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Polyprotein

 E7ELW9_9HEPC            Unreviewed;      3014 AA.
E7ELW9;
08-MAR-2011, integrated into UniProtKB/TrEMBL.
08-MAR-2011, sequence version 1.
12-SEP-2018, entry version 53.
RecName: Full=Genome polyprotein {ECO:0000256|SAAS:SAAS00368684};
Recombinant Hepatitis C virus J6/JFH1(J4-NS5A).
Viruses; ssRNA viruses; ssRNA positive-strand viruses, no DNA stage;
Flaviviridae; Hepacivirus.
NCBI_TaxID=945067 {ECO:0000313|EMBL:ADV40002.1, ECO:0000313|Proteomes:UP000099632};
[1] {ECO:0000313|EMBL:ADV40002.1, ECO:0000313|Proteomes:UP000099632}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=J6/JFH1 {ECO:0000313|EMBL:ADV40002.1};
PubMed=21111742; DOI=10.1053/j.gastro.2010.11.036;
Scheel T.K., Gottwein J.M., Mikkelsen L.S., Jensen T.B., Bukh J.;
"Recombinant HCV variants with NS5A from genotypes 1-7 have different
sensitivities to an NS5A inhibitor but not interferon-alpha.";
Gastroenterology 140:1032-1042(2011).
-!- CATALYTIC ACTIVITY: ATP + H(2)O = ADP + phosphate.
{ECO:0000256|SAAS:SAAS00368577}.
-!- CATALYTIC ACTIVITY: NTP + H(2)O = NDP + phosphate.
{ECO:0000256|SAAS:SAAS00368620}.
-!- CATALYTIC ACTIVITY: Nucleoside triphosphate + RNA(n) = diphosphate
+ RNA(n+1). {ECO:0000256|SAAS:SAAS00383097}.
-!- SUBCELLULAR LOCATION: Virion membrane
{ECO:0000256|SAAS:SAAS01046204}.
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EMBL; HQ852460; ADV40002.1; -; Other_RNA.
ProteinModelPortal; E7ELW9; -.
Proteomes; UP000099632; Genome.
GO; GO:0033644; C:host cell membrane; IEA:UniProtKB-KW.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0019028; C:viral capsid; IEA:UniProtKB-KW.
GO; GO:0019031; C:viral envelope; IEA:InterPro.
GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO; GO:0008026; F:ATP-dependent helicase activity; IEA:InterPro.
GO; GO:0004197; F:cysteine-type endopeptidase activity; IEA:UniProtKB-UniRule.
GO; GO:0003723; F:RNA binding; IEA:InterPro.
GO; GO:0003968; F:RNA-directed 5'-3' RNA polymerase activity; IEA:UniProtKB-KW.
GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
GO; GO:0039520; P:induction by virus of host autophagy; IEA:UniProtKB-KW.
GO; GO:0039503; P:suppression by virus of host innate immune response; IEA:UniProtKB-KW.
GO; GO:0019087; P:transformation of host cell by virus; IEA:InterPro.
GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-KW.
GO; GO:0039694; P:viral RNA genome replication; IEA:InterPro.
GO; GO:0019062; P:virion attachment to host cell; IEA:UniProtKB-KW.
CDD; cd00079; HELICc; 1.
Gene3D; 2.20.25.210; -; 1.
Gene3D; 2.20.25.220; -; 1.
InterPro; IPR011492; DEAD_Flavivir.
InterPro; IPR002521; HCV_core_C.
InterPro; IPR002522; HCV_core_N.
InterPro; IPR002519; HCV_env.
InterPro; IPR002531; HCV_NS1.
InterPro; IPR002518; HCV_NS2.
InterPro; IPR000745; HCV_NS4a.
InterPro; IPR001490; HCV_NS4b.
InterPro; IPR002868; HCV_NS5a.
InterPro; IPR013193; HCV_NS5a_1B_dom.
InterPro; IPR038568; HCV_NS5A_1B_sf.
InterPro; IPR024350; HCV_NS5a_C.
InterPro; IPR014001; Helicase_ATP-bd.
InterPro; IPR001650; Helicase_C.
InterPro; IPR013192; NS5A_1a.
InterPro; IPR038170; NS5A_1a_sf.
InterPro; IPR027417; P-loop_NTPase.
InterPro; IPR009003; Peptidase_S1_PA.
InterPro; IPR004109; Peptidase_S29_NS3.
InterPro; IPR007094; RNA-dir_pol_PSvirus.
InterPro; IPR002166; RNA_pol_HCV.
Pfam; PF07652; Flavi_DEAD; 1.
Pfam; PF01543; HCV_capsid; 1.
Pfam; PF01542; HCV_core; 1.
Pfam; PF01539; HCV_env; 1.
Pfam; PF01560; HCV_NS1; 1.
Pfam; PF01538; HCV_NS2; 1.
Pfam; PF01006; HCV_NS4a; 1.
Pfam; PF01001; HCV_NS4b; 1.
Pfam; PF01506; HCV_NS5a; 1.
Pfam; PF08300; HCV_NS5a_1a; 1.
Pfam; PF08301; HCV_NS5a_1b; 1.
Pfam; PF12941; HCV_NS5a_C; 1.
Pfam; PF02907; Peptidase_S29; 1.
Pfam; PF00998; RdRP_3; 1.
ProDom; PD001388; HCV_env; 1.
SMART; SM00487; DEXDc; 1.
SUPFAM; SSF50494; SSF50494; 1.
SUPFAM; SSF52540; SSF52540; 2.
PROSITE; PS51693; HCV_NS2_PRO; 1.
PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
PROSITE; PS51194; HELICASE_CTER; 1.
PROSITE; PS51822; HV_PV_NS3_PRO; 1.
PROSITE; PS50507; RDRP_SSRNA_POS; 1.
4: Predicted;
Activation of host autophagy by virus {ECO:0000256|SAAS:SAAS00445756};
ATP-binding {ECO:0000256|SAAS:SAAS00058020};
Capsid protein {ECO:0000256|SAAS:SAAS00969288};
Complete proteome {ECO:0000313|Proteomes:UP000099632};
Helicase {ECO:0000256|SAAS:SAAS00058020};
Host membrane {ECO:0000256|SAAS:SAAS00445977};
Host-virus interaction {ECO:0000256|SAAS:SAAS00445756,
ECO:0000256|SAAS:SAAS00445995, ECO:0000256|SAAS:SAAS00941647};
Hydrolase {ECO:0000256|PROSITE-ProRule:PRU01030,
ECO:0000256|SAAS:SAAS00058020};
Inhibition of host innate immune response by virus
{ECO:0000256|SAAS:SAAS00941647};
Membrane {ECO:0000256|SAAS:SAAS00445939,
ECO:0000256|SAAS:SAAS00445977, ECO:0000256|SAM:Phobius};
Nucleotide-binding {ECO:0000256|SAAS:SAAS00058020};
Nucleotidyltransferase {ECO:0000256|SAAS:SAAS00510600};
Protease {ECO:0000256|PROSITE-ProRule:PRU01030};
RNA-directed RNA polymerase {ECO:0000256|SAAS:SAAS00510600};
Thiol protease {ECO:0000256|PROSITE-ProRule:PRU01030};
Transferase {ECO:0000256|SAAS:SAAS00510600};
Transmembrane {ECO:0000256|SAAS:SAAS00445939,
ECO:0000256|SAM:Phobius};
Transmembrane helix {ECO:0000256|SAAS:SAAS00445939,
ECO:0000256|SAM:Phobius};
Viral attachment to host cell {ECO:0000256|SAAS:SAAS00445995};
Viral immunoevasion {ECO:0000256|SAAS:SAAS00941647};
Viral RNA replication {ECO:0000256|SAAS:SAAS00664279};
Virion {ECO:0000256|SAAS:SAAS00445995, ECO:0000256|SAAS:SAAS00969288};
Virus entry into host cell {ECO:0000256|SAAS:SAAS00445995}.
TRANSMEM 722 745 Helical. {ECO:0000256|SAM:Phobius}.
TRANSMEM 757 782 Helical. {ECO:0000256|SAM:Phobius}.
TRANSMEM 788 807 Helical. {ECO:0000256|SAM:Phobius}.
TRANSMEM 819 840 Helical. {ECO:0000256|SAM:Phobius}.
TRANSMEM 877 897 Helical. {ECO:0000256|SAM:Phobius}.
TRANSMEM 1664 1687 Helical. {ECO:0000256|SAM:Phobius}.
TRANSMEM 1828 1849 Helical. {ECO:0000256|SAM:Phobius}.
TRANSMEM 1855 1874 Helical. {ECO:0000256|SAM:Phobius}.
TRANSMEM 1886 1906 Helical. {ECO:0000256|SAM:Phobius}.
TRANSMEM 2995 3013 Helical. {ECO:0000256|SAM:Phobius}.
DOMAIN 907 1030 Peptidase C18.
{ECO:0000259|PROSITE:PS51693}.
DOMAIN 1031 1212 Peptidase S29.
{ECO:0000259|PROSITE:PS51822}.
DOMAIN 1221 1373 Helicase ATP-binding.
{ECO:0000259|PROSITE:PS51192}.
DOMAIN 1365 1542 Helicase C-terminal.
{ECO:0000259|PROSITE:PS51194}.
DOMAIN 2637 2755 RdRp catalytic.
{ECO:0000259|PROSITE:PS50507}.
ACT_SITE 956 956 For protease NS2-3 activity; shared with
dimeric partner. {ECO:0000256|PROSITE-
ProRule:PRU01030}.
ACT_SITE 976 976 For protease NS2-3 activity; shared with
dimeric partner. {ECO:0000256|PROSITE-
ProRule:PRU01030}.
ACT_SITE 997 997 For protease NS2-3 activity; shared with
dimeric partner. {ECO:0000256|PROSITE-
ProRule:PRU01030}.
SITE 1030 1031 Cleavage; by protease NS2-3.
{ECO:0000256|PROSITE-ProRule:PRU01030}.
SEQUENCE 3014 AA; 327666 MW; 92853D31F4D3BAF1 CRC64;
MSTNPKPQRK TKRNTNRRPQ DVKFPGGGQI VGGVYLLPRR GPRLGVRATR KTSERSQPRG
RRQPIPKDRR STGKSWGKPG YPWPLYGNEG LGWAGWLLSP RGSRPSWGPN DPRHRSRNVG
KVIDTLTCGF ADLMGYIPVV GAPLGGVARA LAHGVRVLED GVNFATGNLP GCSFSIFLLA
LLSCITTPVS AAEVKNISTG YMVTNDCTND SITWQLQAAV LHVPGCVPCE KVGNASQCWI
PVSPNVAVQR PGALTQGLRT HIDMVVMSAT LCSALYVGDL CGGVMLAAQM FIVSPQHHWF
VQDCNCSIYP GTITGHRMAW DMMMNWSPTA TMILAYAMRV PEVIIDIISG AHWGVMFGLA
YFSMQGAWAK VVVILLLAAG VDARTHTVGG SAAQTTGRLT SLFDMGPRQK IQLVNTNGSW
HINRTALNCN DSLHTGFIAS LFYTHSFNSS GCPERMSACR SIEAFRVGWG ALQYEDNVTN
PEDMRPYCWH YPPRQCGVVS AKTVCGPVYC FTPSPVVVGT TDRLGAPTYT WGENETDVFL
LNSTRPPLGS WFGCTWMNSS GYTKTCGAPP CRTRADFNAS TDLLCPTDCF RKHPDTTYLK
CGSGPWLTPR CLIDYPYRLW HYPCTVNYTI FKIRMYVGGV EHRLTAACNF TRGDRCNLED
RDRSQLSPLL HSTTEWAILP CSYSDLPALS TGLLHLHQNI VDVQFMYGLS PALTKYIVRW
EWVILLFLLL ADARVCACLW MLILLGQAEA ALEKLVILHA ASAASCNGFL YFVIFFVAAW
YIKGRVVPLA TYSLTGLWSF SLLLLALPQQ AYAYDASVHG QIGAALLVMI TLFTLTPGYK
TLLSRFLWWL CYLLTLGEAM VQEWAPPMQV RGGRDGIIWA VAIFYPGVVF DITKWLLAVL
GPAYLLKGAL TRVPYFVRAH ALLRMCTMAR HLAGGRYVQM ALLALGRWTG TYIYDHLTPM
SDWAASGLRD LAVAVEPIIF SPMEKKVIVW GAETAACGDI LHGLPVSARL GREVLLGPAD
GYTSKGWSLL APITAYAQQT RGLLGAIVVS MTGRDRTEQA GEVQILSTVS QSFLGTTISG
VLWTVYHGAG NKTLAGLRGP VTQMYSSAEG DLVGWPSPPG TKSLEPCKCG AVDLYLVTRN
ADVIPARRRG DKRGALLSPR PISTLKGSSG GPVLCPRGHV VGLFRAAVCS RGVAKSIDFI
PVETLDVVTR SPTFSDNSTP PAVPQTYQVG YLHAPTGSGK STKVPVAYAA QGYKVLVLNP
SVAATLGFGA YLSKAHGINP NIRTGVRTVM TGEAITYSTY GKFLADGGCA SGAYDIIICD
ECHAVDATSI LGIGTVLDQA ETAGVRLTVL ATATPPGSVT TPHPDIEEVG LGREGEIPFY
GRAIPLSCIK GGRHLIFCHS KKKCDELAAA LRGMGLNAVA YYRGLDVSII PAQGDVVVVA
TDALMTGYTG DFDSVIDCNV AVTQAVDFSL DPTFTITTQT VPQDAVSRSQ RRGRTGRGRQ
GTYRYVSTGE RASGMFDSVV LCECYDAGAA WYDLTPAETT VRLRAYFNTP GLPVCQDHLE
FWEAVFTGLT HIDAHFLSQT KQAGENFAYL VAYQATVCAR AKAPPPSWDA MWKCLARLKP
TLAGPTPLLY RLGPITNEVT LTHPGTKYIA TCMQADLEVM TSTWVLAGGV LAAVAAYCLA
TGCVSIIGRL HVNQRVVVAP DKEVLYEAFD EMEECASRAA LIEEGQRIAE MLKSKIQGLL
QQASKQAQDI QPAMQASWPK VEQFWARHMW NFISGIQYLA GLSTLPGNPA VASMMAFSAA
LTSPLSTSTT ILLNIMGGWL ASQIAPPAGA TGFVVSGLVG AAVGSIGLGK VLVDILAGYG
AGISGALVAF KIMSGEKPSM EDVINLLPGI LSPGALVVGV ICAAILRRHV GPGEGAVQWM
NRLIAFASRG NHVAPTHYVT ESDASQRVTQ LLGSLTITSL LRRLHNWITE DCPIPCSGSW
LRDVWDWICT VLTDFKTWLQ SKLLPRLPGV PFLSCQRGYK GVWRGDGIMQ TTCPCGAQIA
GHVKNGSMRI VGPRTCSNTW HGTFPINAYT TGPCTPSPAP NYSRALWRVA AEEYVEVTRV
GDFHYVTGMT TDNVKCPCQV PAPEFFTEVD GVRLHRYAPA CKPLLREDVT FQVGLNQYLV
GSQLPCEPEP DVTVLTSMLT DPSHITAETA KRRLARGSPP SLASSSASQL SAPSLKATCT
THHDSPDADL IEANLLWRQE MGGNITRVES ENKVVILDSF EPLHAEGDER EISVAAEILR
KSRKFPSALP IWARPDYNPP LLESWKDPDY VPPVVHGCPL PPTKAPPIPP PRRKRTVVLT
ESNVSSALAE LATKTFGSSG SSAVDSGTAT ALPDLASDDG DKGSDVESYS SMPPLEGEPG
DPDLSDGSWS TVSEEASEDV VCCSMSYSWT GALITPCSPE EEKLPINPLS NSLLRYHNKV
YCTTSKSASQ RAKKVTFDRT QVLDAHYDSV LKDIKLAASK VSARLLTLEE ACQLTPPHSA
RSKYGFGAKE VRSLSGRAVN HIKSVWKDLL EDPQTPIPTT IMAKNEVFCV DPAKGGKKPA
RLIVYPDLGV RVCEKMALYD ITQKLPQAVM GASYGFQYSP AQRVEYLLKA WAEKKDPMGF
SYDTRCFDST VTERDIRTEE SIYQACSLPE EARTAIHSLT ERLYVGGPMF NSKGQTCGYR
RCRASGVLTT SMGNTITCYV KALAACKAAG IVAPTMLVCG DDLVVISESQ GTEEDERNLR
AFTEAMTRYS APPGDPPRPE YDLELITSCS SNVSVALGPR GRRRYYLTRD PTTPLARAAW
ETVRHSPINS WLGNIIQYAP TIWVRMVLMT HFFSILMVQD TLDQNLNFEM YGSVYSVNPL
DLPAIIERLH GLDAFSMHTY SHHELTRVAS ALRKLGAPPL RVWKSRARAV RASLISRGGK
AAVCGRYLFN WAVKTKLKLT PLPEARLLDL SSWFTVGAGG GDIFHSVSRA RPRSLLFGLL
LLFVGVGLFL LPAR


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