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Polymerase

 B6S1Z1_RVFV             Unreviewed;      2092 AA.
B6S1Z1;
16-DEC-2008, integrated into UniProtKB/TrEMBL.
16-DEC-2008, sequence version 1.
25-OCT-2017, entry version 32.
SubName: Full=Polymerase {ECO:0000313|EMBL:ACE78347.1};
Rift valley fever virus (RVFV).
Viruses; ssRNA viruses; ssRNA negative-strand viruses; Bunyavirales;
Phenuiviridae; Phlebovirus.
NCBI_TaxID=11588 {ECO:0000313|EMBL:ACE78347.1, ECO:0000313|Proteomes:UP000145054};
NCBI_TaxID=7158; Aedes.
NCBI_TaxID=9913; Bos taurus (Bovine).
NCBI_TaxID=297284; Bos taurus x Bison bison (beefalo).
NCBI_TaxID=9837; Camelus bactrianus (Bactrian camel).
NCBI_TaxID=9925; Capra hircus (Goat).
NCBI_TaxID=9606; Homo sapiens (Human).
NCBI_TaxID=9940; Ovis aries (Sheep).
NCBI_TaxID=29031; Phlebotomus papatasi (Sandfly).
[1] {ECO:0000313|EMBL:ACE78347.1, ECO:0000313|Proteomes:UP000145054}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=2007002820 {ECO:0000313|EMBL:ACE78347.1};
PubMed=18786992; DOI=10.1128/JVI.01519-08;
Bird B.H., Githinji J.W., Macharia J.M., Kasiiti J.L., Muriithi R.M.,
Gacheru S.G., Musaa J.O., Towner J.S., Reeder S.A., Oliver J.B.,
Stevens T.L., Erickson B.R., Morgan L.T., Khristova M.L.,
Hartman A.L., Comer J.A., Rollin P.E., Ksiazek T.G., Nichol S.T.;
"Multiple virus lineages sharing recent common ancestry were
associated with a Large Rift Valley fever outbreak among livestock in
Kenya during 2006-2007.";
J. Virol. 82:11152-11166(2008).
-!- CATALYTIC ACTIVITY: Nucleoside triphosphate + RNA(n) = diphosphate
+ RNA(n+1). {ECO:0000256|SAAS:SAAS00605060}.
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EMBL; EU574008; ACE78347.1; -; Genomic_RNA.
Proteomes; UP000145054; Genome.
GO; GO:0001882; F:nucleoside binding; IEA:InterPro.
GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
GO; GO:0003968; F:RNA-directed 5'-3' RNA polymerase activity; IEA:UniProtKB-KW.
GO; GO:0006351; P:transcription, DNA-templated; IEA:InterPro.
GO; GO:0039694; P:viral RNA genome replication; IEA:InterPro.
InterPro; IPR022531; DUF3770.
InterPro; IPR029124; L_protein_N.
InterPro; IPR007099; RNA-dir_pol_NSvirus.
InterPro; IPR014385; RNA-dir_pol_phlebovirus.
InterPro; IPR007322; RNA_pol_bunyavir.
Pfam; PF04196; Bunya_RdRp; 1.
Pfam; PF12603; DUF3770; 1.
Pfam; PF15518; L_protein_N; 1.
PIRSF; PIRSF000826; L_PhleboV; 1.
PROSITE; PS50525; RDRP_SSRNA_NEG_SEG; 1.
4: Predicted;
Complete proteome {ECO:0000313|Proteomes:UP000145054};
Nucleotide-binding {ECO:0000256|SAAS:SAAS00605058};
Nucleotidyltransferase {ECO:0000256|SAAS:SAAS00605053};
RNA-directed RNA polymerase {ECO:0000256|SAAS:SAAS00605053};
Transferase {ECO:0000256|SAAS:SAAS00605053};
Viral RNA replication {ECO:0000256|SAAS:SAAS00605045}.
DOMAIN 975 1166 RdRp catalytic.
{ECO:0000259|PROSITE:PS50525}.
SEQUENCE 2092 AA; 238014 MW; 9154C1DE4877189E CRC64;
MDSILSKQLV DKTGFVRVPI KHYDCTMLTL ALPTFDVSKM VDRITIDFNL DDIQGASEIG
STLLPSMSID VEDMANFVHD FTFGHLADKT DRLLMREFPM MNDGFDHLSP DMIIKTTSGM
YNIVEFTTFR GDERGAFQAA MTKLAKYEVP CENRSQGRTV VLYVVSAYRH GVWSNLELED
SEAEEMVYRY RLALSVMDEL RTLFPELSST DEELGKTERE LLAMVSSIQI NWSVTESVFP
PFSREMFDKF RSSPPDSEYI TRIVSRCLIN SQEKLINNSF FAEGNDKVLR FSKNAEECSL
AIERALNQYR AEDNLRDLND HKSTIQLPPW LSYHDVDGKD LCPLQGLDIR GDHPMCNLWR
EVVTSANLEE IERMHDDAAA ELEFALSGVK DRPDERNRYH RVHLNVGSDD SVYIAALGVN
GKKHKADTLV QQMRNRSKQL FSPDHNVDHI SEFLSACSSD LWATDEDLYN PLSCDKELRL
AAQRIHQPSL SEKGFNEIIT EHYKFMGSRI GSWCQMVSLI GAELSASVKQ HVKPNYFVIK
RLLGSGIFLL IKPTSSKSHI FVSFAIKRSC WAFDLSTSRV FKPYIDAGDL LVTDFVSYKL
SKLTNLCKCV SLMESSFSFW AEAFGIPSWN FVGDLFRSSD SAAMDASYMG KLSLLTLLED
KATTEELQTI ARYIIMEGFV SPPEIPKPHK MTSKFPKVLR SELQVYLLNC LCRTIQRIAG
EPFILKKKDG SISWGGMFNP FSGRPLLDMQ PLISCCYNGY FKNKEEETEP SSLSGMYKKI
IELEHLRPQS DAFLGYKDPE LPRMHEFSVS YLKEACNHAK LVLRSLYGQN FMEQIDNQII
RELSGLTLER LATLKATSNF NENWYVYKDV ADKNYTRDKL LVKMSKYASE GKSLAIQKFE
DCMRQIESQG CMHICLFKKQ QHGGLREIYV MGAEERIVQS VVETIAKSIG KFFASDTLCN
PPNKVKIPET HGIRARKQCK GPVWTCATSD DARKWNQGHF VTKFALMLCE FTSPKWWPLI
IRGCSMFTRK RMMMNLNYLK ILDGHRELDI RDDFVMDLFK AYHGEAEVPW AFKGKTYLET
TTGMMQGILH YTSSLLHTIH QEYIRSLSFK IFNLKVAPEM SKSLVCDMMQ GSDDSSMLIS
FPADDEKVLT RCKVAAAICF RMKKELGVYL AIYPSEKSTA NTDFVMEYNS EFYFHTQHVR
PTIRWIAACC SLPEVETLVA RQEEASNLMT SVTEGGGSFS LAAMIQQAQC TLHYMLMGMG
VSELFLEYKK AVLKWNDPGL GFFLLDNPYA CGLGGFRFNL FKAITRTDLQ KLYAFFMKKV
KGSAARDWAD EDITIPETCS VSPGGALILS SSLKWGSRKK FQKLRDRLNI PENWIELINE
NPEVLYRAPR TGPEILLRIA EKVHSPGVVS SLSSGNAVCK VMASAVYFLS ATIFEDTGRP
EFNFLEDSKY SLLQKMAAYS GFHGFNDMEP EDILFLFPNI EELESLDSIV YNKGEIDIIP
RVNIRDATQT RVTIFNEQKT LRTSPEKLVS DKWFGTQKSR IGKTTFLAEW EKLKKIVKWL
EDTPEATLAH TPLNNHIQVR NFFARMESKP RTVRITGAPV KKRSGVSKIA MVIRDNFSRM
GHLRGVEDLA GFTRSVSAEI LKHFLFCILQ GPYSESYKLQ LIYRVLSSVS NVEIKESDGK
TKTNLIGILQ RFLDGDHVVP IIEEMGAGTV GGFIKRQQSK VVQNKVVYYG VGIWRGFMDG
YQVHLEIEND IGQPPRLRNV TTNCQSSPWD LSIPIRQWAE DMGVTNNQDY SSKSSRGARY
WMHSFRMQGP SKPFGCPVYI IKGDMSDVIR LRKEEVEMKV RGSTLNLYTK HHSHQDLHIL
SYTASDNDLS PGIFKSISDE GVAQALQLFE REPSNCWVRC ESVAPKFISA ILEICEGKRQ
IKGINRTRLS EIVRICSESS LRSKVGSMFS FVANVEEAHD VDYDALMDLM IEDAKNNAFS
HVVNCIELDV SGPYEMESFD ASDVNLFGPA HYKDISSLSM IAHPLMDKFV DYAISKMGRA
SVRKVLETGR CSSKDYDLSK VLFRTLQRPE ESIRIDDLEL YEETDVADDM LG


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