Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Potassium channel toxin alpha-KTx 4.1 (TSK4) (Tityustoxin K-alpha) (TsTX-K-alpha) (TyKalpha) (Toxin II-9) (Ts7)

 KAX41_TITSE             Reviewed;          37 AA.
P46114; P08816;
01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
01-NOV-1995, sequence version 1.
22-NOV-2017, entry version 89.
RecName: Full=Potassium channel toxin alpha-KTx 4.1 {ECO:0000303|PubMed:24590385};
AltName: Full=TSK4 {ECO:0000303|PubMed:7509073};
AltName: Full=Tityustoxin K-alpha {ECO:0000303|PubMed:7509073};
Short=TsTX-K-alpha {ECO:0000303|PubMed:7509073};
Short=TyKalpha {ECO:0000305};
AltName: Full=Toxin II-9;
AltName: Full=Ts7 {ECO:0000303|PubMed:24590385};
Tityus serrulatus (Brazilian scorpion).
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida;
Scorpiones; Buthida; Buthoidea; Buthidae; Tityus.
NCBI_TaxID=6887;
[1]
PROTEIN SEQUENCE, AND FUNCTION.
TISSUE=Venom;
PubMed=7509073; DOI=10.1073/pnas.91.4.1475;
Rogowski R.S., Krueger B.K., Collins J.H., Blaustein M.P.;
"Tityustoxin K alpha blocks voltage-gated noninactivating K+ channels
and unblocks inactivating K+ channels blocked by alpha-dendrotoxin in
synaptosomes.";
Proc. Natl. Acad. Sci. U.S.A. 91:1475-1479(1994).
[2]
ERRATUM.
Rogowski R.S., Krueger B.K., Collins J.H., Blaustein M.P.;
Proc. Natl. Acad. Sci. U.S.A. 93:12051-12051(1996).
[3]
PROTEIN SEQUENCE OF 1-30, AND SUBCELLULAR LOCATION.
TISSUE=Venom;
Possani L.D., Martin B.M., Svendsen I.;
"The primary structure of noxiustoxin. A K channel blocking peptide,
purified from the venom of the scorpion Centruroides noxius
Hoffmann.";
Carlsberg Res. Commun. 47:285-289(1982).
[4]
PARTIAL PROTEIN SEQUENCE, FUNCTION, AND NOMENCLATURE.
TISSUE=Venom;
PubMed=24590385; DOI=10.3390/toxins6030892;
Cerni F.A., Pucca M.B., Peigneur S., Cremonez C.M., Bordon K.C.,
Tytgat J., Arantes E.C.;
"Electrophysiological characterization of Ts6 and Ts7, K+ channel
toxins isolated through an improved Tityus serrulatus venom
purification procedure.";
Toxins 6:892-913(2014).
[5]
FUNCTION AS KV1.3 CHANNEL BLOCKER, AND MASS SPECTROMETRY.
PubMed=12871837; DOI=10.1038/sj.bjp.0705343;
Rodrigues A.R., Arantes E.C., Monje F., Stuehmer W., Varanda W.A.;
"Tityustoxin-K(alpha) blockade of the voltage-gated potassium channel
Kv1.3.";
Br. J. Pharmacol. 139:1180-1186(2003).
[6]
PHARMACOLOGICAL CHARACTERIZATION.
PubMed=18687312; DOI=10.1016/j.bcp.2008.07.008;
Abdel-Mottaleb Y., Corzo G., Martin-Eauclaire M.F., Satake H.,
Ceard B., Peigneur S., Nambaru P., Bougis P.E., Possani L.D.,
Tytgat J.;
"A common 'hot spot' confers hERG blockade activity to alpha-scorpion
toxins affecting K+ channels.";
Biochem. Pharmacol. 76:805-815(2008).
[7]
STRUCTURE BY NMR, DISULFIDE BONDS, AND MUTAGENESIS OF LYS-27.
PubMed=11352729; DOI=10.1021/bi010173g;
Ellis K.C., Tenenholz T.C., Jerng H., Hayhurst M., Dudlak C.S.,
Gilly W.F., Blaustein M.P., Weber D.J.;
"Interaction of a toxin from the scorpion Tityus serrulatus with a
cloned K+ channel from squid (sqKv1A).";
Biochemistry 40:5942-5953(2001).
-!- FUNCTION: Potently blocks Kv1.1/KCNA1 (85%), Kv1.2/KCNA2 (91%),
Kv1.3/KCNA3 (89%), Kv1.6/KCNA6 (94%), and Shaker (97%).
{ECO:0000269|PubMed:12871837, ECO:0000269|PubMed:24590385,
ECO:0000269|PubMed:7509073}.
-!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|Ref.3}.
-!- TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305}.
-!- DOMAIN: Has the structural arrangement of an alpha-helix connected
to a beta-sheet by disulfide bonds (CSalpha/beta).
-!- MASS SPECTROMETRY: Mass=3942; Method=Unknown; Range=1-37;
Evidence={ECO:0000269|PubMed:12871837};
-!- MISCELLANEOUS: Inhibits with low efficiency Kv1.5/KCNA5,
Kv2.1/KCNB1, Kv7.1/KCNQ1 and ERG/KCNH2. Does not inhibit
Kv1.4/KCNA4, Kv3.1/KCNC1, Kv7.2/KCNQ2 (PubMed:24590385) and
ERG1/Kv11.1/KCNH2 (PubMed:18687312). {ECO:0000269|PubMed:18687312,
ECO:0000269|PubMed:24590385}.
-!- SIMILARITY: Belongs to the short scorpion toxin superfamily.
Potassium channel inhibitor family. Alpha-KTx 04 subfamily.
{ECO:0000305}.
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
Distributed under the Creative Commons Attribution (CC BY 4.0) License
-----------------------------------------------------------------------
PDB; 1HP2; NMR; -; A=1-37.
PDBsum; 1HP2; -.
ProteinModelPortal; P46114; -.
SMR; P46114; -.
EvolutionaryTrace; P46114; -.
GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
GO; GO:0008200; F:ion channel inhibitor activity; IEA:InterPro.
GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
Gene3D; 3.30.30.10; -; 1.
InterPro; IPR036574; Scorpion_toxin-like_sf.
InterPro; IPR001947; Scorpion_toxinS_K_inh.
Pfam; PF00451; Toxin_2; 1.
PRINTS; PR00286; CHARYBDTOXIN.
ProDom; PD003586; Scorpion_toxinS; 1.
SUPFAM; SSF57095; SSF57095; 1.
PROSITE; PS01138; SCORP_SHORT_TOXIN; 1.
1: Evidence at protein level;
3D-structure; Direct protein sequencing; Disulfide bond;
Ion channel impairing toxin; Neurotoxin;
Potassium channel impairing toxin; Secreted; Toxin;
Voltage-gated potassium channel impairing toxin.
PEPTIDE 1 37 Potassium channel toxin alpha-KTx 4.1.
{ECO:0000269|PubMed:7509073}.
/FTId=PRO_0000044923.
REGION 26 33 Interaction with Ca(2+)-activated K(+)
channels. {ECO:0000255}.
SITE 27 27 Basic residue of the functional dyad.
{ECO:0000250}.
SITE 36 36 Aromatic residue of the functional dyad.
{ECO:0000250}.
DISULFID 7 28 {ECO:0000269|PubMed:11352729}.
DISULFID 13 33 {ECO:0000269|PubMed:11352729}.
DISULFID 17 35 {ECO:0000269|PubMed:11352729}.
MUTAGEN 27 27 K->A,E,R: Significant loss of affinity
for squid Kv1A channel.
{ECO:0000269|PubMed:11352729}.
HELIX 10 20 {ECO:0000244|PDB:1HP2}.
STRAND 26 29 {ECO:0000244|PDB:1HP2}.
STRAND 32 35 {ECO:0000244|PDB:1HP2}.
SEQUENCE 37 AA; 3948 MW; 639B98A977335929 CRC64;
VFINAKCRGS PECLPKCKEA IGKAAGKCMN GKCKCYP


Related products :

Catalog number Product name Quantity
EIAAB37628 Alpha-ENaC,Alpha-NaCH,Amiloride-sensitive sodium channel subunit alpha,Epithelial Na(+) channel subunit alpha,Nonvoltage-gated sodium channel 1 subunit alpha,Rat,Rattus norvegicus,Renac,SCNEA,Scnn1a
EIAAB37631 Alpha-ENaC,Alpha-NaCH,Amiloride-sensitive sodium channel subunit alpha,Epithelial Na(+) channel subunit alpha,Nonvoltage-gated sodium channel 1 subunit alpha,Oryctolagus cuniculus,Rabbit,SCNEA,SCNN1A
BYA2111-1 Hemolysin, alpha (Staphylococcal Alpha Toxin), Rabbit anti_ 1 ml.
EIAAB37629 Alpha-ENaC,Alpha-NaCH,Amiloride-sensitive sodium channel subunit alpha,Bos taurus,Bovine,Epithelial Na(+) channel subunit alpha,Nonvoltage-gated sodium channel 1 subunit alpha,SCNEA,SCNN1A
EIAAB37632 Alpha-ENaC,Alpha-NaCH,Amiloride-sensitive sodium channel subunit alpha,Epithelial Na(+) channel subunit alpha,Mouse,Mus musculus,Nonvoltage-gated sodium channel 1 subunit alpha,SCNEA,Scnn1a
orb71047 Staphylococcal Alpha Toxin P1 peptide This is Staphylococcal Alpha Toxin P1 peptide. For research use only. 1 mg
EIAAB37627 Alpha-ENaC,Alpha-NaCH,Amiloride-sensitive sodium channel subunit alpha,ENaCA,Epithelial Na(+) channel subunit alpha,Homo sapiens,Human,Nonvoltage-gated sodium channel 1 subunit alpha,SCNEA,SCNN1,SCNN1
TXL8221-250 Lqh alpha IT (alpha Insect Toxin from Lqh) 5x50 µg.
EIAAB08181 CNCG3,CNG channel alpha-3,CNG3,CNG-3,CNGA3,Cone photoreceptor cGMP-gated channel subunit alpha,Cyclic nucleotide-gated cation channel alpha-3,Cyclic nucleotide-gated channel alpha-3,Homo sapiens,Human
EIAAB08179 Bos taurus,Bovine,CNCG3,CNG channel alpha-3,CNG3,CNG-3,CNGA3,Cone photoreceptor cGMP-gated channel subunit alpha,Cyclic nucleotide-gated cation channel alpha-3,Cyclic nucleotide-gated channel alpha-3
EIAAB37630 Alpha-ENaC,Alpha-NaCH,Amiloride-sensitive sodium channel subunit alpha,Chicken,ENAC,Epithelial Na(+) channel subunit alpha,Gallus gallus,Nonvoltage-gated sodium channel 1 subunit alpha,SCNEA,SCNN1A
EIAAB08180 CNG channel alpha-3,CNG3,Cng3,CNG-3,Cnga3,Cone photoreceptor cGMP-gated channel subunit alpha,Cyclic nucleotide-gated cation channel alpha-3,Cyclic nucleotide-gated channel alpha-3,Mouse,Mus musculus
9540-0008 MOUSE ANTI CHOLERA TOXIN ALPHA, Product Type Monoclonal Antibody, Specificity CHOLERA TOXIN, Target Species Bacterial, Host Mouse, Format Purified, Isotypes IgM, Applications E, Clone 2_166 0.2 mg
SCH-9540-0008 MOUSE ANTI CHOLERA TOXIN ALPHA, Product Type Monoclonal Antibody, Specificity CHOLERA TOXIN, Target Species Bacterial, Host Mouse, Format Purified, Isotypes IgM, Applications E, Clone 2_166 0.2 mg
120 Alpha Toxin from Staphylococcus aureus 1,4,8 0.25mg
120 Alpha Toxin from Staphylococcus aureu1,4 0,25mg
120 Alpha Toxin from Staphylococcus aureus1,4,8 0,25 mg
18-003-42663 Potassium voltage-gated channel subfamily KQT member 2 - Voltage-gated potassium channel subunit Kv7.2; Neuroblastoma-specific potassium channel subunit alpha KvLQT2; KQT-like 2 Polyclonal 0.05 mg Aff Pur
18-003-42664 Potassium voltage-gated channel subfamily KQT member 2 - Voltage-gated potassium channel subunit Kv7.2; Neuroblastoma-specific potassium channel subunit alpha KvLQT2; KQT-like 2 Polyclonal 0.1 mg Protein A
K250 Clostridium perfringens α (alpha) Toxin 100
LST120 Alpha Toxin from Staphylococcus aureus 0.25 mg.
SP-86628-5 Staphylococcal Alpha - Toxin P 1 (AA: Lys-Thr-Gly-Asp-Leu-Val-Thr-Tyr-Asp-Lys-Glu-Asn-Gly) (MW: 1439.55) 5 mg
EIAAB08183 CNG channel alpha-4,CNG4,CNG-4,CNGA4,Cyclic nucleotide-gated cation channel alpha-4,Cyclic nucleotide-gated channel alpha-4,Homo sapiens,Human
EIAAB37605 Homo sapiens,Human,Putative voltage-gated sodium channel subunit alpha Nax,SCN6A,SCN7A,Sodium channel protein cardiac and skeletal muscle subunit alpha,Sodium channel protein type 7 subunit alpha,Sodi
DS-MB-00998 Mouse Anti-Cholera Toxin alpha 200


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur