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Potassium voltage-gated channel subfamily E member 2 (MinK-related peptide 1) (Minimum potassium ion channel-related peptide 1) (Potassium channel subunit beta MiRP1)

 KCNE2_RAT               Reviewed;         123 AA.
P63161; Q5FVT9; Q9WTW0;
27-SEP-2004, integrated into UniProtKB/Swiss-Prot.
27-SEP-2004, sequence version 1.
12-SEP-2018, entry version 94.
RecName: Full=Potassium voltage-gated channel subfamily E member 2;
AltName: Full=MinK-related peptide 1;
AltName: Full=Minimum potassium ion channel-related peptide 1;
AltName: Full=Potassium channel subunit beta MiRP1;
Name=Kcne2;
Rattus norvegicus (Rat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
NCBI_TaxID=10116;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=Sprague-Dawley; TISSUE=Heart;
PubMed=10219239; DOI=10.1016/S0092-8674(00)80728-X;
Abbott G.W., Sesti F., Splawski I., Buck M.E., Lehmann M.H.,
Timothy K.W., Keating M.T., Goldstein S.A.N.;
"MiRP1 forms IKr potassium channels with HERG and is associated with
cardiac arrhythmia.";
Cell 97:175-187(1999).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Ovary;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[3]
INTERACTION WITH HCN1.
PubMed=11420311; DOI=10.1161/hh1201.093511;
Yu H., Wu J., Potapova I., Wymore R.T., Holmes B., Zuckerman J.,
Pan Z., Wang H., Shi W., Robinson R.B., El-Maghrabi M.R., Benjamin W.,
Dixon J.E., McKinnon D., Cohen I.S., Wymore R.;
"MinK-related peptide 1: a beta subunit for the HCN ion channel
subunit family enhances expression and speeds activation.";
Circ. Res. 88:E84-E87(2001).
[4]
SUBUNIT, INTERACTION WITH KCNC2, AND SUBCELLULAR LOCATION.
PubMed=14679187; DOI=10.1074/jbc.M310501200;
Lewis A., McCrossan Z.A., Abbott G.W.;
"MinK, MiRP1, and MiRP2 diversify Kv3.1 and Kv3.2 potassium channel
gating.";
J. Biol. Chem. 279:7884-7892(2004).
[5]
FUNCTION, INTERACTION WITH KCNB1, SUBCELLULAR LOCATION, AND TISSUE
SPECIFICITY.
PubMed=19219384; DOI=10.1007/s00232-009-9154-8;
McCrossan Z.A., Roepke T.K., Lewis A., Panaghie G., Abbott G.W.;
"Regulation of the Kv2.1 potassium channel by MinK and MiRP1.";
J. Membr. Biol. 228:1-14(2009).
-!- FUNCTION: Ancillary protein that assembles as a beta subunit with
a voltage-gated potassium channel complex of pore-forming alpha
subunits. Modulates the gating kinetics and enhances stability of
the channel complex. Assembled with KCNB1 modulates the gating
characteristics of the delayed rectifier voltage-dependent
potassium channel KCNB1 (PubMed:19219384). Associated with
KCNH2/HERG is proposed to form the rapidly activating component of
the delayed rectifying potassium current in heart (IKr). May
associate with KCNQ2 and/or KCNQ3 and modulate the native M-type
current. May associate with HCN1 and HCN2 and increase potassium
current (By similarity). Interacts with KCNQ1; forms a
heterooligomer complex leading to currents with an apparently
instantaneous activation, a rapid deactivation process and a
linear current-voltage relationship and decreases the amplitude of
the outward current (By similarity).
{ECO:0000250|UniProtKB:Q9Y6J6, ECO:0000269|PubMed:19219384}.
-!- SUBUNIT: Interacts with KCNB1 (PubMed:19219384). Associates with
KCNH2/ERG1 (By similarity). May associate with KCNQ2 and KCNQ3 (By
similarity). Associates with HCN1 and probably HCN2
(PubMed:11420311). Heteromultimer with KCNC2. Interacts with KCNC2
(PubMed:14679187). Interacts with KCNQ1; forms a heterooligomer
complex that targets to the membrane raft and leading to currents
with an apparently instantaneous activation, a rapid deactivation
process and a linear current-voltage relationship and decreases
the amplitude of the outward current (By similarity).
{ECO:0000250|UniProtKB:Q9Y6J6, ECO:0000269|PubMed:11420311,
ECO:0000269|PubMed:14679187, ECO:0000269|PubMed:19219384}.
-!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:14679187,
ECO:0000269|PubMed:19219384}; Single-pass type I membrane protein
{ECO:0000305}. Note=Colocalizes with KCNB1 at the plasma membrane.
{ECO:0000269|PubMed:19219384}.
-!- TISSUE SPECIFICITY: Expressed in the heart (PubMed:19219384).
{ECO:0000269|PubMed:19219384}.
-!- SIMILARITY: Belongs to the potassium channel KCNE family.
{ECO:0000305}.
-----------------------------------------------------------------------
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EMBL; AF071003; AAD28087.1; -; mRNA.
EMBL; BC089778; AAH89778.1; -; mRNA.
RefSeq; NP_598287.1; NM_133603.2.
RefSeq; XP_006248085.1; XM_006248023.3.
RefSeq; XP_008766776.1; XM_008768554.2.
UniGene; Rn.48691; -.
SMR; P63161; -.
STRING; 10116.ENSRNOP00000045279; -.
iPTMnet; P63161; -.
PhosphoSitePlus; P63161; -.
PaxDb; P63161; -.
PRIDE; P63161; -.
Ensembl; ENSRNOT00000040844; ENSRNOP00000045279; ENSRNOG00000029811.
GeneID; 171138; -.
KEGG; rno:171138; -.
UCSC; RGD:621383; rat.
CTD; 9992; -.
RGD; 621383; Kcne2.
eggNOG; ENOG410IX4Y; Eukaryota.
eggNOG; ENOG411297Y; LUCA.
GeneTree; ENSGT00510000048894; -.
HOGENOM; HOG000113208; -.
HOVERGEN; HBG052227; -.
InParanoid; P63161; -.
KO; K04896; -.
OMA; NWRRNTT; -.
OrthoDB; EOG091G0UDJ; -.
PhylomeDB; P63161; -.
TreeFam; TF336058; -.
Reactome; R-RNO-5576890; Phase 3 - rapid repolarisation.
Reactome; R-RNO-5576893; Phase 2 - plateau phase.
PRO; PR:P63161; -.
Proteomes; UP000002494; Chromosome 11.
Bgee; ENSRNOG00000029811; Expressed in 9 organ(s), highest expression level in lung.
Genevisible; P63161; RN.
GO; GO:0009986; C:cell surface; IDA:RGD.
GO; GO:0005783; C:endoplasmic reticulum; IDA:RGD.
GO; GO:0005794; C:Golgi apparatus; IDA:RGD.
GO; GO:0016021; C:integral component of membrane; IDA:RGD.
GO; GO:0005886; C:plasma membrane; IDA:UniProtKB.
GO; GO:0008076; C:voltage-gated potassium channel complex; IDA:BHF-UCL.
GO; GO:0005261; F:cation channel activity; TAS:RGD.
GO; GO:0005251; F:delayed rectifier potassium channel activity; IEA:Ensembl.
GO; GO:0005242; F:inward rectifier potassium channel activity; IEA:Ensembl.
GO; GO:0044325; F:ion channel binding; IDA:BHF-UCL.
GO; GO:0015459; F:potassium channel regulator activity; IDA:UniProtKB.
GO; GO:0042803; F:protein homodimerization activity; IDA:RGD.
GO; GO:0005249; F:voltage-gated potassium channel activity; IDA:RGD.
GO; GO:1902282; F:voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization; IEA:Ensembl.
GO; GO:0007568; P:aging; IEP:RGD.
GO; GO:0035690; P:cellular response to drug; IDA:BHF-UCL.
GO; GO:0086009; P:membrane repolarization; IDA:BHF-UCL.
GO; GO:0086011; P:membrane repolarization during action potential; IDA:BHF-UCL.
GO; GO:1902260; P:negative regulation of delayed rectifier potassium channel activity; IDA:UniProtKB.
GO; GO:1903817; P:negative regulation of voltage-gated potassium channel activity; IDA:RGD.
GO; GO:1901800; P:positive regulation of proteasomal protein catabolic process; IEA:Ensembl.
GO; GO:1901387; P:positive regulation of voltage-gated calcium channel activity; IDA:RGD.
GO; GO:0071435; P:potassium ion export; IDA:BHF-UCL.
GO; GO:0010107; P:potassium ion import; IMP:BHF-UCL.
GO; GO:0071805; P:potassium ion transmembrane transport; IDA:BHF-UCL.
GO; GO:1902159; P:regulation of cyclic nucleotide-gated ion channel activity; IDA:RGD.
GO; GO:1902259; P:regulation of delayed rectifier potassium channel activity; IDA:BHF-UCL.
GO; GO:0086091; P:regulation of heart rate by cardiac conduction; IEA:Ensembl.
GO; GO:1901979; P:regulation of inward rectifier potassium channel activity; IDA:BHF-UCL.
GO; GO:0060306; P:regulation of membrane repolarization; IDA:BHF-UCL.
GO; GO:1901379; P:regulation of potassium ion transmembrane transport; IDA:BHF-UCL.
GO; GO:0060307; P:regulation of ventricular cardiac muscle cell membrane repolarization; IEA:Ensembl.
GO; GO:0043586; P:tongue development; IEP:RGD.
InterPro; IPR000369; K_chnl_KCNE.
InterPro; IPR005425; K_chnl_volt-dep_bsu_KCNE2.
PANTHER; PTHR15282; PTHR15282; 1.
Pfam; PF02060; ISK_Channel; 1.
PRINTS; PR01605; KCNE2CHANNEL.
1: Evidence at protein level;
Cell membrane; Complete proteome; Glycoprotein; Ion channel;
Ion transport; Membrane; Potassium; Potassium channel;
Potassium transport; Reference proteome; Transmembrane;
Transmembrane helix; Transport; Voltage-gated channel.
CHAIN 1 123 Potassium voltage-gated channel subfamily
E member 2.
/FTId=PRO_0000144288.
TRANSMEM 49 69 Helical. {ECO:0000255}.
TOPO_DOM 70 123 Cytoplasmic. {ECO:0000255}.
CARBOHYD 6 6 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 29 29 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
SEQUENCE 123 AA; 14356 MW; CB91870E7B1EB82A CRC64;
MTTLANLTQT LEDAFKKVFI TYMDSWRRNT TAEQQALQAR VDAENFYYVI LYLMVMIGMF
AFIVVAILVS TVKSKRREHS QDPYHQYIVE DWQQKYRSQI LHLEDSKATI HENLGATGFT
VSP


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