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Pre-protein-C8 [Cleaved into: Immunity protein HalI; Halocin-C8 (HalC8)]

 HAC8_HALAS              Reviewed;         283 AA.
P83716; Q6JSL9;
16-FEB-2004, integrated into UniProtKB/Swiss-Prot.
14-MAY-2014, sequence version 2.
30-NOV-2016, entry version 28.
RecName: Full=Pre-protein-C8;
Contains:
RecName: Full=Immunity protein HalI;
Contains:
RecName: Full=Halocin-C8;
Short=HalC8;
Flags: Precursor;
Name=proC8;
Halobacterium sp. (strain AS7092).
Archaea; Euryarchaeota; Halobacteria; Halobacteriales;
Halobacteriaceae; Halobacterium.
NCBI_TaxID=245739;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA], MASS SPECTROMETRY, INDUCTION, AND
PROTEOLYTIC PROCESSING.
STRAIN=AS7092;
PubMed=15978083; DOI=10.1111/j.1365-2958.2005.04705.x;
Sun C., Li Y., Mei S., Lu Q., Zhou L., Xiang H.;
"A single gene directs both production and immunity of halocin C8 in a
haloarchaeal strain AS7092.";
Mol. Microbiol. 57:537-549(2005).
[2]
PROTEIN SEQUENCE OF 208-222, AND SUBCELLULAR LOCATION.
STRAIN=AS7092;
PubMed=12811620; DOI=10.1007/s00792-003-0335-6;
Li Y., Xiang H., Liu J., Zhou M., Tan H.;
"Purification and biological characterization of halocin C8, a novel
peptide antibiotic from Halobacterium strain AS7092.";
Extremophiles 7:401-407(2003).
[3]
SUBUNIT, AND MUTAGENESIS OF ALA-61; ARG-62; GLU-63; LEU-64; ALA-65;
LYS-66; THR-67; PRO-68; ALA-69; PHE-70; ARG-71; GLU-72; LEU-73; ALA-74
AND GLN-75.
STRAIN=AS7092;
PubMed=18658263; DOI=10.1128/JB.00665-08;
Mei S., Sun C., Liu X., Lu Q., Cai L., Li Y., Xiang H.;
"The helix-loop-helix motif at the N terminus of HalI is essential for
its immunity function against halocin C8.";
J. Bacteriol. 190:6501-6508(2008).
-!- FUNCTION: Halocin-C8: Has antibacterial activity against a wide
variety of haloarchaeons. Causes cell lysis and death, possibly by
disrupting the cell wall (PubMed:12811620).
{ECO:0000269|PubMed:12811620}.
-!- FUNCTION: Immunity protein HalI: Acts as an immunity protein for
halocin-C8. Able to block the halocin-C8 activity by sequestering
the activity of halocin-C8 through specific and direct binding
(PubMed:15978083, PubMed:18658263). {ECO:0000269|PubMed:15978083,
ECO:0000269|PubMed:18658263}.
-!- SUBUNIT: Immunity protein HalI interacts with Halocin-C8; the
interaction is direct. {ECO:0000269|PubMed:18658263}.
-!- SUBCELLULAR LOCATION: Halocin-C8: Secreted. Note=Secreted
(PubMed:15978083, PubMed:12811620). {ECO:0000269|PubMed:12811620,
ECO:0000269|PubMed:15978083}.
-!- SUBCELLULAR LOCATION: Immunity protein HalI: Cell membrane.
Note=Exclusively localizes to the cell membrane.
{ECO:0000269|PubMed:15978083}.
-!- INDUCTION: Increases to maximal levels upon transition from
exponential to stationary phase. {ECO:0000269|PubMed:15978083}.
-!- DOMAIN: The helix-loop-helix (HLH) region is essential for
immunity function of Immunity protein HalI and interaction with
Halocin-C8. {ECO:0000269|PubMed:18658263}.
-!- PTM: Predicted to be exported by the Tat system. The position of
the signal peptide cleavage has not been experimentally proven.
{ECO:0000255|PROSITE-ProRule:PRU00648,
ECO:0000269|PubMed:15978083}.
-!- MASS SPECTROMETRY: Mass=7427.1; Method=MALDI; Range=208-283;
Evidence={ECO:0000269|PubMed:15978083};
-!- MISCELLANEOUS: Halocin-C8: Is quite robust, as it can be desalted,
boiled, subjected to organic solvents, and stored at 4 degrees
Celsius for extended periods without losing activity.
{ECO:0000305|PubMed:12811620}.
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EMBL; DQ137141; AAQ82548.1; -; Genomic_DNA.
TCDB; 9.A.45.1.1; the archaeocin/halocin c8 (halc8) family.
GO; GO:0005576; C:extracellular region; IDA:UniProtKB.
GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO; GO:0019835; P:cytolysis; IEA:UniProtKB-KW.
GO; GO:0042742; P:defense response to bacterium; IDA:UniProtKB.
InterPro; IPR031033; Halocin_C8_dom.
InterPro; IPR006311; TAT_signal.
TIGRFAMs; TIGR04449; halocin_C8_dom; 1.
PROSITE; PS51318; TAT; 1.
1: Evidence at protein level;
Antibiotic; Antimicrobial; Bacteriocin; Cell membrane;
Direct protein sequencing; Membrane; Secreted; Signal.
SIGNAL 1 40 Tat-type signal. {ECO:0000255|PROSITE-
ProRule:PRU00648}.
CHAIN 41 207 Immunity protein HalI.
/FTId=PRO_0000429048.
CHAIN 208 283 Halocin-C8.
/FTId=PRO_0000195165.
REGION 61 75 Helix-loop-helix (HLH) region.
MUTAGEN 61 61 A->D: No effect on immunity function of
Immunity protein HalI and interaction
with Halocin-C8.
{ECO:0000269|PubMed:18658263}.
MUTAGEN 62 62 R->A: Slightly decreased immunity
function of Immunity protein HalI and
interaction with Halocin-C8.
{ECO:0000269|PubMed:18658263}.
MUTAGEN 63 63 E->A: Slightly decreased immunity
function of Immunity protein HalI and
interaction with Halocin-C8.
{ECO:0000269|PubMed:18658263}.
MUTAGEN 64 64 L->A: Impaired immunity function of
Immunity protein HalI and interaction
with Halocin-C8.
{ECO:0000269|PubMed:18658263}.
MUTAGEN 65 65 A->P: No effect on immunity function of
Immunity protein HalI and interaction
with Halocin-C8.
{ECO:0000269|PubMed:18658263}.
MUTAGEN 66 66 K->P: No effect on immunity function of
Immunity protein HalI and interaction
with Halocin-C8.
{ECO:0000269|PubMed:18658263}.
MUTAGEN 67 67 T->A: No effect on immunity function of
Immunity protein HalI and interaction
with Halocin-C8.
{ECO:0000269|PubMed:18658263}.
MUTAGEN 68 68 P->A: No effect on immunity function of
Immunity protein HalI and interaction
with Halocin-C8.
{ECO:0000269|PubMed:18658263}.
MUTAGEN 69 69 A->V: No effect on immunity function of
Immunity protein HalI and interaction
with Halocin-C8.
{ECO:0000269|PubMed:18658263}.
MUTAGEN 70 70 F->A: No effect on immunity function of
Immunity protein HalI and interaction
with Halocin-C8.
{ECO:0000269|PubMed:18658263}.
MUTAGEN 71 71 R->A: No effect on immunity function of
Immunity protein HalI and interaction
with Halocin-C8.
{ECO:0000269|PubMed:18658263}.
MUTAGEN 72 72 E->A: No effect on immunity function of
Immunity protein HalI and interaction
with Halocin-C8.
{ECO:0000269|PubMed:18658263}.
MUTAGEN 73 73 L->A: Impaired immunity function of
Immunity protein HalI and interaction
with Halocin-C8.
{ECO:0000269|PubMed:18658263}.
MUTAGEN 74 74 A->V: No effect on immunity function of
Immunity protein HalI and interaction
with Halocin-C8.
{ECO:0000269|PubMed:18658263}.
MUTAGEN 75 75 Q->A: No effect on immunity function of
Immunity protein HalI and interaction
with Halocin-C8.
{ECO:0000269|PubMed:18658263}.
SEQUENCE 283 AA; 29379 MW; FF5B95B523D29A12 CRC64;
MKEDNNTSEE SGRINRRNVL KTVGAAGLFA AGSTGMAAAA DSLSQAEEPK LLTGTEKRTL
ARELAKTPAF RELAQRARAD GAQIRSDADS IVAGYARGED FAREVVQYDL ENLTDAAEAS
IVIGRNPETG EIEVANLDYY YETDDGVLDE VHRFEPTNAS ETDGVQSAAT SDGATVIAVD
TDAIREAQNS EIDVDESSPS NAAPTPADID ITGCSACKYA AGQVCTIGCS AAGGFICGLL
GITIPVAGLS CLGFVEIVCT VADEYSGCGD AVAKEACNRA GLC


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