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Pre-mRNA-splicing factor SPF27 homolog (Modifier of SNC1 member 4) (Protein BCAS2 homolog)

 SPF27_ARATH             Reviewed;         253 AA.
Q949S9; Q9LV24;
09-FEB-2010, integrated into UniProtKB/Swiss-Prot.
01-DEC-2001, sequence version 1.
23-MAY-2018, entry version 92.
RecName: Full=Pre-mRNA-splicing factor SPF27 homolog;
AltName: Full=Modifier of SNC1 member 4;
AltName: Full=Protein BCAS2 homolog;
Name=MOS4; Synonyms=BCAS2, SPF27; OrderedLocusNames=At3g18165;
ORFNames=MRC8.16;
Arabidopsis thaliana (Mouse-ear cress).
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
Spermatophyta; Magnoliophyta; eudicotyledons; Gunneridae;
Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae;
Arabidopsis.
NCBI_TaxID=3702;
[1]
NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, INTERACTION WITH
CDC5, DISRUPTION PHENOTYPE, COMPONENT OF THE MAC COMPLEX, AND
FUNCTION.
STRAIN=cv. Columbia;
PubMed=17575050; DOI=10.1101/gad.1559607;
Palma K., Zhao Q., Cheng Y.T., Bi D., Monaghan J., Cheng W., Zhang Y.,
Li X.;
"Regulation of plant innate immunity by three proteins in a complex
conserved across the plant and animal kingdoms.";
Genes Dev. 21:1484-1493(2007).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=cv. Columbia;
PubMed=10907853; DOI=10.1093/dnares/7.3.217;
Kaneko T., Katoh T., Sato S., Nakamura Y., Asamizu E., Tabata S.;
"Structural analysis of Arabidopsis thaliana chromosome 3. II.
Sequence features of the 4,251,695 bp regions covered by 90 P1, TAC
and BAC clones.";
DNA Res. 7:217-221(2000).
[3]
GENOME REANNOTATION.
STRAIN=cv. Columbia;
PubMed=27862469; DOI=10.1111/tpj.13415;
Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
Town C.D.;
"Araport11: a complete reannotation of the Arabidopsis thaliana
reference genome.";
Plant J. 89:789-804(2017).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=cv. Columbia;
PubMed=14593172; DOI=10.1126/science.1088305;
Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J.,
Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F.,
Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.,
Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J.,
Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y.,
Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P.,
Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F.,
Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M.,
Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J.,
Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T.,
Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y.,
Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.;
"Empirical analysis of transcriptional activity in the Arabidopsis
genome.";
Science 302:842-846(2003).
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
Feldmann K.A.;
"Full-length cDNA from Arabidopsis thaliana.";
Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
[6]
IDENTIFICATION BY MASS SPECTROMETRY, AND COMPONENT OF THE MAC COMPLEX.
PubMed=19629177; DOI=10.1371/journal.ppat.1000526;
Monaghan J., Xu F., Gao M., Zhao Q., Palma K., Long C., Chen S.,
Zhang Y., Li X.;
"Two Prp19-like U-box proteins in the MOS4-associated complex play
redundant roles in plant innate immunity.";
PLoS Pathog. 5:E1000526-E1000526(2009).
[7]
FUNCTION, AND INTERACTION WITH CYCL1-1.
PubMed=22248079; DOI=10.1111/j.1365-313X.2012.04906.x;
Xu F., Xu S., Wiermer M., Zhang Y., Li X.;
"The cyclin L homolog MOS12 and the MOS4-associated complex are
required for the proper splicing of plant resistance genes.";
Plant J. 70:916-928(2012).
-!- FUNCTION: Component of the MAC complex that probably regulates
defense responses through transcriptional control and thereby is
essential for plant innate immunity. Involved in mRNA splicing.
{ECO:0000269|PubMed:17575050, ECO:0000269|PubMed:22248079}.
-!- SUBUNIT: Component of the multiprotein assembly MOS4-associated
complex (MAC) at least composed of MOS4, CDC5 and PRL1. Interacts
with CYCL1-1 and CDC5. Associated with the spliceosome (By
similarity). {ECO:0000250}.
-!- INTERACTION:
P92948:CDC5; NbExp=3; IntAct=EBI-1382943, EBI-1382948;
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:17575050}.
-!- DISRUPTION PHENOTYPE: Enhanced susceptibility to virulent and
avirulent pathogens. {ECO:0000269|PubMed:17575050}.
-!- SIMILARITY: Belongs to the SPF27 family. {ECO:0000305}.
-!- SEQUENCE CAUTION:
Sequence=BAB02029.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
-----------------------------------------------------------------------
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Distributed under the Creative Commons Attribution (CC BY 4.0) License
-----------------------------------------------------------------------
EMBL; EF688334; ABS20115.1; -; mRNA.
EMBL; AB020749; BAB02029.1; ALT_SEQ; Genomic_DNA.
EMBL; CP002686; AEE76058.1; -; Genomic_DNA.
EMBL; AY050910; AAK93587.1; -; mRNA.
EMBL; AY091412; AAM14351.1; -; mRNA.
EMBL; AY088112; AAM65658.1; -; mRNA.
RefSeq; NP_566599.1; NM_112699.3.
UniGene; At.22929; -.
ProteinModelPortal; Q949S9; -.
SMR; Q949S9; -.
BioGrid; 6676; 4.
IntAct; Q949S9; 23.
STRING; 3702.AT3G18165.1; -.
PaxDb; Q949S9; -.
PRIDE; Q949S9; -.
EnsemblPlants; AT3G18165.1; AT3G18165.1; AT3G18165.
GeneID; 821343; -.
Gramene; AT3G18165.1; AT3G18165.1; AT3G18165.
KEGG; ath:AT3G18165; -.
Araport; AT3G18165; -.
TAIR; locus:505006356; AT3G18165.
eggNOG; KOG3096; Eukaryota.
eggNOG; ENOG41101IB; LUCA.
HOGENOM; HOG000007540; -.
InParanoid; Q949S9; -.
KO; K12861; -.
OMA; LPYIDHG; -.
OrthoDB; EOG09360K7R; -.
PhylomeDB; Q949S9; -.
Reactome; R-ATH-72163; mRNA Splicing - Major Pathway.
PRO; PR:Q949S9; -.
Proteomes; UP000006548; Chromosome 3.
ExpressionAtlas; Q949S9; baseline and differential.
Genevisible; Q949S9; AT.
GO; GO:0071013; C:catalytic step 2 spliceosome; IBA:GO_Central.
GO; GO:0005730; C:nucleolus; IDA:TAIR.
GO; GO:0005634; C:nucleus; IDA:TAIR.
GO; GO:0071011; C:precatalytic spliceosome; IBA:GO_Central.
GO; GO:0000974; C:Prp19 complex; IBA:GO_Central.
GO; GO:0009870; P:defense response signaling pathway, resistance gene-dependent; IMP:TAIR.
GO; GO:0010204; P:defense response signaling pathway, resistance gene-independent; IMP:TAIR.
GO; GO:0042742; P:defense response to bacterium; IMP:TAIR.
GO; GO:0050832; P:defense response to fungus; IMP:TAIR.
GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
GO; GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
InterPro; IPR008409; SPF27.
PANTHER; PTHR13296; PTHR13296; 1.
Pfam; PF05700; BCAS2; 1.
1: Evidence at protein level;
Coiled coil; Complete proteome; Immunity; Innate immunity;
mRNA processing; mRNA splicing; Nucleus; Plant defense;
Reference proteome; Spliceosome.
CHAIN 1 253 Pre-mRNA-splicing factor SPF27 homolog.
/FTId=PRO_0000391631.
COILED 124 235 {ECO:0000255}.
SEQUENCE 253 AA; 29680 MW; 04323FBBFD7F92FD CRC64;
MATNNGDVLM LEATPEAARP WASAANAEVI DALPYIDDDY GNPLIKSEVD RLVEEEMRRS
SKKPADFLKD LPPLPKFDFK NCPVLGKEYE RVRAGKPPVR IDFESRYKLE MPPANKRNDD
AAWKQYLQKN QRSLQQKLIE LENLELMSKL GPELWRQNNH RLEVFLTRMQ RLAQEQNEEI
EKVNRERKYH QQTTSYELNA LSQEWRQLCV KNMEIQSACA MLETQIDSFK KEAAERGWNL
EEKLENVEPL QMQ


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