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Potassium voltage-gated channel subfamily E member 1 (Delayed rectifier potassium channel subunit IsK) (IKs producing slow voltage-gated potassium channel subunit beta Mink) (Minimal potassium channel)

 KCNE1_RAT               Reviewed;         130 AA.
P15383;
01-APR-1990, integrated into UniProtKB/Swiss-Prot.
01-APR-1990, sequence version 1.
22-NOV-2017, entry version 131.
RecName: Full=Potassium voltage-gated channel subfamily E member 1;
AltName: Full=Delayed rectifier potassium channel subunit IsK;
AltName: Full=IKs producing slow voltage-gated potassium channel subunit beta Mink;
AltName: Full=Minimal potassium channel;
Name=Kcne1;
Rattus norvegicus (Rat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
NCBI_TaxID=10116;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Kidney;
PubMed=3194754; DOI=10.1126/science.3194754;
Takumi T., Ohkubo H., Nakanishi S.;
"Cloning of a membrane protein that induces a slow voltage-gated
potassium current.";
Science 242:1042-1045(1988).
[2]
NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
TISSUE=Heart;
PubMed=2183220; DOI=10.1073/pnas.87.8.2975;
Folander K., Smith J.S., Antanavage J., Bennett C., Stein R.B.,
Swanson R.;
"Cloning and expression of the delayed-rectifier IsK channel from
neonatal rat heart and diethylstilbestrol-primed rat uterus.";
Proc. Natl. Acad. Sci. U.S.A. 87:2975-2979(1990).
[3]
NUCLEOTIDE SEQUENCE, INDUCTION, AND TISSUE SPECIFICITY.
TISSUE=Uterus;
PubMed=2344412; DOI=10.1016/0896-6273(90)90207-V;
Pragnell M., Snay K.J., Trimmer J.S., Maclusky N.J., Naftolin F.,
Kaczmarek L.K., Boyle M.B.;
"Estrogen induction of a small, putative K+ channel mRNA in rat
uterus.";
Neuron 4:807-812(1990).
[4]
NUCLEOTIDE SEQUENCE.
PubMed=2229022;
Iwai M., Masu M., Tsuchida K., Mori T., Ohkubo H., Nakanishi S.;
"Characterization of gene organization and generation of heterogeneous
mRNA species of rat ISK protein.";
J. Biochem. 108:200-206(1990).
[5]
MUTAGENESIS OF SER-103.
PubMed=1553557; DOI=10.1126/science.1553557;
Busch A.E., Varnum M.D., North R.A., Adelman J.P.;
"An amino acid mutation in a potassium channel that prevents
inhibition by protein kinase C.";
Science 255:1705-1707(1992).
[6]
MUTAGENESIS OF ASP-77.
PubMed=7605639; DOI=10.1016/0896-6273(95)90277-5;
Wang K.-W., Goldstein S.A.N.;
"Subunit composition of minK potassium channels.";
Neuron 14:1303-1309(1995).
[7]
SUBUNIT, INTERACTION WITH KCNC2, AND SUBCELLULAR LOCATION.
PubMed=14679187; DOI=10.1074/jbc.M310501200;
Lewis A., McCrossan Z.A., Abbott G.W.;
"MinK, MiRP1, and MiRP2 diversify Kv3.1 and Kv3.2 potassium channel
gating.";
J. Biol. Chem. 279:7884-7892(2004).
[8]
FUNCTION, INTERACTION WITH KCNB1, SUBCELLULAR LOCATION, AND TISSUE
SPECIFICITY.
PubMed=19219384; DOI=10.1007/s00232-009-9154-8;
McCrossan Z.A., Roepke T.K., Lewis A., Panaghie G., Abbott G.W.;
"Regulation of the Kv2.1 potassium channel by MinK and MiRP1.";
J. Membr. Biol. 228:1-14(2009).
-!- FUNCTION: Ancillary protein that assembles as a beta subunit with
a voltage-gated potassium channel complex of pore-forming alpha
subunits. Modulates the gating kinetics and enhances stability of
the channel complex. Assembled with KCNB1 modulates the gating
characteristics of the delayed rectifier voltage-dependent
potassium channel KCNB1 (PubMed:19219384). Assembled with
KCNQ1/KVLQT1 is proposed to form the slowly activating delayed
rectifier cardiac potassium (IKs) channel. The outward current
reaches its steady state only after 50 seconds. Assembled with
KCNH2/HERG may modulate the rapidly activating component of the
delayed rectifying potassium current in heart (IKr) (By
similarity). {ECO:0000250|UniProtKB:P15382,
ECO:0000269|PubMed:19219384}.
-!- SUBUNIT: Interacts with KCNB1 (PubMed:19219384). Interacts with
KCNC2 (PubMed:14679187). Associates with KCNH2/HERG (By
similarity). Interacts with KNCQ1; targets the complex KNCQ1-KCNE1
to the membrane raft (By similarity).
{ECO:0000250|UniProtKB:P15382, ECO:0000250|UniProtKB:P23299,
ECO:0000269|PubMed:14679187, ECO:0000269|PubMed:19219384}.
-!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:14679187,
ECO:0000269|PubMed:19219384}; Single-pass type I membrane protein
{ECO:0000305}. Apical cell membrane {ECO:0000269|PubMed:19219384}.
Membrane raft {ECO:0000250|UniProtKB:P15382}. Note=Colocalizes
with KCNB1 at the plasma membrane. Restrictively localized in the
apical membrane portion of epithelial cells. Targets to the
membrane raft when associated with KNCQ1 (By similarity).
{ECO:0000250|UniProtKB:P15382, ECO:0000269|PubMed:19219384}.
-!- TISSUE SPECIFICITY: Expressed in the heart (PubMed:2183220,
PubMed:19219384). Expressed in kidney (PubMed:2344412). Expressed
in estrogen-induced uterus (PubMed:2344412).
{ECO:0000269|PubMed:19219384, ECO:0000269|PubMed:2183220,
ECO:0000269|PubMed:2344412}.
-!- INDUCTION: By estrogen. {ECO:0000269|PubMed:2344412}.
-!- PTM: Phosphorylation inhibits the potassium current.
-!- PTM: N-glycosylation at Asn-26 occurs post-translationally, and
requires prior cotranslational glycosylation at Asn-5.
{ECO:0000250}.
-!- MISCELLANEOUS: Mutagenesis experiments were carried out by
expressing in Xenopus oocytes the mutant Asn-77 either
individually (homomultimers) or in combination with wild-type
KCNE1 (heteromultimers) in a 1:1 ratio (PubMed:7605639).
{ECO:0000269|PubMed:7605639}.
-!- SIMILARITY: Belongs to the potassium channel KCNE family.
{ECO:0000305}.
-----------------------------------------------------------------------
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EMBL; M22412; AAA41822.1; -; mRNA.
EMBL; M36461; AAA41098.1; -; mRNA.
EMBL; D10709; BAA01553.1; ALT_SEQ; Genomic_DNA.
PIR; A35633; A35633.
RefSeq; NP_037105.1; NM_012973.1.
RefSeq; XP_006248096.1; XM_006248034.3.
RefSeq; XP_006248097.1; XM_006248035.2.
RefSeq; XP_008766788.1; XM_008768566.2.
RefSeq; XP_017453375.1; XM_017597886.1.
RefSeq; XP_017453376.1; XM_017597887.1.
UniGene; Rn.9734; -.
SMR; P15383; -.
CORUM; P15383; -.
STRING; 10116.ENSRNOP00000002717; -.
TCDB; 8.A.10.1.1; the slow voltage-gated k+) channel accessory protein (mink) family.
iPTMnet; P15383; -.
PhosphoSitePlus; P15383; -.
PaxDb; P15383; -.
Ensembl; ENSRNOT00000002717; ENSRNOP00000002717; ENSRNOG00000001984.
GeneID; 25471; -.
KEGG; rno:25471; -.
UCSC; RGD:2956; rat.
CTD; 3753; -.
RGD; 2956; Kcne1.
eggNOG; ENOG410IY71; Eukaryota.
eggNOG; ENOG410Y1SF; LUCA.
GeneTree; ENSGT00510000048994; -.
HOGENOM; HOG000113207; -.
HOVERGEN; HBG052226; -.
InParanoid; P15383; -.
KO; K04894; -.
OMA; ALYILMV; -.
OrthoDB; EOG091G0UDJ; -.
PhylomeDB; P15383; -.
TreeFam; TF335976; -.
Reactome; R-RNO-5576890; Phase 3 - rapid repolarisation.
Reactome; R-RNO-5576893; Phase 2 - plateau phase.
PRO; PR:P15383; -.
Proteomes; UP000002494; Chromosome 11.
Bgee; ENSRNOG00000001984; -.
Genevisible; P15383; RN.
GO; GO:0016324; C:apical plasma membrane; IDA:RGD.
GO; GO:0009986; C:cell surface; ISO:RGD.
GO; GO:0005783; C:endoplasmic reticulum; IDA:RGD.
GO; GO:0005764; C:lysosome; ISO:RGD.
GO; GO:0045121; C:membrane raft; IEA:UniProtKB-SubCell.
GO; GO:0005886; C:plasma membrane; IDA:UniProtKB.
GO; GO:0008076; C:voltage-gated potassium channel complex; IDA:RGD.
GO; GO:0030018; C:Z disc; IDA:BHF-UCL.
GO; GO:0005251; F:delayed rectifier potassium channel activity; IMP:RGD.
GO; GO:0044325; F:ion channel binding; IPI:UniProtKB.
GO; GO:0015459; F:potassium channel regulator activity; IDA:UniProtKB.
GO; GO:0046982; F:protein heterodimerization activity; IPI:RGD.
GO; GO:0031433; F:telethonin binding; ISO:RGD.
GO; GO:0005249; F:voltage-gated potassium channel activity; IMP:RGD.
GO; GO:0086002; P:cardiac muscle cell action potential involved in contraction; ISO:RGD.
GO; GO:0071468; P:cellular response to acidic pH; IDA:RGD.
GO; GO:0071320; P:cellular response to cAMP; ISO:RGD.
GO; GO:0071482; P:cellular response to light stimulus; IEP:RGD.
GO; GO:0002070; P:epithelial cell maturation; ISO:RGD.
GO; GO:0060047; P:heart contraction; ISO:RGD.
GO; GO:0008584; P:male gonad development; IEP:RGD.
GO; GO:0086009; P:membrane repolarization; ISO:RGD.
GO; GO:0086011; P:membrane repolarization during action potential; ISO:RGD.
GO; GO:0086013; P:membrane repolarization during cardiac muscle cell action potential; ISO:RGD.
GO; GO:0098915; P:membrane repolarization during ventricular cardiac muscle cell action potential; ISO:RGD.
GO; GO:1902260; P:negative regulation of delayed rectifier potassium channel activity; IDA:UniProtKB.
GO; GO:0090315; P:negative regulation of protein targeting to membrane; IDA:RGD.
GO; GO:1903817; P:negative regulation of voltage-gated potassium channel activity; IDA:RGD.
GO; GO:1901381; P:positive regulation of potassium ion transmembrane transport; IDA:RGD.
GO; GO:1901387; P:positive regulation of voltage-gated calcium channel activity; IDA:RGD.
GO; GO:1903818; P:positive regulation of voltage-gated potassium channel activity; IMP:RGD.
GO; GO:0071435; P:potassium ion export; ISO:RGD.
GO; GO:0071805; P:potassium ion transmembrane transport; ISO:RGD.
GO; GO:0006487; P:protein N-linked glycosylation; ISS:UniProtKB.
GO; GO:0006493; P:protein O-linked glycosylation; ISS:UniProtKB.
GO; GO:1902259; P:regulation of delayed rectifier potassium channel activity; ISO:RGD.
GO; GO:0086091; P:regulation of heart rate by cardiac conduction; ISO:RGD.
GO; GO:1901379; P:regulation of potassium ion transmembrane transport; ISO:RGD.
GO; GO:0060307; P:regulation of ventricular cardiac muscle cell membrane repolarization; ISO:RGD.
GO; GO:0086005; P:ventricular cardiac muscle cell action potential; ISO:RGD.
InterPro; IPR000369; K_chnl_KCNE.
InterPro; IPR005424; K_chnl_volt-dep_bsu_KCNE1.
PANTHER; PTHR15282; PTHR15282; 1.
Pfam; PF02060; ISK_Channel; 1.
PRINTS; PR01604; KCNE1CHANNEL.
PRINTS; PR00168; KCNECHANNEL.
1: Evidence at protein level;
Cell membrane; Complete proteome; Glycoprotein; Ion channel;
Ion transport; Membrane; Phosphoprotein; Potassium; Potassium channel;
Potassium transport; Reference proteome; Transmembrane;
Transmembrane helix; Transport; Voltage-gated channel.
CHAIN 1 130 Potassium voltage-gated channel subfamily
E member 1.
/FTId=PRO_0000144283.
TRANSMEM 45 67 Helical. {ECO:0000255}.
TOPO_DOM 68 130 Cytoplasmic. {ECO:0000255}.
MOD_RES 103 103 Phosphoserine; by PKC. {ECO:0000305}.
CARBOHYD 5 5 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 26 26 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
MUTAGEN 77 77 D->N: No current (homomultimers); one
fourth of the WT current
(heteromultimers).
{ECO:0000269|PubMed:7605639}.
MUTAGEN 103 103 S->A: Abolishes inhibition by
phosphorylation.
{ECO:0000269|PubMed:1553557}.
SEQUENCE 130 AA; 14699 MW; 76717E7ED73C5E4D CRC64;
MALSNSTTVL PFLASLWQET DEPGGNMSAD LARRSQLRDD SKLEALYILM VLGFFGFFTL
GIMLSYIRSK KLEHSHDPFN VYIESDAWQE KGKALFQARV LESFRACYVI ENQAAVEQPA
THLPELKPLS


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