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Pre-miRNA 5'-monophosphate methyltransferase (EC 2.1.1.-) (BCDIN3 domain-containing protein)

 BN3D2_HUMAN             Reviewed;         292 AA.
Q7Z5W3; A8K829;
29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
01-OCT-2003, sequence version 1.
07-JUN-2017, entry version 102.
RecName: Full=Pre-miRNA 5'-monophosphate methyltransferase;
EC=2.1.1.-;
AltName: Full=BCDIN3 domain-containing protein;
Name=BCDIN3D;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Cervix;
PubMed=14702039; DOI=10.1038/ng1285;
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
"Complete sequencing and characterization of 21,243 full-length human
cDNAs.";
Nat. Genet. 36:40-45(2004).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
Venter J.C.;
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Skin;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[4]
FUNCTION, CATALYTIC ACTIVITY, INTERACTION WITH DICER1, MUTAGENESIS OF
72-ASP--GLU-74, AND SUBCELLULAR LOCATION.
PubMed=23063121; DOI=10.1016/j.cell.2012.08.041;
Xhemalce B., Robson S.C., Kouzarides T.;
"Human RNA methyltransferase BCDIN3D regulates microRNA processing.";
Cell 151:278-288(2012).
-!- FUNCTION: O-methyltransferase that specifically dimethylates the
5' monophosphate of pre-miRNAs, acting as a negative regulator of
miRNA processing. The 5' monophosphate of pre-miRNAs is recognized
by DICER1 and is required for pre-miRNAs processing: methylation
at this position reduces the processing of pre-miRNAs by DICER1.
Able to mediate methylation of pre-miR-145, as well as other pre-
miRNAs. {ECO:0000269|PubMed:23063121}.
-!- SUBUNIT: Interacts with DICER1; the interaction may be mediated by
RNA. {ECO:0000269|PubMed:23063121}.
-!- INTERACTION:
Q6ZN57:ZFP2; NbExp=3; IntAct=EBI-10257921, EBI-7236323;
-!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:23063121}.
-!- SIMILARITY: Belongs to the methyltransferase superfamily.
{ECO:0000305}.
-----------------------------------------------------------------------
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EMBL; AK292194; BAF84883.1; -; mRNA.
EMBL; CH471111; EAW58101.1; -; Genomic_DNA.
EMBL; BC053560; AAH53560.1; -; mRNA.
CCDS; CCDS8790.1; -.
RefSeq; NP_859059.1; NM_181708.2.
UniGene; Hs.142736; -.
ProteinModelPortal; Q7Z5W3; -.
SMR; Q7Z5W3; -.
BioGrid; 126839; 4.
IntAct; Q7Z5W3; 1.
STRING; 9606.ENSP00000335201; -.
ChEMBL; CHEMBL3588740; -.
iPTMnet; Q7Z5W3; -.
PhosphoSitePlus; Q7Z5W3; -.
BioMuta; BCDIN3D; -.
DMDM; 74738762; -.
MaxQB; Q7Z5W3; -.
PaxDb; Q7Z5W3; -.
PeptideAtlas; Q7Z5W3; -.
PRIDE; Q7Z5W3; -.
DNASU; 144233; -.
Ensembl; ENST00000333924; ENSP00000335201; ENSG00000186666.
GeneID; 144233; -.
KEGG; hsa:144233; -.
UCSC; uc001rvh.4; human.
CTD; 144233; -.
DisGeNET; 144233; -.
GeneCards; BCDIN3D; -.
HGNC; HGNC:27050; BCDIN3D.
HPA; HPA039911; -.
neXtProt; NX_Q7Z5W3; -.
OpenTargets; ENSG00000186666; -.
PharmGKB; PA162377410; -.
eggNOG; KOG2899; Eukaryota.
eggNOG; ENOG410XZ7T; LUCA.
GeneTree; ENSGT00390000014918; -.
HOGENOM; HOG000013152; -.
HOVERGEN; HBG057674; -.
OMA; YSITMWI; -.
OrthoDB; EOG091G0KYU; -.
PhylomeDB; Q7Z5W3; -.
TreeFam; TF324061; -.
GenomeRNAi; 144233; -.
PRO; PR:Q7Z5W3; -.
Proteomes; UP000005640; Chromosome 12.
Bgee; ENSG00000186666; -.
CleanEx; HS_BCDIN3D; -.
Genevisible; Q7Z5W3; HS.
GO; GO:0005737; C:cytoplasm; IDA:UniProtKB.
GO; GO:0005829; C:cytosol; IDA:HPA.
GO; GO:0005634; C:nucleus; IDA:HPA.
GO; GO:0008171; F:O-methyltransferase activity; IDA:UniProtKB.
GO; GO:0008173; F:RNA methyltransferase activity; IDA:UniProtKB.
GO; GO:0010586; P:miRNA metabolic process; IDA:UniProtKB.
GO; GO:2000632; P:negative regulation of pre-miRNA processing; IDA:UniProtKB.
GO; GO:0001510; P:RNA methylation; IDA:UniProtKB.
InterPro; IPR010675; Bin3_C.
InterPro; IPR024160; BIN3_SAM-bd_dom.
InterPro; IPR029063; SAM-dependent_MTases.
Pfam; PF06859; Bin3; 1.
SUPFAM; SSF53335; SSF53335; 1.
PROSITE; PS51515; BIN3_SAM; 1.
1: Evidence at protein level;
Complete proteome; Cytoplasm; Methyltransferase; Polymorphism;
Reference proteome; S-adenosyl-L-methionine; Transferase.
CHAIN 1 292 Pre-miRNA 5'-monophosphate
methyltransferase.
/FTId=PRO_0000289265.
DOMAIN 53 274 Bin3-type SAM. {ECO:0000255|PROSITE-
ProRule:PRU00848}.
VARIANT 288 288 S -> R (in dbSNP:rs11169172).
/FTId=VAR_032614.
MUTAGEN 72 74 DVG->AVA: Abolishes methyltransferase
activity. {ECO:0000269|PubMed:23063121}.
SEQUENCE 292 AA; 33200 MW; 361EF0BBAAC0CCAF CRC64;
MAVPTELDGG SVKETAAEEE SRVLAPGAAP FGNFPHYSRF HPPEQRLRLL PPELLRQLFP
ESPENGPILG LDVGCNSGDL SVALYKHFLS LPDGETCSDA SREFRLLCCD IDPVLVKRAE
KECPFPDALT FITLDFMNQR TRKVLLSSFL SQFGRSVFDI GFCMSITMWI HLNHGDHGLW
EFLAHLSSLC HYLLVEPQPW KCYRAAARRL RKLGLHDFDH FHSLAIRGDM PNQIVQILTQ
DHGMELICCF GNTSWDRSLL LFRAKQTIET HPIPESLIEK GKEKNRLSFQ KQ


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