Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Presenilin (EC 3.4.23.-)

 F1S3K9_PIG              Unreviewed;       467 AA.
F1S3K9;
03-MAY-2011, integrated into UniProtKB/TrEMBL.
11-JUL-2012, sequence version 2.
25-OCT-2017, entry version 49.
RecName: Full=Presenilin {ECO:0000256|RuleBase:RU361148};
EC=3.4.23.- {ECO:0000256|RuleBase:RU361148};
Name=PSEN1 {ECO:0000313|Ensembl:ENSSSCP00000002538};
Sus scrofa (Pig).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Suina; Suidae;
Sus.
NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000002538, ECO:0000313|Proteomes:UP000008227};
[1] {ECO:0000313|Ensembl:ENSSSCP00000002538, ECO:0000313|Proteomes:UP000008227}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000002538};
Porcine genome sequencing project;
Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
[2] {ECO:0000313|Ensembl:ENSSSCP00000002538}
IDENTIFICATION.
Ensembl;
Submitted (MAY-2011) to UniProtKB.
-!- FUNCTION: Probable subunit of the gamma-secretase complex, an
endoprotease complex that catalyzes the intramembrane cleavage of
integral membrane proteins such as Notch receptors.
{ECO:0000256|RuleBase:RU361148}.
-!- SUBUNIT: Homodimer. {ECO:0000256|RuleBase:RU361148}.
-!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
{ECO:0000256|RuleBase:RU361148}; Multi-pass membrane protein
{ECO:0000256|RuleBase:RU361148}.
-!- SUBCELLULAR LOCATION: Golgi apparatus membrane
{ECO:0000256|RuleBase:RU361148}; Multi-pass membrane protein
{ECO:0000256|RuleBase:RU361148}.
-!- DOMAIN: The PAL motif is required for normal active site
conformation. {ECO:0000256|RuleBase:RU361148}.
-!- SIMILARITY: Belongs to the peptidase A22A family.
{ECO:0000256|RuleBase:RU361148}.
-!- CAUTION: The sequence shown here is derived from an Ensembl
automatic analysis pipeline and should be considered as
preliminary data. {ECO:0000313|Ensembl:ENSSSCP00000002538}.
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
Distributed under the Creative Commons Attribution-NoDerivs License
-----------------------------------------------------------------------
EMBL; AEMK02000061; -; NOT_ANNOTATED_CDS; Genomic_DNA.
STRING; 9823.ENSSSCP00000002538; -.
PaxDb; F1S3K9; -.
PeptideAtlas; F1S3K9; -.
Ensembl; ENSSSCT00000002603; ENSSSCP00000002538; ENSSSCG00000002340.
eggNOG; KOG2736; Eukaryota.
eggNOG; ENOG410XPZD; LUCA.
GeneTree; ENSGT00390000016593; -.
InParanoid; F1S3K9; -.
OMA; IAIHWKG; -.
OrthoDB; EOG091G0C72; -.
TreeFam; TF315040; -.
Reactome; R-SSC-6798695; Neutrophil degranulation.
Proteomes; UP000008227; Chromosome 7.
Bgee; ENSSSCG00000002340; -.
GO; GO:0016235; C:aggresome; IEA:Ensembl.
GO; GO:0030424; C:axon; IBA:GO_Central.
GO; GO:0005938; C:cell cortex; IBA:GO_Central.
GO; GO:0030054; C:cell junction; IEA:Ensembl.
GO; GO:0009986; C:cell surface; IBA:GO_Central.
GO; GO:0005813; C:centrosome; IEA:Ensembl.
GO; GO:0035253; C:ciliary rootlet; IBA:GO_Central.
GO; GO:0031410; C:cytoplasmic vesicle; IEA:Ensembl.
GO; GO:0043198; C:dendritic shaft; IBA:GO_Central.
GO; GO:0005783; C:endoplasmic reticulum; IBA:GO_Central.
GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
GO; GO:0070765; C:gamma-secretase complex; IEA:Ensembl.
GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
GO; GO:0030426; C:growth cone; IBA:GO_Central.
GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
GO; GO:0000776; C:kinetochore; IEA:Ensembl.
GO; GO:0005765; C:lysosomal membrane; IBA:GO_Central.
GO; GO:0045121; C:membrane raft; IBA:GO_Central.
GO; GO:0005743; C:mitochondrial inner membrane; IBA:GO_Central.
GO; GO:0031594; C:neuromuscular junction; IBA:GO_Central.
