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Pro-MCH [Cleaved into: Neuropeptide-glycine-glutamic acid (NGE) (Neuropeptide G-E); Neuropeptide-glutamic acid-isoleucine (NEI) (Neuropeptide E-I); Melanin-concentrating hormone (MCH)]

 MCH_HUMAN               Reviewed;         165 AA.
P20382; Q16044; Q8WVG0;
01-FEB-1991, integrated into UniProtKB/Swiss-Prot.
05-MAY-2009, sequence version 3.
10-OCT-2018, entry version 153.
RecName: Full=Pro-MCH;
Contains:
RecName: Full=Neuropeptide-glycine-glutamic acid;
Short=NGE;
Short=Neuropeptide G-E;
Contains:
RecName: Full=Neuropeptide-glutamic acid-isoleucine;
Short=NEI;
Short=Neuropeptide E-I;
Contains:
RecName: Full=Melanin-concentrating hormone;
Short=MCH;
Flags: Precursor;
Name=PMCH; Synonyms=MCH;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Hypothalamus;
PubMed=2149166; DOI=10.1210/mend-4-4-632;
Presse F., Nahon J.-L., Fischer W.H., Vale W.;
"Structure of the human melanin concentrating hormone mRNA.";
Mol. Endocrinol. 4:632-637(1990).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
TISSUE=Mammary cancer;
PubMed=8326825; DOI=10.1016/0169-328X(93)90093-5;
Breton C., Schorpp M., Nahon J.-L.;
"Isolation and characterization of the human melanin-concentrating
hormone gene and a variant gene.";
Brain Res. Mol. Brain Res. 18:297-310(1993).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
Venter J.C.;
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Brain;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[5]
PROTEOLYTIC PROCESSING.
PubMed=10037747; DOI=10.1074/jbc.274.10.6536;
Viale A., Ortola C., Hervieu G., Furuta M., Barbero P., Steiner D.F.,
Seidah N.G., Nahon J.-L.;
"Cellular localization and role of prohormone convertases in the
processing of pro-melanin concentrating hormone in mammals.";
J. Biol. Chem. 274:6536-6545(1999).
[6]
TISSUE SPECIFICITY.
PubMed=9191099; DOI=10.1016/S0169-328X(97)00018-1;
Viale A., Zhixing Y., Breton C., Pedeutour F., Coquerel A., Jordan D.,
Nahon J.-L.;
"The melanin-concentrating hormone gene in human: flanking region
analysis, fine chromosome mapping, and tissue-specific expression.";
Brain Res. Mol. Brain Res. 46:243-255(1997).
-!- FUNCTION: MCH may act as a neurotransmitter or neuromodulator in a
broad array of neuronal functions directed toward the regulation
of goal-directed behavior, such as food intake, and general
arousal. May also have a role in spermatocyte differentiation.
-!- SUBCELLULAR LOCATION: Secreted.
-!- TISSUE SPECIFICITY: Predominantly expressed in lateral
hypothalamus, also detected in pallidum, neocortex and cerebellum.
Also found in thymus, brown adipose tissue, duodenum and testis
(spermatogonia, early spermatocytes and Sertoli cells). No
expression in peripheral blood. In brain exclusively mature MCH
and NEI peptides are present. In peripheral tissues a large
product, encompassing the NEI and MCH domains of the precursor, is
found predominantly. {ECO:0000269|PubMed:9191099}.
-!- PTM: Differentially processed in the brain and in peripheral
organs producing two neuropeptides; NEI and MCH. A third peptide,
NGE, may also be produced. Preferential processing in neurons by
prohormone convertase 2 (PC2) generates NEI. MCH is generated in
neurons of the lateral hypothalmic area by several prohormone
convertases including PC1/3, PC2 and PC5/6.
{ECO:0000269|PubMed:10037747}.
-!- SIMILARITY: Belongs to the melanin-concentrating hormone family.
{ECO:0000305}.
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EMBL; M57703; AAA63214.1; -; mRNA.
EMBL; S63697; AAB27493.1; -; Genomic_DNA.
EMBL; CH471054; EAW97693.1; -; Genomic_DNA.
EMBL; BC018048; AAH18048.1; -; mRNA.
CCDS; CCDS31885.1; -.
PIR; I52634; I52634.
RefSeq; NP_002665.2; NM_002674.3.
UniGene; Hs.707990; -.
ProteinModelPortal; P20382; -.
SMR; P20382; -.
BioGrid; 111380; 14.
STRING; 9606.ENSP00000332225; -.
BioMuta; PMCH; -.
DMDM; 229462960; -.
PaxDb; P20382; -.
PeptideAtlas; P20382; -.
PRIDE; P20382; -.
ProteomicsDB; 53758; -.
DNASU; 5367; -.
Ensembl; ENST00000329406; ENSP00000332225; ENSG00000183395.
GeneID; 5367; -.
KEGG; hsa:5367; -.
UCSC; uc001tjl.4; human.
CTD; 5367; -.
DisGeNET; 5367; -.
EuPathDB; HostDB:ENSG00000183395.4; -.
GeneCards; PMCH; -.
HGNC; HGNC:9109; PMCH.
HPA; HPA046055; -.
HPA; HPA061884; -.
MIM; 176795; gene.
neXtProt; NX_P20382; -.
OpenTargets; ENSG00000183395; -.
PharmGKB; PA33435; -.
eggNOG; ENOG410IW1Y; Eukaryota.
eggNOG; ENOG410XWB7; LUCA.
GeneTree; ENSGT00390000004984; -.
HOGENOM; HOG000230520; -.
HOVERGEN; HBG052429; -.
InParanoid; P20382; -.
KO; K05229; -.
OMA; AGSKHNF; -.
OrthoDB; EOG091G0R53; -.
PhylomeDB; P20382; -.
TreeFam; TF330944; -.
Reactome; R-HSA-375276; Peptide ligand-binding receptors.
Reactome; R-HSA-416476; G alpha (q) signalling events.
Reactome; R-HSA-418594; G alpha (i) signalling events.
SIGNOR; P20382; -.
GenomeRNAi; 5367; -.
PRO; PR:P20382; -.
Proteomes; UP000005640; Chromosome 12.
Bgee; ENSG00000183395; Expressed in 79 organ(s), highest expression level in hypothalamus.
CleanEx; HS_PMCH; -.
Genevisible; P20382; HS.
GO; GO:0005576; C:extracellular region; TAS:Reactome.
GO; GO:0005634; C:nucleus; IEA:Ensembl.
GO; GO:0030354; F:melanin-concentrating hormone activity; IEA:InterPro.
GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
GO; GO:0007268; P:chemical synaptic transmission; IEA:InterPro.
GO; GO:0007631; P:feeding behavior; ISS:UniProtKB.
GO; GO:0007186; P:G-protein coupled receptor signaling pathway; TAS:Reactome.
GO; GO:0007275; P:multicellular organism development; IEA:UniProtKB-KW.
GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
GO; GO:0007283; P:spermatogenesis; IEA:UniProtKB-KW.
InterPro; IPR005456; Prepro-melanin_conc_hormone.
PANTHER; PTHR12091; PTHR12091; 1.
Pfam; PF05824; Pro-MCH; 1.
PRINTS; PR01641; PROMCHFAMILY.
1: Evidence at protein level;
Amidation; Cleavage on pair of basic residues; Complete proteome;
Developmental protein; Differentiation; Disulfide bond; Hormone;
Neuropeptide; Reference proteome; Secreted; Signal; Spermatogenesis.
SIGNAL 1 21 {ECO:0000255}.
CHAIN 22 165 Pro-MCH.
/FTId=PRO_0000019104.
PEPTIDE 110 128 Neuropeptide-glycine-glutamic acid.
{ECO:0000255}.
/FTId=PRO_0000019105.
PEPTIDE 131 143 Neuropeptide-glutamic acid-isoleucine.
/FTId=PRO_0000019106.
PEPTIDE 147 165 Melanin-concentrating hormone.
/FTId=PRO_0000019107.
MOD_RES 143 143 Isoleucine amide. {ECO:0000250}.
DISULFID 153 162 {ECO:0000250}.
CONFLICT 42 42 F -> S (in Ref. 2; AAB27493).
{ECO:0000305}.
CONFLICT 104 106 PYL -> GYQ (in Ref. 1; AAA63214).
{ECO:0000305}.
CONFLICT 113 113 A -> D (in Ref. 1; AAA63214).
{ECO:0000305}.
SEQUENCE 165 AA; 18679 MW; 2339E8938EBEC499 CRC64;
MAKMNLSSYI LILTFSLFSQ GILLSASKSI RNLDDDMVFN TFRLGKGFQK EDTAEKSVIA
PSLEQYKNDE SSFMNEEENK VSKNTGSKHN FLNHGLPLNL AIKPYLALKG SVAFPAENGV
QNTESTQEKR EIGDEENSAK FPIGRRDFDM LRCMLGRVYR PCWQV


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