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Polycomb protein mes-6 (ESC homolog) (Maternal-effect sterile protein 6)

 MES6_CAEEL              Reviewed;         459 AA.
Q9GYS1; O16187;
28-MAR-2003, integrated into UniProtKB/Swiss-Prot.
24-MAY-2005, sequence version 2.
05-DEC-2018, entry version 136.
RecName: Full=Polycomb protein mes-6;
AltName: Full=ESC homolog;
AltName: Full=Maternal-effect sterile protein 6;
Name=mes-6; ORFNames=C09G4.5;
Caenorhabditis elegans.
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
Caenorhabditis.
NCBI_TaxID=6239;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA], CHARACTERIZATION, DEVELOPMENTAL
STAGE, AND MUTAGENESIS OF GLY-188.
STRAIN=Bristol N2;
PubMed=9609830;
Korf I., Fan Y., Strome S.;
"The polycomb group in Caenorhabditis elegans and maternal control of
germline development.";
Development 125:2469-2478(1998).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Bristol N2;
PubMed=9851916; DOI=10.1126/science.282.5396.2012;
The C. elegans sequencing consortium;
"Genome sequence of the nematode C. elegans: a platform for
investigating biology.";
Science 282:2012-2018(1998).
[3]
IDENTIFICATION IN A COMPLEX WITH MES-2 AND MES-3.
PubMed=11320248; DOI=10.1073/pnas.081016198;
Xu L., Fong Y., Strome S.;
"The Caenorhabditis elegans maternal-effect sterile proteins, MES-2,
MES-3, and MES-6, are associated in a complex in embryos.";
Proc. Natl. Acad. Sci. U.S.A. 98:5061-5066(2001).
[4]
FUNCTION.
PubMed=12077420; DOI=10.1126/science.1070790;
Fong Y., Bender L., Wang W., Strome S.;
"Regulation of the different chromatin states of autosomes and X
chromosomes in the germ line of C. elegans.";
Science 296:2235-2238(2002).
[5]
FUNCTION, AND IDENTIFICATION IN A COMPLEX WITH MES-2 AND MES-3.
PubMed=15380065; DOI=10.1016/j.cub.2004.08.062;
Bender L.B., Cao R., Zhang Y., Strome S.;
"The MES-2/MES-3/MES-6 complex and regulation of histone H3
methylation in C. elegans.";
Curr. Biol. 14:1639-1643(2004).
[6]
FUNCTION.
PubMed=26365259; DOI=10.1016/j.cub.2015.07.051;
Mao H., Zhu C., Zong D., Weng C., Yang X., Huang H., Liu D., Feng X.,
Guang S.;
"The Nrde pathway mediates small-RNA-directed histone H3 lysine 27
trimethylation in Caenorhabditis elegans.";
Curr. Biol. 25:2398-2403(2015).
-!- FUNCTION: Polycomb group (PcG) protein. PcG proteins act by
forming multiprotein complexes, which are required to maintain the
transcriptionally repressive state of homeotic genes throughout
development. PcG proteins are not required to initiate repression,
but to maintain it during later stages of development. The mes-
2/mes-3/mes-6 complex may participate in the global inactivation
of the X chromosomes in germline cells. The complex may act via
methylation of histone H3 'Lys-27', rendering chromatin heritably
changed in its expressibility. This complex is required to exclude
mes-4 from the inactivated X-chromosomes in germline cells
(PubMed:12077420, PubMed:15380065). Required for small-RNA-induced
H3K27 trimethylation (PubMed:26365259).
{ECO:0000269|PubMed:12077420, ECO:0000269|PubMed:15380065,
ECO:0000269|PubMed:26365259}.
-!- SUBUNIT: Interacts directly with the N-terminal domain of mes-2.
Forms a heterotrimeric complex with mes-2 and mes-3. Does not
interact with mes-4. {ECO:0000269|PubMed:11320248,
ECO:0000269|PubMed:15380065}.
-!- INTERACTION:
O17514:mes-2; NbExp=5; IntAct=EBI-314965, EBI-11615731;
-!- SUBCELLULAR LOCATION: Nucleus.
-!- TISSUE SPECIFICITY: In adults, it is predominantly expressed in
the germline, and weakly expressed in intestinal cells.
-!- DEVELOPMENTAL STAGE: Expressed both maternally and zygotically.
Expressed in all cells of early embryos. In late embryos and L1
larva, it is weakly expressed. {ECO:0000269|PubMed:9609830}.
-!- SIMILARITY: Belongs to the WD repeat ESC family. {ECO:0000305}.
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EMBL; AF016224; AAC27121.1; -; Genomic_DNA.
EMBL; FO080478; CCD64001.1; -; Genomic_DNA.
RefSeq; NP_001021320.1; NM_001026149.4.
UniGene; Cel.9137; -.
