Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Potassium voltage-gated channel subfamily A member 5 (HPCN1) (Voltage-gated potassium channel HK2) (Voltage-gated potassium channel subunit Kv1.5)

 KCNA5_HUMAN             Reviewed;         613 AA.
P22460; Q4KKT8; Q4VAJ1; Q4VAJ2; Q9UDA4;
01-AUG-1991, integrated into UniProtKB/Swiss-Prot.
01-MAY-2007, sequence version 4.
28-MAR-2018, entry version 178.
RecName: Full=Potassium voltage-gated channel subfamily A member 5;
AltName: Full=HPCN1;
AltName: Full=Voltage-gated potassium channel HK2;
AltName: Full=Voltage-gated potassium channel subunit Kv1.5;
Name=KCNA5;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
TISSUE=Heart;
PubMed=2001794;
Tamkun M.M., Knoth K.M., Walbridge J.A., Kroemer H., Roden D.M.,
Glover D.M.;
"Molecular cloning and characterization of two voltage-gated K+
channel cDNAs from human ventricle.";
FASEB J. 5:331-337(1991).
[2]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
TISSUE=Insulinoma;
PubMed=1986382; DOI=10.1073/pnas.88.1.53;
Philipson L.H., Hice R.E., Schaefer K., Lamendola J., Bell G.I.,
Nelson D.J., Steiner D.F.;
"Sequence and functional expression in Xenopus oocytes of a human
insulinoma and islet potassium channel.";
Proc. Natl. Acad. Sci. U.S.A. 88:53-57(1991).
[3]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
TISSUE=Heart;
PubMed=1349297; DOI=10.1016/0888-7543(92)90302-9;
Curran M.E., Landes G.M., Keating M.T.;
"Molecular cloning, characterization, and genomic localization of a
human potassium channel gene.";
Genomics 12:729-737(1992).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[5]
FUNCTION, AND SUBCELLULAR LOCATION.
PubMed=8505626; DOI=10.1085/jgp.101.4.513;
Snyders D.J., Tamkun M.M., Bennett P.B.;
"A rapidly activating and slowly inactivating potassium channel cloned
from human heart. Functional analysis after stable mammalian cell
culture expression.";
J. Gen. Physiol. 101:513-543(1993).
[6]
FUNCTION, AND ALTERNATIVE SPLICING (ISOFORMS 1 AND 2).
PubMed=11524461; DOI=10.1085/jgp.118.3.315;
Kurata H.T., Soon G.S., Fedida D.;
"Altered state dependence of c-type inactivation in the long and short
forms of human Kv1.5.";
J. Gen. Physiol. 118:315-332(2001).
[7]
FUNCTION, SUBCELLULAR LOCATION, AND INTERACTION WITH KCNAB1.
PubMed=12130714; DOI=10.1124/jpet.102.033357;
Williams C.P., Hu N., Shen W., Mashburn A.B., Murray K.T.;
"Modulation of the human Kv1.5 channel by protein kinase C activation:
role of the Kvbeta1.2 subunit.";
J. Pharmacol. Exp. Ther. 302:545-550(2002).
[8]
INTERACTION WITH DLG1, AND MUTAGENESIS OF THR-15.
PubMed=16466689; DOI=10.1016/j.bbrc.2006.01.110;
Mathur R., Choi W.S., Eldstrom J., Wang Z., Kim J., Steele D.F.,
Fedida D.;
"A specific N-terminal residue in Kv1.5 is required for upregulation
of the channel by SAP97.";
Biochem. Biophys. Res. Commun. 342:1-8(2006).
[9]
INVOLVEMENT IN ATFB7.
PubMed=16772329; DOI=10.1093/hmg/ddl143;
Olson T.M., Alekseev A.E., Liu X.K., Park S., Zingman L.V.,
Bienengraeber M., Sattiraju S., Ballew J.D., Jahangir A., Terzic A.;
"Kv1.5 channelopathy due to KCNA5 loss-of-function mutation causes
human atrial fibrillation.";
Hum. Mol. Genet. 15:2185-2191(2006).
[10]
SUMOYLATION AT LYS-221 AND LYS-536, INTERACTION WITH UBE2I, AND
MUTAGENESIS OF ILE-220; LYS-221; LEU-535 AND LYS-536.
