex with the Polycomb proteins
mes-2 and mes-3. Does not interact with mes-4.
{ECO:0000269|PubMed:11320248, ECO:0000269|PubMed:15380065}.
-!- SUBCELLULAR LOCATION: Nucleus.
-!- TISSUE SPECIFICITY: In adults, it is predominantly expressed in
the germline, and weakly expressed in intestinal cells.
-!- DEVELOPMENTAL STAGE: Expressed maternally and zygotically.
Expressed in all cells of early embryos. In late embryos and L1
larva, it is weakly expressed, mainly in Z2 and Z3 cells.
{ECO:0000269|PubMed:11729149}.
-!- INDUCTION: Repressed by GLD-1, which associates with the 3'-UTR of
the mRNA and prevents its translation.
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EMBL; U34812; AAB01719.1; -; mRNA.
EMBL; FO080890; CCD67544.1; -; Genomic_DNA.
PIR; G87767; G87767.
PIR; S60464; S60464.
RefSeq; NP_001021492.1; NM_001026321.2.
UniGene; Cel.5859; -.
ProteinModelPortal; Q10665; -.
SMR; Q10665; -.
BioGrid; 37584; 7.
IntAct; Q10665; 2.
STRING; 6239.F54C1.3a; -.
iPTMnet; Q10665; -.
PaxDb; Q10665; -.
PRIDE; Q10665; -.
EnsemblMetazoa; F54C1.3a; F54C1.3a; WBGene00003221.
GeneID; 172123; -.
KEGG; cel:CELE_F54C1.3; -.
UCSC; F54C1.3a; c. elegans.
CTD; 172123; -.
WormBase; F54C1.3a; CE11046; WBGene00003221; mes-3.
eggNOG; ENOG410KAGE; Eukaryota.
eggNOG; ENOG4110I9Z; LUCA.
InParanoid; Q10665; -.
OMA; MFEKQVQ; -.
OrthoDB; EOG091G0QUQ; -.
PRO; PR:Q10665; -.
Proteomes; UP000001940; Chromosome I.
Bgee; WBGene00003221; -.
ExpressionAtlas; Q10665; baseline and differential.
GO; GO:0000786; C:nucleosome; IDA:WormBase.
GO; GO:0005634; C:nucleus; IDA:WormBase.
GO; GO:0031519; C:PcG protein complex; IPI:WormBase.
GO; GO:0070734; P:histone H3-K27 methylation; IMP:WormBase.
GO; GO:0016571; P:histone methylation; IDA:WormBase.
GO; GO:0007275; P:multicellular organism development; IEA:UniProtKB-KW.
GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:UniProtKB-KW.
GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
1: Evidence at protein level;
Complete proteome; Developmental protein; Nucleus; Reference proteome;
Repressor; Transcription; Transcription regulation.
CHAIN 1 754 Polycomb protein mes-3.
/FTId=PRO_0000096439.
MUTAGEN 283 283 C->Y: In BN21; temperature-sensitive
allele, which produces fertile progeny at
permissive temperature (16 degrees
Celsius) and sterile progeny at
restrictive temperature (25 degrees
Celsius), probably due to a mislocation
into the cytoplasm.
{ECO:0000269|PubMed:11729149}.
CONFLICT 264 264 A -> V (in Ref. 1; AAB01719).
{ECO:0000305}.
SEQUENCE 754 AA; 86305 MW; B7B3EFCFAC0FA512 CRC64;
MTPATAEVKV GGRKRKNDEP VFIKTKQSRS ARREEEKENL LNKSLPSTPT SSEAGSSRES
SNPVTSSSRR KNPPTKLENI QKTLPTCSDG LEIRNYVKKY GLPEDNKFLV RNVFDKQLLF
GKKYVCRRRV IKSIDEFFPR LKTDAHRENG LYNFCTLQFM KISSWGSSMD EKIYVTSAAI
VQSYVIIVDD NDSVTCIENG ISVIPMANRT LPSISYNSSN VKNITLTGPE LKKAKNVYLA
VIVKRKTPKL GENRVGTRGK STRASFETAA SSENFQQLVR FGCTLMYDKD AEINCLNDGV
QRIILLDREE KPAYLKIFGK ADEPELENAW MNNVKHLEFI SDTNYNKEDS HLARLIFSSN
THNYFDRPDI SKFSPWQPRS RRTTLKSGIS VEPGTSCDED CGSQYEDTIT LKQLLLGTKK
LCGRRKRHLT RLTSRWPCFS VDPTKINSYF NETGVTLLEN SCSYRPGTQR SIPIKPTRVI
RVREETPVSV PIEVITIEDD SDDSPCFSAR NRAPGGTRKY GLDFIQSSGH MPYIRYVYMN
RANDLVPQLN GEENGKIEGL MEAYPMNNAH MYSDIEFLRK EKLNLPKNAQ KYGEMTILDY
PLTKTETDEY NKKMSVMNVK DFAVKPRKPI PTVGNTTLSL DLEGCPISTF SEIFFPSGKT
ELFNILCRHF YSEAGQRPGC FSAQWKSRVL TGFINKYHQY IFDMKLNSLF EKQINLIAMV
SPDWKLEDFE LPMVRYKQLK KEWKNRQRDI PSSN


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