ProteinModelPortal; Q9GYS1; -.
BioGrid; 42769; 10.
ComplexPortal; CPX-368; Polycomb Repressive Complex 2.
IntAct; Q9GYS1; 2.
STRING; 6239.C09G4.5; -.
EPD; Q9GYS1; -.
PaxDb; Q9GYS1; -.
PeptideAtlas; Q9GYS1; -.
PRIDE; Q9GYS1; -.
EnsemblMetazoa; C09G4.5; C09G4.5; WBGene00003224.
GeneID; 177657; -.
KEGG; cel:CELE_C09G4.5; -.
UCSC; C09G4.5; c. elegans.
CTD; 177657; -.
WormBase; C09G4.5; CE24796; WBGene00003224; mes-6.
eggNOG; KOG1034; Eukaryota.
eggNOG; ENOG410XRQI; LUCA.
GeneTree; ENSGT00510000047334; -.
HOGENOM; HOG000020629; -.
InParanoid; Q9GYS1; -.
KO; K11462; -.
OMA; HVCIAIF; -.
OrthoDB; EOG091G082Z; -.
PhylomeDB; Q9GYS1; -.
Reactome; R-CEL-212300; PRC2 methylates histones and DNA.
Reactome; R-CEL-2559580; Oxidative Stress Induced Senescence.
Reactome; R-CEL-8943724; Regulation of PTEN gene transcription.
Reactome; R-CEL-8953750; Transcriptional Regulation by E2F6.
SignaLink; Q9GYS1; -.
PRO; PR:Q9GYS1; -.
Proteomes; UP000001940; Chromosome IV.
Bgee; WBGene00003224; Expressed in 3 organ(s), highest expression level in multi-cellular organism.
GO; GO:0035098; C:ESC/E(Z) complex; IBA:GO_Central.
GO; GO:0000786; C:nucleosome; IDA:WormBase.
GO; GO:0031519; C:PcG protein complex; IPI:WormBase.
GO; GO:0006342; P:chromatin silencing; IBA:GO_Central.
GO; GO:0070734; P:histone H3-K27 methylation; IMP:WormBase.
GO; GO:0016571; P:histone methylation; IDA:WormBase.
GO; GO:0007275; P:multicellular organism development; IEA:UniProtKB-KW.
GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IBA:GO_Central.
InterPro; IPR037352; Polycomb_EED.
InterPro; IPR001680; WD40_repeat.
InterPro; IPR017986; WD40_repeat_dom.
InterPro; IPR036322; WD40_repeat_dom_sf.
PANTHER; PTHR10253; PTHR10253; 1.
Pfam; PF00400; WD40; 1.
SMART; SM00320; WD40; 4.
SUPFAM; SSF50978; SSF50978; 1.
PROSITE; PS50082; WD_REPEATS_2; 1.
PROSITE; PS50294; WD_REPEATS_REGION; 1.
1: Evidence at protein level;
Complete proteome; Developmental protein; Nucleus; Reference proteome;
Repeat; Repressor; Transcription; Transcription regulation; WD repeat.
CHAIN 1 459 Polycomb protein mes-6.
/FTId=PRO_0000051076.
REPEAT 146 186 WD 1.
REPEAT 192 231 WD 2.
REPEAT 305 346 WD 3.
REPEAT 370 409 WD 4.
REPEAT 415 454 WD 5.
MUTAGEN 188 188 G->E: In BN66; maternal-effect mutation.
Progeny show defects in gonad
proliferation. Germ cell degeneration.
{ECO:0000269|PubMed:9609830}.
SEQUENCE 459 AA; 51823 MW; 0524A674ABAB2671 CRC64;
MEHTKKFKSL NLHGFDRSTE DYGKRPFVLT AKLLEDQKKA IYGCAFNQYA GIDEEQAVAT
VGGSFLHMYS VPIDINNIEL QWSCNFPTDK SSKVEREESL FTVTWCYDTY EAENDRNPFK
VVTGGTLGHI YVIDYVSRKL SNRLRSVGWE INDIRTCPAN SNLIVCASSD QSIRIHHIRN
EACLIVIGGL ECHAGTILSV DWSTDGDFIL SCGFDHQLME WDLSVKQVKE HLERACKALH
QDKINVLTQS QDIPYVSKGT MRKSAVSRNI PDKEEDQLLE LHRELIPRPS CLLPIYTPSS
VSTDMHSDYV DCIRFLIGTN YALSKGCGNE KAIHFWRFGP PKGEVENRIH GNVLRPKSCT
TKFRTMNVPS GSAWFIKFAV DPRRRWLVCG GAGGSVMFFD LRNNEETNPT HTCSVGSRTV
RQASFSTCGR FLVLVTDEGF VCRFDRVSAS VDAKDLAKF


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