PubMed=17261810; DOI=10.1073/pnas.0606702104;
Benson M.D., Li Q.J., Kieckhafer K., Dudek D., Whorton M.R.,
Sunahara R.K., Iniguez-Lluhi J.A., Martens J.R.;
"SUMO modification regulates inactivation of the voltage-gated
potassium channel Kv1.5.";
Proc. Natl. Acad. Sci. U.S.A. 104:1805-1810(2007).
[11]
VARIANT [LARGE SCALE ANALYSIS] SER-300.
PubMed=16959974; DOI=10.1126/science.1133427;
Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D.,
Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S.,
Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J.,
Dawson D., Willson J.K.V., Gazdar A.F., Hartigan J., Wu L., Liu C.,
Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N.,
Vogelstein B., Kinzler K.W., Velculescu V.E.;
"The consensus coding sequences of human breast and colorectal
cancers.";
Science 314:268-274(2006).
[12]
VARIANTS HIS-42; MET-85; PRO-114; ARG-170 AND PRO-184.
PubMed=24936649; DOI=10.1371/journal.pone.0100261;
Pousada G., Baloira A., Vilarino C., Cifrian J.M., Valverde D.;
"Novel mutations in BMPR2, ACVRL1 and KCNA5 genes and hemodynamic
parameters in patients with pulmonary arterial hypertension.";
PLoS ONE 9:E100261-E100261(2014).
-!- FUNCTION: Voltage-gated potassium channel that mediates
transmembrane potassium transport in excitable membranes. Forms
tetrameric potassium-selective channels through which potassium
ions pass in accordance with their electrochemical gradient. The
channel alternates between opened and closed conformations in
response to the voltage difference across the membrane. Can form
functional homotetrameric channels and heterotetrameric channels
that contain variable proportions of KCNA1, KCNA2, KCNA4, KCNA5,
and possibly other family members as well; channel properties
depend on the type of alpha subunits that are part of the channel
(PubMed:12130714). Channel properties are modulated by cytoplasmic
beta subunits that regulate the subcellular location of the alpha
subunits and promote rapid inactivation (PubMed:12130714).
Homotetrameric channels display rapid activation and slow
inactivation (PubMed:8505626, PubMed:12130714). May play a role in
regulating the secretion of insulin in normal pancreatic islets.
Isoform 2 exhibits a voltage-dependent recovery from inactivation
and an excessive cumulative inactivation (PubMed:11524461).
{ECO:0000269|PubMed:11524461, ECO:0000269|PubMed:12130714,
ECO:0000269|PubMed:8505626}.
-!- SUBUNIT: Homotetramer and heterotetramer of potassium channel
proteins. Interacts with DLG1, which enhances channel currents.
Forms a ternary complex with DLG1 and CAV3 (By similarity).
Interacts with KCNAB1 (PubMed:12130714). Interacts with UBE2I
(PubMed:17261810). {ECO:0000250|UniProtKB:P19024,
ECO:0000269|PubMed:11524461, ECO:0000269|PubMed:12130714,
ECO:0000269|PubMed:16466689, ECO:0000269|PubMed:17261810,
ECO:0000269|PubMed:8505626}.
-!- INTERACTION:
P35609:ACTN2; NbExp=7; IntAct=EBI-6426121, EBI-77797;
Q14160:SCRIB; NbExp=2; IntAct=EBI-6426121, EBI-357345;
-!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:12130714,
ECO:0000269|PubMed:8505626}; Multi-pass membrane protein
{ECO:0000305}.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=2;
Name=1;
IsoId=P22460-1; Sequence=Displayed;
Name=2; Synonyms=Short;
IsoId=P22460-2; Sequence=VSP_037110;
-!- TISSUE SPECIFICITY: Pancreatic islets and insulinoma.
-!- DOMAIN: The amino terminus may be important in determining the
rate of inactivation of the channel while the C-terminal PDZ-
binding motif may play a role in modulation of channel activity
and/or targeting of the channel to specific subcellular
compartments.
-!- DOMAIN: The transmembrane segment S4 functions as voltage-sensor
and is characterized by a series of positively charged amino acids
at every third position. Channel opening and closing is effected
by a conformation change that affects the position and orientation
of the voltage-sensor paddle formed by S3 and S4 within the
membrane. A transmembrane electric field that is positive inside
would push the positively charged S4 segment outwards, thereby
opening the pore, while a field that is negative inside would pull
the S4 segment inwards and close the pore. Changes in the position
and orientation of S4 are then transmitted to the activation gate
formed by the inner helix bundle via the S4-S5 linker region.
{ECO:0000250|UniProtKB:P63142}.
-!- PTM: Sumoylated on Lys-221, and Lys-536, preferentially with
SUMO3. Sumoylation regulates the voltage sensitivity of the
channel. {ECO:0000269|PubMed:17261810}.
-!- DISEASE: Atrial fibrillation, familial, 7 (ATFB7) [MIM:612240]: A
familial form of atrial fibrillation, a common sustained cardiac
rhythm disturbance. Atrial fibrillation is characterized by
disorganized atrial electrical activity and ineffective atrial
contraction promoting blood stasis in the atria and reduces
ventricular filling. It can result in palpitations, syncope,
thromboembolic stroke, and congestive heart failure.
{ECO:0000269|PubMed:16772329}. Note=The disease is caused by
mutations affecting the gene represented in this entry.
-!- SIMILARITY: Belongs to the potassium channel family. A (Shaker)
(TC 1.A.1.2) subfamily. Kv1.5/KCNA5 sub-subfamily. {ECO:0000305}.
-!- SEQUENCE CAUTION:
Sequence=AAA60146.1; Type=Frameshift; Positions=579; Evidence={ECO:0000305};
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
Distributed under the Creative Commons Attribution-NoDerivs License
-----------------------------------------------------------------------
EMBL; M60451; AAA61276.1; -; mRNA.
EMBL; M55513; AAA36422.1; -; mRNA.
EMBL; M83254; AAA60146.1; ALT_FRAME; mRNA.
EMBL; BC096357; AAH96357.1; -; mRNA.
EMBL; BC096358; AAH96358.3; -; mRNA.
EMBL; BC099665; AAH99665.3; -; mRNA.
EMBL; BC099666; AAH99666.3; -; mRNA.
CCDS; CCDS8536.1; -. [P22460-1]
PIR; A56031; A56031.
RefSeq; NP_002225.2; NM_002234.3. [P22460-1]
UniGene; Hs.150208; -.
UniGene; Hs.741439; -.
ProteinModelPortal; P22460; -.
SMR; P22460; -.
BioGrid; 109943; 58.
DIP; DIP-42010N; -.
IntAct; P22460; 10.
MINT; P22460; -.
STRING; 9606.ENSP00000252321; -.
BindingDB; P22460; -.
ChEMBL; CHEMBL4306; -.
DrugBank; DB06637; Dalfampridine.
GuidetoPHARMACOLOGY; 542; -.
TCDB; 1.A.1.2.4; the voltage-gated ion channel (vic) superfamily.
iPTMnet; P22460; -.
PhosphoSitePlus; P22460; -.
BioMuta; KCNA5; -.
DMDM; 146345443; -.
PaxDb; P22460; -.
PeptideAtlas; P22460; -.
PRIDE; P22460; -.
Ensembl; ENST00000252321; ENSP00000252321; ENSG00000130037. [P22460-1]
GeneID; 3741; -.
KEGG; hsa:3741; -.
UCSC; uc001qni.5; human. [P22460-1]
CTD; 3741; -.
DisGeNET; 3741; -.
EuPathDB; HostDB:ENSG00000130037.4; -.
GeneCards; KCNA5; -.
HGNC; HGNC:6224; KCNA5.
HPA; CAB022562; -.
HPA; HPA021516; -.
MalaCards; KCNA5; -.
MIM; 176267; gene.
MIM; 612240; phenotype.
neXtProt; NX_P22460; -.
OpenTargets; ENSG00000130037; -.
Orphanet; 334; Familial atrial fibrillation.
PharmGKB; PA208; -.
eggNOG; KOG1545; Eukaryota.
eggNOG; COG1226; LUCA.
GeneTree; ENSGT00760000118846; -.
HOGENOM; HOG000231015; -.
HOVERGEN; HBG052230; -.
InParanoid; P22460; -.
KO; K04878; -.
OMA; LPRNEFQ; -.
OrthoDB; EOG091G10NU; -.
PhylomeDB; P22460; -.
TreeFam; TF313103; -.
Reactome; R-HSA-1296072; Voltage gated Potassium channels.
GeneWiki; KCNA5; -.
GenomeRNAi; 3741; -.
PRO; PR:P22460; -.
Proteomes; UP000005640; Chromosome 12.
Bgee; ENSG00000130037; -.
CleanEx; HS_KCNA5; -.
Genevisible; P22460; HS.
GO; GO:0005783; C:endoplasmic reticulum; IEA:Ensembl.
GO; GO:0005794; C:Golgi apparatus; HDA:UniProtKB.
GO; GO:0005887; C:integral component of plasma membrane; IDA:UniProtKB.
GO; GO:0014704; C:intercalated disc; IDA:BHF-UCL.
GO; GO:0046691; C:intracellular canaliculus; IEA:Ensembl.
GO; GO:0045121; C:membrane raft; IDA:BHF-UCL.
GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:Ensembl.
GO; GO:0005886; C:plasma membrane; IDA:BHF-UCL.
GO; GO:0034705; C:potassium channel complex; IDA:UniProtKB.
GO; GO:0008076; C:voltage-gated potassium channel complex; IDA:BHF-UCL.
GO; GO:0030018; C:Z disc; IEA:Ensembl.
GO; GO:0051393; F:alpha-actinin binding; IPI:BHF-UCL.
GO; GO:0005251; F:delayed rectifier potassium channel activity; IDA:UniProtKB.
GO; GO:0015271; F:outward rectifier potassium channel activity; IDA:BHF-UCL.
GO; GO:0019870; F:potassium channel inhibitor activity; IEA:Ensembl.
GO; GO:0019901; F:protein kinase binding; IPI:BHF-UCL.
GO; GO:0005102; F:receptor binding; IEA:Ensembl.
GO; GO:0097110; F:scaffold protein binding; IPI:BHF-UCL.
GO; GO:0086089; F:voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization; IMP:BHF-UCL.
GO; GO:0086087; F:voltage-gated potassium channel activity involved in bundle of His cell action potential repolarization; IMP:BHF-UCL.
GO; GO:0086090; F:voltage-gated potassium channel activity involved in SA node cell action potential repolarization; IMP:BHF-UCL.
GO; GO:0086014; P:atrial cardiac muscle cell action potential; IMP:BHF-UCL.
GO; GO:0060081; P:membrane hyperpolarization; IMP:BHF-UCL.
GO; GO:0098914; P:membrane repolarization during atrial cardiac muscle cell action potential; IMP:BHF-UCL.
GO; GO:0086050; P:membrane repolarization during bundle of His cell action potential; IMP:BHF-UCL.
GO; GO:0086052; P:membrane repolarization during SA node cell action potential; IMP:BHF-UCL.
GO; GO:0051481; P:negative regulation of cytosolic calcium ion concentration; IEA:Ensembl.
GO; GO:0043267; P:negative regulation of potassium ion transport; IEA:Ensembl.
GO; GO:0007219; P:Notch signaling pathway; IEA:Ensembl.
GO; GO:1900087; P:positive regulation of G1/S transition of mitotic cell cycle; IEA:Ensembl.
GO; GO:2000288; P:positive regulation of myoblast proliferation; IEA:Ensembl.
GO; GO:0071435; P:potassium ion export; IDA:BHF-UCL.
GO; GO:0055075; P:potassium ion homeostasis; IEA:Ensembl.
GO; GO:0071805; P:potassium ion transmembrane transport; IDA:UniProtKB.
GO; GO:0006813; P:potassium ion transport; IDA:MGI.
GO; GO:0051260; P:protein homooligomerization; IEA:InterPro.
GO; GO:0060372; P:regulation of atrial cardiac muscle cell membrane repolarization; IMP:BHF-UCL.
GO; GO:0086091; P:regulation of heart rate by cardiac conduction; IMP:BHF-UCL.
GO; GO:0050796; P:regulation of insulin secretion; TAS:BHF-UCL.
GO; GO:0042391; P:regulation of membrane potential; IDA:BHF-UCL.
GO; GO:0043266; P:regulation of potassium ion transport; IMP:BHF-UCL.
GO; GO:0019229; P:regulation of vasoconstriction; IEA:Ensembl.
GO; GO:0042542; P:response to hydrogen peroxide; IEA:Ensembl.
GO; GO:0055093; P:response to hyperoxia; IEA:Ensembl.
GO; GO:0001666; P:response to hypoxia; IEA:Ensembl.