GO; GO:0043025; C:neuronal cell body; IBA:GO_Central.
GO; GO:0005640; C:nuclear outer membrane; IEA:Ensembl.
GO; GO:0005634; C:nucleus; IBA:GO_Central.
GO; GO:0048471; C:perinuclear region of cytoplasm; IBA:GO_Central.
GO; GO:0098793; C:presynapse; IEA:GOC.
GO; GO:0005791; C:rough endoplasmic reticulum; IEA:Ensembl.
GO; GO:0005790; C:smooth endoplasmic reticulum; IEA:Ensembl.
GO; GO:0030018; C:Z disc; IBA:GO_Central.
GO; GO:0042500; F:aspartic endopeptidase activity, intramembrane cleaving; IEA:Ensembl.
GO; GO:0008013; F:beta-catenin binding; IBA:GO_Central.
GO; GO:0045296; F:cadherin binding; IBA:GO_Central.
GO; GO:0005262; F:calcium channel activity; IEA:Ensembl.
GO; GO:0004175; F:endopeptidase activity; IBA:GO_Central.
GO; GO:0030165; F:PDZ domain binding; IEA:Ensembl.
GO; GO:0000186; P:activation of MAPKK activity; IEA:Ensembl.
GO; GO:0042987; P:amyloid precursor protein catabolic process; IBA:GO_Central.
GO; GO:0034205; P:amyloid-beta formation; IEA:Ensembl.
GO; GO:0050435; P:amyloid-beta metabolic process; IBA:GO_Central.
GO; GO:0002265; P:astrocyte activation involved in immune response; IEA:Ensembl.
GO; GO:0000045; P:autophagosome assembly; IEA:Ensembl.
GO; GO:0001568; P:blood vessel development; IEA:Ensembl.
GO; GO:0048854; P:brain morphogenesis; IEA:Ensembl.
GO; GO:0021870; P:Cajal-Retzius cell differentiation; IEA:Ensembl.
GO; GO:0006816; P:calcium ion transport; IBA:GO_Central.
GO; GO:0060070; P:canonical Wnt signaling pathway; IBA:GO_Central.
GO; GO:0001708; P:cell fate specification; IEA:Ensembl.
GO; GO:0098609; P:cell-cell adhesion; IEA:Ensembl.
GO; GO:1904646; P:cellular response to amyloid-beta; IEA:Ensembl.
GO; GO:0006974; P:cellular response to DNA damage stimulus; IEA:Ensembl.
GO; GO:0021795; P:cerebral cortex cell migration; IEA:Ensembl.
GO; GO:0015871; P:choline transport; IEA:Ensembl.
GO; GO:0021904; P:dorsal/ventral neural tube patterning; IEA:Ensembl.
GO; GO:0030326; P:embryonic limb morphogenesis; IEA:Ensembl.
GO; GO:0050673; P:epithelial cell proliferation; IEA:Ensembl.
GO; GO:0001947; P:heart looping; IEA:Ensembl.
GO; GO:0002244; P:hematopoietic progenitor cell differentiation; IEA:Ensembl.
GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
GO; GO:0015813; P:L-glutamate transport; IEA:Ensembl.
GO; GO:0006509; P:membrane protein ectodomain proteolysis; IBA:GO_Central.
GO; GO:0007613; P:memory; IEA:Ensembl.
GO; GO:0006839; P:mitochondrial transport; IEA:Ensembl.
GO; GO:0090647; P:modulation of age-related behavioral decline; IEA:Ensembl.
GO; GO:0043011; P:myeloid dendritic cell differentiation; IEA:Ensembl.
GO; GO:0043066; P:negative regulation of apoptotic process; IBA:GO_Central.
GO; GO:2001234; P:negative regulation of apoptotic signaling pathway; IEA:Ensembl.
GO; GO:0050771; P:negative regulation of axonogenesis; IEA:Ensembl.
GO; GO:1904797; P:negative regulation of core promoter binding; IEA:Ensembl.
GO; GO:0007175; P:negative regulation of epidermal growth factor-activated receptor activity; IEA:Ensembl.
GO; GO:2000059; P:negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IEA:Ensembl.
GO; GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IEA:Ensembl.
GO; GO:0051444; P:negative regulation of ubiquitin-protein transferase activity; IEA:Ensembl.
GO; GO:0051402; P:neuron apoptotic process; IEA:Ensembl.
GO; GO:0048666; P:neuron development; IEA:Ensembl.
GO; GO:0001764; P:neuron migration; IEA:Ensembl.
GO; GO:1990535; P:neuron projection maintenance; IEA:Ensembl.
GO; GO:0007220; P:Notch receptor processing; IBA:GO_Central.
GO; GO:0007219; P:Notch signaling pathway; IEA:UniProtKB-KW.
GO; GO:1905908; P:positive regulation of amyloid fibril formation; IEA:Ensembl.
GO; GO:0043065; P:positive regulation of apoptotic process; IEA:Ensembl.
GO; GO:0050820; P:positive regulation of coagulation; IEA:Ensembl.
GO; GO:0060999; P:positive regulation of dendritic spine development; IEA:Ensembl.
GO; GO:0032436; P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process; IEA:Ensembl.
GO; GO:0032092; P:positive regulation of protein binding; IEA:Ensembl.
GO; GO:0033160; P:positive regulation of protein import into nucleus, translocation; IEA:Ensembl.
GO; GO:0001921; P:positive regulation of receptor recycling; IEA:Ensembl.
GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IEA:Ensembl.
GO; GO:0009791; P:post-embryonic development; IEA:Ensembl.
GO; GO:0006486; P:protein glycosylation; IEA:Ensembl.
GO; GO:0016485; P:protein processing; IEA:Ensembl.
GO; GO:0015031; P:protein transport; IEA:Ensembl.
GO; GO:0060828; P:regulation of canonical Wnt signaling pathway; IEA:Ensembl.
GO; GO:0060075; P:regulation of resting membrane potential; IEA:Ensembl.
GO; GO:0048167; P:regulation of synaptic plasticity; IEA:Ensembl.
GO; GO:0051966; P:regulation of synaptic transmission, glutamatergic; IEA:Ensembl.
GO; GO:0006979; P:response to oxidative stress; IEA:Ensembl.
GO; GO:0048705; P:skeletal system morphogenesis; IEA:Ensembl.
GO; GO:0043589; P:skin morphogenesis; IEA:Ensembl.
GO; GO:0051563; P:smooth endoplasmic reticulum calcium ion homeostasis; IBA:GO_Central.
GO; GO:0001756; P:somitogenesis; IEA:Ensembl.
GO; GO:0050808; P:synapse organization; IEA:Ensembl.
GO; GO:0016080; P:synaptic vesicle targeting; IEA:Ensembl.
GO; GO:0002286; P:T cell activation involved in immune response; IEA:Ensembl.
GO; GO:0050852; P:T cell receptor signaling pathway; IEA:Ensembl.
GO; GO:0048538; P:thymus development; IEA:Ensembl.
InterPro; IPR002031; Pept_A22A_PS1.
InterPro; IPR001108; Peptidase_A22A.
InterPro; IPR006639; Preselin/SPP.
PANTHER; PTHR10202; PTHR10202; 1.
Pfam; PF01080; Presenilin; 1.
PRINTS; PR01072; PRESENILIN.
PRINTS; PR01073; PRESENILIN1.
SMART; SM00730; PSN; 1.
1: Evidence at protein level;
Complete proteome {ECO:0000313|Proteomes:UP000008227};
Endoplasmic reticulum {ECO:0000256|RuleBase:RU361148};
Golgi apparatus {ECO:0000256|RuleBase:RU361148};
Hydrolase {ECO:0000256|RuleBase:RU361148};
Membrane {ECO:0000256|RuleBase:RU361148,
ECO:0000256|SAAS:SAAS00075488};
Notch signaling pathway {ECO:0000256|RuleBase:RU361148};
Protease {ECO:0000256|RuleBase:RU361148};
Proteomics identification {ECO:0000213|PeptideAtlas:F1S3K9};
Reference proteome {ECO:0000313|Proteomes:UP000008227};
Transmembrane {ECO:0000256|RuleBase:RU361148,
ECO:0000256|SAAS:SAAS00075488};
Transmembrane helix {ECO:0000256|RuleBase:RU361148,
ECO:0000256|SAAS:SAAS00075488}.
TRANSMEM 83 101 Helical. {ECO:0000256|RuleBase:RU361148}.
TRANSMEM 134 155 Helical. {ECO:0000256|RuleBase:RU361148}.
TRANSMEM 162 184 Helical. {ECO:0000256|RuleBase:RU361148}.
TRANSMEM 196 214 Helical. {ECO:0000256|RuleBase:RU361148}.
TRANSMEM 226 242 Helical. {ECO:0000256|RuleBase:RU361148}.
TRANSMEM 248 269 Helical. {ECO:0000256|RuleBase:RU361148}.
TRANSMEM 408 428 Helical. {ECO:0000256|RuleBase:RU361148}.
TRANSMEM 434 453 Helical. {ECO:0000256|RuleBase:RU361148}.
SEQUENCE 467 AA; 52483 MW; 2AF0468E3B0BA20F CRC64;
MTELPAPLSY FQNAQMSEDN HLSNTVRSQN DSRERHEHSI ERRRRGNSES LSNGGAQGNS
RQVVEQEEEE DEELTLKYGA KHVIMLFVPV TLCMVVVVAT IKSVSFYTRK DGQLIYTPFT
EDTETVGQRA LHSILNAAIM ISVIVVMTIL LVVLYKYRCY KVIHAWLIIS SLLLLFFFSF
IYLGEVFKTY NVAMDYITVA LLIWNFGVVG MIAIHWKGPL RLQQAYLIMI SALMALVFIK
YLPEWTAWLI LAVISVYDLV AVLCPNGPLR LLVETAQERN ETLFPALIYS STMVWLVNMA
EGDPEAQRKV SKNSNYNAQS TGESQDSVTE SDDGGFSEEW EAQRDSRLGP HHSTAESRSA
VQDLSRSIPA TEDPEERGVK LGLGDFIFYS VLVGKASATA SGDWNTTIAC FVAILIGLCL
TLLLLAIFKK ALPALPISIT FGLVFYFATD YLVQPFMDQL AFHQFYI


Related products :

Catalog number Product name Quantity
LF-PA50211 anti-Presenilin 2, Rabbit polyclonal to Presenilin 2, Isotype IgG, Host Rabbit 200 ul
18-783-75579 RABBIT ANTI HUMAN PEN2 (N-TERMINAL) - PRESENILIN ENHANCER PROTEIN 2; Presenilin enhancer protein 2 Polyclonal 0.1 mg
18-783-75578 RABBIT ANTI HUMAN PEN2 (C-TERMINAL) - PRESENILIN ENHANCER PROTEIN 2; Presenilin enhancer protein 2 Polyclonal 0.1 mg
20-272-190981 Presenilin 2 - Mouse monoclonal [198C679.2.1] to Presenilin 2 Monoclonal 0.2 ml
LF-PA42514 Anti-Presenilin (PSEN1_PSEN2), Rabbit Polyclonal to Presenilin (PSEN1_PSEN2), Isotype , Host Rabbit 50
LF-PA40949 anti-Presenilin 1 (PSEN1) , Rabbit polyclonal to Presenilin 1 (PSEN1) , Isotype IgG, Host Rabbit 50 ug
18-272-195356 Presenilin 1 - Rabbit polyclonal to Presenilin 1 Polyclonal 0.05 ml
18-272-195358 Presenilin 2 - Goat polyclonal to Presenilin 2 Polyclonal 0.05 ml
20-272-191196 Presenilin 1 - Mouse monoclonal [APS 18] to Presenilin 1 Monoclonal 0.2 mg
orb72134 Presenilin 1 peptide This is Presenilin 1 peptide. For research use only. 1 mg
20-272-191195 Presenilin 1 - Mouse monoclonal [APS 11] to Presenilin 1 Monoclonal 0.2 mg
18-272-195017 Presenilin 1 - Rabbit polyclonal to Presenilin 1 Polyclonal 0.1 ml
18-272-196425 Presenilin 1 prediluted - Rabbit polyclonal to Presenilin 1 prediluted Polyclonal 7 ml
GTX116016 Presenilin 1 100 µl
PA1358 Presenilin 2 100μg
Y104296 Presenilin 1 1mg
SP2742b Presenilin 1 (349-361) 5 mg
GTX101028 Presenilin 1 100 µl
SP2741a [Ala 353, 367]Presenilin 1 (349-361) 1 mg
SP2742b Presenilin 1 (349-361)
SP2741b [Ala 353, 367]Presenilin 1 (349-361)
SP2741b [Ala 353, 367]Presenilin 1 (349-361) 5 mg
SP2742a Presenilin 1 (349-361) 2
SP2741a [Ala 353, 367]Presenilin 1 (349-361) 2
AP06290PU-N Presenilin 1 100 µg


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur