Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Polypeptide N-acetylgalactosaminyltransferase 11 (EC 2.4.1.41) (Polypeptide GalNAc transferase 11) (GalNAc-T11) (pp-GaNTase 11) (Protein-UDP acetylgalactosaminyltransferase 11) (UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 11)

 GLT11_XENTR             Reviewed;         601 AA.
Q6DJR8;
22-JAN-2014, integrated into UniProtKB/Swiss-Prot.
22-JAN-2014, sequence version 2.
25-OCT-2017, entry version 77.
RecName: Full=Polypeptide N-acetylgalactosaminyltransferase 11;
EC=2.4.1.41;
AltName: Full=Polypeptide GalNAc transferase 11;
Short=GalNAc-T11;
Short=pp-GaNTase 11;
AltName: Full=Protein-UDP acetylgalactosaminyltransferase 11;
AltName: Full=UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 11;
Name=galnt11;
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus;
Silurana.
NCBI_TaxID=8364;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Embryo;
NIH - Xenopus Gene Collection (XGC) project;
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
[2]
FUNCTION, DISRUPTION PHENOTYPE, AND INTERACTION WITH NOTCH1.
PubMed=24226769; DOI=10.1038/nature12723;
Boskovski M.T., Yuan S., Pedersen N.B., Goth C.K., Makova S.,
Clausen H., Brueckner M., Khokha M.K.;
"The heterotaxy gene GALNT11 glycosylates Notch to orchestrate cilia
type and laterality.";
Nature 504:456-459(2013).
-!- FUNCTION: Polypeptide N-acetylgalactosaminyltransferase that
catalyzes the initiation of protein O-linked glycosylation and is
involved in left/right asymmetry by mediating O-glycosylation of
NOTCH1. O-glycosylation of NOTCH1 promotes activation of NOTCH1,
modulating the balance between motile and immotile (sensory) cilia
at the left-right organiser (LRO). Polypeptide N-
acetylgalactosaminyltransferases catalyze the transfer of an N-
acetyl-D-galactosamine residue to a serine or threonine residue on
the protein receptor. {ECO:0000269|PubMed:24226769}.
-!- CATALYTIC ACTIVITY: UDP-N-acetyl-alpha-D-galactosamine +
polypeptide = UDP + N-acetyl-alpha-D-galactosaminyl-polypeptide.
-!- COFACTOR:
Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000250};
-!- COFACTOR:
Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence={ECO:0000250};
-!- PATHWAY: Protein modification; protein glycosylation.
-!- SUBUNIT: Interacts with notch1. {ECO:0000269|PubMed:24226769}.
-!- SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250};
Single-pass type II membrane protein {ECO:0000250}.
-!- DOMAIN: There are two conserved domains in the glycosyltransferase
region: the N-terminal domain (domain A, also called GT1 motif),
which is probably involved in manganese coordination and substrate
binding and the C-terminal domain (domain B, also called
Gal/GalNAc-T motif), which is probably involved in catalytic
reaction and UDP-Gal binding. {ECO:0000250}.
-!- DOMAIN: The ricin B-type lectin domain binds to GalNAc and
contributes to the glycopeptide specificity. {ECO:0000250}.
-!- DISRUPTION PHENOTYPE: Aberrant left-right patterning resulting in
abnormal cardiac loops, including leftward and symmetric/midline
loops. {ECO:0000269|PubMed:24226769}.
-!- SIMILARITY: Belongs to the glycosyltransferase 2 family. GalNAc-T
subfamily. {ECO:0000305}.
-!- SEQUENCE CAUTION:
Sequence=AAH75106.1; Type=Frameshift; Positions=39; Evidence={ECO:0000305};
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
Distributed under the Creative Commons Attribution-NoDerivs License
-----------------------------------------------------------------------
EMBL; BC075106; AAH75106.1; ALT_FRAME; mRNA.
RefSeq; NP_001006904.1; NM_001006903.1.
UniGene; Str.1760; -.
SMR; Q6DJR8; -.
CAZy; CBM13; Carbohydrate-Binding Module Family 13.
CAZy; GT27; Glycosyltransferase Family 27.
GeneID; 448751; -.
KEGG; xtr:448751; -.
CTD; 63917; -.
Xenbase; XB-GENE-981830; galnt11.
HOVERGEN; HBG051699; -.
KO; K00710; -.
UniPathway; UPA00378; -.
Proteomes; UP000008143; Unassembled WGS sequence.
GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0030246; F:carbohydrate binding; IEA:UniProtKB-KW.
GO; GO:0005112; F:Notch binding; IDA:UniProtKB.
GO; GO:0004653; F:polypeptide N-acetylgalactosaminyltransferase activity; IDA:UniProtKB.
GO; GO:0060271; P:cilium assembly; IMP:UniProtKB.
GO; GO:0007368; P:determination of left/right symmetry; IMP:UniProtKB.
GO; GO:0007220; P:Notch receptor processing; IMP:UniProtKB.
GO; GO:0061314; P:Notch signaling involved in heart development; IMP:UniProtKB.
GO; GO:0018243; P:protein O-linked glycosylation via threonine; IDA:UniProtKB.
GO; GO:0008593; P:regulation of Notch signaling pathway; IMP:UniProtKB.
CDD; cd00161; RICIN; 1.
Gene3D; 3.90.550.10; -; 1.
InterPro; IPR001173; Glyco_trans_2-like.
InterPro; IPR029044; Nucleotide-diphossugar_trans.
InterPro; IPR035992; Ricin_B-like_lectins.
InterPro; IPR000772; Ricin_B_lectin.
Pfam; PF00535; Glycos_transf_2; 1.
Pfam; PF00652; Ricin_B_lectin; 1.
SMART; SM00458; RICIN; 1.
SUPFAM; SSF50370; SSF50370; 1.
SUPFAM; SSF53448; SSF53448; 1.
PROSITE; PS50231; RICIN_B_LECTIN; 1.
1: Evidence at protein level;
Calcium; Complete proteome; Disulfide bond; Glycoprotein;
Glycosyltransferase; Golgi apparatus; Lectin; Manganese; Membrane;
Notch signaling pathway; Reference proteome; Signal-anchor;
Transferase; Transmembrane; Transmembrane helix.
CHAIN 1 601 Polypeptide N-
acetylgalactosaminyltransferase 11.
/FTId=PRO_0000425208.
TOPO_DOM 1 7 Cytoplasmic. {ECO:0000255}.
TRANSMEM 8 28 Helical; Signal-anchor for type II
membrane protein. {ECO:0000255}.
TOPO_DOM 29 601 Lumenal. {ECO:0000255}.
DOMAIN 469 600 Ricin B-type lectin.
{ECO:0000255|PROSITE-ProRule:PRU00174}.
REGION 143 254 Catalytic subdomain A. {ECO:0000250}.
REGION 312 374 Catalytic subdomain B. {ECO:0000250}.
CARBOHYD 29 29 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 202 202 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 508 508 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 486 505 {ECO:0000255|PROSITE-ProRule:PRU00174}.
DISULFID 529 546 {ECO:0000255|PROSITE-ProRule:PRU00174}.
DISULFID 571 589 {ECO:0000255|PROSITE-ProRule:PRU00174}.
SEQUENCE 601 AA; 68383 MW; 1FA0294A3CEEA236 CRC64;
MGSAALRCFC YGCLFTSVTW TLLLFIYFNF SEESQGFRHV PVKGLEPYKP LPKKIYPRFS
RDSMGQHSDP RKGHNGNQLE TEANADLSPE LGMIFNEQDQ DVRDVGYQKH AFNLLISNRL
GYHRDVPDTR DSKCAKKTYP PDLPMASIVI CFYNEAFSAL LRTVHSVLDR TPAQLLHEII
LVDDNSELDD LKKDLDGYMQ ENLSKKVKLV RNKQREGLIR GRMVGASHAT GDVLVFLDSH
CEVNEMWLQP LLAPIKENPR TVVCPVIDII SADTLIYSSS PVVRGGFNWG LHFKWDPVPL
AELGGPEGFS APFRSPTMAG GLFAMDREYF NMLGQYDSGM DIWGGENLEI SFRIWMCGGS
LLIVPCSRVG HIFRKRRPYG SPGGHDTMAH NSLRLAHVWM DEYKDQYFAL RPELRNRDFG
DIRERLALRR RLNCKSFKWY LDNIYPEMQV SGPNAKPQPP VFMNKGQKRP KILQRGRLIN
MQTNRCLVAQ GHPSQKGGLV VAKECDYNDS EQVWSYNEEH ELILSNLLCL DMSETRSSDP
PRLMKCHGSG GSQQWVFGKS NRLYQVSVGQ CLKLVDPMSR KGYVSMAICD GSPSQQWHLE
N


Related products :

Catalog number Product name Quantity
26-349 GALNT10 belongs to the polypeptide N-acetylgalactosaminyltransferase (pp-GalNAc-T) family. Polypeptide GalNAc transferases initiate the synthesis of mucin-type oligosaccharides by transferring GalNAc 0.05 mg
30-452 GALNT10 belongs to the polypeptide N-acetylgalactosaminyltransferase (pp-GalNAc-T) family. Polypeptide GalNAc transferases initiate the synthesis of mucin-type oligosaccharides by transferring GalNAc 0.05 mg