GO; GO:0009612; P:response to mechanical stimulus; IEA:Ensembl.
GO; GO:0010033; P:response to organic substance; IEA:Ensembl.
Gene3D; 1.20.120.350; -; 1.
InterPro; IPR000210; BTB/POZ_dom.
InterPro; IPR005821; Ion_trans_dom.
InterPro; IPR003968; K_chnl_volt-dep_Kv.
InterPro; IPR003972; K_chnl_volt-dep_Kv1.
InterPro; IPR004052; K_chnl_volt-dep_Kv1.5.
InterPro; IPR011333; SKP1/BTB/POZ_sf.
InterPro; IPR003131; T1-type_BTB.
InterPro; IPR028325; VG_K_chnl.
InterPro; IPR027359; Volt_channel_dom_sf.
PANTHER; PTHR11537; PTHR11537; 1.
Pfam; PF02214; BTB_2; 1.
Pfam; PF00520; Ion_trans; 1.
PRINTS; PR00169; KCHANNEL.
PRINTS; PR01512; KV15CHANNEL.
PRINTS; PR01491; KVCHANNEL.
PRINTS; PR01496; SHAKERCHANEL.
SMART; SM00225; BTB; 1.
SUPFAM; SSF54695; SSF54695; 1.
1: Evidence at protein level;
Alternative splicing; Atrial fibrillation; Cell membrane;
Complete proteome; Ion channel; Ion transport; Isopeptide bond;
Lipoprotein; Membrane; Palmitate; Phosphoprotein; Polymorphism;
Potassium; Potassium channel; Potassium transport; Reference proteome;
Repeat; Transmembrane; Transmembrane helix; Transport;
Ubl conjugation; Voltage-gated channel.
CHAIN 1 613 Potassium voltage-gated channel subfamily
A member 5.
/FTId=PRO_0000053985.
TOPO_DOM 1 247 Cytoplasmic.
{ECO:0000250|UniProtKB:P63142}.
TRANSMEM 248 269 Helical; Name=Segment S1.
{ECO:0000250|UniProtKB:P63142}.
TOPO_DOM 270 323 Extracellular.
{ECO:0000250|UniProtKB:P63142}.
TRANSMEM 324 345 Helical; Name=Segment S2.
{ECO:0000250|UniProtKB:P63142}.
TOPO_DOM 346 356 Cytoplasmic.
{ECO:0000250|UniProtKB:P63142}.
TRANSMEM 357 377 Helical; Name=Segment S3.
{ECO:0000250|UniProtKB:P63142}.
TOPO_DOM 378 395 Extracellular.
{ECO:0000250|UniProtKB:P63142}.
TRANSMEM 396 416 Helical; Voltage-sensor; Name=Segment S4.
{ECO:0000250|UniProtKB:P63142}.
TOPO_DOM 417 431 Cytoplasmic.
{ECO:0000250|UniProtKB:P63142}.
TRANSMEM 432 453 Helical; Name=Segment S5.
{ECO:0000250|UniProtKB:P63142}.
TOPO_DOM 454 467 Extracellular.
{ECO:0000250|UniProtKB:P63142}.
INTRAMEM 468 479 Helical; Name=Pore helix.
{ECO:0000250|UniProtKB:P63142}.
INTRAMEM 480 487 {ECO:0000250|UniProtKB:P63142}.
TOPO_DOM 488 494 Extracellular.
{ECO:0000250|UniProtKB:P63142}.
TRANSMEM 495 523 Helical; Name=Segment S6.
{ECO:0000250|UniProtKB:P63142}.
TOPO_DOM 524 613 Cytoplasmic.
{ECO:0000250|UniProtKB:P63142}.
REPEAT 61 71 1.
REPEAT 72 82 2.
REGION 61 82 2 X 11 AA tandem repeat of D-[SP]-G-V-R-
P-L-P-P-L-P.
REGION 418 431 S4-S5 linker.
{ECO:0000250|UniProtKB:P63142}.
MOTIF 480 485 Selectivity filter.
{ECO:0000250|UniProtKB:P63142}.
MOTIF 611 613 PDZ-binding. {ECO:0000250}.
COMPBIAS 94 99 Poly-Glu.
COMPBIAS 382 387 Poly-Gly.
MOD_RES 557 557 Phosphoserine; by PKA. {ECO:0000255}.
LIPID 346 346 S-palmitoyl cysteine. {ECO:0000255}.
CROSSLNK 221 221 Glycyl lysine isopeptide (Lys-Gly)
(interchain with G-Cter in SUMO).
{ECO:0000269|PubMed:17261810}.
CROSSLNK 536 536 Glycyl lysine isopeptide (Lys-Gly)
(interchain with G-Cter in SUMO).
{ECO:0000269|PubMed:17261810}.
VAR_SEQ 1 209 Missing (in isoform 2). {ECO:0000305}.
/FTId=VSP_037110.
VARIANT 42 42 L -> H (found in a patient with pulmonary
arterial hypertension; unknown
pathological significance).
{ECO:0000269|PubMed:24936649}.
/FTId=VAR_079602.
VARIANT 85 85 L -> M. {ECO:0000269|PubMed:24936649}.
/FTId=VAR_079603.
VARIANT 114 114 T -> P (found in a patient with pulmonary
arterial hypertension; unknown
pathological significance).
{ECO:0000269|PubMed:24936649}.
/FTId=VAR_079604.
VARIANT 170 170 P -> R (found in a patient with pulmonary
arterial hypertension; unknown
pathological significance).
{ECO:0000269|PubMed:24936649}.
/FTId=VAR_079605.
VARIANT 184 184 R -> P (found in a patient with pulmonary
arterial hypertension; unknown
pathological significance).
{ECO:0000269|PubMed:24936649}.
/FTId=VAR_079606.
VARIANT 228 228 P -> S (in dbSNP:rs1056464).
/FTId=VAR_053856.
VARIANT 300 300 G -> S (in a breast cancer sample;
somatic mutation; dbSNP:rs148708451).
{ECO:0000269|PubMed:16959974}.
/FTId=VAR_035770.
VARIANT 578 578 R -> K (in dbSNP:rs12720445).
/FTId=VAR_054786.
MUTAGEN 15 15 T->A: Loss of DLG1 effect on channel
current. {ECO:0000269|PubMed:16466689}.
MUTAGEN 220 220 I->N: Reduces sumoylation; when
associated with N-535.
{ECO:0000269|PubMed:17261810}.
MUTAGEN 221 221 K->R: Abolishes sumoylation; when
associated with R-536.
{ECO:0000269|PubMed:17261810}.
MUTAGEN 535 535 L->N: Reduces sumoylation; when
associated with N-220.
{ECO:0000269|PubMed:17261810}.
MUTAGEN 536 536 K->R: Abolishes sumoylation; when
associated with R-221.
{ECO:0000269|PubMed:17261810}.
CONFLICT 55 55 Missing (in Ref. 1; AAA61276).
{ECO:0000305}.
CONFLICT 138 138 L -> Q (in Ref. 2; AAA36422).
{ECO:0000305}.
CONFLICT 154 154 R -> P (in Ref. 1; AAA61276 and 2;
AAA36422). {ECO:0000305}.
CONFLICT 187 188 RP -> G (in Ref. 1; AAA61276).
{ECO:0000305}.
CONFLICT 214 214 R -> G (in Ref. 2; AAA36422).
{ECO:0000305}.
CONFLICT 228 228 P -> V (in Ref. 2; AAA36422).
{ECO:0000305}.
CONFLICT 282 282 L -> V (in Ref. 3; AAA60146).
{ECO:0000305}.
CONFLICT 307 307 P -> A (in Ref. 1; AAA61276).
{ECO:0000305}.
SEQUENCE 613 AA; 67228 MW; A5B02B27F8396E3D CRC64;
MEIALVPLEN GGAMTVRGGD EARAGCGQAT GGELQCPPTA GLSDGPKEPA PKGRGAQRDA
DSGVRPLPPL PDPGVRPLPP LPEELPRPRR PPPEDEEEEG DPGLGTVEDQ ALGTASLHHQ
RVHINISGLR FETQLGTLAQ FPNTLLGDPA KRLRYFDPLR NEYFFDRNRP SFDGILYYYQ
SGGRLRRPVN VSLDVFADEI RFYQLGDEAM ERFREDEGFI KEEEKPLPRN EFQRQVWLIF
EYPESSGSAR AIAIVSVLVI LISIITFCLE TLPEFRDERE LLRHPPAPHQ PPAPAPGANG
SGVMAPPSGP TVAPLLPRTL ADPFFIVETT CVIWFTFELL VRFFACPSKA GFSRNIMNII
DVVAIFPYFI TLGTELAEQQ PGGGGGGQNG QQAMSLAILR VIRLVRVFRI FKLSRHSKGL
QILGKTLQAS MRELGLLIFF LFIGVILFSS AVYFAEADNQ GTHFSSIPDA FWWAVVTMTT
VGYGDMRPIT VGGKIVGSLC AIAGVLTIAL PVPVIVSNFN YFYHRETDHE EPAVLKEEQG
TQSQGPGLDR GVQRKVSGSR GSFCKAGGTL ENADSARRGS CPLEKCNVKA KSNVDLRRSL
YALCLDTSRE TDL


Related products :

Catalog number Product name Quantity
18-003-42663 Potassium voltage-gated channel subfamily KQT member 2 - Voltage-gated potassium channel subunit Kv7.2; Neuroblastoma-specific potassium channel subunit alpha KvLQT2; KQT-like 2 Polyclonal 0.05 mg Aff Pur
18-003-42664 Potassium voltage-gated channel subfamily KQT member 2 - Voltage-gated potassium channel subunit Kv7.2; Neuroblastoma-specific potassium channel subunit alpha KvLQT2; KQT-like 2 Polyclonal 0.1 mg Protein A
18-662-20074 Potassium voltage-gated channel subfamily C member 1 - Voltage-gated potassium channel subunit Kv3.1; Kv4; NGK2; RAW2 Polyclonal 0.1 ml
28-297 This gene encodes a member of the potassium channel, voltage-gated, subfamily H. This member is a pore-forming (alpha) subunit of a voltage-gated non-inactivating delayed rectifier potassium channel. 0.1 mg
18-662-20009 Potassium voltage-gated channel subfamily B member 2 - Voltage-gated potassium channel subunit Kv2.2; CDRK Polyclonal 0.1 ml
18-003-43133 Potassium voltage-gated channel subfamily G member 1 - Voltage-gated potassium channel subunit Kv6.1; kH2 Polyclonal 0.05 mg Aff Pur
18-003-42629 Potassium voltage-gated channel subfamily D member 3 - Voltage-gated potassium channel subunit Kv4.3 Polyclonal 0.1 mg Protein A
18-003-42631 Cyclic GMP gated potassium channel - Potassium voltage-gated channel. shaker-related subfamily. member 10 Polyclonal 0.1 mg Protein A
KCNH4_RAT Rat ELISA Kit FOR Potassium voltage-gated channel subfamily H member 4 96T
PPAC_MOUSE Rat ELISA Kit FOR Potassium voltage-gated channel subfamily KQT member 1 96T
EH2214 Potassium voltage-gated channel subfamily B member 2 Elisa Kit 96T
E13768r Rat ELISA Kit FOR Potassium voltage-gated channel subfamily KQT member 4 96T
KCNQ1_PIG Pig ELISA Kit FOR Potassium voltage-gated channel subfamily KQT member 1 96T
KCNA5_RAT Rat ELISA Kit FOR Potassium voltage-gated channel subfamily A member 5 96T
WDR64_MOUSE Rat ELISA Kit FOR Potassium voltage-gated channel subfamily KQT member 2 96T
E0522m Rat ELISA Kit FOR Potassium voltage-gated channel subfamily KQT member 1 96T
E1366h Rat ELISA Kit FOR Potassium voltage-gated channel subfamily H member 1 96T
E0614m Rat ELISA Kit FOR Potassium voltage-gated channel subfamily KQT member 2 96T
KCNG3_RAT Rat ELISA Kit FOR Potassium voltage-gated channel subfamily G member 3 96T
E15045p Pig ELISA Kit FOR Potassium voltage-gated channel subfamily H member 2 96T
KCNH2_RAT Rat ELISA Kit FOR Potassium voltage-gated channel subfamily H member 2 96T
ZN300_HUMAN Mouse ELISA Kit FOR Potassium voltage-gated channel subfamily D member 3 96T
E0655m Mouse ELISA Kit FOR Potassium voltage-gated channel subfamily D member 3 96T
E0816b Mouse ELISA Kit FOR Potassium voltage-gated channel subfamily E member 3 96T
KCNH7_MOUSE Mouse ELISA Kit FOR Potassium voltage-gated channel subfamily H member 7 96T


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur