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Pre T-cell antigen receptor alpha (pT-alpha) (pTa) (gp33) (pT-alpha-TCR)

 PTCRA_MOUSE             Reviewed;         199 AA.
P0C6B2;
26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
26-FEB-2008, sequence version 1.
22-NOV-2017, entry version 66.
RecName: Full=Pre T-cell antigen receptor alpha;
Short=pT-alpha;
Short=pTa;
AltName: Full=gp33;
AltName: Full=pT-alpha-TCR;
Flags: Precursor;
Name=Ptcra;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBUNIT, AND TISSUE
SPECIFICITY.
PubMed=7973703; DOI=10.1126/science.7973703;
Saint-Ruf C., Ungewiss K., Groettrup M., Bruno L., Fehling H.J.,
von Boehmer H.;
"Analysis and expression of a cloned pre-T cell receptor gene.";
Science 266:1208-1212(1994).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1).
STRAIN=129/Ola, and 129/Sv; TISSUE=Liver;
PubMed=7672822; DOI=10.1007/BF00176445;
Fehling H.J., Laplace C., Mattei M.-G., Saint-Ruf C., von Boehmer H.;
"Genomic structure and chromosomal location of the mouse pre-T-cell
receptor alpha gene.";
Immunogenetics 42:275-281(1995).
[3]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), FUNCTION, AND TISSUE
SPECIFICITY.
PubMed=9647201;
Barber D.F., Passoni L., Wen L., Geng L., Hayday A.C.;
"The expression in vivo of a second isoform of pT alpha: implications
for the mechanism of pT alpha action.";
J. Immunol. 161:11-16(1998).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
-!- FUNCTION: The pre-T-cell receptor complex (composed of PTCRA, TCRB
and the CD3 complex) regulates early T-cell development. Isoform 1
acts to retain most TCRB intracellularly, while isoform 2 permits
higher levels of cell surface TCRB expression and facilitates
signaling from the CD3-TCRB complex. {ECO:0000269|PubMed:9647201}.
-!- SUBUNIT: Interacts with RHBDD1 (By similarity). Heterodimer with
TCRB; disulfide linked. This heterodimer assembles with CD3
proteins into a signaling-competent pre-T-cell receptor complex.
{ECO:0000250, ECO:0000269|PubMed:7973703}.
-!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
membrane protein {ECO:0000305}.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=2;
Name=1; Synonyms=pTalpha-a;
IsoId=P0C6B2-1; Sequence=Displayed;
Name=2; Synonyms=pTalpha-b;
IsoId=P0C6B2-2; Sequence=VSP_031447;
-!- TISSUE SPECIFICITY: Isoform 1 is expressed at higher levels than
isoform 2 in the thymus while only isoform 2 is expressed in
polyclonal beta-only cells. Isoform 1 shows a predominant
expression in immature thymocytes. {ECO:0000269|PubMed:7973703,
ECO:0000269|PubMed:9647201}.
-!- SEQUENCE CAUTION:
Sequence=AAA58963.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Sequence=AAI19063.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Sequence=AAI20747.1; Type=Erroneous initiation; Evidence={ECO:0000305};
-----------------------------------------------------------------------
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Distributed under the Creative Commons Attribution-NoDerivs License
-----------------------------------------------------------------------
EMBL; U16958; AAA58963.1; ALT_INIT; mRNA.
EMBL; U27268; AAA84398.1; -; Genomic_DNA.
EMBL; BC119062; AAI19063.1; ALT_INIT; mRNA.
EMBL; BC120746; AAI20747.1; ALT_INIT; mRNA.
RefSeq; NP_035325.1; NM_011195.2.
UniGene; Mm.215173; -.
ProteinModelPortal; P0C6B2; -.
SMR; P0C6B2; -.
PhosphoSitePlus; P0C6B2; -.
PRIDE; P0C6B2; -.
GeneID; 19208; -.
KEGG; mmu:19208; -.
UCSC; uc008cuh.1; mouse. [P0C6B2-1]
CTD; 171558; -.
MGI; MGI:104857; Ptcra.
HOGENOM; HOG000204058; -.
HOVERGEN; HBG108303; -.
InParanoid; P0C6B2; -.
KO; K06056; -.
TreeFam; TF337868; -.
PRO; PR:P0C6B2; -.
Proteomes; UP000000589; Unplaced.
CleanEx; MM_PTCRA; -.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0070244; P:negative regulation of thymocyte apoptotic process; IMP:MGI.
Gene3D; 2.60.40.10; -; 1.
InterPro; IPR036179; Ig-like_dom_sf.
InterPro; IPR013783; Ig-like_fold.
InterPro; IPR027834; PTCRA.
PANTHER; PTHR37866; PTHR37866; 1.
Pfam; PF15028; PTCRA; 1.
SUPFAM; SSF48726; SSF48726; 1.
1: Evidence at protein level;
Alternative splicing; Complete proteome; Disulfide bond; Glycoprotein;
Membrane; Receptor; Reference proteome; Signal; Transmembrane;
Transmembrane helix.
SIGNAL 1 16 {ECO:0000255}.
CHAIN 17 199 Pre T-cell antigen receptor alpha.
/FTId=PRO_0000319109.
TOPO_DOM 17 146 Extracellular. {ECO:0000255}.
TRANSMEM 147 167 Helical. {ECO:0000255}.
TOPO_DOM 168 199 Cytoplasmic. {ECO:0000255}.
COMPBIAS 160 163 Poly-Leu.
CARBOHYD 67 67 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 117 117 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 47 107 {ECO:0000250}.
DISULFID 135 135 Interchain (with TCRB). {ECO:0000250}.
VAR_SEQ 20 126 Missing (in isoform 2).
{ECO:0000303|PubMed:9647201}.
/FTId=VSP_031447.
SEQUENCE 199 AA; 21491 MW; 5141E9361BF494BA CRC64;
MARTWLLLLL GVRCQALPSG IAGTPFPSLA PPITLLVDGR QHMLVVCLVL DAAPPGLDNP
VWFSAGNGSA LDAFTYGPSL APDGTWTSLA QLSLPSEELE AWEPLVCHTR PGAGGQNRST
HPLQLSGESS TARSCFPEPL GGTQRQVLWL SLLRLLLFKL LLLDVLLTCS HLRLHVLAGQ
HLQPPPSRKS LPPTHRIWT


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