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Pre-mRNA-splicing factor CWC26 (Bud site selection protein 13) (Complexed with CEF1 protein 26) (Synthetic lethal with CLF1 protein 7)

 CWC26_YEAST             Reviewed;         266 AA.
P46947; D6VTX8;
01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
01-NOV-1995, sequence version 1.
27-SEP-2017, entry version 126.
RecName: Full=Pre-mRNA-splicing factor CWC26;
AltName: Full=Bud site selection protein 13;
AltName: Full=Complexed with CEF1 protein 26;
AltName: Full=Synthetic lethal with CLF1 protein 7;
Name=BUD13; Synonyms=CWC26, SLC7; OrderedLocusNames=YGL174W;
ORFNames=G1642;
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces.
NCBI_TaxID=559292;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=ATCC 96604 / S288c / FY1679;
PubMed=8619317; DOI=10.1002/yea.320111209;
Bertani I., Coglievina M., Zaccaria P., Klima R., Bruschi C.V.;
"The sequence of an 11.1 kb fragment on the left arm of Saccharomyces
cerevisiae chromosome VII reveals six open reading frames including
NSP49, KEM1 and four putative new genes.";
Yeast 11:1187-1194(1995).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 204508 / S288c;
PubMed=9169869;
Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M.,
Arroyo J., Backes U., Barreiros T., Bertani I., Bjourson A.J.,
Brueckner M., Bruschi C.V., Carignani G., Castagnoli L., Cerdan E.,
Clemente M.L., Coblenz A., Coglievina M., Coissac E., Defoor E.,
Del Bino S., Delius H., Delneri D., de Wergifosse P., Dujon B.,
Durand P., Entian K.-D., Eraso P., Escribano V., Fabiani L.,
Fartmann B., Feroli F., Feuermann M., Frontali L., Garcia-Gonzalez M.,
Garcia-Saez M.I., Goffeau A., Guerreiro P., Hani J., Hansen M.,
Hebling U., Hernandez K., Heumann K., Hilger F., Hofmann B.,
Indge K.J., James C.M., Klima R., Koetter P., Kramer B., Kramer W.,
Lauquin G., Leuther H., Louis E.J., Maillier E., Marconi A.,
Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K.,
Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S.,
Nawrocki A., Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L.,
Paoluzi S., Plevani P., Portetelle D., Portillo F., Potier S.,
Purnelle B., Rieger M., Riles L., Rinaldi T., Robben J.,
Rodrigues-Pousada C., Rodriguez-Belmonte E., Rodriguez-Torres A.M.,
Rose M., Ruzzi M., Saliola M., Sanchez-Perez M., Schaefer B.,
Schaefer M., Scharfe M., Schmidheini T., Schreer A., Skala J.,
Souciet J.-L., Steensma H.Y., Talla E., Thierry A., Vandenbol M.,
van der Aart Q.J.M., Van Dyck L., Vanoni M., Verhasselt P., Voet M.,
Volckaert G., Wambutt R., Watson M.D., Weber N., Wedler E., Wedler H.,
Wipfli P., Wolf K., Wright L.F., Zaccaria P., Zimmermann M.,
Zollner A., Kleine K.;
"The nucleotide sequence of Saccharomyces cerevisiae chromosome VII.";
Nature 387:81-84(1997).
[3]
GENOME REANNOTATION.
STRAIN=ATCC 204508 / S288c;
PubMed=24374639; DOI=10.1534/g3.113.008995;
Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M.,
Cherry J.M.;
"The reference genome sequence of Saccharomyces cerevisiae: Then and
now.";
G3 (Bethesda) 4:389-398(2014).
[4]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=ATCC 204508 / S288c;
PubMed=17322287; DOI=10.1101/gr.6037607;
Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F.,
Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A.,
Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F.,
Williamson J., Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G.,
Kolodner R.D., LaBaer J.;
"Approaching a complete repository of sequence-verified protein-
encoding clones for Saccharomyces cerevisiae.";
Genome Res. 17:536-543(2007).
[5]
FUNCTION.
PubMed=8657162; DOI=10.1128/MCB.16.4.1857;
Zahner J.E., Harkins H.A., Pringle J.R.;
"Genetic analysis of the bipolar pattern of bud site selection in the
yeast Saccharomyces cerevisiae.";
Mol. Cell. Biol. 16:1857-1870(1996).
[6]
FUNCTION, AND SUBCELLULAR LOCATION.
PubMed=11452010; DOI=10.1091/mbc.12.7.2147;
Ni L., Snyder M.;
"A genomic study of the bipolar bud site selection pattern in
Saccharomyces cerevisiae.";
Mol. Biol. Cell 12:2147-2170(2001).
[7]
IDENTIFICATION IN THE CWC COMPLEX, AND IDENTIFICATION BY MASS
SPECTROMETRY.
PubMed=11884590; DOI=10.1128/MCB.22.7.2011-2024.2002;
Ohi M.D., Link A.J., Ren L., Jennings J.L., McDonald W.H., Gould K.L.;
"Proteomics analysis reveals stable multiprotein complexes in both
fission and budding yeasts containing Myb-related Cdc5p/Cef1p, novel
pre-mRNA splicing factors, and snRNAs.";
Mol. Cell. Biol. 22:2011-2024(2002).
[8]
FUNCTION.
PubMed=12871902;
Vincent K., Wang Q., Jay S., Hobbs K., Rymond B.C.;
"Genetic interactions with CLF1 identify additional pre-mRNA splicing
factors and a link between activators of yeast vesicular transport and
splicing.";
Genetics 164:895-907(2003).
[9]
SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
PubMed=14562095; DOI=10.1038/nature02026;
Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W.,
Weissman J.S., O'Shea E.K.;
"Global analysis of protein localization in budding yeast.";
Nature 425:686-691(2003).
[10]
FUNCTION, IDENTIFICATION BY MASS SPECTROMETRY, AND INTERACTION WITH
IST3 AND PML1.
PubMed=15565172; DOI=10.1038/sj.emboj.7600482;
Dziembowski A., Ventura A.-P., Rutz B., Caspary F., Faux C.,
Halgand F., Laprevote O., Seraphin B.;
"Proteomic analysis identifies a new complex required for nuclear pre-
mRNA retention and splicing.";
EMBO J. 23:4847-4856(2004).
-!- FUNCTION: Required for efficient splicing and pre-mRNA nuclear
retention. May also be involved in positioning the proximal bud
pole signal. {ECO:0000269|PubMed:11452010,
ECO:0000269|PubMed:12871902, ECO:0000269|PubMed:15565172,
ECO:0000269|PubMed:8657162}.
-!- SUBUNIT: Belongs to the pre-mRNA retention and splicing (RES)
complex composed of at least BUD13, IST3 and PML1. May also belong
to the CWC complex (or CEF1-associated complex) composed of the
U2, U5 and U6 snRNAs and at least BUD13, BUD31, BRR2, CDC40, CEF1,
CLF1, CUS1, CWC2, CWC15, CWC21, CWC22, CWC23, CWC24, CWC25, CWC27,
ECM2, HSH155, IST3, ISY1, LEA1, MSL1, NTC20, PRP8, PRP9, PRP11,
PRP19, PRP21, PRP22, PRP45, PRP46, SLU7, SMB1, SMD1, SMD2, SMD3,
SMX2, SMX3, SNT309, SNU114, SPP2, SYF1, SYF2, RSE1 and YJU2.
Interacts with IST3 and PML1. {ECO:0000269|PubMed:11884590,
ECO:0000269|PubMed:15565172}.
-!- INTERACTION:
Q02554:CUS1; NbExp=2; IntAct=EBI-24073, EBI-654;
P40565:IST3; NbExp=9; IntAct=EBI-24073, EBI-25387;
-!- SUBCELLULAR LOCATION: Cytoplasm. Nucleus.
-!- SIMILARITY: Belongs to the CWC26 family. {ECO:0000305}.
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EMBL; X84705; CAA59179.1; -; Genomic_DNA.
EMBL; Z72696; CAA96886.1; -; Genomic_DNA.
EMBL; AY558504; AAS56830.1; -; Genomic_DNA.
EMBL; BK006941; DAA07939.1; -; Genomic_DNA.
PIR; S59237; S59237.
RefSeq; NP_011341.3; NM_001181039.3.
PDB; 2MKC; NMR; -; C=215-245.
PDB; 2MY2; NMR; -; B=215-255.
PDB; 4UQT; NMR; -; B=222-256.
PDB; 5GM6; EM; 3.50 A; W=1-266.
PDB; 5LQW; EM; 5.80 A; L=1-266.
PDBsum; 2MKC; -.
PDBsum; 2MY2; -.
PDBsum; 4UQT; -.
PDBsum; 5GM6; -.
PDBsum; 5LQW; -.
ProteinModelPortal; P46947; -.
SMR; P46947; -.
BioGrid; 33079; 372.
DIP; DIP-2075N; -.
IntAct; P46947; 18.
MINT; MINT-389797; -.
STRING; 4932.YGL174W; -.
MaxQB; P46947; -.
PRIDE; P46947; -.
EnsemblFungi; YGL174W; YGL174W; YGL174W.
GeneID; 852701; -.
KEGG; sce:YGL174W; -.
EuPathDB; FungiDB:YGL174W; -.
SGD; S000003142; BUD13.
HOGENOM; HOG000112094; -.
InParanoid; P46947; -.
KO; K13106; -.
OMA; ETNELSH; -.
OrthoDB; EOG092C5DZC; -.
BioCyc; YEAST:G3O-30662-MONOMER; -.
PRO; PR:P46947; -.
Proteomes; UP000002311; Chromosome VII.
GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO; GO:0005634; C:nucleus; IDA:SGD.
GO; GO:0070274; C:RES complex; IDA:SGD.
GO; GO:0005681; C:spliceosomal complex; IEA:UniProtKB-KW.
GO; GO:0006406; P:mRNA export from nucleus; IMP:SGD.
GO; GO:0000398; P:mRNA splicing, via spliceosome; IDA:SGD.
InterPro; IPR018609; Bud13.
Pfam; PF09736; Bud13; 1.
1: Evidence at protein level;
3D-structure; Complete proteome; Cytoplasm; mRNA processing;
mRNA splicing; Nucleus; Reference proteome; Spliceosome.
CHAIN 1 266 Pre-mRNA-splicing factor CWC26.
/FTId=PRO_0000079610.
COMPBIAS 15 25 Poly-Lys.
HELIX 230 232 {ECO:0000244|PDB:2MY2}.
HELIX 243 250 {ECO:0000244|PDB:2MY2}.
STRAND 252 254 {ECO:0000244|PDB:4UQT}.
SEQUENCE 266 AA; 30472 MW; 1584B390121325CD CRC64;
MALHQYLSET YGPTKPKNKT KKKKKESKSD ANSDKTSLIV KERLSTLQQE QEKSGVASFS
KFDKQKSKNI WKNLETNELS HAITHPSASS ITGNESKNDL KEIRAQEPLV TVADKSKTRK
TIYRDAQGHK IQEDSKIDDS SFSRSKYEDE KAAEREQYLK NLNMGDVQKL GINVDAHDKK
KNQTASSLTI EDPAITFTHD KERTVKTSLL GRKLYDKPAP ENRFAIMPGS RWDGVHRSNG
FEEKWFAKQN EINEKKVQSY TLQEDY


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