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Pre-mRNA-splicing factor cwf4 (Complexed with cdc5 protein 4)

 CLF1_SCHPO              Reviewed;         674 AA.
P87312;
14-AUG-2001, integrated into UniProtKB/Swiss-Prot.
01-JUL-1997, sequence version 1.
28-FEB-2018, entry version 138.
RecName: Full=Pre-mRNA-splicing factor cwf4;
AltName: Full=Complexed with cdc5 protein 4;
Name=cwf4; Synonyms=syf3; ORFNames=SPBC31F10.11c;
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
Schizosaccharomycetes; Schizosaccharomycetales;
Schizosaccharomycetaceae; Schizosaccharomyces.
NCBI_TaxID=284812;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND PROTEIN SEQUENCE OF 12-25;
40-54 AND 225-242.
PubMed=10409726; DOI=10.1128/MCB.19.8.5352;
McDonald W.H., Ohi R., Smelkova N., Frendewey D., Gould K.L.;
"Myb-related fission yeast cdc5p is a component of a 40S snRNP-
containing complex and is essential for pre-mRNA splicing.";
Mol. Cell. Biol. 19:5352-5362(1999).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=972 / ATCC 24843;
PubMed=11859360; DOI=10.1038/nature724;
Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M.,
Collins M., Connor R., Cronin A., Davis P., Feltwell T., Fraser A.,
Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G.,
Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K.,
James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J.,
Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C.,
Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E.,
Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S.,
Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K.,
Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S.,
Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B.,
Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S.,
Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D.,
Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R.,
Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B.,
Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S.,
Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M.,
Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G.,
Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J.,
Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L.,
Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J.,
Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.;
"The genome sequence of Schizosaccharomyces pombe.";
Nature 415:871-880(2002).
[3]
IDENTIFICATION IN THE CWF COMPLEX, AND IDENTIFICATION BY MASS
SPECTROMETRY.
PubMed=11884590; DOI=10.1128/MCB.22.7.2011-2024.2002;
Ohi M.D., Link A.J., Ren L., Jennings J.L., McDonald W.H., Gould K.L.;
"Proteomics analysis reveals stable multiprotein complexes in both
fission and budding yeasts containing Myb-related Cdc5p/Cef1p, novel
pre-mRNA splicing factors, and snRNAs.";
Mol. Cell. Biol. 22:2011-2024(2002).
-!- FUNCTION: Involved in pre-mRNA splicing and cell cycle
progression. Required for the spliceosome assembly and initiation
of the DNA replication (By similarity). {ECO:0000250}.
-!- SUBUNIT: Belongs to the 40S cdc5-associated complex (or cwf
complex), a spliceosome sub-complex reminiscent of a late-stage
spliceosome composed of the U2, U5 and U6 snRNAs and at least
brr2, cdc5, cwf2/prp3, cwf3/syf1, cwf4/syf3, cwf5/ecm2,
spp42/cwf6, cwf7/spf27, cwf8, cwf9, cwf10, cwf11, cwf12,
prp45/cwf13, cwf14, cwf15, cwf16, cwf17, cwf18, cwf19, cwf20,
cwf21, cwf22, cwf23, cwf24, cwf25, cwf26, cyp7/cwf27, cwf28,
cwf29/ist3, lea1, msl1, prp5/cwf1, prp10, prp12/sap130, prp17,
prp22, sap61, sap62, sap114, sap145, slu7, smb1, smd1, smd3, smf1,
smg1 and syf2. {ECO:0000269|PubMed:11884590}.
-!- INTERACTION:
P39964:cdc5; NbExp=7; IntAct=EBI-538818, EBI-538771;
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
-!- SIMILARITY: Belongs to the crooked-neck family. {ECO:0000305}.
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EMBL; AF254353; AAF67752.1; -; Genomic_DNA.
EMBL; CU329671; CAB10088.1; -; Genomic_DNA.
PIR; T40214; T40214.
RefSeq; NP_596573.1; NM_001022494.2.
PDB; 3JB9; EM; 3.60 A; R=41-290.
PDBsum; 3JB9; -.
ProteinModelPortal; P87312; -.
BioGrid; 276858; 23.
IntAct; P87312; 7.
STRING; 4896.SPBC31F10.11c.1; -.
MaxQB; P87312; -.
PaxDb; P87312; -.
PRIDE; P87312; -.
EnsemblFungi; SPBC31F10.11c.1; SPBC31F10.11c.1:pep; SPBC31F10.11c.
GeneID; 2540328; -.
KEGG; spo:SPBC31F10.11c; -.
EuPathDB; FungiDB:SPBC31F10.11c; -.
PomBase; SPBC31F10.11c; cwf4.
HOGENOM; HOG000207972; -.
InParanoid; P87312; -.
KO; K12869; -.
OMA; FTFSKIW; -.
OrthoDB; EOG092C0UBN; -.
PhylomeDB; P87312; -.
PRO; PR:P87312; -.
Proteomes; UP000002485; Chromosome II.
GO; GO:0071012; C:catalytic step 1 spliceosome; IBA:GO_Central.
GO; GO:0071013; C:catalytic step 2 spliceosome; IBA:GO_Central.
GO; GO:0005634; C:nucleus; HDA:PomBase.
GO; GO:0071014; C:post-mRNA release spliceosomal complex; IDA:PomBase.
GO; GO:0071011; C:precatalytic spliceosome; IBA:GO_Central.
GO; GO:0071010; C:prespliceosome; IBA:GO_Central.
GO; GO:0000974; C:Prp19 complex; IDA:PomBase.
GO; GO:0005681; C:spliceosomal complex; IDA:PomBase.
GO; GO:0071004; C:U2-type prespliceosome; ISO:PomBase.
GO; GO:0045292; P:mRNA cis splicing, via spliceosome; IC:PomBase.
GO; GO:0000245; P:spliceosomal complex assembly; IBA:GO_Central.
Gene3D; 1.25.40.10; -; 3.
InterPro; IPR003107; HAT.
InterPro; IPR013026; TPR-contain_dom.
InterPro; IPR011990; TPR-like_helical_dom_sf.
Pfam; PF02184; HAT; 2.
SMART; SM00386; HAT; 14.
SUPFAM; SSF48452; SSF48452; 2.
1: Evidence at protein level;
3D-structure; Complete proteome; Direct protein sequencing;
mRNA processing; mRNA splicing; Nucleus; Reference proteome; Repeat;
Spliceosome.
CHAIN 1 674 Pre-mRNA-splicing factor cwf4.
/FTId=PRO_0000205750.
REPEAT 50 82 HAT 1.
REPEAT 84 116 HAT 2.
REPEAT 118 150 HAT 3.
REPEAT 152 183 HAT 4.
REPEAT 185 216 HAT 5.
REPEAT 218 253 HAT 6.
REPEAT 255 289 HAT 7.
REPEAT 299 331 HAT 8.
REPEAT 333 367 HAT 9.
REPEAT 377 413 HAT 10.
REPEAT 415 446 HAT 11.
REPEAT 448 480 HAT 12.
REPEAT 482 516 HAT 13.
REPEAT 518 549 HAT 14.
REPEAT 567 608 HAT 15.
REPEAT 610 643 HAT 16.
SEQUENCE 674 AA; 80841 MW; 1AFAA23A68CB2A9F CRC64;
MTSEAPRVKN KNPAPIQISA EQLLREAVER QDVAFVPPKI NITDLEELQE FQGRKRKEFE
DAIRRNRLAM GHWMRYGQWE LDQKEFARAR SVFERALDVD STYIPLWLKY IECEMKNRNI
NHARNLFDRA VTQLPRVDKL WYKYVYMEEM LGNITGCRQV FERWLKWEPD ENCWMSYIRM
ERRYHENERA RGIYERFVVV HPEVTNWLRW ARFEEECGNA ANVRQVYLAA IDALGQEFLN
ERFFIAFAKF EIRQKEYERA RTIFKYAIDF MPRSKSMELY KEYTHFEKQF GDHLGVESTV
LDKRRLQYEK LLKDSPYDYD TWLDLLKLEE SAGDINTIRE TYEKAIAKVP EVVEKNAWRR
YVYIWLNYCL FEEIDVKDVD RARKVYQEAL KLIPHKKFTF AKLWLMYAMF ELRQRKIDVA
RKTLGRALGM CPKPKLFRGY IEFEDAIKQF DRCRILYEKW ILYDPEACAP WLGYAALETK
LGDSDRARAL YNLAVNQPIL ETPELVWKAY IDFEFEEMEY GKARSIYQQL LRTAPHVKVW
ISFANFEIAH LEDDDEEPPN EEVASPTAVV RARNVFENAL AHLRQQGLKE ERVVLLEAWK
QFEAMHGTED TRKHVSSLMP QVVKKRRRLE DGSFEEYLDY LFPDTATDQG DKMRKMLELS
RKWKEEMAKK KLEA


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