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Potassium voltage-gated channel subfamily A member 5 (Voltage-gated potassium channel subunit Kv1.5)

 KCNA5_RABIT             Reviewed;         598 AA.
P50638;
01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
01-OCT-1996, sequence version 1.
23-MAY-2018, entry version 116.
RecName: Full=Potassium voltage-gated channel subfamily A member 5;
AltName: Full=Voltage-gated potassium channel subunit Kv1.5;
Name=KCNA5;
Oryctolagus cuniculus (Rabbit).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae;
Oryctolagus.
NCBI_TaxID=9986;
[1]
NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND SUBCELLULAR LOCATION.
STRAIN=Japanese white; TISSUE=Heart;
PubMed=7556635; DOI=10.1016/0014-5793(95)00954-8;
Sasaki Y., Ishii K., Nunoki K., Yamagishi T., Taira N.;
"The voltage-dependent K+ channel (Kv1.5) cloned from rabbit heart and
facilitation of inactivation of the delayed rectifier current by the
rat beta subunit.";
FEBS Lett. 372:20-24(1995).
[2]
NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=New Zealand white; TISSUE=Portal vein;
Clement-Chomienne O., Ishii K., Walsh M.P., Cole W.C.;
"Rabbit portal vein Kv1.5.";
Submitted (APR-1998) to the EMBL/GenBank/DDBJ databases.
[3]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Smooth muscle;
Tate R.J., Osipenko O.N., Kempsil F.E.J., Gurney A.M.;
"Identification of a voltage-gated potassium channel (KV1.5) in rabbit
pulmonary artery smooth muscle.";
Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases.
-!- FUNCTION: Voltage-gated potassium channel that mediates
transmembrane potassium transport in excitable membranes. Forms
tetrameric potassium-selective channels through which potassium
ions pass in accordance with their electrochemical gradient. The
channel alternates between opened and closed conformations in
response to the voltage difference across the membrane
(PubMed:7556635). Can form functional homotetrameric channels and
heterotetrameric channels that contain variable proportions of
KCNA1, KCNA2, KCNA4, KCNA5, and possibly other family members as
well; channel properties depend on the type of alpha subunits that
are part of the channel (By similarity). Channel properties are
modulated by cytoplasmic beta subunits that regulate the
subcellular location of the alpha subunits and promote rapid
inactivation (PubMed:7556635). Homotetrameric channels display
rapid activation and slow inactivation (PubMed:7556635). May play
a role in regulating the secretion of insulin in normal pancreatic
islets (By similarity). {ECO:0000250|UniProtKB:P19024,
ECO:0000250|UniProtKB:P22460, ECO:0000269|PubMed:7556635}.
-!- SUBUNIT: Homotetramer and heterotetramer of potassium channel
proteins. Interacts with DLG1, which enhances channel currents.
Forms a ternary complex with DLG1 and CAV3 (By similarity).
Interacts with KCNAB1 (By similarity). Interacts with UBE2I (By
similarity). {ECO:0000250|UniProtKB:P19024,
ECO:0000250|UniProtKB:P22460}.
-!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:7556635};
Multi-pass membrane protein {ECO:0000305}.
-!- DOMAIN: The transmembrane segment S4 functions as voltage-sensor
and is characterized by a series of positively charged amino acids
at every third position. Channel opening and closing is effected
by a conformation change that affects the position and orientation
of the voltage-sensor paddle formed by S3 and S4 within the
membrane. A transmembrane electric field that is positive inside
would push the positively charged S4 segment outwards, thereby
opening the pore, while a field that is negative inside would pull
the S4 segment inwards and close the pore. Changes in the position
and orientation of S4 are then transmitted to the activation gate
formed by the inner helix bundle via the S4-S5 linker region.
{ECO:0000250|UniProtKB:P63142}.
-!- DOMAIN: The amino terminus may be important in determining the
rate of inactivation of the channel while the C-terminal PDZ-
binding motif may play a role in modulation of channel activity
and/or targeting of the channel to specific subcellular
compartments. Interacts with UBE2I. {ECO:0000250}.
-!- SIMILARITY: Belongs to the potassium channel family. A (Shaker)
(TC 1.A.1.2) subfamily. Kv1.5/KCNA5 sub-subfamily. {ECO:0000305}.
-----------------------------------------------------------------------
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EMBL; D45025; BAA08082.1; -; mRNA.
EMBL; AF056943; AAC13312.1; -; mRNA.
EMBL; AF149787; AAD56772.1; -; mRNA.
PIR; S66669; S66669.
RefSeq; NP_001075505.1; NM_001082036.1.
UniGene; Ocu.2386; -.
ProteinModelPortal; P50638; -.
STRING; 9986.ENSOCUP00000017544; -.
PRIDE; P50638; -.
Ensembl; ENSOCUT00000000674; ENSOCUP00000017544; ENSOCUG00000000674.
GeneID; 100008684; -.
KEGG; ocu:100008684; -.
CTD; 3741; -.
eggNOG; KOG1545; Eukaryota.
eggNOG; COG1226; LUCA.
GeneTree; ENSGT00760000118846; -.
HOGENOM; HOG000231015; -.
HOVERGEN; HBG052230; -.
InParanoid; P50638; -.
KO; K04878; -.
OMA; LPRNEFQ; -.
OrthoDB; EOG091G10NU; -.
TreeFam; TF313103; -.
Proteomes; UP000001811; Chromosome 8.
Bgee; ENSOCUG00000000674; -.
GO; GO:0009986; C:cell surface; IEA:Ensembl.
GO; GO:0005887; C:integral component of plasma membrane; ISS:UniProtKB.
GO; GO:0014704; C:intercalated disc; IEA:Ensembl.
GO; GO:0045121; C:membrane raft; IEA:Ensembl.
GO; GO:0034705; C:potassium channel complex; ISS:UniProtKB.
GO; GO:0008076; C:voltage-gated potassium channel complex; ISS:UniProtKB.
GO; GO:0051393; F:alpha-actinin binding; IEA:Ensembl.
GO; GO:0005251; F:delayed rectifier potassium channel activity; ISS:UniProtKB.
GO; GO:0015271; F:outward rectifier potassium channel activity; IEA:Ensembl.
GO; GO:0019870; F:potassium channel inhibitor activity; IEA:Ensembl.
GO; GO:0019901; F:protein kinase binding; IEA:Ensembl.
GO; GO:0097110; F:scaffold protein binding; IEA:Ensembl.
GO; GO:0086089; F:voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization; IEA:Ensembl.
GO; GO:0086087; F:voltage-gated potassium channel activity involved in bundle of His cell action potential repolarization; IEA:Ensembl.
GO; GO:0086090; F:voltage-gated potassium channel activity involved in SA node cell action potential repolarization; IEA:Ensembl.
GO; GO:0060081; P:membrane hyperpolarization; IEA:Ensembl.
GO; GO:0098914; P:membrane repolarization during atrial cardiac muscle cell action potential; IEA:Ensembl.
GO; GO:0043267; P:negative regulation of potassium ion transport; IEA:Ensembl.
GO; GO:0007219; P:Notch signaling pathway; IEA:Ensembl.
GO; GO:0071435; P:potassium ion export; IEA:Ensembl.
GO; GO:0071805; P:potassium ion transmembrane transport; ISS:UniProtKB.
GO; GO:0051260; P:protein homooligomerization; IEA:InterPro.
GO; GO:0060372; P:regulation of atrial cardiac muscle cell membrane repolarization; IEA:Ensembl.
GO; GO:0086091; P:regulation of heart rate by cardiac conduction; IEA:Ensembl.
GO; GO:0019229; P:regulation of vasoconstriction; IEA:Ensembl.
Gene3D; 1.20.120.350; -; 1.
InterPro; IPR000210; BTB/POZ_dom.
InterPro; IPR005821; Ion_trans_dom.
InterPro; IPR003968; K_chnl_volt-dep_Kv.
InterPro; IPR003972; K_chnl_volt-dep_Kv1.
InterPro; IPR004052; K_chnl_volt-dep_Kv1.5.
InterPro; IPR011333; SKP1/BTB/POZ_sf.
InterPro; IPR003131; T1-type_BTB.
InterPro; IPR028325; VG_K_chnl.
InterPro; IPR027359; Volt_channel_dom_sf.
PANTHER; PTHR11537; PTHR11537; 1.
Pfam; PF02214; BTB_2; 1.
Pfam; PF00520; Ion_trans; 1.
PRINTS; PR00169; KCHANNEL.
PRINTS; PR01512; KV15CHANNEL.
PRINTS; PR01491; KVCHANNEL.
PRINTS; PR01496; SHAKERCHANEL.
SMART; SM00225; BTB; 1.
SUPFAM; SSF54695; SSF54695; 1.
2: Evidence at transcript level;
Cell membrane; Complete proteome; Ion channel; Ion transport;
Isopeptide bond; Lipoprotein; Membrane; Palmitate; Potassium;
Potassium channel; Potassium transport; Reference proteome;
Transmembrane; Transmembrane helix; Transport; Ubl conjugation;
Voltage-gated channel.
CHAIN 1 598 Potassium voltage-gated channel subfamily
A member 5.
/FTId=PRO_0000053988.
TOPO_DOM 1 231 Cytoplasmic.
{ECO:0000250|UniProtKB:P63142}.
TRANSMEM 232 253 Helical; Name=Segment S1.
{ECO:0000250|UniProtKB:P63142}.
TOPO_DOM 254 308 Extracellular.
{ECO:0000250|UniProtKB:P63142}.
TRANSMEM 309 330 Helical; Name=Segment S2.
{ECO:0000250|UniProtKB:P63142}.
TOPO_DOM 331 341 Cytoplasmic.
{ECO:0000250|UniProtKB:P63142}.
TRANSMEM 342 362 Helical; Name=Segment S3.
{ECO:0000250|UniProtKB:P63142}.
TOPO_DOM 363 380 Extracellular.
{ECO:0000250|UniProtKB:P63142}.
TRANSMEM 381 401 Helical; Voltage-sensor; Name=Segment S4.
{ECO:0000250|UniProtKB:P63142}.
TOPO_DOM 402 416 Cytoplasmic.
{ECO:0000250|UniProtKB:P63142}.
TRANSMEM 417 438 Helical; Name=Segment S5.
{ECO:0000250|UniProtKB:P63142}.
TOPO_DOM 439 452 Extracellular.
{ECO:0000250|UniProtKB:P63142}.
INTRAMEM 453 464 Helical; Name=Pore helix.
{ECO:0000250|UniProtKB:P63142}.
INTRAMEM 465 472 {ECO:0000250|UniProtKB:P63142}.
TRANSMEM 480 508 Helical; Name=Segment S6.
{ECO:0000250|UniProtKB:P63142}.
TOPO_DOM 509 598 Cytoplasmic.
{ECO:0000250|UniProtKB:P63142}.
REGION 403 416 S4-S5 linker.
{ECO:0000250|UniProtKB:P63142}.
MOTIF 465 470 Selectivity filter.
{ECO:0000250|UniProtKB:P63142}.
MOTIF 596 598 PDZ-binding.
COMPBIAS 78 83 Poly-Glu.
COMPBIAS 367 372 Poly-Gly.
LIPID 331 331 S-palmitoyl cysteine. {ECO:0000255}.
CROSSLNK 205 205 Glycyl lysine isopeptide (Lys-Gly)
(interchain with G-Cter in SUMO).
{ECO:0000250}.
CROSSLNK 521 521 Glycyl lysine isopeptide (Lys-Gly)
(interchain with G-Cter in SUMO).
{ECO:0000250}.
SEQUENCE 598 AA; 65476 MW; B06D235AC7A8E1F0 CRC64;
MEIALGPLEN GGAMTIRGGG EETAGCSQAA PTAGLGDGSQ EPAPRGRGCS ARRGAEPGER
PLPPQPPELP QSRRSPLEEE EGEGDPGLSV AEEQTLGAGA LHHQRVLINI SGLRFETQLG
TLAQFPNTLL GDPAKRLRYF DPLRNEYFFD RNRPSFDGIL YYYQSGGRLR RPVNVSLDVF
ADEIRFYQLG DEAMERFRED EGFIKDEEKP LPRNEFQRQV WLIFEYPESS GSARAIAIVS
VLVILISIIT FCLETLPEFK DERELLRHPP VPHQPPAAPA LGANGSGAVA PASGSTVAPL
LPRTLADPFF IVETTCVIWF TFELLVRFFA CPSKAEFSRN IMNIIDIVAI FPYFITLGTE
LAEQQPGGGG GGQNGQQAMS LAILRVIRLV RVFRIFKLSR HSKGLQILGK TLQASMRELG
LLIFFLFIGV ILFSSAVYFA EADNQGTHFS SIPDAFWWAV VTMTTVGYGD MRPITVGGKI
VGSLCAIAGV LTIALPVPVI VSNFNYFYHR ETDHEEQAAL KEEPGSQSRG TSLDAGGQRK
ASWSKASLCK AGGSLETADS VRRGSCLLEK YNLKAKSNVD LRRSLYALCL DTSRETDL


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