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Pre-B-cell leukemia transcription factor 1 (Xpbx1) (Homeobox protein pbx1) (Pre-B-cell leukemia transcription factor 1b) (Xpbx1b)

 PBX1_XENLA              Reviewed;         347 AA.
Q8QGC4;
03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
01-JUN-2002, sequence version 1.
07-NOV-2018, entry version 96.
RecName: Full=Pre-B-cell leukemia transcription factor 1 {ECO:0000250|UniProtKB:P40424};
Short=Xpbx1 {ECO:0000303|PubMed:11960001};
AltName: Full=Homeobox protein pbx1 {ECO:0000250|UniProtKB:P40424};
AltName: Full=Pre-B-cell leukemia transcription factor 1b {ECO:0000312|EMBL:AAM18914.1};
Short=Xpbx1b {ECO:0000303|PubMed:11960001};
Name=pbx1; Synonyms=pbx1b {ECO:0000312|EMBL:AAM18914.1};
Xenopus laevis (African clawed frog).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus;
Xenopus.
NCBI_TaxID=8355;
[1] {ECO:0000305, ECO:0000312|EMBL:AAM18914.1}
NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH MEIS1,
SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
TISSUE=Embryonic head {ECO:0000269|PubMed:11960001};
PubMed=11960001; DOI=10.1073/pnas.082654899;
Maeda R., Ishimura A., Mood K., Park E.K., Buchberg A.M., Daar I.O.;
"Xpbx1b and Xmeis1b play a collaborative role in hindbrain and neural
crest gene expression in Xenopus embryos.";
Proc. Natl. Acad. Sci. U.S.A. 99:5448-5453(2002).
[2] {ECO:0000312|EMBL:AAI06423.1}
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Neurula {ECO:0000312|EMBL:AAI06423.1};
NIH - Xenopus Gene Collection (XGC) project;
Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases.
[3] {ECO:0000305}
FUNCTION.
PubMed=16631621; DOI=10.1016/j.bbrc.2006.03.235;
Kelly L.E., Carrel T.L., Herman G.E., El-Hodiri H.M.;
"Pbx1 and Meis1 regulate activity of the Xenopus laevis Zic3 promoter
through a highly conserved region.";
Biochem. Biophys. Res. Commun. 344:1031-1037(2006).
-!- FUNCTION: Acts as a transcriptional activator in complex with
isoform 2 of meis1, to induce posterior neural and neural crest
gene expression, and thereby specify hindbrain and neural crest
cell fate. Binds to a highly conserved region in the promoter of
the neural crest gene zic3. Required for the nuclear transport or
retention of isoform 2 of meis1. {ECO:0000269|PubMed:11960001,
ECO:0000269|PubMed:16631621}.
-!- SUBUNIT: Forms a heterodimer with isoform 2 of meis1; the
interaction is necessary for neural fate induction.
{ECO:0000269|PubMed:11960001}.
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P40424}.
-!- TISSUE SPECIFICITY: Shows broad, weak expression from blastula
through gastrula stages. At stage 14/15, expressed in a broad arc
that gives rise to the forebrain and eyes. More intensely
expressed in the lateral neural folds (presumptive neural crest)
and as horizontal stripes in the posterior neural plate that give
rise to the hindbrain. As development proceeds, expression
progresses posteriorly along the neural folds and at stage 21,
expression is pronounced in the prospective hindbrain and in
migratory neural crest cells. At later stages (stage 26),
expression becomes intense within the dorsal portion of the
forebrain, and in the optic cup, caudal branchial arch, peripheral
to the pronephric anlage, and in the dorsal anterior half of the
spinal cord. Expression remains robust in the hindbrain but
gradually becomes more restricted. At stage 28, expressed in the
dorsal lateral portion of the neural tube and in the somatic layer
of the lateral plate mesoderm that surrounds the pronephric
anlage. {ECO:0000269|PubMed:11960001}.
-!- DEVELOPMENTAL STAGE: Expressed both maternally and zygotically.
Expressed at a low level in unfertilized eggs with increased
expression during late gastrula through neurula and tailbud
stages. {ECO:0000269|PubMed:11960001}.
-!- MISCELLANEOUS: The displayed sequence corresponds to the ortholog
of the mammalian isoform B sequences. There is currently no
X.laevis ortholog sequence for isoform A. {ECO:0000305}.
-!- SIMILARITY: Belongs to the TALE/PBX homeobox family.
{ECO:0000255}.
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EMBL; AF480430; AAM18914.1; -; mRNA.
EMBL; BC106422; AAI06423.1; -; mRNA.
RefSeq; NP_001083906.1; NM_001090437.1.
UniGene; Xl.40234; -.
ProteinModelPortal; Q8QGC4; -.
SMR; Q8QGC4; -.
GeneID; 399184; -.
KEGG; xla:399184; -.
CTD; 399184; -.
Xenbase; XB-GENE-1217596; pbx1.
HOVERGEN; HBG000122; -.
KO; K09355; -.
GO; GO:0030496; C:midbody; ISS:UniProtKB.
GO; GO:0005634; C:nucleus; IDA:UniProtKB.
GO; GO:0005667; C:transcription factor complex; IGI:UniProtKB.
GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
GO; GO:0043565; F:sequence-specific DNA binding; IDA:UniProtKB.
GO; GO:1904888; P:cranial skeletal system development; ISS:UniProtKB.
GO; GO:0007399; P:nervous system development; IEA:UniProtKB-KW.
GO; GO:0014036; P:neural crest cell fate specification; IGI:UniProtKB.
GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IDA:UniProtKB.
GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IDA:UniProtKB.
GO; GO:0072001; P:renal system development; ISS:UniProtKB.
CDD; cd00086; homeodomain; 1.
InterPro; IPR009057; Homeobox-like_sf.
InterPro; IPR017970; Homeobox_CS.
InterPro; IPR001356; Homeobox_dom.
InterPro; IPR005542; PBX.
Pfam; PF00046; Homeobox; 1.
Pfam; PF03792; PBC; 1.
SMART; SM00389; HOX; 1.
SUPFAM; SSF46689; SSF46689; 1.
PROSITE; PS00027; HOMEOBOX_1; 1.
PROSITE; PS50071; HOMEOBOX_2; 1.
1: Evidence at protein level;
Activator; Developmental protein; Differentiation; DNA-binding;
Homeobox; Neurogenesis; Nucleus; Transcription;
Transcription regulation.
CHAIN 1 347 Pre-B-cell leukemia transcription factor
1.
/FTId=PRO_0000365098.
DNA_BIND 233 295 Homeobox; TALE-type.
{ECO:0000255|PROSITE-ProRule:PRU00108}.
COMPBIAS 127 135 Poly-Ala. {ECO:0000255}.
SEQUENCE 347 AA; 38562 MW; 6931ABD2B86EFF6C CRC64;
MDDQPRLMHS HPGVGMAGHP SLSQHMQDGT GANEGDVGRK QDIGDILQQI MTITDQSLDE
AQARKHALNC HRMKPALFNV LCEIKEKTVL SIRGAQEEEP SDPQLMRLDN MLLAEGVAGP
EKGGGSAAAA AAAAASGGAG ADNSTEHSDY RAKLSQIRQI YHTELEKYEQ ACNEFTTHVM
NLLREQSRTR PISPKEIERM VSIIHRKFSS IQMQLKQSTC EAVMILRSRF LDARRKRRNF
NKQATEILNE YFYSHLSNPY PSEEAKEELA KKCAITVSQV SNWFGNKRIR YKKNIGKFQE
EANIYAAKTA VNATNVSVHG SQANSPSTPS SAGGYPSPCY QSDRRIQ


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