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Polymerase basic protein 2

 Q10UL6_9INFA            Unreviewed;       759 AA.
Q10UL6;
22-AUG-2006, integrated into UniProtKB/TrEMBL.
22-AUG-2006, sequence version 1.
22-NOV-2017, entry version 56.
RecName: Full=Polymerase basic protein 2 {ECO:0000256|RuleBase:RU361246, ECO:0000256|SAAS:SAAS00943514};
Name=PB2 {ECO:0000256|RuleBase:RU361246, ECO:0000313|EMBL:ABG47883.1};
Influenza A virus (A/New York/684/1995(H3N2)).
Viruses; ssRNA viruses; ssRNA negative-strand viruses;
Orthomyxoviridae; Influenzavirus A.
NCBI_TaxID=383025 {ECO:0000313|EMBL:ABG47883.1};
[1] {ECO:0000313|EMBL:ABG47883.1}
NUCLEOTIDE SEQUENCE.
STRAIN=A/New York/684/1995 {ECO:0000313|EMBL:ABG47883.1};
The NIAID Influenza Genome Sequencing Consortium;
Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases.
[2] {ECO:0000313|EMBL:ABG47883.1}
NUCLEOTIDE SEQUENCE.
STRAIN=A/New York/684/1995 {ECO:0000313|EMBL:ABG47883.1};
Ghedin E., Miller N., Zaborsky J., Feldblyum T., Subbu V., Shumway M.,
Sitz J., Kosack D., Koo H., Salzberg S.L., Griesemer S., StGeorge K.,
Bennett R., Taylor J., Bao Y., Bolotov P., Dernovoy D., Lipman D.J.,
Tatusova T.;
"The NIAID Influenza Genome Sequencing Project.";
Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
-!- SUBCELLULAR LOCATION: Host nucleus
{ECO:0000256|SAAS:SAAS00943502}.
-!- SIMILARITY: Belongs to the influenza viruses PB2 family.
{ECO:0000256|RuleBase:RU361246, ECO:0000256|SAAS:SAAS00943527}.
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EMBL; CY011831; ABG47883.1; -; Genomic_RNA.
GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
GO; GO:0019012; C:virion; IEA:UniProtKB-KW.
GO; GO:0003723; F:RNA binding; IEA:InterPro.
GO; GO:0003968; F:RNA-directed 5'-3' RNA polymerase activity; IEA:InterPro.
GO; GO:0006370; P:7-methylguanosine mRNA capping; IEA:UniProtKB-KW.
GO; GO:0075526; P:cap snatching; IEA:UniProtKB-KW.
GO; GO:0039523; P:suppression by virus of host RNA polymerase II activity; IEA:UniProtKB-KW.
GO; GO:0006351; P:transcription, DNA-templated; IEA:InterPro.
InterPro; IPR037258; PDB2_C.
InterPro; IPR001591; RNA_pol_PB2_orthomyxovir.
Pfam; PF00604; Flu_PB2; 1.
ProDom; PD001667; RNA_pol_PB2_orthomyxovir; 1.
SUPFAM; SSF160453; SSF160453; 1.
3: Inferred from homology;
Cap snatching {ECO:0000256|SAAS:SAAS00943529};
Eukaryotic host gene expression shutoff by virus
{ECO:0000256|SAAS:SAAS00943508};
Eukaryotic host transcription shutoff by virus
{ECO:0000256|SAAS:SAAS00943508};
Host gene expression shutoff by virus {ECO:0000256|SAAS:SAAS00943508};
Host nucleus {ECO:0000256|RuleBase:RU361246,
ECO:0000256|SAAS:SAAS00943496};
Host-virus interaction {ECO:0000256|SAAS:SAAS00943508};
Inhibition of host RNA polymerase II by virus
{ECO:0000256|SAAS:SAAS00943508};
mRNA capping {ECO:0000256|RuleBase:RU361246,
ECO:0000256|SAAS:SAAS00943498};
mRNA processing {ECO:0000256|RuleBase:RU361246,
ECO:0000256|SAAS:SAAS00943498};
Viral transcription {ECO:0000256|SAAS:SAAS00943507};
Virion {ECO:0000256|RuleBase:RU361246, ECO:0000256|SAAS:SAAS00943495}.
SEQUENCE 759 AA; 86073 MW; 64051DD22A1728B5 CRC64;
MERIKELRNL MSQSRTREIL TKTTVDHMAI IKKYTSGRQE KNPSLRMKWM MAMKYPITAD
KRITEMVPER NEQGQTLWSK MSDAGSDRVM VSPLAVTWWN RNGPVTNTVH YPKVYKTYFD
KVERLKHGTF GPVHFRNQVK IRRRVDINPG HADLSAKEAQ DVIMEVVFPN EVGARILTSE
SQLTITKEKK EELRDCKISP LMVAYMLERE LVRKTRFLPV AGGTSSIYIE VLHLTQGTCW
EQMYTPGGEV RNDDVDQSLI IAARNIVRRA AVSADPLASL LEMCHSTQIG GTRMVDILRQ
NPTEEQAVDI CKAAMGLRIS SSFSFGGFTF KRTSGSSVKK EEEMLTGNLQ TLKIRVHEGY
EEFTMVGKRA TAILRKATRR LVQLIVSGRD EQSIAEAIIV AMVFSQEDCM IKAVRGDLNF
VNRANQRLNP MHQLLRHFQK DAKVLFQNWG IEHIDNVMGM VGVLPDMTPS TEMSMRGIRV
SKMGVDEYSS TERVVVSIDR FLRVRDQRGN VLLSPEEVSE TQGTERLTIT YSSSMMWEIN
GPESVLVNTY QWIIRNWETV KIQWSQNPAM LYNKMEFEPF QSLVPKAIRG QYSGFVRALF
QQMRDVLGTF DTTQIIKLLP FAAAPPKQSR MQFSSLTVNV RGSGMRILVR GNSPVFNYNK
TTKRLTILGK DAGTLTEDPD ESTSGVESAV LRGFLILGKE DRRYGPALSI NELSNLAKGE
KANVLIGQGD VVLVMKRKRD SSILTDSQTA TKRIRMAIN


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