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Polymerase acidic protein

 Q286R9_9INFA            Unreviewed;       716 AA.
Q286R9;
04-APR-2006, integrated into UniProtKB/TrEMBL.
04-APR-2006, sequence version 1.
30-AUG-2017, entry version 34.
RecName: Full=Polymerase acidic protein {ECO:0000256|RuleBase:RU361280, ECO:0000256|SAAS:SAAS00405176};
Name=PA {ECO:0000256|RuleBase:RU361280, ECO:0000313|EMBL:AAZ72957.1};
Influenza A virus (A/duck/Viet Nam/CM-V7/2004(H5N1)).
Viruses; ssRNA viruses; ssRNA negative-strand viruses;
Orthomyxoviridae; Influenzavirus A.
NCBI_TaxID=340003 {ECO:0000313|EMBL:AAZ72957.1};
[1] {ECO:0000313|EMBL:AAZ72957.1}
NUCLEOTIDE SEQUENCE.
STRAIN=A/duck/Viet Nam/CM-V7/2004 {ECO:0000313|EMBL:AAZ72957.1};
Cao V., Hai V.H., Duong L.H., Ngoc N.T., Vu N.P., Hiep N.T.,
Long N.T., Hoa D.M.;
"Genetic characterization of H5N1 influenza viruses from the outbreaks
2005 in Vietnam.";
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
-!- FUNCTION: Plays an essential role in viral RNA transcription and
replication by forming the heterotrimeric polymerase complex
together with PB1 and PB2 subunits. The complex transcribes viral
mRNAs by using a unique mechanism called cap-snatching. It
consists in the hijacking and cleavage of host capped pre-mRNAs.
These short capped RNAs are then used as primers for viral mRNAs.
The PB2 subunit is responsible for the binding of the 5' cap of
cellular pre-mRNAs which are subsequently cleaved after 10-13
nucleotides by the PA subunit that carries the endonuclease
activity. {ECO:0000256|SAAS:SAAS00836215}.
-!- COFACTOR:
Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
Evidence={ECO:0000256|SAAS:SAAS00836355};
-!- SUBUNIT: Influenza RNA polymerase is composed of three subunits:
PB1, PB2 and PA. {ECO:0000256|RuleBase:RU361280}.
-!- SUBCELLULAR LOCATION: Host cytoplasm
{ECO:0000256|SAAS:SAAS00836308}.
-!- SUBCELLULAR LOCATION: Host nucleus
{ECO:0000256|SAAS:SAAS00836205}.
-!- SIMILARITY: Belongs to the influenza viruses PA family.
{ECO:0000256|RuleBase:RU361280, ECO:0000256|SAAS:SAAS00589177}.
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EMBL; DQ138183; AAZ72957.1; -; Genomic_RNA.
GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO; GO:0003723; F:RNA binding; IEA:InterPro.
GO; GO:0003968; F:RNA-directed 5'-3' RNA polymerase activity; IEA:InterPro.
GO; GO:0075526; P:cap snatching; IEA:UniProtKB-KW.
GO; GO:0039523; P:suppression by virus of host RNA polymerase II activity; IEA:UniProtKB-KW.
GO; GO:0006351; P:transcription, DNA-templated; IEA:InterPro.
InterPro; IPR001009; RNA-dir_pol_influenzavirus.
Pfam; PF00603; Flu_PA; 1.
3: Inferred from homology;
Cap snatching {ECO:0000256|SAAS:SAAS00836340};
Endonuclease {ECO:0000256|SAAS:SAAS00836319};
Eukaryotic host gene expression shutoff by virus
{ECO:0000256|SAAS:SAAS00836208};
Eukaryotic host transcription shutoff by virus
{ECO:0000256|SAAS:SAAS00836208};
Host cytoplasm {ECO:0000256|SAAS:SAAS00836347};
Host gene expression shutoff by virus {ECO:0000256|SAAS:SAAS00836208};
Host nucleus {ECO:0000256|SAAS:SAAS00836298};
Host-virus interaction {ECO:0000256|SAAS:SAAS00836208};
Hydrolase {ECO:0000256|SAAS:SAAS00836319};
Inhibition of host RNA polymerase II by virus
{ECO:0000256|SAAS:SAAS00836208};
Manganese {ECO:0000256|SAAS:SAAS00836185};
Metal-binding {ECO:0000256|SAAS:SAAS00836270};
Nuclease {ECO:0000256|SAAS:SAAS00836319};
Ribosomal frameshifting {ECO:0000256|SAAS:SAAS00836323}.
SEQUENCE 716 AA; 82534 MW; E5922F26287ED030 CRC64;
MEDFVRQCFN PMIVELAEKA MKEYGEDPKI ETNKFAAICT HLEVCFMYSD FHFIDERSES
IIVESGDPNA LLKHRFEIIE GRDRTMAWTV VNSICNTTGV EKPKFLPDLY DYKENRFIEI
GVTRREVHTY YLEKANKIKS EKTHIHIFSF TGEEMATKAD YTLDEESRAR IKTRLFTIRQ
EMASRGLWDS FRQSERGEET IEEKFEITGT MRRLADQSLP PNFSSLENFR AYVDGFEPNG
CIEGKLSQMS KEVNARIEPF LKTTPRPLRL PDGPPCSQRS KFLLMDALKL SIEDPSHEGE
GIPLYDAIKC MKTFFGWKEP NIVKPHEKGI NPNYLLAWKQ VLAELQDIEN EEKIPKTKNM
KKTSQLKWTL GENMAPEKVD FEDCKDVSDL RQYDSDEPES RSLASWIQSE FNKACELTDS
SWIELDEIGE DVAPIEHIAS MRRNYFTAEV SHCRATEYIM KGVYINTALL NASCAAMDDF
QLIPMMSKCR TKEGRRKTNL YGFIIKGRSH LRNDTDVVNF VSMEFSLTDP RLEPHKWEKY
CVLEIGDMLL RTAVGQVSRP MFLYVRTNGT SKIKMKWGME MRRCLLQSLQ QIESMIEAES
SVKEKDMTKE FFENKSETWP IGESPKGVEE GSIGKVCRTL LAKSVFNSLY ASPQLEGFSA
ESRKLLLIVQ ALRDNLEPGT FDLGGLYEAI EECLINDPWV LLNASWFNSF LAHALK


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