30-240 GALNT6 is a member of the UDP-N-acetyl-alpha-D-galactosamine polypeptide N-acetylgalactosaminyltransferase (GalNAc-T) family of enzymes. GalNAc-Ts initiate mucin-type O-linked glycosylation in the Gol 0.1 mg
26-171 GALNT6 is a member of the UDP-N-acetyl-alpha-D-galactosamine polypeptide N-acetylgalactosaminyltransferase (GalNAc-T) family of enzymes. GalNAc-Ts initiate mucin-type O-linked glycosylation in the Gol 0.05 mg
GALNT14 GALNT12 Gene UDP-N-acetyl-alpha-D-galactosamine polypeptide N-acetylgalactosaminyltransferase 12 (GalNAc-T12)
GALNT11 GALNT1 Gene UDP-N-acetyl-alpha-D-galactosamine polypeptide N-acetylgalactosaminyltransferase 1 (GalNAc-T1)
GALNTL1 GALNT8 Gene UDP-N-acetyl-alpha-D-galactosamine polypeptide N-acetylgalactosaminyltransferase 8 (GalNAc-T8)
GALNT9 GALNT7 Gene UDP-N-acetyl-alpha-D-galactosamine polypeptide N-acetylgalactosaminyltransferase 7 (GalNAc-T7)
GALNT13 GALNT11 Gene UDP-N-acetyl-alpha-D-galactosamine polypeptide N-acetylgalactosaminyltransferase 11 (GalNAc-T11)
GALNT7 GALNT5 Gene UDP-N-acetyl-alpha-D-galactosamine polypeptide N-acetylgalactosaminyltransferase 5 (GalNAc-T5)
GALNT6 GALNT4 Gene UDP-N-acetyl-alpha-D-galactosamine polypeptide N-acetylgalactosaminyltransferase 4 (GalNAc-T4)
GALNT3 GALNT14 Gene UDP-N-acetyl-alpha-D-galactosamine polypeptide N-acetylgalactosaminyltransferase 14 (GalNAc-T14)
GALNT2 GALNT13 Gene UDP-N-acetyl-alpha-D-galactosamine polypeptide N-acetylgalactosaminyltransferase 13 (GalNAc-T13)
GALNT5 GALNT3 Gene UDP-N-acetyl-alpha-D-galactosamine polypeptide N-acetylgalactosaminyltransferase 3 (GalNAc-T3)
GALNT4 GALNT2 Gene UDP-N-acetyl-alpha-D-galactosamine polypeptide N-acetylgalactosaminyltransferase 2 (GalNAc-T2)
GALNT12 GALNT10 Gene UDP-N-acetyl-alpha-D-galactosamine polypeptide N-acetylgalactosaminyltransferase 10 (GalNAc-T10)
GALNTL2 GALNT9 Gene UDP-N-acetyl-alpha-D-galactosamine polypeptide N-acetylgalactosaminyltransferase 9 (GalNAc-T9)
201-20-2176 GALNT14{UDP-N-acetyl-alpha-D-galactosamine polypeptide N-acetylgalactosaminyltransferase 14 (GalNAc-T14)}rabbit.pAb 0.2ml
201-20-2177 GALNT4{UDP-N-acetyl-alpha-D-galactosamine polypeptide N-acetylgalactosaminyltransferase 4 (GalNAc-T4)}rabbit.pAb 0.2ml
201-20-2178 GALNT7{UDP-N-acetyl-alpha-D-galactosamine polypeptide N-acetylgalactosaminyltransferase 7 (GalNAc-T7)}rabbit.pAb 0.2ml
GALNT8 GALNT6 Gene UDP-N-acetyl-alpha-D-galactosamine polypeptide N-acetylgalactosaminyltransferase 6 (GalNAc-T6)
CSB-EL009203PI Pig UDP-N-acetyl-alpha-D-galactosamine polypeptide N-acetylgalactosaminyltransferase 1 (GalNAc-T1) (GALNT1) ELISA kit, Species Pig, Sample Type serum, plasma 96T
CSB-EL009212RA Rat UDP-N-acetyl-alpha-D-galactosamine polypeptide N-acetylgalactosaminyltransferase 5 (GalNAc-T5) (GALNT5) ELISA kit, Species Rat, Sample Type serum, plasma 96T
CSB-EL009214RA Rat UDP-N-acetyl-alpha-D-galactosamine polypeptide N-acetylgalactosaminyltransferase 7 (GalNAc-T7) (GALNT7) ELISA kit, Species Rat, Sample Type serum, plasma 96T
CSB-EL009207RA Rat UDP-N-acetyl-alpha-D-galactosamine polypeptide N-acetylgalactosaminyltransferase 13 (GalNAc-T13) (GALNT13) ELISA kit, Species Rat, Sample Type serum, plasma 96T


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur